DK1283217T3 - Antistoffer mod IL-8-receptoren og deres terapeutiske anvendelser - Google Patents

Antistoffer mod IL-8-receptoren og deres terapeutiske anvendelser

Info

Publication number: DK1283217T3
Authority: DK; Denmark
Prior art keywords: receptor; antibodies; therapeutic uses; inhibitors; binding
Prior art date: 1993-09-14

Application number

DK02017044T

Other languages

English (en)

Inventor

Patricia A Tekamp-Olson

Guy Mullenbach

Mary Ellen Wernette-Hammond

Original Assignee

Novartis Vaccines & Diagnostic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-14

Filing date

1994-09-13

Publication date

2008-07-07

1994-09-13 Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic

2008-07-07 Application granted granted Critical

2008-07-07 Publication of DK1283217T3 publication Critical patent/DK1283217T3/da

Links

102000010681 interleukin-8 receptors Human genes 0.000 title abstract 3
108010038415 interleukin-8 receptors Proteins 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 2
102000005962 receptors Human genes 0.000 abstract 2
108020003175 receptors Proteins 0.000 abstract 2
230000004071 biological effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Biophysics (AREA)
AIDS & HIV (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02017044T 1993-09-14 1994-09-13 Antistoffer mod IL-8-receptoren og deres terapeutiske anvendelser DK1283217T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/121,105 US6448379B1 (en)	1993-09-14	1993-09-14	IL8 inhibitors
PCT/US1994/010356 WO1995007934A2 (en)	1993-09-14	1994-09-13	Il8 inhibitors

Publications (1)

Publication Number	Publication Date
DK1283217T3 true DK1283217T3 (da)	2008-07-07

Family

ID=22394586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02017044T DK1283217T3 (da)	1993-09-14	1994-09-13	Antistoffer mod IL-8-receptoren og deres terapeutiske anvendelser

Country Status (11)

Country	Link
US (2)	US6448379B1 (da)
EP (3)	EP1932856A3 (da)
JP (3)	JPH09502725A (da)
AT (2)	ATE388168T1 (da)
AU (1)	AU697190B2 (da)
CA (1)	CA2171289C (da)
DE (2)	DE69435083T2 (da)
DK (1)	DK1283217T3 (da)
ES (1)	ES2302774T3 (da)
PT (1)	PT1283217E (da)
WO (1)	WO1995007934A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997000893A1 (en) *	1995-06-20	1997-01-09	Chiron Corporation	Interleukin-8 receptor binding compounds
US7083983B2 (en)	1996-07-05	2006-08-01	Cancer Research Campaign Technology Limited	Inhibitors of the interaction between P53 and MDM2
AU777766B2 (en) *	1996-07-05	2004-10-28	Cancer Research Technology Limited	Inhibitors of the interaction between p53 and MDM2
EP0939634A4 (en) *	1996-08-15	2001-02-21	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
WO1998046597A1 (en) *	1997-04-14	1998-10-22	Emory University	Serine protease inhibitors
ES2156534B1 (es) *	1999-02-03	2002-02-01	Smithkline Beecham Sa	Nuevos inhibidores de la interaccion entre la interleuquina-8 y sus receptores
JP2003530325A (ja) *	2000-03-31	2003-10-14	イーペーエフファルマシューティカルスゲゼルシャフトミットベシュレンクテルハフツング	好ましくは特異的ケモカインレセプター分析、及びケモカインレセプター／リガンド相互作用の助けによる、腫瘍及び炎症細胞の細胞表面プロテオームの調査、並びに腫瘍疾患及び炎症性疾患の治療のための診断薬及び薬剤
AU2003299641C1 (en) *	2002-12-16	2016-06-02	Cormorant Pharmaceuticals Ab	Human monoclonal antibodies against interleukin 8 (IL-8)
CL2008001071A1 (es) *	2007-04-17	2009-05-22	Smithkline Beecham Corp	Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
KR101650995B1 (ko)	2010-11-08	2016-08-25	노파르티스 아게	Ｃｘｃｒ２ 결합 폴리펩티드
US9328174B2 (en)	2012-05-09	2016-05-03	Novartis Ag	Chemokine receptor binding polypeptides
WO2014006115A1 (en)	2012-07-06	2014-01-09	Novartis Ag	Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction
AU2017339942B2 (en) *	2016-10-03	2023-06-29	Dompe Farmaceutici S.P.A.	Prevention and treatment of diabetic nephropathy
AU2019207812A1 (en)	2018-01-12	2020-07-23	Bristol-Myers Squibb Company	Combination therapy with anti-IL-8 antibodies and anti-PD-1 antibodies for treating cancer
JP7429427B2 (ja)	2020-01-31	2024-02-08	株式会社大都技研	抽出装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ207394A (en) *	1983-03-08	1987-03-06	Commw Serum Lab Commission	Detecting or determining sequence of amino acids
IE913192A1 (en)	1990-09-12	1992-02-25	Scripps Research Inst	Active site of interleukin-8: polypeptide analogs and¹antibodies
JP2866182B2 (ja)	1990-10-08	1999-03-08	日本ケミファ株式会社	エンドセリン受容体
US5552284A (en) *	1991-03-29	1996-09-03	Genentech, Inc.	Detection of interleukin-8 receptors by nudeic acid hybridization
US5440021A (en) *	1991-03-29	1995-08-08	Chuntharapai; Anan	Antibodies to human IL-8 type B receptor
JPH06506596A (ja) *	1991-04-10	1994-07-28	ザ　トラスティーズ　オブ　ボストン　ユニバーシティー	インターロイキン−８受容体及び関連分子及び方法
US5374506A (en)	1991-09-13	1994-12-20	The United States Of America As Represented By The Department Of Health And Human Services	Amino acid sequence for a functional human interleukin-8 receptor

