DK1125929T3 - Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester - Google Patents

Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester

Info

Publication number
DK1125929T3
DK1125929T3 DK00310064T DK00310064T DK1125929T3 DK 1125929 T3 DK1125929 T3 DK 1125929T3 DK 00310064 T DK00310064 T DK 00310064T DK 00310064 T DK00310064 T DK 00310064T DK 1125929 T3 DK1125929 T3 DK 1125929T3
Authority
DK
Denmark
Prior art keywords
trifluoromethyl
methoxycarbonylamino
quinoline
dihydro
benzyl
Prior art date
Application number
DK00310064T
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1125929T3 publication Critical patent/DK1125929T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00310064T 1999-11-30 2000-11-13 Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester DK1125929T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
DK1125929T3 true DK1125929T3 (da) 2006-04-03

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00310064T DK1125929T3 (da) 1999-11-30 2000-11-13 Fremgangsmåde til fremstilling af (-)-(2R,4S)-4-[(3,5-bis-trifluormethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluormethyl-3,4-dihydro-2H-quinolin-1-carboxylsyreethylester

Country Status (45)

Country Link
US (1) US6313142B1 (da)
EP (1) EP1125929B1 (da)
JP (1) JP3579345B2 (da)
KR (1) KR100408177B1 (da)
CN (1) CN1173953C (da)
AP (1) AP2000002011A0 (da)
AR (1) AR029775A1 (da)
AT (1) ATE315028T1 (da)
AU (1) AU784694B2 (da)
BG (1) BG105009A (da)
BR (1) BR0005636A (da)
CA (1) CA2327029C (da)
CO (1) CO5261552A1 (da)
CY (1) CY1104989T1 (da)
CZ (1) CZ20004407A3 (da)
DE (1) DE60025317T2 (da)
DK (1) DK1125929T3 (da)
DZ (1) DZ3079A1 (da)
EA (1) EA003668B1 (da)
EE (1) EE200000659A (da)
ES (1) ES2254109T3 (da)
GE (1) GEP20022798B (da)
GT (1) GT200000190A (da)
HK (1) HK1038007A1 (da)
HN (1) HN2000000203A (da)
HR (1) HRP20000804A2 (da)
HU (1) HUP0004747A3 (da)
ID (1) ID28489A (da)
IL (1) IL139849A (da)
IS (1) IS5715A (da)
MA (1) MA25223A1 (da)
NO (1) NO20006039L (da)
NZ (1) NZ508509A (da)
OA (1) OA11494A (da)
PA (1) PA8503801A1 (da)
PE (1) PE20010913A1 (da)
PL (1) PL344208A1 (da)
SG (1) SG102603A1 (da)
SK (1) SK17792000A3 (da)
TN (1) TNSN00230A1 (da)
TW (1) TW591016B (da)
UA (1) UA65615C2 (da)
UY (1) UY26451A1 (da)
YU (1) YU71500A (da)
ZA (1) ZA200006947B (da)

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TW200303302A (en) * 2001-12-19 2003-09-01 Atherogenics Inc Chalcone derivatives and their use to treat diseases
WO2003053359A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
US7279297B2 (en) * 2002-04-11 2007-10-09 Roar Holding Llc Ex vivo method for determination of CETP activity and efficacy of heart disease treatment
MXPA05003456A (es) * 2002-10-04 2005-07-05 Millennium Pharm Inc Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias.
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
DE60323536D1 (de) 2002-12-20 2008-10-23 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US20060100239A1 (en) * 2003-03-04 2006-05-11 Izuru Nagasaki Method for producing optically active amines
PL1603553T3 (pl) * 2003-03-17 2012-04-30 Japan Tobacco Inc Kompozycje farmaceutyczne inhibitorów CETP
KR20050110017A (ko) * 2003-03-17 2005-11-22 니뽄 다바코 산교 가부시키가이샤 Ｓ-'２-(''１-(２-에틸부틸)시클로헥실!카르보닐!아미노)페닐!-２-메틸프로판티오에이트의 경구 생체이용율을증가시키는 방법
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
JP4773969B2 (ja) * 2003-10-08 2011-09-14 イーライ リリー アンド カンパニー 脂質代謝異常の治療ための化合物及び方法
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
JP2008543726A (ja) * 2005-02-24 2008-12-04 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症性疾患の処置のためのｐｇｄ２受容体アンタゴニスト
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
CL2008000684A1 (es) 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica.
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸

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US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
AU784694B2 (en) 2006-06-01
EA200001129A3 (ru) 2001-10-22
HN2000000203A (es) 2001-06-13
US6313142B1 (en) 2001-11-06
AU7178900A (en) 2001-05-31
CA2327029C (en) 2005-08-09
DE60025317D1 (de) 2006-03-30
HUP0004747A3 (en) 2002-12-28
ATE315028T1 (de) 2006-02-15
CA2327029A1 (en) 2001-05-30
AR029775A1 (es) 2003-07-16
HU0004747D0 (da) 2001-02-28
KR100408177B1 (ko) 2003-12-01
ID28489A (id) 2001-05-31
BR0005636A (pt) 2001-07-17
EA200001129A2 (ru) 2001-06-25
SG102603A1 (en) 2004-03-26
CN1302800A (zh) 2001-07-11
CO5261552A1 (es) 2003-03-31
TNSN00230A1 (fr) 2005-11-10
HUP0004747A2 (hu) 2001-10-28
ZA200006947B (en) 2002-05-27
DE60025317T2 (de) 2006-08-03
CN1173953C (zh) 2004-11-03
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
KR20010052012A (ko) 2001-06-25
OA11494A (en) 2004-05-07
EA003668B1 (ru) 2003-08-28
EP1125929A1 (en) 2001-08-22
NZ508509A (en) 2001-06-29
EE200000659A (et) 2001-08-15
IS5715A (is) 2001-05-31
CY1104989T1 (el) 2010-03-03
JP2001163859A (ja) 2001-06-19
IL139849A0 (en) 2002-02-10
GEP20022798B (en) 2002-09-25
DZ3079A1 (fr) 2004-10-24
BG105009A (en) 2001-11-30
AP2000002011A0 (en) 2000-12-31
MA25223A1 (fr) 2001-07-02
PE20010913A1 (es) 2001-09-10
NO20006039L (no) 2001-05-31
NO20006039D0 (no) 2000-11-29
EP1125929B1 (en) 2006-01-04
HK1038007A1 (en) 2002-03-01
IL139849A (en) 2006-10-31
SK17792000A3 (sk) 2002-10-08
TW591016B (en) 2004-06-11
UY26451A1 (es) 2001-06-29
ES2254109T3 (es) 2006-06-16
YU71500A (sh) 2003-02-28
HRP20000804A2 (en) 2001-06-30
GT200000190A (es) 2002-04-27
UA65615C2 (uk) 2004-04-15
CZ20004407A3 (cs) 2002-06-12
PA8503801A1 (es) 2002-07-30

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