DK0992580T3 - Epitoper på human T-celler, som er immundominante for hepatitis C-virus - Google Patents
Epitoper på human T-celler, som er immundominante for hepatitis C-virusInfo
- Publication number
- DK0992580T3 DK0992580T3 DK99116671T DK99116671T DK0992580T3 DK 0992580 T3 DK0992580 T3 DK 0992580T3 DK 99116671 T DK99116671 T DK 99116671T DK 99116671 T DK99116671 T DK 99116671T DK 0992580 T3 DK0992580 T3 DK 0992580T3
- Authority
- DK
- Denmark
- Prior art keywords
- epitopes
- hepatitis
- dominant
- immune
- virus
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402718 | 1993-11-04 | ||
EP94931000A EP0725824B1 (en) | 1993-11-04 | 1994-10-28 | Immunodominant human t-cell epitopes of hepatitis c virus |
PCT/EP1994/003555 WO1995012677A2 (en) | 1993-11-04 | 1994-10-28 | Immunodominant human t-cell epitopes of hepatitis c virus |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0992580T3 true DK0992580T3 (da) | 2005-07-11 |
Family
ID=8214764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99116671T DK0992580T3 (da) | 1993-11-04 | 1994-10-28 | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
DK94931000T DK0725824T3 (da) | 1993-11-04 | 1994-10-28 | Immunodominante humane T-celleepitoper af hepatitis C virus |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94931000T DK0725824T3 (da) | 1993-11-04 | 1994-10-28 | Immunodominante humane T-celleepitoper af hepatitis C virus |
Country Status (11)
Country | Link |
---|---|
US (4) | US6555114B1 (da) |
EP (4) | EP0725824B1 (da) |
JP (2) | JPH09504534A (da) |
AT (3) | ATE274578T1 (da) |
AU (1) | AU698878B2 (da) |
CA (1) | CA2175692A1 (da) |
DE (3) | DE69432475T2 (da) |
DK (2) | DK0992580T3 (da) |
ES (2) | ES2239819T3 (da) |
PT (2) | PT725824E (da) |
WO (1) | WO1995012677A2 (da) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
DK0992580T3 (da) * | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
WO1995027733A1 (en) * | 1994-04-08 | 1995-10-19 | The Government Of The United States Of America, Represented By The Department Of Health & Human Services | Hepatitis c virus core peptide for stimulation of cytotoxic t lymphocytes and diagnosis of hcv exposure |
EP1028972B1 (en) | 1997-11-06 | 2010-09-29 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes |
PT1071955E (pt) | 1998-04-17 | 2005-02-28 | Innogenetics Nv | Ensaios melhorados de diagnostico imunologico utilizando agentes redutores |
AU3714499A (en) * | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
NZ508812A (en) * | 1998-06-12 | 2002-11-26 | Aventis Pasteur | Peptides for the prevention or treatment of HIV |
NZ528952A (en) * | 1998-06-24 | 2004-09-24 | Innogenetics N | Particles of HCV envelope proteins: use for vaccination |
US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
EP1105496B1 (en) | 1998-08-21 | 2007-03-21 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Modified hcv peptide vaccines |
DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
EP1535628B1 (en) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-like particle |
US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
RU2286172C2 (ru) * | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
JP2004522415A (ja) * | 2000-09-01 | 2004-07-29 | エピミューン インコーポレーティッド | Hla結合ペプチドおよびその使用方法 |
GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
CA2443781A1 (en) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Core-glycosylated hcv envelope proteins |
FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
CN1622828A (zh) * | 2001-12-18 | 2005-06-01 | 基因创新有限公司 | 用于诊断和治疗用途的纯化的丙型肝炎病毒外被蛋白 |
WO2004041842A2 (en) * | 2002-05-16 | 2004-05-21 | The General Hospital Corporation | Epitopes of hepatitis c virus |
US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
US8025873B2 (en) * | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
WO2004005473A2 (en) * | 2002-07-02 | 2004-01-15 | Chiron Corporation | Hcv fusion proteins with modified ns3 domains |
JP2006516955A (ja) * | 2002-11-08 | 2006-07-13 | イノジェネティックス・ナムローゼ・フェンノートシャップ | E1ペプチド及びns3ペプチドを含むhcvワクチン組成物 |
CN1735628A (zh) * | 2003-01-07 | 2006-02-15 | 拜奥默里克斯公司 | 丙型肝炎病毒的多肽f′,t表位,和其诊断与治疗应用 |
US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
US20080112977A1 (en) * | 2004-07-03 | 2008-05-15 | Mogam Biotechnology Research | Supertype Epitopes, Oligonucleotides Coding The Same Which Induce Effective Ctl Response Against Hcv And The Use Thereof |
US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
WO2006039326A2 (en) * | 2004-09-29 | 2006-04-13 | The Administrators Of The Tulane Educational Fund | Inhibitors of hepatitits c virus |
WO2006044923A2 (en) * | 2004-10-18 | 2006-04-27 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis c infection |
WO2007031867A2 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-stru tural ns3/4a fusion gene |
CN101300355A (zh) * | 2005-10-13 | 2008-11-05 | 威瑞克斯医药公司 | 包含丙型肝炎病毒多肽和用于引起免疫应答的Fc片段的嵌合抗原 |
