DK1228073T3 - Imidazolforbindelser som phosphodiesterase VII-inhibitorer - Google Patents

Imidazolforbindelser som phosphodiesterase VII-inhibitorer

Info

Publication number: DK1228073T3
Authority: DK; Denmark
Prior art keywords: imidazole compounds; phosphodiesterase vii; vii inhibitors; inhibitors; phosphodiesterase
Prior art date: 1999-11-13

Application number

DK00975978T

Other languages

Danish (da)

English (en)

Inventor

Hans Michael Eggenweiler

Rochus Jonas

Michael Wolf

Michael Gassen

Thomas Welge

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-13

Filing date

2000-10-31

Publication date

2003-11-03

2000-10-31 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-11-03 Application granted granted Critical

2003-11-03 Publication of DK1228073T3 publication Critical patent/DK1228073T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems

DK00975978T 1999-11-13 2000-10-31 Imidazolforbindelser som phosphodiesterase VII-inhibitorer DK1228073T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19954707A DE19954707A1 (de)	1999-11-13	1999-11-13	Imidazolverbindungen als Phosphodiesterase VII-Hemmer
PCT/EP2000/010765 WO2001036425A2 (de)	1999-11-13	2000-10-31	Imidazolverbindungen als phosphodiesterase vii-hemmer

Publications (1)

Publication Number	Publication Date
DK1228073T3 true DK1228073T3 (da)	2003-11-03

Family

ID=7928973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00975978T DK1228073T3 (da)	1999-11-13	2000-10-31	Imidazolforbindelser som phosphodiesterase VII-inhibitorer

Country Status (23)

Country	Link
US (1)	US6884800B1 (hu)
EP (1)	EP1228073B1 (hu)
JP (1)	JP4819272B2 (hu)
KR (1)	KR20020049051A (hu)
CN (1)	CN1390222A (hu)
AR (1)	AR026421A1 (hu)
AT (1)	ATE245653T1 (hu)
AU (1)	AU775886B2 (hu)
BR (1)	BR0015487A (hu)
CA (1)	CA2391087A1 (hu)
CZ (1)	CZ20021474A3 (hu)
DE (2)	DE19954707A1 (hu)
DK (1)	DK1228073T3 (hu)
ES (1)	ES2200968T3 (hu)
HU (1)	HUP0203422A3 (hu)
MX (1)	MXPA02004728A (hu)
NO (1)	NO20022232L (hu)
PL (1)	PL355098A1 (hu)
PT (1)	PT1228073E (hu)
RU (1)	RU2002113759A (hu)
SK (1)	SK6012002A3 (hu)
WO (1)	WO2001036425A2 (hu)
ZA (1)	ZA200204729B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2217956B1 (es) *	2003-01-23	2006-04-01	Almirall Prodesfarma, S.A.	Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2026813A2 (en)	2006-05-09	2009-02-25	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2377531A2 (en)	2006-05-09	2011-10-19	Braincells, Inc.	Neurogenesis by modulating angiotensin
US7998971B2 (en)	2006-09-08	2011-08-16	Braincells Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
AU2008230710B2 (en) *	2007-03-27	2014-04-10	Omeros Corporation	The use of PDE7 inhibitors for the treatment of movement disorders
US8637528B2 (en) *	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
DE102007047738A1 (de) *	2007-10-05	2009-04-09	Merck Patent Gmbh	Imidazolderivate
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CN103547267A (zh)	2010-11-08	2014-01-29	奥默罗斯公司	使用pde7抑制剂治疗成瘾和冲动控制障碍
EP2804603A1 (en)	2012-01-10	2014-11-26	President and Fellows of Harvard College	Beta-cell replication promoting compounds and methods of their use
MX2020000295A (es)	2017-07-12	2020-07-22	Dart Neuroscience Llc	Compuestos de benzoxazol y benzofurano sustituidos como inhibidores de pde7.
WO2024038089A1 (en)	2022-08-18	2024-02-22	Mitodicure Gmbh	Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2919271A (en) *	1957-12-05	1959-12-29	Smith Kline French Lab	3-amino-1, 2-dihydro-3h-pyrido [3, 2, 1-kl]-phenothiazines
HU210264B (en) *	1989-06-09	1995-03-28	Upjohn Co	Process for producing amines of condensed ring-systems containing nitrogen and pharmaceutical compositions containing them
US5318965A (en) *	1990-08-24	1994-06-07	Abbott Laboratories	Quinobenzoxazine, antineoplastic agents
ZA9810766B (en) *	1997-11-28	1999-05-25	Mochida Pharm Co Ltd	Novel compounds having cgmp-pde inhibitory activity

