DK1030697T3 - Bionedbrydeligt polymerskelet - Google Patents
Bionedbrydeligt polymerskeletInfo
- Publication number
- DK1030697T3 DK1030697T3 DK98954085T DK98954085T DK1030697T3 DK 1030697 T3 DK1030697 T3 DK 1030697T3 DK 98954085 T DK98954085 T DK 98954085T DK 98954085 T DK98954085 T DK 98954085T DK 1030697 T3 DK1030697 T3 DK 1030697T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer
- scaffold
- polymer scaffold
- particles
- solvent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Biological Depolymerization Polymers (AREA)
- Polyesters Or Polycarbonates (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Polyurethanes Or Polyureas (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002221195A CA2221195A1 (fr) | 1997-11-14 | 1997-11-14 | Matrice en polymere biodegradable |
PCT/CA1998/001052 WO1999025391A2 (fr) | 1997-11-14 | 1998-11-13 | Squelette de polymere biodegradable |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1030697T3 true DK1030697T3 (da) | 2003-12-29 |
Family
ID=4161772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98954085T DK1030697T3 (da) | 1997-11-14 | 1998-11-13 | Bionedbrydeligt polymerskelet |
Country Status (15)
Country | Link |
---|---|
US (1) | US6379962B1 (fr) |
EP (1) | EP1030697B1 (fr) |
JP (1) | JP4636684B2 (fr) |
KR (1) | KR100664772B1 (fr) |
CN (1) | CN1212866C (fr) |
AT (1) | ATE247994T1 (fr) |
AU (2) | AU749041B2 (fr) |
BR (1) | BR9814036B1 (fr) |
CA (2) | CA2221195A1 (fr) |
DE (1) | DE69817600T2 (fr) |
DK (1) | DK1030697T3 (fr) |
ES (1) | ES2207861T3 (fr) |
IL (1) | IL136093A0 (fr) |
NZ (1) | NZ504973A (fr) |
WO (1) | WO1999025391A2 (fr) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR876M (fr) | 1960-10-12 | 1961-10-16 | ||
US7022522B2 (en) * | 1998-11-13 | 2006-04-04 | Limin Guan | Macroporous polymer scaffold containing calcium phosphate particles |
WO2000067815A1 (fr) * | 1999-05-07 | 2000-11-16 | Salviac Limited | Charpente pour genie tissulaire |
AU3844599A (en) * | 1999-05-07 | 2000-11-21 | Salviac Limited | Biostable polyether polyurethane product |
JP3421741B2 (ja) * | 2000-05-18 | 2003-06-30 | 筑波大学長 | 人工骨髄、血球細胞の増殖方法 |
US6835390B1 (en) * | 2000-11-17 | 2004-12-28 | Jon Vein | Method for producing tissue engineered meat for consumption |
DE10126137C1 (de) * | 2001-05-29 | 2002-11-07 | Andreas Haisch | Verfahren zur Herstellung von Zellen, Geweben und Organen |
WO2003004254A1 (fr) * | 2001-07-03 | 2003-01-16 | The Regents Of The University Of California | Matrices de biopolymeres microfabriquees et methode d'elaboration correspondante |
DE60215895T2 (de) * | 2001-09-13 | 2007-05-31 | Akira Myoi, Toyonaka | Poröse Calciumphosphat-Keramik für in vivo-Anwendungen |
US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
NL1019888C2 (nl) * | 2002-02-01 | 2003-08-25 | Univ Twente | Werkwijze voor het vervaardigen van een poreuze polymeerstructuur. |
AU2003265228A1 (en) * | 2002-03-12 | 2003-12-22 | Surface Logix, Inc. | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
US20030181978A1 (en) | 2002-03-25 | 2003-09-25 | Brown Kelly R. | Channeled biomedical foams and method for producing same |
WO2003082366A1 (fr) * | 2002-03-28 | 2003-10-09 | Japan As Represented By President Of National Cardiovascular Center | Materiau support d'ingenierie tissulaire, vaisseau artificiel, element de manchette et revetement destine a des implants |
