DK1092716T3 - Benzothiophenderivater, benzofuranderivater og indolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse - Google Patents

Benzothiophenderivater, benzofuranderivater og indolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse

Info

Publication number: DK1092716T3
Authority: DK; Denmark
Prior art keywords: alkyl; aryl; optionally substituted; derivatives; heteroaryl
Prior art date: 1999-10-15

Application number

DK00402831T

Other languages

Danish (da)

English (en)

Inventor

Nanteuil Guillaume De

Tony Verbeuren

Alain Rupin

Christine Lila

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-15

Filing date

2000-10-13

Publication date

2005-05-17

2000-10-13 Application filed by Servier Lab filed Critical Servier Lab

2005-05-17 Application granted granted Critical

2005-05-17 Publication of DK1092716T3 publication Critical patent/DK1092716T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)

DK00402831T 1999-10-15 2000-10-13 Benzothiophenderivater, benzofuranderivater og indolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse DK1092716T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9912899A FR2799756B1 (fr)	1999-10-15	1999-10-15	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
DK1092716T3 true DK1092716T3 (da)	2005-05-17

Family

ID=9550989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00402831T DK1092716T3 (da)	1999-10-15	2000-10-13	Benzothiophenderivater, benzofuranderivater og indolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse

Country Status (23)

Country	Link
US (1)	US6302837B1 (zh)
EP (1)	EP1092716B1 (zh)
JP (1)	JP3488683B2 (zh)
KR (1)	KR100474753B1 (zh)
CN (1)	CN1136213C (zh)
AT (1)	ATE289305T1 (zh)
AU (1)	AU774527B2 (zh)
BR (1)	BR0005171A (zh)
CA (1)	CA2323707C (zh)
DE (1)	DE60018135T2 (zh)
DK (1)	DK1092716T3 (zh)
EA (1)	EA004147B1 (zh)
ES (1)	ES2238261T3 (zh)
FR (1)	FR2799756B1 (zh)
HK (1)	HK1036447A1 (zh)
HU (1)	HUP0004006A2 (zh)
MX (1)	MXPA00010096A (zh)
NO (1)	NO320693B1 (zh)
NZ (1)	NZ507524A (zh)
PL (1)	PL198579B1 (zh)
PT (1)	PT1092716E (zh)
SI (1)	SI1092716T1 (zh)
ZA (1)	ZA200005668B (zh)

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JP2002529444A (ja) *	1998-11-12	2002-09-10	アリアド・ファーマシューティカルズ・インコーポレイテッド	二環式シグナル伝達阻害剤、それを含む組成物とその用途
JP2001261674A (ja) *	2000-03-22	2001-09-26	Mitsui Chemicals Inc	ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
AU2001268051A1 (en) *	2000-06-28	2002-01-08	Eli Lilly And Company	Spla2 inhibitors
US6969730B2 (en) *	2001-03-16	2005-11-29	Abbott Laboratories	Amines as histamine-3 receptor ligands and their therapeutic applications
TWI224101B (en)	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
EP1844771A3 (en)	2001-06-20	2007-11-07	Wyeth	Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
ATE367812T1 (de)	2001-06-20	2007-08-15	Wyeth Corp	Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)
UA80453C2 (en) *	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
AU2003296324A1 (en)	2002-12-10	2004-06-30	Wyeth	Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7056943B2 (en) *	2002-12-10	2006-06-06	Wyeth	Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
ES2266907T3 (es) *	2002-12-10	2007-03-01	Wyeth	Derivados sustituidos del acido 3-carbonil-indol-1-il-acetico como inhibidor del activador del plasminogeno-1 (pal-1).
AU2003297727A1 (en)	2002-12-10	2004-06-30	Wyeth	Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7141592B2 (en) *	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7446201B2 (en)	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7411083B2 (en)	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7163954B2 (en)	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7442805B2 (en) *	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7332521B2 (en)	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7342039B2 (en)	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7268159B2 (en)	2003-09-25	2007-09-11	Wyeth	Substituted indoles
US7351726B2 (en) *	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7265148B2 (en)	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7582773B2 (en)	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
WO2006023864A1 (en)	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as pai-1 inhibitors
MX2007002178A (es)	2004-08-23	2007-04-02	Wyeth Corp	Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
KR20070045353A (ko)	2004-08-23	2007-05-02	와이어쓰	플라스미노겐 활성화제 억제제-1의 억제제로서티아졸로-나프틸 산
US7674822B2 (en)	2004-11-24	2010-03-09	Wyeth	PTP1b inhibitors
CN101263115A (zh) *	2005-08-17	2008-09-10	惠氏公司	经取代吲哚和其用途
KR101428116B1 (ko) *	2006-08-21	2014-08-07	제넨테크, 인크.	아자-벤조푸라닐 화합물 및 사용 방법
CA2660963A1 (en) *	2006-08-21	2008-02-28	Genentech, Inc.	Aza-benzothiophenyl compounds and methods of use
EP2091534A1 (en) *	2006-09-15	2009-08-26	Schering Corporation	Azetidinone derivatives and methods of use thereof
WO2008033464A2 (en) *	2006-09-15	2008-03-20	Schering Corporation	Azetidinone derivatives for the treatment of disorders of the lipid metabolism
CN101528746A (zh) *	2006-09-15	2009-09-09	先灵公司	治疗脂质代谢障碍、疼痛、糖尿病和其它障碍的螺环氮杂环丁酮衍生物
EP2379076B1 (en)	2008-12-23	2014-11-12	The Trustees of Columbia University in the City of New York	Phosphodiesterase inhibitors and uses thereof

