DK0984960T3 - N-triazole-2-indole carboxamides and their use as CCK-A agonists - Google Patents

N-triazole-2-indole carboxamides and their use as CCK-A agonists

Info

Publication number: DK0984960T3
Authority: DK; Denmark
Prior art keywords: cck; triazole; agonists; indole carboxamides; carboxamides
Prior art date: 1997-05-13

Application number

DK98924383T

Other languages

Danish (da)

Inventor

Eric Bignon

Jean-Pierre Bras

Cointet Paul De

Pierre Despeyroux

Daniel Frehel

Danielle Gully

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-13

Filing date

1998-05-06

Publication date

2003-05-26

1998-05-06 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK0984960T3 publication Critical patent/DK0984960T3/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Child & Adolescent Psychology (AREA)
Neurosurgery (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK98924383T 1997-05-13 1998-05-06 N-triazole-2-indole carboxamides and their use as CCK-A agonists DK0984960T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9705850A FR2763337B1 (en)	1997-05-13	1997-05-13	NOVEL TRIAZOLE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR1998/000905 WO1998051686A1 (en)	1997-05-13	1998-05-06	N-triazolyl-2-indolecarboxamides and their use as cck-a agonists

Publications (1)

Publication Number	Publication Date
DK0984960T3 true DK0984960T3 (en)	2003-05-26

Family

ID=9506830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98924383T DK0984960T3 (en)	1997-05-13	1998-05-06	N-triazole-2-indole carboxamides and their use as CCK-A agonists

Country Status (35)

Country	Link
EP (1)	EP0984960B1 (en)
JP (1)	JP2001524980A (en)
KR (1)	KR20010012541A (en)
CN (1)	CN1263528A (en)
AR (1)	AR011729A1 (en)
AT (1)	ATE232207T1 (en)
AU (1)	AU725530B2 (en)
BR (1)	BR9811465A (en)
CA (1)	CA2289573A1 (en)
CO (1)	CO4940485A1 (en)
CZ (1)	CZ289484B6 (en)
DE (1)	DE69811223T2 (en)
DK (1)	DK0984960T3 (en)
DZ (1)	DZ2486A1 (en)
EE (1)	EE9900524A (en)
ES (1)	ES2190081T3 (en)
FR (1)	FR2763337B1 (en)
GT (1)	GT199800068A (en)
HR (1)	HRP980258B1 (en)
HU (1)	HUP0002763A3 (en)
ID (1)	ID22911A (en)
IL (1)	IL132903A0 (en)
IS (1)	IS5235A (en)
NO (1)	NO995513L (en)
NZ (1)	NZ500637A (en)
PL (1)	PL336772A1 (en)
RU (1)	RU2175323C2 (en)
SI (1)	SI0984960T1 (en)
SK (1)	SK154299A3 (en)
TR (1)	TR199902795T2 (en)
TW (1)	TW396155B (en)
UY (1)	UY24997A1 (en)
WO (1)	WO1998051686A1 (en)
YU (1)	YU57999A (en)
ZA (1)	ZA983997B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2802530B1 (en) *	1999-12-17	2002-02-22	Sanofi Synthelabo	NOVEL BRANCHED SUBSTITUTED AMINO DERIVATIVES OF 3-AMINO-1-PHENYL-1H [1,2,4] TRIAZOLE, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IL155055A0 (en) *	2000-10-26	2003-10-31	Sanofi Synthelabo	Triazole derivatives and pharmaceutical compositions comprising them
FR2815963B1 (en) *	2000-10-26	2003-02-28	Sanofi Synthelabo	NOVEL TRIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUP0004741A2 (en) *	2000-11-28	2002-12-28	Sanofi-Synthelabo	Chemical process for the preparation of thiazole derivatives and new intermediate
JP2005507932A (en) *	2001-10-12	2005-03-24	バイエル・フアーマシユーチカルズ・コーポレーシヨン	Phenyl-substituted 5-membered nitrogen-containing heterocycles for the treatment of obesity
EP1314733A1 (en) *	2001-11-22	2003-05-28	Aventis Pharma Deutschland GmbH	Indole-2-carboxamides as factor Xa inhibitors
EP1479677A1 (en) *	2003-05-19	2004-11-24	Aventis Pharma Deutschland GmbH	New indole derivatives as factor xa inhibitors
EP1532980A1 (en)	2003-11-24	2005-05-25	Novo Nordisk A/S	N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
GB0403038D0 (en) *	2004-02-11	2004-03-17	Novartis Ag	Organic compounds
ATE528006T1 (en)	2007-01-26	2011-10-15	Merck Sharp & Dohme	SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS
EP2548618A3 (en) *	2008-07-15	2013-02-27	Novartis AG	Heteroaryl derivatives as DGAT1 inhibitors
SG175363A1 (en) *	2009-06-09	2011-12-29	Actelion Pharmaceuticals Ltd	Fluorinated aminotriazole derivatives
WO2011048175A1 (en) *	2009-10-22	2011-04-28	Henkel Ag & Co. Kgaa	Agent for treating keratin-containing fibres, containing a non-ionic starch modified by propylene oxide an anionic polymer
CN106928147A (en) *	2017-03-14	2017-07-07	华东师范大学	Tricyclic diterpene analog and preparation method thereof and its application in antiprostate cancer is prepared
CN107271623A (en) *	2017-07-27	2017-10-20	青岛啤酒股份有限公司	Beer potableness evaluation method based on human body satiety
KR20220150270A (en)	2019-10-07	2022-11-10	칼리오페, 인크.	GPR119 agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2701708B1 (en) *	1993-02-19	1995-05-19	Sanofi Elf	Polysubstituted 2-amido-4-phenylthiazole derivatives, process for their preparation, pharmaceutical composition and use of these derivatives for the preparation of a medicament.
FR2703995B1 (en) *	1993-04-16	1995-07-21	Sanofi Elf	5-ACYLAMINO 1,2,4-THIADIAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

