DK1076657T3 - Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling - Google Patents

Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

Info

Publication number: DK1076657T3
Authority: DK; Denmark
Prior art keywords: phosphodiesterase; inhibitors; preparation; new hydroxy; hydroxy indoles
Prior art date: 1998-04-28

Application number

DK99920779T

Other languages

English (en)

Inventor

Hildegard Poppe

Thomas Kronbach

Norbert Hoefgen

Ute Egerland

Degenhard Marx

Stefan Szelenyi

Emmanuel Polymeropoulos

Sabine Heer

Original Assignee

Elbion Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-28

Filing date

1999-04-24

Publication date

2004-11-08

1998-04-28 Priority claimed from DE19818964A external-priority patent/DE19818964A1/de

1999-04-17 Priority claimed from DE1999117504 external-priority patent/DE19917504A1/de

1999-04-24 Application filed by Elbion Ag filed Critical Elbion Ag

2004-11-08 Application granted granted Critical

2004-11-08 Publication of DK1076657T3 publication Critical patent/DK1076657T3/da

Links

MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 title 1
102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Pharmacology & Pharmacy (AREA)
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Biomedical Technology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
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DK99920779T 1998-04-28 1999-04-24 Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling DK1076657T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19818964A DE19818964A1 (de)	1998-04-28	1998-04-28	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE1999117504 DE19917504A1 (de)	1999-04-17	1999-04-17	Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
EP99920779A EP1076657B1 (de)	1998-04-28	1999-04-24	Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
DK1076657T3 true DK1076657T3 (da)	2004-11-08

Family

ID=26045814

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99920779T DK1076657T3 (da)	1998-04-28	1999-04-24	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
DK04018391T DK1475377T3 (da)	1998-04-28	1999-04-24	Indol-derivater og deres anvendelse som inhibitorer for phosphodiesterase 4

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04018391T DK1475377T3 (da)	1998-04-28	1999-04-24	Indol-derivater og deres anvendelse som inhibitorer for phosphodiesterase 4

Country Status (28)

Country	Link
US (8)	US6251923B1 (da)
EP (2)	EP1076657B1 (da)
JP (2)	JP3842043B2 (da)
KR (1)	KR100448748B1 (da)
CN (1)	CN1234705C (da)
AR (1)	AR016236A1 (da)
AT (2)	ATE330955T1 (da)
AU (1)	AU748403B2 (da)
BG (1)	BG65023B1 (da)
BR (1)	BR9910029A (da)
CY (1)	CY1105075T1 (da)
CZ (1)	CZ20003985A3 (da)
DE (2)	DE59910142D1 (da)
DK (2)	DK1076657T3 (da)
ES (2)	ES2222706T3 (da)
HK (1)	HK1035183A1 (da)
HU (1)	HUP0101625A3 (da)
IL (2)	IL138847A0 (da)
NO (1)	NO321867B1 (da)
NZ (1)	NZ507406A (da)
PL (1)	PL198983B1 (da)
PT (2)	PT1475377E (da)
SI (2)	SI1475377T1 (da)
SK (1)	SK286192B6 (da)
TR (1)	TR200003130T2 (da)
TW (1)	TW530048B (da)
UA (1)	UA59443C2 (da)
WO (1)	WO1999055696A1 (da)

