DK1231898T3 - Apparat og fremgangsmåde til fremstilling af mikropartikler - Google Patents

Apparat og fremgangsmåde til fremstilling af mikropartikler

Info

Publication number
DK1231898T3
DK1231898T3 DK00991722T DK00991722T DK1231898T3 DK 1231898 T3 DK1231898 T3 DK 1231898T3 DK 00991722 T DK00991722 T DK 00991722T DK 00991722 T DK00991722 T DK 00991722T DK 1231898 T3 DK1231898 T3 DK 1231898T3
Authority
DK
Denmark
Prior art keywords
emulsion
mixing assembly
static mixing
microparticles
static
Prior art date
Application number
DK00991722T
Other languages
English (en)
Inventor
Shawn L Lyons
Steven G Wright
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of DK1231898T3 publication Critical patent/DK1231898T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00991722T 1999-11-12 2000-11-03 Apparat og fremgangsmåde til fremstilling af mikropartikler DK1231898T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/438,659 US6331317B1 (en) 1999-11-12 1999-11-12 Apparatus and method for preparing microparticles
PCT/US2000/041842 WO2001034113A2 (en) 1999-11-12 2000-11-03 Apparatus and method for preparing microparticles

Publications (1)

Publication Number Publication Date
DK1231898T3 true DK1231898T3 (da) 2007-04-10

Family

ID=23741495

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00991722T DK1231898T3 (da) 1999-11-12 2000-11-03 Apparat og fremgangsmåde til fremstilling af mikropartikler

Country Status (12)

Country Link
US (7) US6331317B1 (da)
EP (1) EP1231898B1 (da)
JP (1) JP4146639B2 (da)
AT (1) ATE349201T1 (da)
AU (1) AU771497B2 (da)
CA (1) CA2390284C (da)
CY (1) CY1106372T1 (da)
DE (1) DE60032631T2 (da)
DK (1) DK1231898T3 (da)
ES (1) ES2277867T3 (da)
PT (1) PT1231898E (da)
WO (1) WO2001034113A2 (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495166B1 (en) * 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6705757B2 (en) * 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
WO2001069245A2 (en) * 2000-03-14 2001-09-20 Trustees Of Tufts College Cross-reactive sensors
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US20030168731A1 (en) * 2002-03-11 2003-09-11 Matayabas James Christopher Thermal interface material and method of fabricating the same
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US6998074B1 (en) 2002-08-30 2006-02-14 Microfab Technologies, Inc. Method for forming polymer microspheres
BR0306204A (pt) * 2002-08-30 2004-09-08 Torrent Pharmaceuticals Ltd Processo melhorado para a preparação de risperidona
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
WO2004070026A1 (en) * 2003-02-07 2004-08-19 Labatt Brewing Company Limited Continuous process for immobilization of yeast in k-carrageenan gel beads
US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
DE10334593B3 (de) * 2003-07-28 2005-04-21 Framatome Anp Gmbh Mischsystem
EP1742979A4 (en) * 2004-04-23 2008-05-21 Eugenia Kumacheva METHOD FOR PRODUCING POLYMER PARTICLES OF SELECTED SIZE, MOLD, MORPHOLOGY AND COMPOSITION
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
US20090204104A1 (en) * 2004-05-13 2009-08-13 Medtronic Vascular, Inc Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
US7789983B1 (en) * 2005-04-13 2010-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for making insensitive enhanced blast explosive molding powders
US20070047384A1 (en) * 2005-09-01 2007-03-01 Mclaughlin Jon K Control system for and method of combining materials
US8616760B2 (en) * 2005-09-01 2013-12-31 The Procter & Gamble Company Control system for and method of combining materials
US20080031085A1 (en) * 2005-09-01 2008-02-07 Mclaughlin Jon K Control system for and method of combining materials
US8240908B2 (en) * 2005-09-01 2012-08-14 The Procter & Gamble Company Control system for and method of combining materials
US8153180B2 (en) * 2005-09-06 2012-04-10 Pepsico, Inc. Method and apparatus for making beverages
BRPI0706947B8 (pt) * 2006-01-24 2021-05-25 Ansun Biopharma Inc método de preparação de uma composição de micropartícula
JP5629432B2 (ja) * 2006-04-10 2014-11-19 Ｊｘ日鉱日石エネルギー株式会社 連続乳化方法およびそのための乳化装置
JP2010512705A (ja) * 2006-12-12 2010-04-22 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 高効率変調ｒｆ増幅器
US8295692B2 (en) * 2007-02-12 2012-10-23 Gaumer Company, Inc. Scissor baffles for fuel gas conditioning system
US8391696B2 (en) * 2007-02-12 2013-03-05 Gaumer Company, Inc. Fuel gas conditioning system with scissor baffles
US8709827B2 (en) * 2007-06-28 2014-04-29 Surmodics, Inc. Polypeptide microparticles
US20090022805A1 (en) * 2007-06-28 2009-01-22 Joram Slager Polypeptide microparticles having sustained release characteristics, methods and uses
ITSA20070024A1 (it) 2007-07-27 2009-01-28 Univ Degli Studi Salerno Processo continuo per la produzione di microsfere mediante liquidi espansi.
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
EP2306991B1 (en) 2008-06-27 2019-12-25 Tepha, Inc. Injectable delivery of microparticles and compositions therefore
JP5107220B2 (ja) * 2008-12-11 2012-12-26 三菱重工業株式会社 燃料供給装置及びガスタービン
KR101135614B1 (ko) * 2008-12-23 2012-04-17 제일모직주식회사 스태틱 믹서용 혼합부재 및 이를 이용하는 스태틱 믹서
WO2010085607A1 (en) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
CH701225A1 (de) * 2009-06-05 2010-12-15 Medmix Systems Ag Mischvorrichtung zur Herstellung einer Mischung aus mindestens drei Komponenten.
US8207290B2 (en) * 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
SI2394664T1 (sl) * 2010-05-31 2016-10-28 Laboratorios Farmaceuticos Rovi, S.A. Antipsihotični depojski sestavek za injiciranje
US8393782B2 (en) * 2010-07-15 2013-03-12 Robert S. Smith Motionless mixing device having primary and secondary feed ports
US8546521B2 (en) 2011-01-28 2013-10-01 Cerulean Pharma Inc. Method for fabricating nanoparticles
JP2015527310A (ja) 2012-06-28 2015-09-17 アンサン バイオファーマ, インコーポレイテッドAnsun Biopharma, Inc. 下気道および中枢気道への送達用微粒子製剤ならびに製造方法
JP5314794B2 (ja) * 2012-08-27 2013-10-16 三菱重工業株式会社 燃料供給装置及びガスタービン
RS56427B2 (sr) 2013-06-20 2023-04-28 Pharmathen Sa Priprema polilaktidnih-poliglikolidnih mikročestica koje imaju sigmoidalni profil oslobađanja
WO2015178892A1 (en) * 2014-05-20 2015-11-26 Texas State University Fluidic system for high throughput preparation of microparticles and nanoparticles
US10783678B2 (en) * 2016-08-24 2020-09-22 Bj Services, Llc System and method for blending of bulk dry materials in oil well cementing
EP3870263A4 (en) 2018-10-23 2022-08-03 ABK Biomedical Incorporated DISPENSING DEVICE
WO2020160323A2 (en) 2019-01-31 2020-08-06 Elektrofi, Inc. Particle formation and morphology
AU2020344675A1 (en) 2019-09-13 2022-03-31 Elektrofi, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
CN115484934A (zh) * 2020-04-17 2022-12-16 伊勒卓菲公司 通过连续液滴形成和脱水形成颗粒的方法
EP4163006B8 (en) 2021-10-11 2024-03-20 leon-nanodrugs GmbH Methods for validating an apparatus for producing nanoparticles