AU2003251874A1 (en) * | 2002-07-12 | 2004-02-02 | Dirk R. Albrecht | Three dimensional cell patterned bioploymer scaffolds and method of making the same |
EP2570440A3 (fr) | 2003-02-19 | 2014-06-11 | Orteq B.V. | Procédé pour la préparation de nouveaux polyuréthannes segmentés présentant des résistances à la traction et à la déchirure élevée et procédé de fabrication d'échafaudages poreux |
GB0307011D0 (en) * | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
US20040197375A1 (en) * | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
GB0311221D0 (en) * | 2003-05-15 | 2003-06-18 | Orthogem Ltd | Biomaterial |
US20080206308A1 (en) * | 2003-08-29 | 2008-08-28 | Esmaiel Jabbari | Hydrogel Porogents for Fabricating Biodegradable Scaffolds |
AU2005212339B2 (en) | 2004-02-06 | 2010-11-25 | Georgia Tech Research Corporation | Load bearing biocompatible device |
WO2005077013A2 (fr) | 2004-02-06 | 2005-08-25 | Georgia Tech Research Corporation | Implantation cellulaire a adhesion de surface |
US7446131B1 (en) | 2004-06-10 | 2008-11-04 | The United States Of America As Represented By The Secretary Of Agriculture | Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making |
WO2006020240A2 (fr) * | 2004-07-16 | 2006-02-23 | The Forsyth Institute | Methodes et compositions utilisees dans la bio-ingenierie du tissu dentaire |
CA2575988C (fr) | 2004-08-04 | 2014-02-18 | Brookwood Pharmaceuticals, Inc. | Procede de production de systemes d'administration, et systemes d'administration |
KR101140490B1 (ko) * | 2004-09-17 | 2012-07-05 | 존 베인 | 식용의 조직 엔지니어링된 식육 및 그의 생산 방법 |
EP1809678B1 (fr) | 2004-11-12 | 2013-05-22 | Mayo Foundation for Medical Education and Research | Poly(caprolactone fumarate) photoreticulable |
JP4897699B2 (ja) * | 2004-11-18 | 2012-03-14 | メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ | ポリカプロラクトンとポリ(プロピレンフマレート)とのブロックコポリマー |
WO2006113984A1 (fr) * | 2005-04-26 | 2006-11-02 | Rimon Therapeutics Ltd. | Echafaudage polymere pro-angiogene |
JP5527968B2 (ja) * | 2005-04-29 | 2014-06-25 | メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ | ポリ(カプロラクトンフマレート)、ポリ(エチレングリコールフマレート)およびそれらのコポリマーに基づく親水性/疎水性ポリマーネットワーク |
CN100453124C (zh) * | 2006-04-28 | 2009-01-21 | 武汉理工大学 | 多孔、分层、三维空间多级结构的组织支架材料及其制备方法 |
US8287895B1 (en) | 2008-04-24 | 2012-10-16 | Hrl Laboratories, Llc | Three-dimensional biological scaffold compromising polymer waveguides |
US8197930B1 (en) | 2007-05-10 | 2012-06-12 | Hrl Laboratories, Llc | Three-dimensional ordered open-cellular structures |
US8048857B2 (en) * | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
BRPI0806899A2 (pt) * | 2007-01-19 | 2014-06-17 | Cinv Ag | Implante parcialmente bioabsorvível |
WO2008112815A2 (fr) * | 2007-03-12 | 2008-09-18 | University Of Washington | Procédés pour modifier la résistance aux chocs de matières thermoplastiques non cellulaires |
US20090069904A1 (en) * | 2007-09-12 | 2009-03-12 | Applied Medical Research | Biomaterial including micropores |
US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
US9616153B2 (en) | 2008-04-17 | 2017-04-11 | Warsaw Orthopedic, Inc. | Rigid bone graft substitute |
US20090263507A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use |
DE102008042401A1 (de) * | 2008-09-26 | 2010-04-08 | Forschungszentrum Karlsruhe Gmbh | Bandscheibenimplantat sowie Verfahren zur Herstellung eines solchen |