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TR200003130T2 (tr) *	1998-04-28	2001-01-22	Arzneimittelwerk Dresden Gmbh	Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
WO2000067802A1 (en) *	1999-05-10	2000-11-16	Protarga, Inc.	Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
DE19924138A1 (de)	1999-05-26	2000-11-30	Henkel Kgaa	Lösbare Klebeverbindungen
US6469006B1 (en) *	1999-06-15	2002-10-22	Bristol-Myers Squibb Company	Antiviral indoleoxoacetyl piperazine derivatives
TWI269654B (en) *	1999-09-28	2007-01-01	Baxter Healthcare Sa	N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19951599A1 (de) *	1999-10-27	2001-05-23	Henkel Kgaa	Verfahren zur adhesiven Trennung von Klebeverbunden
DE19962300A1 (de) *	1999-12-23	2001-06-28	Asta Medica Ag	Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IT1315267B1 (it) *	1999-12-23	2003-02-03	Novuspharma Spa	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
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US6573262B2 (en)	2000-07-10	2003-06-03	Bristol-Myers Sqibb Company	Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
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DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
DE10037884A1 (de) *	2000-08-03	2002-02-21	Henkel Kgaa	Verfahren zur beschleunigten Klebstoffaushärtung
TWI323658B (en) *	2001-12-06	2010-04-21	Nat Health Research Institutes	Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same
WO2003099559A1 (en)	2002-05-24	2003-12-04	Michel Joyce	Article of clothing with moisture absorbent portion
UA78999C2 (en) *	2002-06-04	2007-05-10	Wyeth Corp	1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
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US20040038958A1 (en) *	2002-07-11	2004-02-26	Chris Rundfeldt	Topical treatment of skin diseases
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1999
- 1999-04-24 TR TR2000/03130T patent/TR200003130T2/xx unknown
- 1999-04-24 PL PL343569A patent/PL198983B1/pl unknown
- 1999-04-24 EP EP99920779A patent/EP1076657B1/de not_active Expired - Lifetime
- 1999-04-24 ES ES99920779T patent/ES2222706T3/es not_active Expired - Lifetime
- 1999-04-24 DK DK99920779T patent/DK1076657T3/da active
- 1999-04-24 BR BR9910029-0A patent/BR9910029A/pt not_active Application Discontinuation
- 1999-04-24 AU AU38229/99A patent/AU748403B2/en not_active Ceased
- 1999-04-24 HU HU0101625A patent/HUP0101625A3/hu unknown
- 1999-04-24 PT PT04018391T patent/PT1475377E/pt unknown
- 1999-04-24 JP JP2000545856A patent/JP3842043B2/ja not_active Expired - Fee Related
- 1999-04-24 WO PCT/EP1999/002792 patent/WO1999055696A1/de active IP Right Grant
- 1999-04-24 SI SI9930922T patent/SI1475377T1/sl unknown
- 1999-04-24 NZ NZ507406A patent/NZ507406A/xx unknown
- 1999-04-24 DE DE59910142T patent/DE59910142D1/de not_active Expired - Fee Related
- 1999-04-24 SI SI9930670T patent/SI1076657T1/xx unknown
- 1999-04-24 EP EP04018391A patent/EP1475377B1/de not_active Expired - Lifetime
- 1999-04-24 SK SK1575-2000A patent/SK286192B6/sk not_active IP Right Cessation
- 1999-04-24 AT AT04018391T patent/ATE330955T1/de not_active IP Right Cessation
- 1999-04-24 ES ES04018391T patent/ES2262072T3/es not_active Expired - Lifetime
- 1999-04-24 IL IL13884799A patent/IL138847A0/xx active IP Right Grant
- 1999-04-24 PT PT99920779T patent/PT1076657E/pt unknown
- 1999-04-24 AT AT99920779T patent/ATE272631T1/de not_active IP Right Cessation
- 1999-04-24 CZ CZ20003985A patent/CZ20003985A3/cs unknown
