DK1251846T3 - C4-Carbonattaxaner - Google Patents

C4-Carbonattaxaner

Info

Publication number: DK1251846T3
Authority: DK; Denmark
Prior art keywords: compounds; formula; carbonattaxaner; 3cch2; ch3c
Prior art date: 2000-02-03

Application number

DK00980427T

Other languages

English (en)

Inventor

John F Kadow

James G Tarrant

Harold Mastalerz

Qiufen May Xue

Steven Hansel

Mary Edson Zoeckler

William C Rose

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-03

Filing date

2000-11-16

Publication date

2004-11-29

2000-11-16 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-11-29 Application granted granted Critical

2004-11-29 Publication of DK1251846T3 publication Critical patent/DK1251846T3/da

Links

150000001875 compounds Chemical class 0.000 abstract 2
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
-1 cyclobutyl- Chemical group 0.000 abstract 1
125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
229940126701 oral medication Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Carbon And Carbon Compounds (AREA)

DK00980427T 2000-02-03 2000-11-16 C4-Carbonattaxaner DK1251846T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17996500P	2000-02-03	2000-02-03
PCT/US2000/031484 WO2001056565A1 (en)	2000-02-03	2000-11-16	C-4 carbonate taxanes

Publications (1)

Publication Number	Publication Date
DK1251846T3 true DK1251846T3 (da)	2004-11-29

Family

ID=22658728

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00980427T DK1251846T3 (da)	2000-02-03	2000-11-16	C4-Carbonattaxaner

Country Status (20)

Country	Link
US (1)	US6750246B1 (da)
EP (1)	EP1251846B1 (da)
JP (1)	JP2003523971A (da)
AT (1)	ATE273005T1 (da)
AU (1)	AU778284B2 (da)
CA (1)	CA2399116A1 (da)
CZ (1)	CZ20022956A3 (da)
DE (1)	DE60012988T2 (da)
DK (1)	DK1251846T3 (da)
ES (1)	ES2226954T3 (da)
HK (1)	HK1047891B (da)
MY (1)	MY129310A (da)
NZ (1)	NZ521136A (da)
PE (1)	PE20020747A1 (da)
PT (1)	PT1251846E (da)
RU (1)	RU2243223C2 (da)
TR (1)	TR200402454T4 (da)
TW (2)	TWI245041B (da)
WO (1)	WO2001056565A1 (da)
ZA (1)	ZA200207037B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
US6916942B2 (en) *	2000-02-03	2005-07-12	Bristol-Myers Squibb Company	Process for the preparation of C-4 carbonate taxanes
UY27185A1 (es) *	2001-02-28	2002-09-30	Bristol Myers Squibb Co	Dosificación metronómica de taxanos
EP1623706A3 (en) *	2001-02-28	2006-02-22	Bristol-Myers Squibb Company	Metronomic dosing of taxanes for inhibiting tumor growth
US7063977B2 (en) *	2001-08-21	2006-06-20	Bristol-Myers Squibb Company	Enzymatic resolution of t-butyl taxane derivatives
BR0215184A (pt) *	2001-12-20	2006-06-06	Bristol Myers Squibb Co	composições farmacêuticas de derivados de taxano oralmente ativos tendo biodisponibilidade aumentada
US20070105944A1 (en) *	2002-10-25	2007-05-10	Comezoglu S N	Taxane metabolites
US7371759B2 (en) *	2003-09-25	2008-05-13	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
TW200533339A (en) *	2004-03-16	2005-10-16	Bristol Myers Squibb Co	Therapeutic synergy of anti-cancer compounds
US7459562B2 (en) *	2004-04-23	2008-12-02	Bristol-Myers Squibb Company	Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) *	2004-04-26	2005-12-01	Bristol Myers Squibb Co	Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) *	2004-06-28	2008-10-21	Bristol-Myers Squibb Company	Fused heterocyclic kinase inhibitors
US7432373B2 (en) *	2004-06-28	2008-10-07	Bristol-Meyers Squibb Company	Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7173031B2 (en)	2004-06-28	2007-02-06	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US20060116420A1 (en) *	2004-11-23	2006-06-01	Ramakrishnan Chidambaram	Crystalline forms of 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel
US20060258736A1 (en) *	2005-05-12	2006-11-16	Bristol-Myers Squibb Company	Dosing regimen
US20080221135A1 (en) *	2005-05-13	2008-09-11	Bristol-Myers Squibb Company	Combination therapy
US7348325B2 (en)	2005-11-30	2008-03-25	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
PL217731B1 (pl)	2006-06-01	2014-08-29	Tomasz Byrski	Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
CN105801550B (zh)	2009-11-05	2019-06-14	理森制药股份公司	新型苯并吡喃激酶调节剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY110249A (en)	1989-05-31	1998-03-31	Univ Florida State	Method for preparation of taxol using beta lactam
US5284864A (en)	1991-09-23	1994-02-08	Florida State University	Butenyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en)	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5399726A (en)	1993-01-29	1995-03-21	Florida State University	Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US6521660B2 (en)	1991-09-23	2003-02-18	Florida State University	3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US6335362B1 (en)	1991-09-23	2002-01-01	Florida State University	Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5973160A (en)	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
KR100378612B1 (ko)	1992-12-23	2003-04-03	브리스톨-마이어스스퀴브컴파니	신규 측쇄-함유 탁산 및 그의 중간체 화합물
US5567592A (en)	1994-02-02	1996-10-22	Regents Of The University Of California	Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
EP0764643A1 (en)	1994-06-09	1997-03-26	Daiichi Pharmaceutical Co., Ltd.	Deacetoxytaxol derivative
FR2726272B1 (fr) *	1994-10-26	1996-12-06	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5840929A (en)	1995-04-14	1998-11-24	Bristol-Myers Squibb Company	C4 methoxy ether derivatives of paclitaxel
TW354293B (en)	1995-06-06	1999-03-11	Bristol Myers Squibb Co	Prodrugs of paclitaxel derivatives
US6245805B1 (en)	1995-10-26	2001-06-12	Baker Norton Pharmaceuticals, Inc.	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US6964946B1 (en)	1995-10-26	2005-11-15	Baker Norton Pharmaceuticals, Inc.	Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US5739359A (en) *	1997-01-24	1998-04-14	Virginia Tech Intellectual Properties, Inc.	Methods for preparing 1-deoxy paclitaxels
HUP0101457A3 (en)	1997-12-31	2003-01-28	Bristol Myers Squibb Co	Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
PT1178979E (pt)	1999-05-17	2004-04-30	Bristol Myers Squibb Co	Novas condicoes de reaccao para a clivagem de eteres de sililo na preparacao de paclitaxel (taxol(r)) e analogos de paclitaxel
DE60010476T2 (de)	1999-08-11	2005-04-14	Bristol-Myers Squibb Co.	Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel
JP2003512443A (ja)	1999-10-27	2003-04-02	ベーカーノートンファーマシューティカルズインコーポレイテッド	タキサンをヒト患者に経口投与するための方法及び組成物
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
EP1365759A2 (en)	2001-01-18	2003-12-03	PHARMACIA & UPJOHN COMPANY	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
UY27185A1 (es)	2001-02-28	2002-09-30	Bristol Myers Squibb Co	Dosificación metronómica de taxanos
DE10154464B4 (de)	2001-11-08	2005-10-20	Max Delbrueck Centrum	Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
US20040092428A1 (en)	2001-11-27	2004-05-13	Hongming Chen	Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof

2000
- 2000-11-14 US US09/712,352 patent/US6750246B1/en not_active Expired - Lifetime
- 2000-11-16 RU RU2002123641/04A patent/RU2243223C2/ru not_active IP Right Cessation
- 2000-11-16 AU AU17692/01A patent/AU778284B2/en not_active Ceased
- 2000-11-16 ES ES00980427T patent/ES2226954T3/es not_active Expired - Lifetime
- 2000-11-16 AT AT00980427T patent/ATE273005T1/de active
- 2000-11-16 TR TR2004/02454T patent/TR200402454T4/xx unknown
- 2000-11-16 WO PCT/US2000/031484 patent/WO2001056565A1/en active IP Right Grant
- 2000-11-16 CZ CZ20022956A patent/CZ20022956A3/cs unknown
- 2000-11-16 NZ NZ521136A patent/NZ521136A/en unknown
- 2000-11-16 DK DK00980427T patent/DK1251846T3/da active
- 2000-11-16 CA CA002399116A patent/CA2399116A1/en not_active Abandoned
- 2000-11-16 PT PT00980427T patent/PT1251846E/pt unknown
- 2000-11-16 DE DE60012988T patent/DE60012988T2/de not_active Expired - Lifetime
- 2000-11-16 JP JP2001556256A patent/JP2003523971A/ja active Pending
- 2000-11-16 EP EP00980427A patent/EP1251846B1/en not_active Expired - Lifetime
2001
- 2001-01-29 TW TW090101690A patent/TWI245041B/zh not_active IP Right Cessation
- 2001-01-29 TW TW094114392A patent/TWI245042B/zh not_active IP Right Cessation
- 2001-01-29 MY MYPI20010372A patent/MY129310A/en unknown
- 2001-02-02 PE PE2001000117A patent/PE20020747A1/es not_active Application Discontinuation
2002
- 2002-09-02 ZA ZA200207037A patent/ZA200207037B/en unknown
2003
- 2003-01-02 HK HK03100017.6A patent/HK1047891B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2226954T3 (es)	2005-04-01
TWI245042B (en)	2005-12-11
ATE273005T1 (de)	2004-08-15
JP2003523971A (ja)	2003-08-12
MY129310A (en)	2007-03-30
RU2002123641A (ru)	2004-01-10
DE60012988T2 (de)	2005-08-25
NZ521136A (en)	2004-05-28
WO2001056565A1 (en)	2001-08-09
HK1047891B (zh)	2005-01-28
EP1251846B1 (en)	2004-08-11
EP1251846A4 (en)	2003-03-12
HK1047891A1 (en)	2003-03-14
PT1251846E (pt)	2004-11-30
AU778284B2 (en)	2004-11-25
CA2399116A1 (en)	2001-08-09
US6750246B1 (en)	2004-06-15
TW200526613A (en)	2005-08-16
TWI245041B (en)	2005-12-11
AU1769201A (en)	2001-08-14
EP1251846A1 (en)	2002-10-30
CZ20022956A3 (cs)	2003-02-12
ZA200207037B (en)	2003-12-02
PE20020747A1 (es)	2002-08-17
DE60012988D1 (en)	2004-09-16
RU2243223C2 (ru)	2004-12-27
TR200402454T4 (tr)	2004-12-21

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