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US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
JPH06510063A (ja) *	1992-06-17	1994-11-10	ノバルティス　アクチエンゲゼルシャフト	除草活性を有するピリミジニルおよびトリアジニル化合物
US5334719A (en) *	1992-06-17	1994-08-02	Merck Frosst Canada, Inc.	Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
ATE188379T1 (de) *	1992-10-14	2000-01-15	Merck & Co Inc	Fibrinogenrezeptor-antagonisten
US5288743A (en) *	1992-11-20	1994-02-22	Abbott Laboratories	Indole carboxylate derivatives which inhibit leukotriene biosynthesis
GB9410387D0 (en) *	1994-05-24	1994-07-13	Xenova Ltd	Pharmaceutical compounds
US6048877A (en) *	1997-02-21	2000-04-11	Bristol-Myers Squibb Company	Tetralone derivatives as antiarrhythmic agents
FR2777886B1 (fr) *	1998-04-27	2002-05-31	Adir	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1999
- 1999-10-15 FR FR9912899A patent/FR2799756B1/fr not_active Expired - Fee Related
2000
- 2000-10-12 PL PL343147A patent/PL198579B1/pl unknown
- 2000-10-13 CN CNB001304577A patent/CN1136213C/zh not_active Expired - Fee Related
- 2000-10-13 NZ NZ507524A patent/NZ507524A/en unknown
- 2000-10-13 CA CA002323707A patent/CA2323707C/fr not_active Expired - Fee Related
- 2000-10-13 AU AU66503/00A patent/AU774527B2/en not_active Ceased
- 2000-10-13 EA EA200000947A patent/EA004147B1/ru unknown
- 2000-10-13 ZA ZA200005668A patent/ZA200005668B/xx unknown
- 2000-10-13 DE DE60018135T patent/DE60018135T2/de not_active Expired - Fee Related
- 2000-10-13 AT AT00402831T patent/ATE289305T1/de not_active IP Right Cessation
- 2000-10-13 ES ES00402831T patent/ES2238261T3/es not_active Expired - Lifetime
- 2000-10-13 PT PT00402831T patent/PT1092716E/pt unknown
- 2000-10-13 SI SI200030642T patent/SI1092716T1/xx unknown
- 2000-10-13 DK DK00402831T patent/DK1092716T3/da active
- 2000-10-13 NO NO20005166A patent/NO320693B1/no unknown
- 2000-10-13 EP EP00402831A patent/EP1092716B1/fr not_active Expired - Lifetime
- 2000-10-13 JP JP2000313668A patent/JP3488683B2/ja not_active Expired - Fee Related
- 2000-10-13 KR KR10-2000-0060286A patent/KR100474753B1/ko not_active IP Right Cessation
- 2000-10-13 US US09/687,308 patent/US6302837B1/en not_active Expired - Fee Related
- 2000-10-13 HU HU0004006A patent/HUP0004006A2/hu unknown
- 2000-10-16 MX MXPA00010096A patent/MXPA00010096A/es active IP Right Grant
- 2000-10-16 BR BR0005171-3A patent/BR0005171A/pt not_active Application Discontinuation
2001
- 2001-09-20 HK HK01106634A patent/HK1036447A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100474753B1 (ko)	2005-03-08
CA2323707C (fr)	2005-08-16
EA004147B1 (ru)	2004-02-26
DE60018135T2 (de)	2005-12-29
EP1092716A2 (fr)	2001-04-18
AU6650300A (en)	2001-04-26
MXPA00010096A (es)	2002-08-06
FR2799756B1 (fr)	2001-12-14
SI1092716T1 (en)	2005-06-30
BR0005171A (pt)	2001-05-29
EP1092716A3 (fr)	2001-08-08
HUP0004006A2 (hu)	2002-04-29
CN1136213C (zh)	2004-01-28
JP3488683B2 (ja)	2004-01-19
NO20005166L (no)	2001-04-17
PL198579B1 (pl)	2008-06-30
NZ507524A (en)	2002-03-01
NO320693B1 (no)	2006-01-16
PL343147A1 (en)	2001-04-23
ZA200005668B (en)	2001-05-15
KR20010051018A (ko)	2001-06-25
AU774527B2 (en)	2004-07-01
HU0004006D0 (en)	2000-12-28
PT1092716E (pt)	2005-05-31
CN1293192A (zh)	2001-05-02
JP2001122876A (ja)	2001-05-08
FR2799756A1 (fr)	2001-04-20
EP1092716B1 (fr)	2005-02-16
NO20005166D0 (no)	2000-10-13
EA200000947A1 (ru)	2001-04-23
ATE289305T1 (de)	2005-03-15
ES2238261T3 (es)	2005-09-01
DE60018135D1 (de)	2005-03-24
CA2323707A1 (fr)	2001-04-15
HK1036447A1 (en)	2002-01-04
US6302837B1 (en)	2001-10-16

