DK1105360T3 - Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler - Google Patents
Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekylerInfo
- Publication number
- DK1105360T3 DK1105360T3 DK99948042T DK99948042T DK1105360T3 DK 1105360 T3 DK1105360 T3 DK 1105360T3 DK 99948042 T DK99948042 T DK 99948042T DK 99948042 T DK99948042 T DK 99948042T DK 1105360 T3 DK1105360 T3 DK 1105360T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- protein
- fusion
- nucleic acid
- libraries
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000007787 solid Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9682098P | 1998-08-17 | 1998-08-17 | |
PCT/US1999/018600 WO2000009464A1 (en) | 1998-08-17 | 1999-08-16 | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1105360T3 true DK1105360T3 (da) | 2009-11-02 |
Family
ID=22259237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99948042T DK1105360T3 (da) | 1998-08-17 | 1999-08-16 | Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler |
Country Status (12)
Country | Link |
---|---|
US (1) | US6602685B1 (da) |
EP (1) | EP1105360B1 (da) |
JP (1) | JP4278872B2 (da) |
AT (1) | ATE437844T1 (da) |
AU (1) | AU757955B2 (da) |
CA (1) | CA2337490C (da) |
CY (1) | CY1110515T1 (da) |
DE (1) | DE69941193D1 (da) |
DK (1) | DK1105360T3 (da) |
ES (1) | ES2329205T3 (da) |
PT (1) | PT1105360E (da) |
WO (1) | WO2000009464A1 (da) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
EP1212452B1 (en) * | 1999-08-27 | 2013-07-17 | Bristol-Myers Squibb Company | Methods for encoding and sorting in vitro translated proteins |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
EP1250463B1 (en) | 2000-01-24 | 2006-04-05 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
GB2360282A (en) * | 2000-03-17 | 2001-09-19 | Bioinvent Int Ab | Making and using micro-arrays of biological materials |
US6962781B1 (en) | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
US7410761B2 (en) * | 2000-05-19 | 2008-08-12 | Proteonova, Inc. | System for rapid identification and selection of nucleic acids and polypeptides, and method thereof |
US20040229271A1 (en) * | 2000-05-19 | 2004-11-18 | Williams Richard B. | Compositions and methods for the identification and selection of nucleic acids and polypeptides |
US6980674B2 (en) | 2000-09-01 | 2005-12-27 | Large Scale Proteomics Corp. | Reference database |
US6539102B1 (en) | 2000-09-01 | 2003-03-25 | Large Scale Proteomics | Reference database |
WO2003029490A1 (en) * | 2001-10-01 | 2003-04-10 | Yingjian Wang | Methods and arrays for detecting biological molecules |
WO2003045975A2 (en) * | 2001-11-27 | 2003-06-05 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
WO2003102547A2 (en) * | 2002-04-26 | 2003-12-11 | Genencor International, Inc. | Methods and articles for high throughput analysis of biomolecular interactions |
US20070191402A1 (en) * | 2002-05-17 | 2007-08-16 | Kyowa Hakko Kogyo Co., Ltd. | Method of searching substrate having antidiabetic activity |
US7927791B2 (en) | 2002-07-24 | 2011-04-19 | Ptc Therapeutics, Inc. | Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mRNA decay |
US20040142379A1 (en) * | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
CA2546343A1 (en) * | 2003-11-20 | 2005-06-09 | Sanofi Pasteur, Inc. | Methods for purifying pertussis toxin and peptides useful therefor |
AU2006295515A1 (en) * | 2005-09-27 | 2007-04-05 | Polybatics Limited | Polymer particles and uses thereof |
EP2339014B1 (en) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
WO2009009186A2 (en) * | 2007-04-13 | 2009-01-15 | The Regents Of The University Of California | Receptors useful for gas phase chemical sensing |
US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
US7678883B2 (en) | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