1993
- 1993-09-14 US US08/121,105 patent/US6448379B1/en not_active Expired - Lifetime
1994
- 1994-09-13 DK DK02017044T patent/DK1283217T3/da active
- 1994-09-13 AT AT02017044T patent/ATE388168T1/de not_active IP Right Cessation
- 1994-09-13 JP JP7509317A patent/JPH09502725A/ja not_active Withdrawn
- 1994-09-13 DE DE69435083T patent/DE69435083T2/de not_active Expired - Lifetime
- 1994-09-13 DE DE69431843T patent/DE69431843T2/de not_active Expired - Lifetime
- 1994-09-13 AU AU78348/94A patent/AU697190B2/en not_active Ceased
- 1994-09-13 WO PCT/US1994/010356 patent/WO1995007934A2/en active IP Right Grant
- 1994-09-13 EP EP08000646A patent/EP1932856A3/en not_active Withdrawn
- 1994-09-13 AT AT94929201T patent/ATE229036T1/de not_active IP Right Cessation
- 1994-09-13 EP EP94929201A patent/EP0719285B1/en not_active Expired - Lifetime
- 1994-09-13 CA CA002171289A patent/CA2171289C/en not_active Expired - Fee Related
- 1994-09-13 ES ES02017044T patent/ES2302774T3/es not_active Expired - Lifetime
- 1994-09-13 PT PT02017044T patent/PT1283217E/pt unknown
- 1994-09-13 EP EP02017044A patent/EP1283217B1/en not_active Expired - Lifetime
1995
- 1995-06-07 US US08/487,795 patent/US6436390B1/en not_active Expired - Lifetime
2004
- 2004-09-08 JP JP2004261714A patent/JP4122321B2/ja not_active Expired - Fee Related
2008
- 2008-03-14 JP JP2008066818A patent/JP2008169227A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
CA2171289C (en)	2007-04-10
EP1283217A2 (en)	2003-02-12
PT1283217E (pt)	2008-06-11
DE69431843D1 (de)	2003-01-23
US6448379B1 (en)	2002-09-10
WO1995007934A3 (en)	1995-04-13
EP1932856A2 (en)	2008-06-18
US6436390B1 (en)	2002-08-20
EP0719285A1 (en)	1996-07-03
DE69435083T2 (de)	2009-03-12
CA2171289A1 (en)	1995-03-23
JP2005023085A (ja)	2005-01-27
EP0719285B1 (en)	2002-12-04
ATE229036T1 (de)	2002-12-15
AU697190B2 (en)	1998-10-01
JP4122321B2 (ja)	2008-07-23
AU7834894A (en)	1995-04-03
DE69435083D1 (de)	2008-04-17
JP2008169227A (ja)	2008-07-24
ES2302774T3 (es)	2008-08-01
EP1932856A3 (en)	2009-09-30
ATE388168T1 (de)	2008-03-15
WO1995007934A2 (en)	1995-03-23
EP1283217A3 (en)	2003-09-17
EP1283217B1 (en)	2008-03-05
DE69431843T2 (de)	2003-07-10
JPH09502725A (ja)	1997-03-18

Publication	Publication Date	Title
DK1283217T3 (da)	2008-07-07	Antistoffer mod IL-8-receptoren og deres terapeutiske anvendelser
ES2304795T3 (es)	2008-10-16	Anticuerpos agonistas para el receptor de trombopoyetina y sus usos terapeuticos.
BR0315123A (pt)	2005-08-16	Composições farmacêuticas direcionadas a receptores erb-b1
ATE359090T1 (de)	2007-05-15	Monoklonale antikörper spezifisch gegen vegf- rezeptoren und ihre verwendung
ATE516354T1 (de)	2011-07-15	Apo-2-rezeptor
CY1107133T1 (el)	2012-10-24	Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις
ATE247667T1 (de)	2003-09-15	Gdnf-rezeptor und dessen verwendung
NO960767L (no)	1996-04-26	Protocadherinproteiner og deres anvendelse
DK0851920T3 (da)	2008-09-22	Varianter af vaskulær endotelcellevækstfaktor, anvendelser af disse samt fremgangsmåder til fremstilling deraf
DE69334158D1 (de)	2007-09-06	Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
CY1112101T1 (el)	2015-11-04	Νευροτροφικοι παραγοντες
DE69837606D1 (de)	2007-05-31	Cystein-reiche rezeptoren-train
NO992916D0 (no)	1999-06-15	Fosfodiesterase 8A
ATE312915T1 (de)	2005-12-15	Neurturin-rezeptor
NO20031033D0 (no)	2003-03-06	Reseptor i EDb-fibronectindomene
IT1278034B1 (it)	1997-11-17	Apaprecchio per il controllo del peso di sigarette.
CY1109583T1 (el)	2014-08-13	Κυτοκινες θηλαστικων, αντιστοιχα αντιδραστηρια
MXPA02008462A (es)	2004-05-14	Modulacion de la actividad de receptor de superficie celular endotelial en la regulacion de angiogenesis.
ATE309371T1 (de)	2005-11-15	Protein mit dnase-aktivität