WO2007149485A1 (en) * | 2006-06-20 | 2007-12-27 | Metaproteomics, Llc | Acacia based protein kinase modulation cancer treatment |
WO2008000261A2 (en) * | 2006-06-28 | 2008-01-03 | Statens Serum Institut | Expanding the t cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide cocktails |
US20090214593A1 (en) * | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
US8071561B2 (en) * | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
EP2331125A4 (en) | 2008-09-19 | 2013-03-27 | Globeimmune Inc | IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS |
KR20170124619A (ko) * | 2009-03-27 | 2017-11-10 | 아카데미아 시니카 | 바이러스에 대한 면역을 위한 방법 및 조성물 |
CN102378914B (zh) * | 2009-03-30 | 2014-12-10 | 生物梅里埃公司 | 用于hcv检测的固体支持物 |
WO2012033142A1 (ja) * | 2010-09-08 | 2012-03-15 | 学校法人 埼玉医科大学 | C型肝炎ウイルスリポソームワクチン |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
WO2012072088A1 (en) | 2010-12-02 | 2012-06-07 | Bionor Immuno As | Peptide scaffold design |
EA034031B1 (ru) | 2011-01-06 | 2019-12-20 | Бионор Иммуно Ас | Димерный пептид для индуцирования иммунного ответа против hiv и его применение |
US10501499B2 (en) | 2012-06-06 | 2019-12-10 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
CN105073989A (zh) * | 2013-02-19 | 2015-11-18 | 国立大学法人神户大学 | 免疫原性多肽表层表达双歧杆菌 |
US9371374B2 (en) | 2013-03-14 | 2016-06-21 | Abbott Laboratories | HCV core lipid binding domain monoclonal antibodies |
MX2015012824A (es) | 2013-03-14 | 2016-06-24 | Abbott Lab | Antigenos recombinantes ns3 del vhc y mutantes de los mismos para la deteccion mejorada de anticuerpos. |
CN105228649B (zh) | 2013-03-14 | 2019-01-18 | 雅培制药有限公司 | Hcv抗原-抗体组合测定和方法以及用在其中的组合物 |
EP3019192A4 (en) | 2013-07-08 | 2017-07-05 | Nanjingjinsirui Science&Technology Biology Corporation | Compositions and methods for increasing protein half-life in a serum |
CN109963587A (zh) | 2016-09-21 | 2019-07-02 | 艾伯塔大学理事会 | 丙型肝炎病毒免疫原性组合物及其使用方法 |
WO2019173925A1 (en) * | 2018-03-16 | 2019-09-19 | The Governors Of The University Of Alberta | Hepatitis c virus peptide compositions and methods of use thereof |
CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
JP2022518488A (ja) * | 2019-01-25 | 2022-03-15 | センティ バイオサイエンシズ インコーポレイテッド | タンパク質機能を制御するための融合構築物 |
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US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
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US5639594A (en) | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
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US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
EP0468657A3 (en) | 1990-07-09 | 1992-02-05 | Tonen Corporation | Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis |
CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
EP0485209A1 (en) * | 1990-11-08 | 1992-05-13 | Immuno Japan Inc. | Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides |
WO1992022571A1 (en) | 1991-06-13 | 1992-12-23 | Baxter Diagnostics Inc. | Immunoassay for non-a non-b hepatitis |
DE69232871T2 (de) * | 1991-06-24 | 2003-05-08 | Chiron Corp | Polypeptide des hepatitis c-virus (hiv) |
DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
US5428145A (en) | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
AU2513592A (en) * | 1991-08-21 | 1993-03-16 | Abbott Laboratories | Hepatitis c assay utilizing recombinant antigens to ns1 |
DE69232859T2 (de) * | 1991-09-13 | 2003-04-10 | Chiron Corp | Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden |
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ES2174845T3 (es) * | 1992-02-04 | 2002-11-16 | Chiron Corp | Terapeutica de la hepatitis. |
BR9305435A (pt) * | 1992-03-06 | 1994-12-27 | Innogenetics Nv | Processo para determinação de peptídeos correspondendo a epítopos imunologicamente importantes e seu uso em um processo para determinação de anticorpos ou peptídeos biotinilados correspondendo a epítopos imunologicamente importantes, processo para preparação dos mesmos e composições contendo os mesmos |
CA2173138A1 (en) * | 1993-10-19 | 1995-04-27 | Masafumi Takiguchi | Peptide capable of inducing immune response against hiv and aids preventive or remedy containing the peptide |
DK0992580T3 (da) * | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
- 1994-10-28 CA CA002175692A patent/CA2175692A1/en not_active Abandoned
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 EP EP94931000A patent/EP0725824B1/en not_active Revoked
- 1994-10-28 EP EP99116671A patent/EP0992580B1/en not_active Revoked
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/en not_active Application Discontinuation
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
- 1994-10-28 EP EP99116673A patent/EP0979867A3/en not_active Withdrawn
- 1994-10-28 EP EP99116672A patent/EP0992581B2/en not_active Expired - Lifetime
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
-
1997
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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