DK1294747T3 - Syntetiske fremgangsmåder for aplidine og nye antitumorale derivater, fremgangsmåder til fremstilling og anvendelse deraf - Google Patents

Syntetiske fremgangsmåder for aplidine og nye antitumorale derivater, fremgangsmåder til fremstilling og anvendelse deraf

Info

Publication number
DK1294747T3
DK1294747T3 DK01945484T DK01945484T DK1294747T3 DK 1294747 T3 DK1294747 T3 DK 1294747T3 DK 01945484 T DK01945484 T DK 01945484T DK 01945484 T DK01945484 T DK 01945484T DK 1294747 T3 DK1294747 T3 DK 1294747T3
Authority
DK
Denmark
Prior art keywords
methods
aplidine
preparing
new antitumoral
derivatives
Prior art date
Application number
DK01945484T
Other languages
English (en)
Inventor
Paloma Mendez
Lopez Maria Teresa Garcia
Rodriguez Marta Gutierrez
Herranz Rosario Herranz
Ignacio Rodriguez
Concepci N Polanco
Felix Cuevas
Carmen Cuevas
Pilar Gallego
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016148A external-priority patent/GB0016148D0/en
Priority claimed from GB0103750A external-priority patent/GB0103750D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1294747T3 publication Critical patent/DK1294747T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
DK01945484T 2000-06-30 2001-07-02 Syntetiske fremgangsmåder for aplidine og nye antitumorale derivater, fremgangsmåder til fremstilling og anvendelse deraf DK1294747T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016148A GB0016148D0 (en) 2000-06-30 2000-06-30 Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750A GB0103750D0 (en) 2001-02-15 2001-02-15 Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
PCT/GB2001/002901 WO2002002596A2 (en) 2000-06-30 2001-07-02 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

Publications (1)

Publication Number Publication Date
DK1294747T3 true DK1294747T3 (da) 2008-10-27

Family

ID=26244577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01945484T DK1294747T3 (da) 2000-06-30 2001-07-02 Syntetiske fremgangsmåder for aplidine og nye antitumorale derivater, fremgangsmåder til fremstilling og anvendelse deraf

Country Status (25)

