DK1252184T3 - Human C1-inhibitor produceret i mælk af transgene dyr - Google Patents
Human C1-inhibitor produceret i mælk af transgene dyrInfo
- Publication number
- DK1252184T3 DK1252184T3 DK01906428T DK01906428T DK1252184T3 DK 1252184 T3 DK1252184 T3 DK 1252184T3 DK 01906428 T DK01906428 T DK 01906428T DK 01906428 T DK01906428 T DK 01906428T DK 1252184 T3 DK1252184 T3 DK 1252184T3
- Authority
- DK
- Denmark
- Prior art keywords
- milk
- human
- transgenic animals
- inhibitor produced
- inhibitor
- Prior art date
Links
- 239000008267 milk Substances 0.000 title abstract 2
- 210000004080 milk Anatomy 0.000 title abstract 2
- 235000013336 milk Nutrition 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 title 1
- 241001465754 Metazoa Species 0.000 title 1
- 102000044507 human SERPING1 Human genes 0.000 title 1
- 102000055157 Complement C1 Inhibitor Human genes 0.000 abstract 2
- 108700040183 Complement C1 Inhibitor Proteins 0.000 abstract 2
- 206010019860 Hereditary angioedema Diseases 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C2230/00—Aspects relating to animal feed or genotype
- A23C2230/05—Milk or milk products from transgenic animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Environmental Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17931000P | 2000-01-31 | 2000-01-31 | |
EP00200320 | 2000-01-31 | ||
US18758000P | 2000-03-07 | 2000-03-07 | |
EP00200810 | 2000-03-07 | ||
PCT/NL2001/000068 WO2001057079A2 (en) | 2000-01-31 | 2001-01-31 | C1 inhibitor produced in the milk of transgenic mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1252184T3 true DK1252184T3 (da) | 2008-02-04 |
Family
ID=56290105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01906428T DK1252184T3 (da) | 2000-01-31 | 2001-01-31 | Human C1-inhibitor produceret i mælk af transgene dyr |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1252184B1 (de) |
JP (1) | JP2003521914A (de) |
AT (1) | ATE382635T1 (de) |
CA (1) | CA2398707C (de) |
DE (2) | DE60132169T2 (de) |
DK (1) | DK1252184T3 (de) |
ES (1) | ES2299473T3 (de) |
PT (1) | PT1252184E (de) |
WO (1) | WO2001057079A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7067713B2 (en) * | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
DE10112617A1 (de) * | 2001-03-14 | 2002-10-02 | Aventis Behring Gmbh | Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren |
JP2006503091A (ja) * | 2002-10-17 | 2006-01-26 | ファーミング・インテレクチュアル・プロパティー・ビー.ブイ. | タンパク質の修飾 |
EP1947116B1 (de) | 2003-02-10 | 2017-06-21 | 2-BBB Medicines B.V. | Differenziell exprimierte Nukleinsäuren der Blut-Hirnschranke bei einer Entzündung |
WO2004100982A1 (en) * | 2003-05-16 | 2004-11-25 | Pharming Intellectual Property B.V. | C1 inhibitor with short half-life for transient treatment |
KR101508668B1 (ko) * | 2005-12-21 | 2015-04-06 | 파밍 인텔렉츄얼 프라퍼티 비.브이. | 허혈-재관류 손상의 예방을 위한 c1 억제제의 용도 |
FR2901796A1 (fr) * | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
FR2901707B1 (fr) | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
PT3028716T (pt) | 2006-10-10 | 2020-11-23 | Regenesance B V | Inibição do complemento para regeneração nervosa melhorada |
JP5507555B2 (ja) * | 2008-06-30 | 2014-05-28 | チョ−エー・ファーム・カンパニー・リミテッド | 豚のαS1カゼイン遺伝子、そのプロモーター、及びその用途 |
WO2010087702A1 (en) | 2009-01-30 | 2010-08-05 | Stichting Katholieke Universiteit | TET2 gene as a marker for diagnosing a myelodysuplastic syndrome (MDS) or an acute myeloid leukemia (AML) and determining the prognosis in a subject |
JP2013505232A (ja) | 2009-09-16 | 2013-02-14 | スティヒティング ヘット ネーデルラント カンカー インスティテュート | 癌治療のための薬剤標的としてのFra−1標的遺伝子 |
EP2305717A1 (de) | 2009-09-21 | 2011-04-06 | Koninklijke Nederlandse Akademie van Wetenschappen | Hemmung von TNIK zur Behandlung von Darmkrebs |
EP2354244A1 (de) | 2010-02-04 | 2011-08-10 | Stichting Top Institute Food and Nutrition | MBL2 als Marker für die leberspezifische Insulinresistenz |
EP2354245A1 (de) | 2010-02-04 | 2011-08-10 | Stichting Top Institute Food and Nutrition | MBL2 als Marker für die hepatische PPAR-Aktivität |
