DK1202992T3 - Ascididemin derivatives and their therapeutic uses - Google Patents

Ascididemin derivatives and their therapeutic uses

Info

Publication number
DK1202992T3
DK1202992T3 DK00958678T DK00958678T DK1202992T3 DK 1202992 T3 DK1202992 T3 DK 1202992T3 DK 00958678 T DK00958678 T DK 00958678T DK 00958678 T DK00958678 T DK 00958678T DK 1202992 T3 DK1202992 T3 DK 1202992T3
Authority
DK
Denmark
Prior art keywords
ascididemin
derivatives
therapeutic uses
compounds
antitumoral
Prior art date
Application number
DK00958678T
Other languages
Danish (da)
Inventor
Evelyne Delfourne
Francis Darro
Jean Bastide
Robert Kiss
Armand Frydman
Original Assignee
Cephalon France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9910490A external-priority patent/FR2797445B1/en
Priority claimed from FR0006652A external-priority patent/FR2809399B1/en
Application filed by Cephalon France filed Critical Cephalon France
Application granted granted Critical
Publication of DK1202992T3 publication Critical patent/DK1202992T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention concerns a pharmaceutical composition comprising an efficient amount of a compound selected among the compounds of formulae (I) and (Ia) wherein: R1, R2, R3, R4, R5, R6 and R7 are as defined in Claim 1. Said compounds have interesting cytotoxic properties leading to a therapeutic use as antitumoral medicines.
DK00958678T 1999-08-13 2000-08-11 Ascididemin derivatives and their therapeutic uses DK1202992T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9910490A FR2797445B1 (en) 1999-08-13 1999-08-13 ASCIDIDEMINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
FR0006652A FR2809399B1 (en) 2000-05-24 2000-05-24 NEW ASCIDIDEMINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
PCT/FR2000/002312 WO2001012631A2 (en) 1999-08-13 2000-08-11 Ascididemin derivatives and their therapeutic applications

Publications (1)

Publication Number Publication Date
DK1202992T3 true DK1202992T3 (en) 2005-01-24

Family

ID=26212422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00958678T DK1202992T3 (en) 1999-08-13 2000-08-11 Ascididemin derivatives and their therapeutic uses

Country Status (20)

Country Link
EP (1) EP1202992B1 (en)
JP (1) JP2003507381A (en)
CN (1) CN1195754C (en)
AT (1) ATE276256T1 (en)
AU (1) AU779932B2 (en)
BR (1) BR0013249A (en)
CA (1) CA2393965A1 (en)
CZ (1) CZ2002528A3 (en)
DE (1) DE60013849T2 (en)
DK (1) DK1202992T3 (en)
ES (1) ES2228602T3 (en)
HU (1) HUP0202767A3 (en)
IL (1) IL147900A0 (en)
MX (1) MXPA02001512A (en)
NO (1) NO20020668L (en)
NZ (1) NZ516896A (en)
PL (1) PL353453A1 (en)
PT (1) PT1202992E (en)
SK (1) SK1662002A3 (en)
WO (1) WO2001012631A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466021B2 (en) * 2016-12-05 2022-10-11 Merck Patent Gmbh Materials for organic electroluminescent devices

Also Published As

Publication number Publication date
SK1662002A3 (en) 2002-09-10
HUP0202767A3 (en) 2003-12-29
IL147900A0 (en) 2002-08-14
CZ2002528A3 (en) 2002-05-15
CA2393965A1 (en) 2001-02-22
BR0013249A (en) 2002-04-16
MXPA02001512A (en) 2002-07-02
AU7012400A (en) 2001-03-13
PL353453A1 (en) 2003-11-17
PT1202992E (en) 2004-12-31
EP1202992B1 (en) 2004-09-15
DE60013849D1 (en) 2004-10-21
ATE276256T1 (en) 2004-10-15
NZ516896A (en) 2004-02-27
CN1373762A (en) 2002-10-09
WO2001012631A2 (en) 2001-02-22
JP2003507381A (en) 2003-02-25
NO20020668L (en) 2002-04-15
HUP0202767A2 (en) 2003-01-28
AU779932B2 (en) 2005-02-17
NO20020668D0 (en) 2002-02-11
EP1202992A2 (en) 2002-05-08
CN1195754C (en) 2005-04-06
WO2001012631A3 (en) 2001-07-19
DE60013849T2 (en) 2005-02-03
ES2228602T3 (en) 2005-04-16

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DK1202992T3 (en) Ascididemin derivatives and their therapeutic uses