Publication	Publication Date	Title
DK1092716T3 (da)	2005-05-17	Benzothiophenderivater, benzofuranderivater og indolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse
FR2655988B1 (fr)	1994-05-20	Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE214387T1 (de)	2002-03-15	Benzothiophen-, benzofuran- und indolderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
HUP9902340A2 (hu)	1999-11-29	Kondenzált piridinek és pirimidinek aril-amino-származékai, eljárás előállításukra, valamint e vegyületeket tartalmazó gyógyászati készítmények, továbbá e vegyületek alkalmazása
AR046200A1 (es)	2005-11-30	Derivados de pirazina y su uso farmaceutico. procesos de preparacion y composiciones farmaceuticas
CO4970713A1 (es)	2000-11-07	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
SE9702799D0 (sv)	1997-07-25	New compounds
RU2004119406A (ru)	2005-05-10	5-сульфанил-4н-1,2,4-триазольные производные и их применение в качестве лекарственного препарата
IL57577A (en)	1982-03-31	1,2-dihydroquinolin-2-one derivatives,processes for their preparation and pharmaceutical compositions containing the same
YU6799A (sh)	2000-03-21	Derivati tetrahidrohinolina kao antagonisti eaa
SE9703377D0 (sv)	1997-09-18	New compounds
BR0311840A (pt)	2005-03-15	Composto, formulação farmacêutica, método para tratar ou evitar resistência à insulina, uso de um composto, e, processo para prepará-lo
AR017127A1 (es)	2001-08-22	Nuevos compuestos de piperazina y piperidina, un metodo para su preparacion, composiciones farmaceuticas que las contienen, metodos para prepararlas y nuevos compuestos intermedios para dicho metodo.
FR2674849B1 (fr)	1994-12-23	Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
KR890001957A (ko)	1989-04-06	N-아미노부틸-n-페닐아릴아미드 유도체, 그의 제법 및 치료에의 응용
AR005233A1 (es)	1999-04-28	Derivados de 1,2,3,4-tetrahidroquinolina, procesos para su preparacion, una composicion farmaceutica y el uso en la elaboracion de un medicamento
MX9400681A (es)	1994-08-31	Nuevos derivados de piridinio, procedimiento para su preparacion y composiciones farmaceuticas que los incluyen.
ATE270268T1 (de)	2004-07-15	2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren
AR018632A1 (es)	2001-11-28	Compuestos derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilico, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene, proceso para su preparacion.
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