DK1231898T3 - Apparat og fremgangsmåde til fremstilling af mikropartikler - Google Patents
Apparat og fremgangsmåde til fremstilling af mikropartiklerInfo
- Publication number
- DK1231898T3 DK1231898T3 DK00991722T DK00991722T DK1231898T3 DK 1231898 T3 DK1231898 T3 DK 1231898T3 DK 00991722 T DK00991722 T DK 00991722T DK 00991722 T DK00991722 T DK 00991722T DK 1231898 T3 DK1231898 T3 DK 1231898T3
- Authority
- DK
- Denmark
- Prior art keywords
- emulsion
- mixing assembly
- static mixing
- microparticles
- static
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000003068 static effect Effects 0.000 abstract 5
- 239000000839 emulsion Substances 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/438,659 US6331317B1 (en) | 1999-11-12 | 1999-11-12 | Apparatus and method for preparing microparticles |
PCT/US2000/041842 WO2001034113A2 (en) | 1999-11-12 | 2000-11-03 | Apparatus and method for preparing microparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1231898T3 true DK1231898T3 (da) | 2007-04-10 |
Family
ID=23741495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00991722T DK1231898T3 (da) | 1999-11-12 | 2000-11-03 | Apparat og fremgangsmåde til fremstilling af mikropartikler |
Country Status (12)
Country | Link |
---|---|
US (7) | US6331317B1 (da) |
EP (1) | EP1231898B1 (da) |
JP (1) | JP4146639B2 (da) |
AT (1) | ATE349201T1 (da) |
AU (1) | AU771497B2 (da) |
CA (1) | CA2390284C (da) |
CY (1) | CY1106372T1 (da) |
DE (1) | DE60032631T2 (da) |
DK (1) | DK1231898T3 (da) |
ES (1) | ES2277867T3 (da) |
PT (1) | PT1231898E (da) |
WO (1) | WO2001034113A2 (da) |
Families Citing this family (53)
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US6495166B1 (en) * | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
WO2001069245A2 (en) * | 2000-03-14 | 2001-09-20 | Trustees Of Tufts College | Cross-reactive sensors |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US20030168731A1 (en) * | 2002-03-11 | 2003-09-11 | Matayabas James Christopher | Thermal interface material and method of fabricating the same |
US6998051B2 (en) * | 2002-07-03 | 2006-02-14 | Ferro Corporation | Particles from supercritical fluid extraction of emulsion |
US6998074B1 (en) | 2002-08-30 | 2006-02-14 | Microfab Technologies, Inc. | Method for forming polymer microspheres |
BR0306204A (pt) * | 2002-08-30 | 2004-09-08 | Torrent Pharmaceuticals Ltd | Processo melhorado para a preparação de risperidona |
US6966990B2 (en) | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
US7083748B2 (en) * | 2003-02-07 | 2006-08-01 | Ferro Corporation | Method and apparatus for continuous particle production using supercritical fluid |
WO2004070026A1 (en) * | 2003-02-07 | 2004-08-19 | Labatt Brewing Company Limited | Continuous process for immobilization of yeast in k-carrageenan gel beads |
US20040224030A1 (en) * | 2003-05-06 | 2004-11-11 | Shastri Venkatram R. | Microsphere delivery systems |
US20060008531A1 (en) * | 2003-05-08 | 2006-01-12 | Ferro Corporation | Method for producing solid-lipid composite drug particles |
DE10334593B3 (de) * | 2003-07-28 | 2005-04-21 | Framatome Anp Gmbh | Mischsystem |
EP1742979A4 (en) * | 2004-04-23 | 2008-05-21 | Eugenia Kumacheva | METHOD FOR PRODUCING POLYMER PARTICLES OF SELECTED SIZE, MOLD, MORPHOLOGY AND COMPOSITION |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
US20090204104A1 (en) * | 2004-05-13 | 2009-08-13 | Medtronic Vascular, Inc | Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel |
WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
US7789983B1 (en) * | 2005-04-13 | 2010-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for making insensitive enhanced blast explosive molding powders |
US20070047384A1 (en) * | 2005-09-01 | 2007-03-01 | Mclaughlin Jon K | Control system for and method of combining materials |
US8616760B2 (en) * | 2005-09-01 | 2013-12-31 | The Procter & Gamble Company | Control system for and method of combining materials |
US20080031085A1 (en) * | 2005-09-01 | 2008-02-07 | Mclaughlin Jon K | Control system for and method of combining materials |
US8240908B2 (en) * | 2005-09-01 | 2012-08-14 | The Procter & Gamble Company | Control system for and method of combining materials |
US8153180B2 (en) * | 2005-09-06 | 2012-04-10 | Pepsico, Inc. | Method and apparatus for making beverages |
BRPI0706947B8 (pt) * | 2006-01-24 | 2021-05-25 | Ansun Biopharma Inc | método de preparação de uma composição de micropartícula |