1997
- 1997-05-13 FR FR9705850A patent/FR2763337B1/en not_active Expired - Fee Related
1998
- 1998-05-06 HU HU0002763A patent/HUP0002763A3/en unknown
- 1998-05-06 ES ES98924383T patent/ES2190081T3/en not_active Expired - Lifetime
- 1998-05-06 WO PCT/FR1998/000905 patent/WO1998051686A1/en not_active Application Discontinuation
- 1998-05-06 DZ DZ980096A patent/DZ2486A1/en active
- 1998-05-06 CA CA002289573A patent/CA2289573A1/en not_active Abandoned
- 1998-05-06 ID IDW991374A patent/ID22911A/en unknown
- 1998-05-06 EE EEP199900524A patent/EE9900524A/en unknown
- 1998-05-06 YU YU57999A patent/YU57999A/en unknown
- 1998-05-06 CO CO98024703A patent/CO4940485A1/en unknown
- 1998-05-06 TR TR1999/02795T patent/TR199902795T2/en unknown
- 1998-05-06 KR KR1019997010496A patent/KR20010012541A/en not_active Application Discontinuation
- 1998-05-06 SK SK1542-99A patent/SK154299A3/en unknown
- 1998-05-06 AT AT98924383T patent/ATE232207T1/en not_active IP Right Cessation
- 1998-05-06 CN CN98807175A patent/CN1263528A/en active Pending
- 1998-05-06 DK DK98924383T patent/DK0984960T3/en active
- 1998-05-06 RU RU99125773/04A patent/RU2175323C2/en not_active IP Right Cessation
- 1998-05-06 AU AU76599/98A patent/AU725530B2/en not_active Ceased
- 1998-05-06 BR BR9811465-4A patent/BR9811465A/en not_active IP Right Cessation
- 1998-05-06 SI SI9830372T patent/SI0984960T1/en unknown
- 1998-05-06 JP JP54885398A patent/JP2001524980A/en not_active Ceased
- 1998-05-06 DE DE69811223T patent/DE69811223T2/en not_active Expired - Fee Related
- 1998-05-06 IL IL13290398A patent/IL132903A0/en unknown
- 1998-05-06 NZ NZ500637A patent/NZ500637A/en unknown
- 1998-05-06 CZ CZ19994006A patent/CZ289484B6/en not_active IP Right Cessation
- 1998-05-06 EP EP98924383A patent/EP0984960B1/en not_active Expired - Lifetime
- 1998-05-06 PL PL98336772A patent/PL336772A1/en unknown
- 1998-05-11 AR ARP980102152A patent/AR011729A1/en active IP Right Grant
- 1998-05-12 UY UY24997A patent/UY24997A1/en not_active IP Right Cessation
- 1998-05-12 TW TW087107326A patent/TW396155B/en active
- 1998-05-12 ZA ZA9803997A patent/ZA983997B/en unknown
- 1998-05-13 HR HR980258A patent/HRP980258B1/en not_active IP Right Cessation
- 1998-05-20 GT GT199800068A patent/GT199800068A/en unknown
1999
- 1999-10-29 IS IS5235A patent/IS5235A/en unknown
- 1999-11-11 NO NO995513A patent/NO995513L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ289484B6 (en)	2002-01-16
AU725530B2 (en)	2000-10-12
ATE232207T1 (en)	2003-02-15
CZ400699A3 (en)	2000-02-16
DE69811223D1 (en)	2003-03-13
EP0984960A1 (en)	2000-03-15
WO1998051686A1 (en)	1998-11-19
HRP980258A2 (en)	1999-02-28
TW396155B (en)	2000-07-01
NO995513L (en)	2000-01-12
IS5235A (en)	1999-10-29
ID22911A (en)	1999-12-16
CO4940485A1 (en)	2000-07-24
FR2763337A1 (en)	1998-11-20
GT199800068A (en)	1999-11-11
IL132903A0 (en)	2001-03-19
DE69811223T2 (en)	2003-11-27
EP0984960B1 (en)	2003-02-05
SK154299A3 (en)	2000-05-16
FR2763337B1 (en)	1999-08-20
HUP0002763A3 (en)	2002-05-28
ZA983997B (en)	1999-11-12
UY24997A1 (en)	2000-10-31
CN1263528A (en)	2000-08-16
NZ500637A (en)	2000-11-24
KR20010012541A (en)	2001-02-15
HRP980258B1 (en)	2002-08-31
BR9811465A (en)	2000-09-12
AU7659998A (en)	1998-12-08
CA2289573A1 (en)	1998-11-19
EE9900524A (en)	2000-06-15
NO995513D0 (en)	1999-11-11
YU57999A (en)	2002-06-19
DZ2486A1 (en)	2003-02-01
ES2190081T3 (en)	2003-07-16
TR199902795T2 (en)	2000-02-21
RU2175323C2 (en)	2001-10-27
SI0984960T1 (en)	2003-06-30
HUP0002763A2 (en)	2001-06-28
PL336772A1 (en)	2000-07-17
JP2001524980A (en)	2001-12-04
AR011729A1 (en)	2000-08-30