- 1999-04-24 CN CNB998079766A patent/CN1234705C/zh not_active Expired - Fee Related
- 1999-04-24 DK DK04018391T patent/DK1475377T3/da active
- 1999-04-24 KR KR10-2000-7011992A patent/KR100448748B1/ko not_active IP Right Cessation
- 1999-04-24 DE DE59913617T patent/DE59913617D1/de not_active Expired - Fee Related
- 1999-04-24 UA UA2000116726A patent/UA59443C2/uk unknown
- 1999-04-28 AR ARP990101965A patent/AR016236A1/es active IP Right Grant
- 1999-04-28 TW TW088106886A patent/TW530048B/zh not_active IP Right Cessation
- 1999-04-28 US US09/300,973 patent/US6251923B1/en not_active Ceased
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- 2000-10-04 IL IL138847A patent/IL138847A/en not_active IP Right Cessation
- 2000-10-11 BG BG104842A patent/BG65023B1/bg unknown
- 2000-10-27 NO NO20005454A patent/NO321867B1/no unknown
2001
- 2001-08-14 HK HK01105669A patent/HK1035183A1/xx not_active IP Right Cessation
2002
- 2002-02-21 US US10/081,642 patent/US7161009B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,395 patent/US6545158B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,807 patent/US6602890B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/080,821 patent/US6545025B2/en not_active Expired - Fee Related
- 2002-09-19 US US10/176,435 patent/USRE38624E1/en not_active Expired - Fee Related
2003
- 2003-01-20 US US10/347,659 patent/US6613794B2/en not_active Expired - Fee Related
2004
- 2004-05-27 US US10/856,034 patent/US20040220183A1/en not_active Abandoned
2006
- 2006-03-27 JP JP2006086619A patent/JP2006249091A/ja not_active Withdrawn
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Publication number	Publication date
BG65023B1 (bg)	2006-12-29
BR9910029A (pt)	2000-12-26
IL138847A0 (en)	2001-10-31
AR016236A1 (es)	2001-06-20
US20040220183A1 (en)	2004-11-04
CN1307575A (zh)	2001-08-08
EP1475377A1 (de)	2004-11-10
US20020115651A1 (en)	2002-08-22
ES2222706T3 (es)	2005-02-01
PL343569A1 (en)	2001-08-27
IL138847A (en)	2006-08-20
UA59443C2 (uk)	2003-09-15
US20020111351A1 (en)	2002-08-15
NZ507406A (en)	2002-11-26
EP1475377A8 (de)	2005-01-19
NO20005454D0 (no)	2000-10-27
PT1076657E (pt)	2004-11-30
KR20010043106A (ko)	2001-05-25
HUP0101625A2 (hu)	2001-11-28
EP1475377B1 (de)	2006-06-21
USRE38624E1 (en)	2004-10-12
ATE330955T1 (de)	2006-07-15
US6613794B2 (en)	2003-09-02
NO321867B1 (no)	2006-07-17
SI1475377T1 (sl)	2006-12-31
NO20005454L (no)	2000-12-07
PL198983B1 (pl)	2008-08-29
US6545025B2 (en)	2003-04-08
JP3842043B2 (ja)	2006-11-08
EP1076657A1 (de)	2001-02-21
SK15752000A3 (sk)	2001-08-06
US7161009B2 (en)	2007-01-09
US20020137745A1 (en)	2002-09-26
CZ20003985A3 (cs)	2001-09-12
ATE272631T1 (de)	2004-08-15
DK1475377T3 (da)	2006-10-23
JP2006249091A (ja)	2006-09-21
US20020119971A1 (en)	2002-08-29
JP2002513017A (ja)	2002-05-08
KR100448748B1 (ko)	2004-09-18
SI1076657T1 (en)	2004-12-31
DE59910142D1 (de)	2004-09-09
CN1234705C (zh)	2006-01-04
DE59913617D1 (de)	2006-08-03
SK286192B6 (sk)	2008-05-06
HUP0101625A3 (en)	2002-12-28
BG104842A (en)	2001-10-31
US6545158B2 (en)	2003-04-08
WO1999055696A1 (de)	1999-11-04
TR200003130T2 (tr)	2001-01-22
HK1035183A1 (en)	2001-11-16
ES2262072T3 (es)	2006-11-16
US6602890B2 (en)	2003-08-05
EP1076657B1 (de)	2004-08-04
US6251923B1 (en)	2001-06-26
TW530048B (en)	2003-05-01
CY1105075T1 (el)	2010-03-03
PT1475377E (pt)	2006-11-30
AU748403B2 (en)	2002-06-06
US20030134876A1 (en)	2003-07-17
AU3822999A (en)	1999-11-16

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