JP5629432B2 (ja) * | 2006-04-10 | 2014-11-19 | Jx日鉱日石エネルギー株式会社 | 連続乳化方法およびそのための乳化装置 |
JP2010512705A (ja) * | 2006-12-12 | 2010-04-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 高効率変調rf増幅器 |
US8295692B2 (en) * | 2007-02-12 | 2012-10-23 | Gaumer Company, Inc. | Scissor baffles for fuel gas conditioning system |
US8391696B2 (en) * | 2007-02-12 | 2013-03-05 | Gaumer Company, Inc. | Fuel gas conditioning system with scissor baffles |
US8709827B2 (en) * | 2007-06-28 | 2014-04-29 | Surmodics, Inc. | Polypeptide microparticles |
US20090022805A1 (en) * | 2007-06-28 | 2009-01-22 | Joram Slager | Polypeptide microparticles having sustained release characteristics, methods and uses |
ITSA20070024A1 (it) | 2007-07-27 | 2009-01-28 | Univ Degli Studi Salerno | Processo continuo per la produzione di microsfere mediante liquidi espansi. |
EP2222281B1 (en) | 2007-12-20 | 2018-12-05 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
EP2306991B1 (en) | 2008-06-27 | 2019-12-25 | Tepha, Inc. | Injectable delivery of microparticles and compositions therefore |
JP5107220B2 (ja) * | 2008-12-11 | 2012-12-26 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
KR101135614B1 (ko) * | 2008-12-23 | 2012-04-17 | 제일모직주식회사 | 스태틱 믹서용 혼합부재 및 이를 이용하는 스태틱 믹서 |
WO2010085607A1 (en) * | 2009-01-23 | 2010-07-29 | Surmodics Pharmaceuticals, Inc. | Continuous double emulsion process for making microparticles |
CH701225A1 (de) * | 2009-06-05 | 2010-12-15 | Medmix Systems Ag | Mischvorrichtung zur Herstellung einer Mischung aus mindestens drei Komponenten. |
US8207290B2 (en) * | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
SI2394664T1 (sl) * | 2010-05-31 | 2016-10-28 | Laboratorios Farmaceuticos Rovi, S.A. | Antipsihotični depojski sestavek za injiciranje |
US8393782B2 (en) * | 2010-07-15 | 2013-03-12 | Robert S. Smith | Motionless mixing device having primary and secondary feed ports |
US8546521B2 (en) | 2011-01-28 | 2013-10-01 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
JP2015527310A (ja) | 2012-06-28 | 2015-09-17 | アンサン バイオファーマ, インコーポレイテッドAnsun Biopharma, Inc. | 下気道および中枢気道への送達用微粒子製剤ならびに製造方法 |
JP5314794B2 (ja) * | 2012-08-27 | 2013-10-16 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
RS56427B2 (sr) | 2013-06-20 | 2023-04-28 | Pharmathen Sa | Priprema polilaktidnih-poliglikolidnih mikročestica koje imaju sigmoidalni profil oslobađanja |
WO2015178892A1 (en) * | 2014-05-20 | 2015-11-26 | Texas State University | Fluidic system for high throughput preparation of microparticles and nanoparticles |
US10783678B2 (en) * | 2016-08-24 | 2020-09-22 | Bj Services, Llc | System and method for blending of bulk dry materials in oil well cementing |
EP3870263A4 (en) | 2018-10-23 | 2022-08-03 | ABK Biomedical Incorporated | DISPENSING DEVICE |
WO2020160323A2 (en) | 2019-01-31 | 2020-08-06 | Elektrofi, Inc. | Particle formation and morphology |
AU2020344675A1 (en) | 2019-09-13 | 2022-03-31 | Elektrofi, Inc. | Compositions and methods for the delivery of therapeutic biologics for treatment of disease |
CN115484934A (zh) * | 2020-04-17 | 2022-12-16 | 伊勒卓菲公司 | 通过连续液滴形成和脱水形成颗粒的方法 |
EP4163006B8 (en) | 2021-10-11 | 2024-03-20 | leon-nanodrugs GmbH | Methods for validating an apparatus for producing nanoparticles |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1626487A (en) * | 1924-01-10 | 1927-04-26 | Warren David | Emulsifier |
BE634668A (da) | 1962-07-11 | |||
BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE1964923C2 (de) * | 1969-12-24 | 1982-08-26 | Agfa-Gevaert Ag, 5090 Leverkusen | Mischdüsenventil für eine Vorrichtung zur kontinuierlichen Herstellung einer Mischung |
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
DE2106526C3 (de) * | 1971-02-11 | 1979-03-15 | Agfa-Gevaert Ag, 5090 Leverkusen | Verfahren und Vorrichtung zur kontinuierlichen Zubereitung photographischer Emulsionen |
JPS523342B2 (da) | 1972-01-26 | 1977-01-27 | ||
US3773098A (en) * | 1972-02-04 | 1973-11-20 | Bjorksten J | Method of static mixing to produce metal foam |
GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US4050676A (en) * | 1974-04-19 | 1977-09-27 | Yasushi Morishima | Mixing device and element therefor |
IT1015665B (it) * | 1974-07-04 | 1977-05-20 | Snam Progetti | Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo |
JPS523653A (en) | 1975-06-27 | 1977-01-12 | Fuji Photo Film Co Ltd | Process for producing fine polymer particles |