US20110076396A1 (en) * | 2009-09-28 | 2011-03-31 | Limin Guan | Method of forming a calcium phosphate coating within a porous material |
EP2575441A1 (fr) * | 2010-05-28 | 2013-04-10 | Garnet BioTherapeutics, Inc | Compositions et procédés d'utilisation de dispositifs bioactifs vivants et non vivants avec composants dérivés de cellules souches auto-renouvelées, cultivées et développées in vitro |
EP3323438B1 (fr) * | 2010-08-10 | 2019-10-30 | LifeCell Corporation | Échafaudages tissulaires régénérateurs |
EP2757964B1 (fr) | 2011-05-26 | 2016-05-04 | Cartiva, Inc. | Implant d'articulation conique et outils associés |
US9415562B1 (en) * | 2011-08-17 | 2016-08-16 | Hrl Laboratories, Llc | Ultra-light micro-lattices and a method for forming the same |
CA2857283C (fr) * | 2011-11-29 | 2021-04-27 | The Regents Of The University Of California | Echafaudage glucomannane pour culture et ingenierie tissulaires tridimensionnelles |
US9539773B2 (en) | 2011-12-06 | 2017-01-10 | Hrl Laboratories, Llc | Net-shape structure with micro-truss core |
US8485820B1 (en) | 2011-12-22 | 2013-07-16 | Mohamed Ikbal Ali | Devices and methods for enhancing bone growth |
EP2793962B1 (fr) * | 2011-12-23 | 2016-04-27 | Dang Quang Svend Le | Procédé de modification de la morphologie de surface d'un dispositif médical |
US9017806B2 (en) | 2012-03-23 | 2015-04-28 | Hrl Laboratories, Llc | High airflow micro-truss structural apparatus |
US10350072B2 (en) | 2012-05-24 | 2019-07-16 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
KR101304015B1 (ko) * | 2012-06-15 | 2013-09-04 | 단국대학교 산학협력단 | 조직 공학용 하이드로겔-다공성 생체세라믹 융합형 스캐폴드 및 이의 제조방법 |
CN102961781B (zh) * | 2012-12-18 | 2015-08-05 | 中国科学院长春应用化学研究所 | 一种组织工程支架材料的制备方法 |
MX2015017235A (es) | 2013-06-13 | 2017-05-04 | Orgenesis Ltd | Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos. |
WO2016072017A1 (fr) * | 2014-11-07 | 2016-05-12 | オリンパス株式会社 | Matériau de liaison pour tissu biologique et procédé de liaison pour tissu biologique |
MA41296A (fr) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | Procédés de transdifférenciation et procédés d'utilisation de ceux-ci |
ES2578705B1 (es) * | 2015-01-28 | 2017-08-04 | Universitat Politècnica De Catalunya | Andamio macroporoso para ingeniería de tejidos óseos, método de diseño tridimensional y aplicaciones |
CA2981061A1 (fr) | 2015-03-31 | 2016-10-06 | Cartiva, Inc. | Implants a base d'hydrogel comportant des materiaux poreux et procedes associes |
WO2016161026A1 (fr) | 2015-03-31 | 2016-10-06 | Cartiva, Inc. | Implants carpométacarpiens (cmc) et procédés |
CA2938576A1 (fr) * | 2015-08-12 | 2017-02-12 | Howmedica Osteonics Corp. | Methodes de formation de structures de soutien |
US11331191B2 (en) | 2015-08-12 | 2022-05-17 | Howmedica Osteonics Corp. | Bioactive soft tissue implant and methods of manufacture and use thereof |
BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
EP3782658B1 (fr) | 2016-05-02 | 2024-04-10 | Howmedica Osteonics Corp. | Implant de tissu mou bioactif et leurs procédés de fabrication et d'utilisation |
JP6690001B2 (ja) | 2016-09-27 | 2020-04-28 | 富士フイルム株式会社 | 細胞組織の製造方法、及び多孔フィルム |
JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
SG11201911256UA (en) | 2017-05-08 | 2020-01-30 | Orgenesis Ltd | Transdifferentiated cell populations and methods of use thereof |
