DK1144600T3 - Akt-3-nukleinsyre, polypeptider og anvendelser deraf - Google Patents

Akt-3-nukleinsyre, polypeptider og anvendelser deraf

Info

Publication number
DK1144600T3
DK1144600T3 DK00917899T DK00917899T DK1144600T3 DK 1144600 T3 DK1144600 T3 DK 1144600T3 DK 00917899 T DK00917899 T DK 00917899T DK 00917899 T DK00917899 T DK 00917899T DK 1144600 T3 DK1144600 T3 DK 1144600T3
Authority
DK
Denmark
Prior art keywords
polypeptides
act
nucleic acid
akt3
relates
Prior art date
Application number
DK00917899T
Other languages
English (en)
Inventor
Kun Guo
Marco F Pagnoni
Yuri D Ivashchenko
Kenneth L Clark
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK1144600T3 publication Critical patent/DK1144600T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
DK00917899T 1999-03-19 2000-03-14 Akt-3-nukleinsyre, polypeptider og anvendelser deraf DK1144600T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12510899P 1999-03-19 1999-03-19
PCT/US2000/006574 WO2000056866A2 (en) 1999-03-19 2000-03-14 Akt-3 nucleic acids, polypeptides, and uses thereof

Publications (1)

Publication Number Publication Date
DK1144600T3 true DK1144600T3 (da) 2008-11-24

Family

ID=22418217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917899T DK1144600T3 (da) 1999-03-19 2000-03-14 Akt-3-nukleinsyre, polypeptider og anvendelser deraf

Country Status (18)

Country Link
EP (1) EP1144600B1 (da)
JP (1) JP4237945B2 (da)
KR (1) KR100700908B1 (da)
AT (1) ATE402995T1 (da)
AU (1) AU782448B2 (da)
BR (1) BR0009170A (da)
CA (1) CA2343074C (da)
CY (1) CY1108459T1 (da)
DE (1) DE60039677D1 (da)
DK (1) DK1144600T3 (da)
ES (1) ES2310515T3 (da)
HK (1) HK1041288B (da)
IL (4) IL141984A0 (da)
NO (1) NO20014537L (da)
PT (1) PT1144600E (da)
SI (1) SI1144600T1 (da)
WO (1) WO2000056866A2 (da)
ZA (1) ZA200108414B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881555B2 (en) 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
NZ514305A (en) 1999-04-16 2004-01-30 Univ Yale eNOS mutations useful for gene therapy and therapeutic screening
JP2003530818A (ja) * 1999-06-11 2003-10-21 アベンティス・ファーマスーティカルズ・インコーポレイテツド セリン／トレオニンプロテインキナーゼＡｋｔによる血管内皮成長因子（ＶＥＧＦ）の導入
WO2003063905A1 (fr) * 2002-01-31 2003-08-07 Center For Advanced Science And Technology Incubation, Ltd. Medicaments preventifs ou remedes pour maladies immunologiques
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
WO2005009470A1 (ja) * 2003-07-28 2005-02-03 Osaka Industrial Promotion Organization Ａｓｋ１阻害剤を有効成分とする心不全治療薬およびそのスクリーニング方法
WO2009148896A2 (en) 2008-05-29 2009-12-10 Nuclea Biotechnologies, LLC Anti-phospho-akt antibodies
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
MX2012015105A (es) 2010-07-02 2013-05-28 Gilead Sciences Inc Inhibidores de cinasa de regulacion mediante señal de apoptosis.
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CA2962572A1 (en) 2014-09-24 2016-03-31 Gilead Sciences, Inc. Methods of treating liver disease with a combination of an ask1 inhibitor and a fxr agonist
EP3693366B8 (en) 2014-12-23 2023-08-09 Gilead Sciences, Inc. Processes for preparing ask1 inhibitors
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08109197A (ja) * 1994-10-07 1996-04-30 Sumitomo Electric Ind Ltd 白血病腫瘍拒絶抗原ペプチド
DK0862622T3 (da) * 1995-11-16 2004-12-20 Novartis Ag Fremgangsmåde til identifikation af forbindelser, der vekselvirker med RAC-proteinkinase
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
GB9828375D0 (en) * 1998-12-22 1999-02-17 Janssen Pharmaceutica Nv Human akt-3
US6043090A (en) * 1999-03-23 2000-03-28 Isis Pharmaceuticals Inc. Antisense inhibition of human Akt-2 expression
AU3774500A (en) * 1999-03-31 2000-10-16 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; "orfx"
JP2003530818A (ja) * 1999-06-11 2003-10-21 アベンティス・ファーマスーティカルズ・インコーポレイテツド セリン／トレオニンプロテインキナーゼＡｋｔによる血管内皮成長因子（ＶＥＧＦ）の導入