1999
- 1999-11-13 DE DE19954707A patent/DE19954707A1/de not_active Withdrawn
2000
- 2000-10-31 AU AU13907/01A patent/AU775886B2/en not_active Ceased
- 2000-10-31 US US10/129,629 patent/US6884800B1/en not_active Expired - Fee Related
- 2000-10-31 RU RU2002113759/04A patent/RU2002113759A/ru unknown
- 2000-10-31 HU HU0203422A patent/HUP0203422A3/hu unknown
- 2000-10-31 BR BR0015487-3A patent/BR0015487A/pt not_active Application Discontinuation
- 2000-10-31 CZ CZ20021474A patent/CZ20021474A3/cs unknown
- 2000-10-31 EP EP00975978A patent/EP1228073B1/de not_active Expired - Lifetime
- 2000-10-31 WO PCT/EP2000/010765 patent/WO2001036425A2/de not_active Application Discontinuation
- 2000-10-31 ES ES00975978T patent/ES2200968T3/es not_active Expired - Lifetime
- 2000-10-31 DE DE50003036T patent/DE50003036D1/de not_active Expired - Lifetime
- 2000-10-31 SK SK601-2002A patent/SK6012002A3/sk unknown
- 2000-10-31 KR KR1020027006131A patent/KR20020049051A/ko not_active Application Discontinuation
- 2000-10-31 PL PL00355098A patent/PL355098A1/xx unknown
- 2000-10-31 JP JP2001538914A patent/JP4819272B2/ja not_active Expired - Fee Related
- 2000-10-31 AT AT00975978T patent/ATE245653T1/de not_active IP Right Cessation
- 2000-10-31 CN CN00815534A patent/CN1390222A/zh active Pending
- 2000-10-31 MX MXPA02004728A patent/MXPA02004728A/es not_active Application Discontinuation
- 2000-10-31 DK DK00975978T patent/DK1228073T3/da active
- 2000-10-31 PT PT00975978T patent/PT1228073E/pt unknown
- 2000-10-31 CA CA002391087A patent/CA2391087A1/en not_active Abandoned
- 2000-11-10 AR ARP000105929A patent/AR026421A1/es unknown
2002
- 2002-05-10 NO NO20022232A patent/NO20022232L/no not_active Application Discontinuation
- 2002-06-12 ZA ZA200204729A patent/ZA200204729B/en unknown

Also Published As

Publication number	Publication date
KR20020049051A (ko)	2002-06-24
CZ20021474A3 (cs)	2002-07-17
EP1228073B1 (de)	2003-07-23
ES2200968T3 (es)	2004-03-16
BR0015487A (pt)	2002-07-02
ATE245653T1 (de)	2003-08-15
AU775886B2 (en)	2004-08-19
US6884800B1 (en)	2005-04-26
AU1390701A (en)	2001-05-30
RU2002113759A (ru)	2004-01-10
HUP0203422A2 (hu)	2003-02-28
ZA200204729B (en)	2003-11-26
DE19954707A1 (de)	2001-05-17
CA2391087A1 (en)	2001-05-25
DE50003036D1 (de)	2003-08-28
MXPA02004728A (es)	2002-08-30
AR026421A1 (es)	2003-02-12
SK6012002A3 (en)	2002-09-10
JP4819272B2 (ja)	2011-11-24
CN1390222A (zh)	2003-01-08
EP1228073A2 (de)	2002-08-07
PT1228073E (pt)	2003-12-31
PL355098A1 (en)	2004-04-05
WO2001036425A3 (de)	2002-01-10
NO20022232D0 (no)	2002-05-10
HUP0203422A3 (en)	2004-12-28
WO2001036425A2 (de)	2001-05-25
NO20022232L (no)	2002-05-10
JP2003514821A (ja)	2003-04-22

Publication	Publication Date	Title
NO20021239D0 (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
NO20031006L (no)	2003-03-04	Imidazolo-5-yl-2-anilino-pyrimidiner som midler for inhibering av celleproliferasjon
NO20015650L (no)	2001-11-20	Pyrrolotriazin-inhibitorer for kinaser
ATE256127T1 (de)	2003-12-15	Betacarbolinderivate als phosphodiesterase- inhibitoren
NL300242I1 (nl)	2006-12-01	Mega-carboxyaryl gesubstitueerde difenylureums alsraf kinaseremmers.
ATE294805T1 (de)	2005-05-15	Triazoloverbindungen als mmp-inhibitoren
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
DK1228073T3 (da)	2003-11-03	Imidazolforbindelser som phosphodiesterase VII-inhibitorer
NO20023828L (no)	2002-09-30	Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer
EE200100502A (et)	2002-12-16	Ühendid
EE200300049A (et)	2004-10-15	Imidasooli derivaadid
DE60106252D1 (de)	2004-11-11	Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
DK1185529T3 (da)	2005-02-07	Pyrazolbenzodiazepiner som CDK2-inhibitorer
NO20022125D0 (no)	2002-05-03	Pyrrolderivater som inhibitorer for fosfodiesterase VII
ATE291575T1 (de)	2005-04-15	N-carbamoyloxyalkyl-substituierte azolium- verbindungen
ATE305470T1 (de)	2005-10-15	Naphthyridinverbindungen
DK1226143T3 (da)	2003-06-30	Imidazopyridinderivater som phosphodiesterase VII-inhibitorer
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
NO20021959D0 (no)	2002-04-25	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
ID29533A (id)	2001-09-06	Senyawa-senyawa kalsilitik
DK1222193T3 (da)	2003-12-01	Imidazolderivater som phosphodiesterase VII-inhibitorer
NO20022123D0 (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
DE60009260D1 (de)	2004-04-29	Thiopyranderivate as mmp-inhibitoren
DK1261588T3 (da)	2005-02-14	Imidazolforbindelser som alfa2-adrenoceptorantagonister
ID29984A (id)	2001-10-25	Senyawa-senyawa bis-stirilbifenil