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NO20001323D0 (en)	2000-03-14	Dipeptide-apoptosis inhibitors and their use
NO972983L (en)	1997-12-29	Sulfonamides and their use
NO991922L (en)	1999-04-22	Heteroarlsuccinamides and their use as metalloproteinase inhibitors
NO20022334L (en)	2002-07-09	New composition and application
DK1233964T3 (en)	2005-09-19	New use and novel N-azabicycloamide derivatives
NO993522L (en)	1999-09-16	4- (3-heterocyclyl-1-benzoyl) pyrazoles and their use as herbicides
DK1019358T4 (en)	2008-01-14	3,3-diarylpropylamines, their use and preparation
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DK1012137T3 (en)	2003-03-10	Aromatic C-16-C-20-substituted tetrahydro-prostaglandins and their use as prostaglandin FP agonists
NO973338D0 (en)	1997-07-18	N- (4-aryl-thiazol-2-yl) -sulfonamide derivatives and their use
DK0984960T3 (en)	2003-05-26	N-triazole-2-indole carboxamides and their use as CCK-A agonists
DK0989121T3 (en)	2005-12-12	Substituted benzamides and their use as immunomodulators
DK1112003T3 (en)	2003-08-04	New composition and application
NO962952D0 (en)	1996-07-12	1,2,4-oxadiazole derivatives and their use as parasiticides for animals
NO994510L (en)	1999-09-17	Substituted isoquinoline derivatives and their use as anticonvulsants
NO984761D0 (en)	1998-10-12	Aminoisoquinolines and aminotienopyridine derivatives and their use as anti-inflammatory agents
NO985891D0 (en)	1998-12-16	Substituted benzamide derivatives and their use as anticonvulsants
DK1021156T3 (en)	2002-05-27	Cosmetic washing compositions and their use
DK1214302T3 (en)	2004-02-16	Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones and their use as lipase inhibitors
NO20003142D0 (en)	2000-06-16	Substituted isoquinoline derivatives and their use as anticonvulsants
NO20013085D0 (en)	2001-06-21	Phosphorus-organic compounds and their use
NO972256D0 (en)	1997-05-16	O-Benzyloximeter derivatives and their use as pesticides
NO984921D0 (en)	1998-10-22	Tienopyridine derivatives and their use