NZ602498A (en) | 2007-11-30 | 2014-08-29 | Abbvie Inc | Protein formulations and methods of making same |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
US20100158822A1 (en) | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
US8481678B2 (en) | 2009-03-30 | 2013-07-09 | E I Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
JP2012522057A (ja) * | 2009-03-30 | 2012-09-20 | ジヨンソン・アンド・ジヨンソン・コンシユーマー・カンパニーズ・インコーポレーテツド | 化粧用剤の送達のためのペプチドに基づく系 |
CA2789125A1 (en) | 2010-02-10 | 2011-08-18 | Novartis Ag | Methods and compounds for muscle growth |
DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
ES2926988T3 (es) | 2011-03-15 | 2022-10-31 | X Body Inc | Métodos de cribado de anticuerpos |
EP2688911B1 (en) | 2011-03-24 | 2017-08-02 | OPKO Pharmaceuticals, LLC | Biomarker discovery in complex biological fluid using bead or particle based libraries |
EP3421592B1 (en) | 2011-04-28 | 2023-09-13 | The Board of Trustees of the Leland Stanford Junior University | Identification of polynucleotides associated with a sample |
TWI640537B (zh) | 2011-12-05 | 2018-11-11 | X 染色體有限公司 | PDGF受體β結合多肽 |
US9938523B2 (en) * | 2013-03-15 | 2018-04-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling |
SG10201806428YA (en) | 2013-06-28 | 2018-08-30 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
EP3049811B1 (en) | 2013-09-23 | 2020-09-09 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
EP3102245B1 (en) | 2014-02-05 | 2021-09-08 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
US4587044A (en) | 1983-09-01 | 1986-05-06 | The Johns Hopkins University | Linkage of proteins to nucleic acids |
DE3587814T2 (de) | 1985-03-30 | 1994-11-10 | Marc Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
WO1992002536A1 (en) | 1990-08-02 | 1992-02-20 | The Regents Of The University Of Colorado | Systematic polypeptide evolution by reverse translation |
US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
DE4112440C1 (da) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
US5795747A (en) | 1991-04-16 | 1998-08-18 | Evotec Biosystems Gmbh | Process for manufacturing new biopolymers |
AU2313392A (en) | 1991-08-01 | 1993-03-02 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
ATE243745T1 (de) | 1994-01-31 | 2003-07-15 | Univ Boston | Bibliotheken aus polyklonalen antikörpern |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
EP0763202A4 (en) | 1994-05-23 | 1998-12-09 | Smithkline Beecham Corp | ENCODED COMBINATORIAL LIBRARIES |
US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
US5559000A (en) | 1995-01-18 | 1996-09-24 | The Scripps Research Institute | Encoded reaction cassette |
US6100026A (en) * | 1995-04-25 | 2000-08-08 | Irori | Matrices with memories and uses thereof |
US5751629A (en) * | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US5763263A (en) * | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5872015A (en) * | 1996-05-10 | 1999-02-16 | Board Of Trustees Of The University Of Illinois | Molecular diversity screening method |
US5962645A (en) * | 1996-10-04 | 1999-10-05 | University Of Maryland | Antiproliferative factor from patients with interstitial cystitis |
WO1998016636A1 (fr) | 1996-10-17 | 1998-04-23 | Mitsubishi Chemical Corporation | Molecule permettant d'homologuer un genotype et un phenotype, et utilisation de celle-ci |
RU2233878C2 (ru) * | 1997-01-21 | 2004-08-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления |
GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
GB9712512D0 (en) | 1997-06-16 | 1997-08-20 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
US5985575A (en) | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
-
1999
- 1999-08-16 US US09/374,964 patent/US6602685B1/en not_active Expired - Lifetime
- 1999-08-16 CA CA2337490A patent/CA2337490C/en not_active Expired - Lifetime
- 1999-08-16 JP JP2000564919A patent/JP4278872B2/ja not_active Expired - Lifetime
- 1999-08-16 WO PCT/US1999/018600 patent/WO2000009464A1/en active IP Right Grant