DE2755166A1 (de) * | 1977-12-10 | 1979-06-13 | Agfa Gevaert Ag | Verfahren und vorrichtung zur kontinuierlichen herstellung von photographischen emulsionen |
US4230630A (en) * | 1978-07-19 | 1980-10-28 | Canada Packers Limited | Continuous process and apparatus for adsorbent bleaching of triglyceride oils |
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
AU2810189A (en) | 1987-10-30 | 1989-05-23 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
US5006436A (en) * | 1988-09-20 | 1991-04-09 | Atochem North America, Inc. | UV curable compositions for making tentable solder mask coating |
IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
WO1990013361A1 (en) | 1989-05-04 | 1990-11-15 | Southern Research Institute | Improved encapsulation process and products therefrom |
US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
US5076705A (en) * | 1990-08-01 | 1991-12-31 | Texaco, Inc. | Static mixing system with high turndown ratios to minimize pressure drops |
IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
HU222501B1 (hu) | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
DK0669128T3 (da) | 1992-11-17 | 2000-06-19 | Yoshitomi Pharmaceutical | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
EP1649850A1 (en) | 1993-11-19 | 2006-04-26 | Alkermes Controlled Therapeutics Inc. II | Preparation of biodegradable microparticles containing a biologically active agent |
JP3645906B2 (ja) | 1993-11-19 | 2005-05-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | マイクロカプセル封入された3−ピペリジニル−置換1,2−ベンズイソオキサゾール類及び1,2−ベンズイソチアゾール類 |
US5421408A (en) * | 1994-04-14 | 1995-06-06 | Atlantic Richfield Company | Simultaneous water and gas injection into earth formations |
US5670093A (en) * | 1996-02-14 | 1997-09-23 | Atlantic Richfield Company | Fluid distribution system and method utilizing a radial splitter |
US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
US6495166B1 (en) * | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
-
1999
- 1999-11-12 US US09/438,659 patent/US6331317B1/en not_active Expired - Lifetime
-
2000
- 2000-11-03 AT AT00991722T patent/ATE349201T1/de active
- 2000-11-03 EP EP00991722A patent/EP1231898B1/en not_active Expired - Lifetime
- 2000-11-03 DK DK00991722T patent/DK1231898T3/da active
- 2000-11-03 CA CA002390284A patent/CA2390284C/en not_active Expired - Lifetime
- 2000-11-03 ES ES00991722T patent/ES2277867T3/es not_active Expired - Lifetime
- 2000-11-03 DE DE60032631T patent/DE60032631T2/de not_active Expired - Lifetime
- 2000-11-03 JP JP2001536113A patent/JP4146639B2/ja not_active Expired - Lifetime
- 2000-11-03 WO PCT/US2000/041842 patent/WO2001034113A2/en active IP Right Grant
- 2000-11-03 AU AU34379/01A patent/AU771497B2/en not_active Expired
- 2000-11-03 PT PT00991722T patent/PT1231898E/pt unknown
-
2001
- 2001-04-10 US US09/828,849 patent/US6395304B2/en not_active Expired - Lifetime
- 2001-08-16 US US09/930,450 patent/US6540393B1/en not_active Expired - Lifetime
-
2002
- 2002-04-01 US US10/109,641 patent/US6537586B2/en not_active Expired - Lifetime
-
2003
- 2003-01-31 US US10/355,061 patent/US6713090B2/en not_active Expired - Lifetime
- 2003-11-17 US US10/713,039 patent/US6861016B2/en not_active Expired - Lifetime
-
2005
- 2005-01-26 US US11/041,985 patent/US20050196457A1/en not_active Abandoned
-
2007
- 2007-03-13 CY CY20071100347T patent/CY1106372T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU771497B2 (en) | 2004-03-25 |
US20040197469A1 (en) | 2004-10-07 |
CA2390284A1 (en) | 2001-05-17 |
JP2003513710A (ja) | 2003-04-15 |
ATE349201T1 (de) | 2007-01-15 |
US6713090B2 (en) | 2004-03-30 |
CY1106372T1 (el) | 2011-10-12 |
DE60032631D1 (de) | 2007-02-08 |
ES2277867T3 (es) | 2007-08-01 |
WO2001034113A3 (en) | 2002-03-14 |
JP4146639B2 (ja) | 2008-09-10 |
PT1231898E (pt) | 2007-03-30 |
US6540393B1 (en) | 2003-04-01 |
US20050196457A1 (en) | 2005-09-08 |
EP1231898A2 (en) | 2002-08-21 |
US6331317B1 (en) | 2001-12-18 |
CA2390284C (en) | 2008-10-21 |
WO2001034113A2 (en) | 2001-05-17 |
US20010031801A1 (en) | 2001-10-18 |
DE60032631T2 (de) | 2007-10-04 |
EP1231898B1 (en) | 2006-12-27 |
AU3437901A (en) | 2001-06-06 |
US20020146461A1 (en) | 2002-10-10 |
US6537586B2 (en) | 2003-03-25 |
US20030147967A1 (en) | 2003-08-07 |
US6861016B2 (en) | 2005-03-01 |
US6395304B2 (en) | 2002-05-28 |
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