Also Published As

Publication number Publication date
WO2000056866A2 (en) 2000-09-28
WO2000056866A9 (en) 2002-08-29
ZA200108414B (en) 2003-03-26
JP4237945B2 (ja) 2009-03-11
IL190270A (en) 2012-12-31
KR100700908B1 (ko) 2007-03-29
EP1144600B1 (en) 2008-07-30
IL141984A0 (en) 2002-03-10
CA2343074A1 (en) 2000-09-28
EP1144600A2 (en) 2001-10-17
NO20014537L (no) 2001-10-31
IL145514A (en) 2010-05-17
SI1144600T1 (sl) 2008-12-31
WO2000056866A3 (en) 2001-02-15
IL145514A0 (en) 2002-06-30
ATE402995T1 (de) 2008-08-15
ES2310515T3 (es) 2009-01-16
CA2343074C (en) 2010-09-21
DE60039677D1 (de) 2008-09-11
AU3880200A (en) 2000-10-09
AU782448B2 (en) 2005-07-28
JP2002539781A (ja) 2002-11-26
NO20014537D0 (no) 2001-09-18
BR0009170A (pt) 2002-04-30
PT1144600E (pt) 2008-10-10
KR20020011972A (ko) 2002-02-09
HK1041288B (zh) 2008-11-07
CY1108459T1 (el) 2013-09-04
HK1041288A1 (en) 2002-07-05

Similar Documents

Publication Publication Date Title
CY1108459T1 (el) Ακτ-3 νουκλεϊκα οξεα, πολυπεπτιδια, και χρησεις αυτων
MX344216B (es) Productos geneticos expresados de forma diferencial en tumores y su uso.
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
DK0559884T3 (da) Rekombinante virusvektorer til ekspression i muskelceller
WO2003103589A3 (en) USE OF IL-21 IN THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS
HUP0003533A2 (hu) Interleukin-18-at kötő fehérjék, előállításuk és alkalmazásuk
ATE354638T1 (de) Menschlicher gewebsinhibitor von metalloproteinase-4
ATE374251T1 (de) Zusammensetzungen zur gentherapie von diabetes
WO2002070549A3 (en) Chimeric polypeptides of serum albumin and uses related thereto
WO2005026205A3 (de) Differentiell in tumoren exprimierte genprodukte und deren verwendung
BR0212070A (pt) ácidos nucléicos e polipeptìdeos bv8 com atividade mitogênica
IL174645A0 (en) MODIFIED cDNA FOR HIGH EXPRESSION LEVELS OF FACTOR VIII AND ITS DERIVATIVES
IS5374A (is) Aðferðir og lyfjablöndur til ýmiss konar læknismeðferðar þar sem notuð eru gen sem umrita seytt prótín á borð við interferón-beta
NZ516237A (en) Meth1 and meth2 polynucleotides and polypeptides
DE602005021159D1 (de) Bakteriophagen- und prophagen-proteine in der krebsgentherapie
DE69831231D1 (de) Modulatoren von intrazellulären entzündungs-, zelltod- und zellüberlebenswegen, die card- und kinase-domänen enthalten
WO2002014369A3 (en) Human kininogen d5 domain polypeptides and their use
UA84831C2 (ru) Производные фактора коагуляции vii
DK0811068T3 (da) Humane DNase I varianter
HUP0300813A2 (hu) Gének, fehérjék és alkalmazásuk
DE60034874D1 (de) Interne ribosom eintrittstelle (ires), vektor der diesen enthaltet und dessen therapeutische verwendung
HK1065067A1 (en) Cdna encoding the human alpha2 delta4 calcium channel subunit
WO2002034882A3 (en) Genes regulating programmed cell death
WO2002038188A3 (de) Verwendung der humanen lrp/mvp promotors für einen therapie-induzierbaren vektor
MX340898B (es) Una composicion farmaceutica a base de productos geneticos expresados de manera diferencial en tumores y usos de estos productos.