DK1017667T3 - 2-amino-6-methyl-7-acetyltetralin og farmaceutiske præparater til forebyggelse og terapeutisk behandling af inflammatoriske og/eller autoimmune patalogier - Google Patents

2-amino-6-methyl-7-acetyltetralin og farmaceutiske præparater til forebyggelse og terapeutisk behandling af inflammatoriske og/eller autoimmune patalogier

Info

Publication number
DK1017667T3
DK1017667T3 DK98946706T DK98946706T DK1017667T3 DK 1017667 T3 DK1017667 T3 DK 1017667T3 DK 98946706 T DK98946706 T DK 98946706T DK 98946706 T DK98946706 T DK 98946706T DK 1017667 T3 DK1017667 T3 DK 1017667T3
Authority
DK
Denmark
Prior art keywords
inflammatory
prevention
therapeutic treatment
acetyltetralin
amino
Prior art date
Application number
DK98946706T
Other languages
Danish (da)
English (en)
Inventor
Nicola Fanto
Gian Piero Moretti
Piero Foresta
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1017667T3 publication Critical patent/DK1017667T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98946706T 1997-09-22 1998-09-22 2-amino-6-methyl-7-acetyltetralin og farmaceutiske præparater til forebyggelse og terapeutisk behandling af inflammatoriske og/eller autoimmune patalogier DK1017667T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000568A IT1294931B1 (it) 1997-09-22 1997-09-22 Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
PCT/IT1998/000252 WO1999015494A1 (en) 1997-09-22 1998-09-22 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies

Publications (1)

Publication Number Publication Date
DK1017667T3 true DK1017667T3 (da) 2004-03-29

Family

ID=11405257

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98946706T DK1017667T3 (da) 1997-09-22 1998-09-22 2-amino-6-methyl-7-acetyltetralin og farmaceutiske præparater til forebyggelse og terapeutisk behandling af inflammatoriske og/eller autoimmune patalogier

Country Status (17)

Country Link
US (3) US7041703B2 (pt)
EP (1) EP1017667B1 (pt)
JP (1) JP4181301B2 (pt)
KR (1) KR100583805B1 (pt)
CN (1) CN1145606C (pt)
AT (1) ATE254595T1 (pt)
AU (1) AU738565B2 (pt)
BR (1) BR9812368A (pt)
CA (1) CA2303943A1 (pt)
DE (1) DE69819922T2 (pt)
DK (1) DK1017667T3 (pt)
ES (1) ES2210820T3 (pt)
HK (1) HK1029099A1 (pt)
IT (1) IT1294931B1 (pt)
NZ (1) NZ503492A (pt)
PT (1) PT1017667E (pt)
WO (1) WO1999015494A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
IT1317050B1 (it) * 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Tetraline 2,6,7-sostituite utili per la preparazione di un medicamentoad attivita' inibitrice della fosfodiesterasi iv.
ATE401313T1 (de) * 2000-08-14 2008-08-15 Teva Pharma Herstellung von risperidon
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
CN101768086B (zh) * 2008-12-29 2014-03-26 北京富龙康泰生物技术有限公司 氨基甲醇衍生物及其盐类化合物及其合成方法和其药物用途
WO2019052980A1 (en) 2017-09-14 2019-03-21 F. Hoffmann-La Roche Ag NOVEL COMPOUND FOR USE IN THE MANUFACTURE OF MEDICAMENTS
CN115724758A (zh) * 2021-08-24 2023-03-03 杭州中美华东制药有限公司 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919316A (en) * 1974-08-05 1975-11-11 Lilly Co Eli 2-Aminodichlorotetralins
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4448990A (en) * 1982-11-16 1984-05-15 Eli Lilly And Company Hydroxyaminotetralincarboxamides
ATE38029T1 (de) * 1985-06-26 1988-11-15 Smithkline Beckman Corp Benz-trisubstituierte 2-aminotetraline.
IT1241988B (it) * 1990-06-15 1994-02-02 Sigma Tau Ind Farmaceuti 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
IT1242043B (it) * 1990-12-21 1994-02-02 Sigma Tau Ind Farmaceuti Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono.
US5438150A (en) * 1994-04-26 1995-08-01 Syntex (U.S.A.) Inc. Process for making 1-benzocycloalkyl-1,3-dihydroimidazole-2-thione derivatives
IT1278045B1 (it) * 1995-03-09 1997-11-17 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di
IT1290910B1 (it) * 1997-02-03 1998-12-14 Sigma Tau Ind Farmaceuti 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
IT1294932B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella

Also Published As

Publication number Publication date
KR20010030671A (ko) 2001-04-16
EP1017667B1 (en) 2003-11-19
ATE254595T1 (de) 2003-12-15
CA2303943A1 (en) 1999-04-01
EP1017667A1 (en) 2000-07-12
DE69819922T2 (de) 2004-09-02
WO1999015494A1 (en) 1999-04-01
ITRM970568A1 (it) 1999-03-22
ES2210820T3 (es) 2004-07-01
US20030158266A1 (en) 2003-08-21
US7041703B2 (en) 2006-05-09
JP2001517649A (ja) 2001-10-09
CN1145606C (zh) 2004-04-14
US6849663B2 (en) 2005-02-01
HK1029099A1 (en) 2001-03-23
JP4181301B2 (ja) 2008-11-12
NZ503492A (en) 2002-08-28
US20030229148A1 (en) 2003-12-11
AU9366298A (en) 1999-04-12
PT1017667E (pt) 2004-04-30
CN1276782A (zh) 2000-12-13
DE69819922D1 (de) 2003-12-24
US20020123652A1 (en) 2002-09-05
BR9812368A (pt) 2000-09-19
KR100583805B1 (ko) 2006-05-26
AU738565B2 (en) 2001-09-20
IT1294931B1 (it) 1999-04-23

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