Country Link
US (2) US7348310B2 (da)
EP (1) EP1294747B1 (da)
JP (1) JP5289662B2 (da)
KR (1) KR100866056B1 (da)
CN (2) CN1449408A (da)
AT (1) ATE393775T1 (da)
AU (1) AU6769801A (da)
BR (1) BRPI0112375B8 (da)
CA (1) CA2414609C (da)
CY (1) CY1108549T1 (da)
CZ (1) CZ304204B6 (da)
DE (1) DE60133817T2 (da)
DK (1) DK1294747T3 (da)
ES (1) ES2305083T3 (da)
HK (1) HK1052940B (da)
HU (1) HU228998B1 (da)
IL (2) IL153680A0 (da)
MX (1) MXPA03000202A (da)
NO (1) NO334096B1 (da)
NZ (1) NZ523367A (da)
PL (1) PL208651B1 (da)
PT (1) PT1294747E (da)
SI (1) SI1294747T1 (da)
UA (1) UA76718C2 (da)
WO (1) WO2002002596A2 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
NZ518847A (en) * 1999-11-15 2004-02-27 Pharma Mar S Aplidine treatment of cancers
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
IL152111A0 (en) 2000-04-07 2003-07-31 Univ Pennsylvania Tamandarin and didemnin analogs and methods of making and using them
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
US7507766B2 (en) 2000-10-12 2009-03-24 Pharma Mar, S.A. Treatment of cancers
PL1603584T3 (pl) 2003-03-12 2009-02-27 Dana Farber Cancer Inst Inc Aplidyna do leczenia szpiczaka mnogiego
EP1620117A4 (en) 2003-03-12 2009-07-29 Pharma Mar Sa IMPROVED ANTITUMORAL TREATMENTS
AU2004224418A1 (en) 2003-03-21 2004-10-07 Madeleine M. Joullie Tamandarin analogs and fragments thereof and methods of making and using
EP1942944A2 (en) * 2005-10-31 2008-07-16 Genentech, Inc. Macrocyclic depsipeptide antibody-drug conjugates and methods
EP2029155B1 (en) 2006-02-28 2016-04-13 Pharma Mar S.A. Improved treatment of multiple myeloma
EP2205263A1 (en) * 2007-10-19 2010-07-14 Pharma Mar, S.A. Improved antitumoral treatments
MX2010009697A (es) * 2008-03-07 2010-09-30 Pharm Mar S A Tratamientos anticancerigenos mejorados.
WO2011020913A2 (en) 2009-08-21 2011-02-24 Pharma Mar, S.A. Cyclodepsipeptide antiviral compounds
EP2614089A1 (fr) * 2010-09-10 2013-07-17 Sanofi-Aventis Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
KR20220150348A (ko) 2020-03-02 2022-11-10 파르마 마르, 에스.에이. 코로나바이러스의 치료에 조합하여 사용하기 위한 pld
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
CN115666615A (zh) 2020-03-02 2023-01-31 法马马有限公司 用于治疗冠状病毒感染的化合物
AU2021231197A1 (en) 2020-03-02 2022-10-06 Pharma Mar, S.A. Compounds for use in inflammatory conditions
CN115594739A (zh) * 2021-06-28 2023-01-13 浙江珲达生物科技有限公司（Cn） 一种dehydrodidemnin B类化合物的制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
US4493796A (en) 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
EP0048149B1 (en) 1980-09-12 1983-11-30 University of Illinois Foundation Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
IT1153974B (it) 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) * 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
DE4120327A1 (de) 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
US5462726A (en) 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5861439A (en) 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US6509316B2 (en) * 1995-03-07 2003-01-21 George Washington University Pharmaceutical compositions, methods, and kits for treatment and diagnosis of lung cancer
ES2102322B1 (es) * 1995-07-13 1998-03-01 Pharma Mar Sa Procedimiento de preparacion de didemnina a.
JP4172726B2 (ja) 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6156724A (en) 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
ATE245435T1 (de) * 1996-10-24 2003-08-15 Univ Illinois Totalsynthese des amino hip analogen von didemnin a
JP2001503746A (ja) * 1996-10-24 2001-03-21 ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ ジデムニン類似体の半合成法
US6034058A (en) * 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
CA2288639A1 (en) 1997-05-07 1998-11-12 Pharma Mar, S.A. Aplidine as an l-type calcium channel enhancer
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
PT1100589E (pt) 1998-07-30 2005-05-31 Sigma Tau Ind Farmaceuti Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
JP2003500360A (ja) 1999-05-25 2003-01-07 ポイント セラピューティクス， インコーポレイテッド ボロプロリン化合物類を含む抗癌剤
NZ518847A (en) 1999-11-15 2004-02-27 Pharma Mar S Aplidine treatment of cancers
IL152111A0 (en) * 2000-04-07 2003-07-31 Univ Pennsylvania Tamandarin and didemnin analogs and methods of making and using them
US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
CA2424823A1 (en) 2000-10-12 2002-04-18 Pharma Mar, S.A. Treatment of cancers by aplidine in conjunction with a myoprotector
EP1435991B1 (en) 2001-10-19 2008-10-15 Pharma Mar, S.A. Use of aplidine for the treatment of pancreatic cancer
EP1620117A4 (en) 2003-03-12 2009-07-29 Pharma Mar Sa IMPROVED ANTITUMORAL TREATMENTS

Also Published As

Publication number Publication date
DE60133817T2 (de) 2009-05-20
SI1294747T1 (sl) 2008-12-31
HUP0301387A2 (hu) 2003-08-28
CN1449408A (zh) 2003-10-15
DE60133817D1 (de) 2008-06-12
CZ20024233A3 (cs) 2003-06-18
BRPI0112375B8 (pt) 2021-05-25
HK1052940A1 (en) 2003-10-03
IL153680A0 (en) 2003-07-06
NO20026242L (no) 2003-02-27
IL153680A (en) 2012-05-31
HK1052940B (zh) 2008-10-24
CZ304204B6 (cs) 2014-01-02
WO2002002596A3 (en) 2002-05-23
ATE393775T1 (de) 2008-05-15
MXPA03000202A (es) 2003-10-15
US20080009435A1 (en) 2008-01-10
BRPI0112375B1 (pt) 2020-12-01
PT1294747E (pt) 2008-08-08
NZ523367A (en) 2004-12-24
JP5289662B2 (ja) 2013-09-11
US7348310B2 (en) 2008-03-25
US20040097413A1 (en) 2004-05-20
EP1294747B1 (en) 2008-04-30
CA2414609C (en) 2012-04-24
ES2305083T3 (es) 2008-11-01
HU228998B1 (en) 2013-07-29
WO2002002596A2 (en) 2002-01-10
UA76718C2 (uk) 2006-09-15
CN104650177A (zh) 2015-05-27
HUP0301387A3 (en) 2005-04-28
US7678765B2 (en) 2010-03-16
KR100866056B1 (ko) 2008-10-30
BR0112375A (pt) 2003-06-24
JP2004502702A (ja) 2004-01-29
KR20030013477A (ko) 2003-02-14
PL360531A1 (en) 2004-09-06
PL208651B1 (pl) 2011-05-31
NO20026242D0 (no) 2002-12-27
CY1108549T1 (el) 2014-04-09
NO334096B1 (no) 2013-12-09
EP1294747A2 (en) 2003-03-26
AU6769801A (en) 2002-01-14
CA2414609A1 (en) 2002-01-10

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