CN103179977B (zh) | 2010-08-27 | 2016-10-26 | 潘塔希生物科学股份有限公司 | 治疗***癌的免疫治疗方法 |
EP2465928A1 (de) | 2010-12-16 | 2012-06-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Behandlung von Th17-vermittelten Krankheiten |
WO2014003553A1 (en) | 2012-06-27 | 2014-01-03 | Arthrogen B.V. | Combination for treating an inflammatory disorder |
JP6538561B2 (ja) | 2012-10-25 | 2019-07-03 | バイオベラティブ・ユーエスエイ・インコーポレイテッド | 抗補体C1s抗体とそれらの用途 |
CA2889197A1 (en) | 2012-11-02 | 2014-05-08 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
HUE044285T2 (hu) * | 2013-01-20 | 2019-10-28 | Dyax Corp | PKal-mediálta rendellenességek értékelése, vizsgálata és kezelése |
PT2968434T (pt) | 2013-03-15 | 2017-09-18 | Shire Viropharma Inc | Composições de c1-inh e para uso na prevenção e no tratamento de distúrbios associados a deficiência de inibidor da c1-esterase |
WO2016080830A2 (en) | 2014-11-18 | 2016-05-26 | Pantarhei Bioscience B.V. | Immunotherapeutic method for treating pancreatic cancer |
EP3280440B1 (de) | 2015-04-06 | 2022-11-16 | Bioverativ USA Inc. | Humanisierte anti-c1s-antikörper und verfahren zur verwendung davon |
WO2017087882A1 (en) * | 2015-11-19 | 2017-05-26 | Shire Human Genetic Therapies, Inc. | Recombinant human c1 esterase inhibitor and uses thereof |
WO2019166556A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Treatment and prevention of pre-eclampsia |
WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
CA3137014A1 (en) | 2019-04-16 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Methods for quantitation of functional c1 esterase inhibitor (fc1-inh) |
EP3895726A1 (de) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Verwendung von c1-esterase-inhibitoren zur behandlung von akuter atemnot im zusammenhang mit virusinfektionen |
EP4366761A1 (de) | 2021-07-09 | 2024-05-15 | Pharming Intellectual Property B.V. | Verwendung von c1-esterase-inhibitor zur behandlung von symptomen im zusammenhang mit virusinfektionen |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601034B1 (fr) * | 1986-07-03 | 1989-11-17 | Pasteur Institut | Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese |
WO1991006650A1 (en) * | 1989-10-27 | 1991-05-16 | Cetus Corporation | C1 inhibitor muteins and uses thereof |
WO1992022320A1 (en) * | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
DE4244735A1 (de) * | 1992-08-24 | 1994-03-31 | Behringwerke Ag | Verwendung von C1-Inaktivator zur Bekämpfung von Komplikationen bei der Anwendung von Zytokinen, endogenen Mediatoren, gentechnisch produzierten Mediator-Hybriden oder Wachstumsfaktoren im Rahmen der therapeutischen Anwendung dieser Substanzen |
US6713662B1 (en) * | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
GB9807464D0 (en) * | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
-
2001
- 2001-01-31 EP EP01906428A patent/EP1252184B1/de not_active Expired - Lifetime
- 2001-01-31 ES ES01906428T patent/ES2299473T3/es not_active Expired - Lifetime
- 2001-01-31 DK DK01906428T patent/DK1252184T3/da active
- 2001-01-31 DE DE60132169T patent/DE60132169T2/de not_active Expired - Lifetime
- 2001-01-31 PT PT01906428T patent/PT1252184E/pt unknown
- 2001-01-31 AT AT01906428T patent/ATE382635T1/de active
- 2001-01-31 DE DE122011000002C patent/DE122011000002I1/de active Pending
- 2001-01-31 JP JP2001557910A patent/JP2003521914A/ja not_active Withdrawn
- 2001-01-31 WO PCT/NL2001/000068 patent/WO2001057079A2/en active IP Right Grant
- 2001-01-31 CA CA2398707A patent/CA2398707C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2398707A1 (en) | 2001-08-09 |
WO2001057079A3 (en) | 2002-08-15 |
DE60132169D1 (de) | 2008-02-14 |
DE60132169T2 (de) | 2008-12-11 |
EP1252184B1 (de) | 2008-01-02 |
PT1252184E (pt) | 2008-04-15 |
ES2299473T3 (es) | 2008-06-01 |
ATE382635T1 (de) | 2008-01-15 |
CA2398707C (en) | 2010-10-26 |
JP2003521914A (ja) | 2003-07-22 |
WO2001057079A2 (en) | 2001-08-09 |
EP1252184A2 (de) | 2002-10-30 |
DE122011000002I1 (de) | 2011-05-05 |
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