- 1999-08-16 EP EP99948042A patent/EP1105360B1/en not_active Expired - Lifetime
- 1999-08-16 DK DK99948042T patent/DK1105360T3/da active
- 1999-08-16 AT AT99948042T patent/ATE437844T1/de active
- 1999-08-16 DE DE69941193T patent/DE69941193D1/de not_active Expired - Lifetime
- 1999-08-16 PT PT99948042T patent/PT1105360E/pt unknown
- 1999-08-16 AU AU61296/99A patent/AU757955B2/en not_active Expired
- 1999-08-16 ES ES99948042T patent/ES2329205T3/es not_active Expired - Lifetime
-
2009
- 2009-10-13 CY CY20091101052T patent/CY1110515T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US6602685B1 (en) | 2003-08-05 |
DE69941193D1 (de) | 2009-09-10 |
AU757955B2 (en) | 2003-03-13 |
WO2000009464A1 (en) | 2000-02-24 |
EP1105360A1 (en) | 2001-06-13 |
CA2337490C (en) | 2012-01-03 |
ATE437844T1 (de) | 2009-08-15 |
WO2000009464A9 (en) | 2000-09-28 |
JP2002522057A (ja) | 2002-07-23 |
ES2329205T3 (es) | 2009-11-23 |
PT1105360E (pt) | 2009-09-30 |
CY1110515T1 (el) | 2015-04-29 |
EP1105360B1 (en) | 2009-07-29 |
AU6129699A (en) | 2000-03-06 |
CA2337490A1 (en) | 2000-02-24 |
EP1105360A4 (en) | 2005-06-22 |
JP4278872B2 (ja) | 2009-06-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1105360T3 (da) | Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler | |
Johannsson et al. | A fast highly sensitive colorimetric enzyme immunoassay system demonstrating benefits of enzyme amplification in clinical chemistry | |
DE60118527D1 (de) | Sensible und multiplexe diagnostische tests zur proteinanalyse | |
DE69700902D1 (de) | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit | |
ATE409238T1 (de) | Nachweis der hybridisierung von nukleinsäuren durch fluoreszenzpolarisation | |
Meyer et al. | Orthogonal protein decoration of DNA nanostructures | |
CY1109246T1 (el) | Μεθοδος ανιχνευσης συνδετη | |
WO2001027624A3 (en) | Compositions and methods for detecting protein modification and enzymatic activity | |
DK1252328T3 (da) | Fremgangsmåde og midler til isolering af mikroorganismer | |
WO2000015850A1 (en) | Assays for measuring nucleic acid binding proteins and enzyme activities | |
DK0713921T3 (da) | Fremgangsmåde til dæmpning af fluorescensen i opløsning af fluorescensmærkede oligonukleotidprober | |
CA2447874A1 (en) | Methods for isolating and labeling sample molecules | |
RU2004126254A (ru) | Анализ активности киназы actriib | |
WO2004099441A3 (en) | Selection and evolution of chemical libraries | |
Sheng et al. | A nanopore sensing assay resolves cascade reactions in a multienzyme system | |
Shi et al. | Polymerase-extension-based selection method for DNA-encoded chemical libraries against nonimmobilized protein targets | |
Zee et al. | Suppl 1: Quantitative Proteomic Approaches to Studying Histone Modifications | |
Li et al. | Targeted quantification of functional enzyme dynamics in environmental samples for microbially mediated biogeochemical processes | |
Visser et al. | Surface‐Plasmon‐Resonance‐Based Chemical Proteomics: Efficient Specific Extraction and Semiquantitative Identification of Cyclic Nucleotide‐Binding Proteins from Cellular Lysates by Using a Combination of Surface Plasmon Resonance, Sequential Elution and Liquid Chromatography–Tandem Mass Spectrometry | |
Gramatikova et al. | Pyridoxal 5′-phosphate-dependent catalytic antibody | |
DE69924128D1 (de) | Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen | |
WO2003002752A3 (en) | Methods of using nick translate libraries for snp analysis | |
Fan et al. | Development of a capillary electrophoresis‐based assay of sirtuin enzymes | |
Gramatikova et al. | Monoclonal Antibodies against Nα-(5′-Phosphopyridoxyl)-L-lysine: SCREENING AND SPECTRUM OF PYRIDOXAL 5′-PHOSPHATE-DEPENDENT ACTIVITIES TOWARD AMINO ACIDS | |
Prabhakar et al. | Dynamics of release factor recycling during translation termination in bacteria |