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1626487A (en) * 1924-01-10 1927-04-26 Warren David Emulsifier
BE634668A (da) 1962-07-11
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE1964923C2 (de) * 1969-12-24 1982-08-26 Agfa-Gevaert Ag, 5090 Leverkusen Mischdüsenventil für eine Vorrichtung zur kontinuierlichen Herstellung einer Mischung
DE2010115A1 (de) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
DE2106526C3 (de) * 1971-02-11 1979-03-15 Agfa-Gevaert Ag, 5090 Leverkusen Verfahren und Vorrichtung zur kontinuierlichen Zubereitung photographischer Emulsionen
JPS523342B2 (da) 1972-01-26 1977-01-27
US3773098A (en) * 1972-02-04 1973-11-20 Bjorksten J Method of static mixing to produce metal foam
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4050676A (en) * 1974-04-19 1977-09-27 Yasushi Morishima Mixing device and element therefor
IT1015665B (it) * 1974-07-04 1977-05-20 Snam Progetti Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo
JPS523653A (en) 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
DE2755166A1 (de) * 1977-12-10 1979-06-13 Agfa Gevaert Ag Verfahren und vorrichtung zur kontinuierlichen herstellung von photographischen emulsionen
US4230630A (en) * 1978-07-19 1980-10-28 Canada Packers Limited Continuous process and apparatus for adsorbent bleaching of triglyceride oils
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
AU2810189A (en) 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
US5006436A (en) * 1988-09-20 1991-04-09 Atochem North America, Inc. UV curable compositions for making tentable solder mask coating
IL92344A0 (en) 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
US5076705A (en) * 1990-08-01 1991-12-31 Texaco, Inc. Static mixing system with high turndown ratios to minimize pressure drops
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
HU222501B1 (hu) 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
DK0669128T3 (da) 1992-11-17 2000-06-19 Yoshitomi Pharmaceutical Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
EP1649850A1 (en) 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent
JP3645906B2 (ja) 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された３−ピペリジニル−置換１，２−ベンズイソオキサゾール類及び１，２−ベンズイソチアゾール類
US5421408A (en) * 1994-04-14 1995-06-06 Atlantic Richfield Company Simultaneous water and gas injection into earth formations
US5670093A (en) * 1996-02-14 1997-09-23 Atlantic Richfield Company Fluid distribution system and method utilizing a radial splitter
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6495166B1 (en) * 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles

Also Published As

Publication number Publication date
AU771497B2 (en) 2004-03-25
US20040197469A1 (en) 2004-10-07
CA2390284A1 (en) 2001-05-17
JP2003513710A (ja) 2003-04-15
ATE349201T1 (de) 2007-01-15
US6713090B2 (en) 2004-03-30
CY1106372T1 (el) 2011-10-12
DE60032631D1 (de) 2007-02-08
ES2277867T3 (es) 2007-08-01
WO2001034113A3 (en) 2002-03-14
JP4146639B2 (ja) 2008-09-10
PT1231898E (pt) 2007-03-30
US6540393B1 (en) 2003-04-01
US20050196457A1 (en) 2005-09-08
EP1231898A2 (en) 2002-08-21
US6331317B1 (en) 2001-12-18
CA2390284C (en) 2008-10-21
WO2001034113A2 (en) 2001-05-17
US20010031801A1 (en) 2001-10-18
DE60032631T2 (de) 2007-10-04
EP1231898B1 (en) 2006-12-27
AU3437901A (en) 2001-06-06
US20020146461A1 (en) 2002-10-10
US6537586B2 (en) 2003-03-25
US20030147967A1 (en) 2003-08-07
US6861016B2 (en) 2005-03-01
US6395304B2 (en) 2002-05-28

Similar Documents

Publication Publication Date Title
DK1231898T3 (da) Apparat og fremgangsmåde til fremstilling af mikropartikler
EP1004350A3 (en) Method and device for mixing liquids
ATE16082T1 (de) Vorrichtung zum kontinuierlichen mischen und homogenisieren von pulverfoermigen mit fluessigen stoffen.
DK0702594T3 (da) Fremgangsmåder og apparat til fremstilling og udlevering af knoglecement
ATE485031T1 (de) Verfahren und vorrichtung zur herstellung von liposomen
ATE161204T1 (de) Mischen flüssiger substanzen
DE69405483D1 (de) Apparat zum Mischen und Feststellen der Homogenität "on-line"
DE69937049D1 (de) Verfahren zur herstellung von teilchenförmigen zusammensetzungen
ATE286722T1 (de) Apparat und methode zur herstellung von mikropartikeln auf basis einer in-line lösungsmittel extraktion
DK153593C (da) Apparat til styring af vaeskemaengdestroem, isaer ved intravenoes administration af vaeske
ATE311244T1 (de) Vorrichtung zum mischen und anschliessendem versprühen von flüssigkeiten
SE9602179L (sv) Doseringsanordning för att med ett kontinuerligt förfarande blanda en strömmande primärvätska med en eller flera tillförda sekundärvätskor samt sätt att sammanblanda två eller flera vätskor
DE69301887D1 (de) Verfahren und Apparat zur dosierten Abgabe von Flüssigkeiten, insbesondere von Flüssiggas
DK166190D0 (da) Fremgangsmaade til tilblanding af flydedygtige tilsaetninger til polyol samt apparat til udfoerelse af fremgangsmaaden
DE69817566D1 (de) Verfahren zur herstelung expandierter schlacke
DK0931454T3 (da) Apparat til findeling og blanding af foderkomponenter til dyrefoder
NO20042051L (no) Fremgangsmate og anordning for a danne et skum av en gass og en vaeske
ATE316666T1 (de) Vorrichtung und verfahren zum mischen einer flüssigkeit
ES2122832A1 (es) Instalacion multifuncional y procedimiento para la fabricacion de explosivos de base acuosa.
DE59405412D1 (de) Verfahren zum dosieren und vorrichtung hierfür
DE69033869D1 (de) Phenylpyrimidinderivate, Verfahren zur Herstellung, diese als wirksamen Stoff enthaltende Flüssigkristallzusammensetzungen, und sie verwendende Flüssigkristallelemente
JPS6451129A (en) Method and apparatus for mixing of liquids and delivery of ejection of their mixture
MY112849A (en) Shear mixing apparatus and use thereof
ATE440670T1 (de) Verfahren und vorrichtung zur bildung von gasblasen in einer flüssigkeit
JPS5781821A (en) Mixing feeder for liquid raw-material of synthetic resin