EP3621654A4 (fr) | 2017-05-10 | 2021-02-17 | Graybug Vision, Inc. | Microparticules à libération prolongée et suspensions de celles-ci destinées à une thérapie médicale |
KR102198398B1 (ko) * | 2017-09-22 | 2021-01-05 | 고려대학교 산학협력단 | 비용매상분리법을 이용한 다공성 코어-치밀성 쉘 구조형 스캐폴드 제조 기술 |
WO2023142599A1 (fr) * | 2022-01-27 | 2023-08-03 | 华东理工大学 | Procédé de préparation d'un matériau de collagène retiré d'une électrode, et utilisation de matériau de collagène |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
US5277811A (en) * | 1992-04-14 | 1994-01-11 | Millipore Corporation | Process for forming porous polymeric product from a nonporous polymeric composition and product |
US5228994A (en) * | 1992-10-13 | 1993-07-20 | Millipore Corporation | Composite microporous membranes |
US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
US5502092A (en) * | 1994-02-18 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Biocompatible porous matrix of bioabsorbable material |
GB2301362B (en) * | 1995-05-30 | 1999-01-06 | Johnson & Johnson Medical | Absorbable implant materials having controlled porosity |
-
1997
- 1997-11-14 CA CA002221195A patent/CA2221195A1/fr not_active Abandoned
-
1998
- 1998-11-13 CN CNB988131293A patent/CN1212866C/zh not_active Expired - Fee Related
- 1998-11-13 IL IL13609398A patent/IL136093A0/xx not_active IP Right Cessation
- 1998-11-13 KR KR1020007005274A patent/KR100664772B1/ko not_active IP Right Cessation
- 1998-11-13 EP EP19980954085 patent/EP1030697B1/fr not_active Expired - Lifetime
- 1998-11-13 US US09/191,107 patent/US6379962B1/en not_active Expired - Lifetime
- 1998-11-13 ES ES98954085T patent/ES2207861T3/es not_active Expired - Lifetime
- 1998-11-13 AU AU11380/99A patent/AU749041B2/en not_active Ceased
- 1998-11-13 NZ NZ504973A patent/NZ504973A/en not_active IP Right Cessation
- 1998-11-13 DE DE1998617600 patent/DE69817600T2/de not_active Expired - Lifetime
- 1998-11-13 BR BRPI9814036-1A patent/BR9814036B1/pt not_active IP Right Cessation
- 1998-11-13 DK DK98954085T patent/DK1030697T3/da active
- 1998-11-13 WO PCT/CA1998/001052 patent/WO1999025391A2/fr not_active Application Discontinuation
- 1998-11-13 AT AT98954085T patent/ATE247994T1/de not_active IP Right Cessation
- 1998-11-13 CA CA002310070A patent/CA2310070C/fr not_active Expired - Fee Related
- 1998-11-13 JP JP2000520824A patent/JP4636684B2/ja not_active Expired - Fee Related
-
2002
- 2002-08-09 AU AU2002300496A patent/AU2002300496B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
JP2001523483A (ja) | 2001-11-27 |
ATE247994T1 (de) | 2003-09-15 |
AU1138099A (en) | 1999-06-07 |
WO1999025391A2 (fr) | 1999-05-27 |
CA2221195A1 (fr) | 1999-05-14 |
BR9814036B1 (pt) | 2011-07-26 |
CA2310070A1 (fr) | 1999-05-27 |
US6379962B1 (en) | 2002-04-30 |
BR9814036A (pt) | 2000-11-21 |
CA2310070C (fr) | 2008-01-08 |
WO1999025391A3 (fr) | 1999-08-26 |
CN1285757A (zh) | 2001-02-28 |
AU749041B2 (en) | 2002-06-20 |
EP1030697B1 (fr) | 2003-08-27 |
ES2207861T3 (es) | 2004-06-01 |
DE69817600T2 (de) | 2004-06-24 |
NZ504973A (en) | 2003-07-25 |
CN1212866C (zh) | 2005-08-03 |
IL136093A0 (en) | 2001-05-20 |
JP4636684B2 (ja) | 2011-02-23 |
DE69817600D1 (de) | 2003-10-02 |
EP1030697A2 (fr) | 2000-08-30 |
KR20010015819A (ko) | 2001-02-26 |
KR100664772B1 (ko) | 2007-01-04 |
AU2002300496B2 (en) | 2005-04-21 |
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