DK0971938T3 - Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf - Google Patents

Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf

Info

Publication number: DK0971938T3
Authority: DK; Denmark
Prior art keywords: salts; amino; hydroxybutyldien; producing; acid
Prior art date: 1997-02-11

Application number

DK98902890T

Other languages

Danish (da)

English (en)

Inventor

Rudolf Kubela

Yong Tao

Original Assignee

Apotex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-11

Filing date

1998-02-06

Publication date

2002-10-14

1998-02-06 Application filed by Apotex Inc filed Critical Apotex Inc

2002-10-14 Application granted granted Critical

2002-10-14 Publication of DK0971938T3 publication Critical patent/DK0971938T3/da

Links

239000002253 acid Substances 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
229920001515 polyalkylene glycol Polymers 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK98902890T 1997-02-11 1998-02-06 Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf DK0971938T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002197267A CA2197267C (en)	1997-02-11	1997-02-11	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en)	1997-02-11	1998-02-06	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (1)

Publication Number	Publication Date
DK0971938T3 true DK0971938T3 (da)	2002-10-14

Family

ID=4159900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98902890T DK0971938T3 (da)	1997-02-11	1998-02-06	Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf

Country Status (12)

Country	Link
US (1)	US5908959A (pt)
EP (1)	EP0971938B1 (pt)
AT (1)	ATE220404T1 (pt)
AU (1)	AU728164B2 (pt)
BR (1)	BR9807568A (pt)
CA (1)	CA2197267C (pt)
DE (1)	DE69806470T2 (pt)
DK (1)	DK0971938T3 (pt)
ES (1)	ES2180141T3 (pt)
PL (1)	PL335053A1 (pt)
PT (1)	PT971938E (pt)
WO (1)	WO1998034940A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3930251B2 (ja) *	1999-02-17	2007-06-13	テバファーマシューティカルインダストリーズリミティド	アレンドロン酸を製造するための新規な方法
ES2153794B1 (es)	1999-08-06	2001-10-16	Medichem Sa	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011065A1 (es) *	2000-02-01	2001-11-21	Procter & Gamble	Proceso para fabricar bisfosfonatos geminales
TR200101250A2 (tr)	2001-05-10	2003-04-21	E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) *	2001-06-28	2001-08-22	Rhodia Cons Spec Ltd	Improved solvent systems
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
CA2470495A1 (en) *	2001-12-24	2003-07-17	Teva Pharmaceutical Industries Ltd.	Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it)	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
US7038083B2 (en) *	2002-05-17	2006-05-02	Teva Pharmaceutical Industries, Ltd.	Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons
US20040138180A1 (en) *	2002-10-03	2004-07-15	Barr Laboratories, Inc.	Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu)	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) *	2003-04-23	2004-10-28	Courtney Douglas L.	Spray booth and filter system
US7411087B2 (en) *	2003-08-21	2008-08-12	Sun Pharmaceutical Industries Limited	Process for preparation of bisphosphonic acid compounds
US7361761B2 (en) *	2004-09-28	2008-04-22	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of bisphosphonic acid
EP1891081B1 (en) *	2005-06-13	2014-08-20	Jubilant Organosys Limited	Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en)	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
AR058168A1 (es) *	2005-11-07	2008-01-23	Merck & Co Inc	Sintesis del alendronato de sodio trihidratado
EP1803727B1 (en)	2005-12-27	2009-03-11	IPCA Laboratories Limited	Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
WO2007109542A2 (en) *	2006-03-21	2007-09-27	Albemarle Corporation	Process for manufacturing bisphosphonic acids
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
US8076483B2 (en)	2006-05-11	2011-12-13	M/S. Ind Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
AU2007270897A1 (en) *	2006-07-03	2008-01-10	Generics [Uk] Limited	Novel process for the preparation of bisphosphonic acids
CA2570949A1 (en) *	2006-12-12	2008-06-12	Apotex Pharmachem Inc.	Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
WO2008157050A1 (en) *	2007-06-19	2008-12-24	Albemarle Corporation	Processes for manufacturing bisphosphonic acids
US8026388B2 (en)	2008-07-11	2011-09-27	Synthon Bv	Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
EP2192126B1 (en)	2008-11-26	2013-03-27	Synthon B.V.	Process for making zoledronic acid
WO2010060619A1 (en) *	2008-11-26	2010-06-03	Synthon B.V.	Process for making zoledronic acid
US20100130746A1 (en) *	2008-11-26	2010-05-27	Martin Kas	Process for Making Zoledronic Acid
EA201270328A1 (ru)	2009-08-28	2012-09-28	Синтон Б. В.	Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
BR112012007554B1 (pt)	2009-10-02	2018-09-04	Monsanto Technology Llc	método para a fabricação de ácidos amino hidróxi disfofônico

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4163733A (en) *	1977-10-25	1979-08-07	Buckman Laboratories, Inc.	Synergistic compositions for corrosion and scale control
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) *	1980-10-16	1981-12-08	Vysoka Skola Chemicko-Technologicka	6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) *	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) *	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) *	1993-08-25	1996-04-23	Merck & Co., Inc.	Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

1997
- 1997-02-11 CA CA002197267A patent/CA2197267C/en not_active Expired - Fee Related
1998
- 1998-02-06 ES ES98902890T patent/ES2180141T3/es not_active Expired - Lifetime
- 1998-02-06 EP EP98902890A patent/EP0971938B1/en not_active Expired - Lifetime
- 1998-02-06 US US09/019,806 patent/US5908959A/en not_active Expired - Fee Related
- 1998-02-06 DK DK98902890T patent/DK0971938T3/da active
- 1998-02-06 DE DE69806470T patent/DE69806470T2/de not_active Expired - Fee Related
- 1998-02-06 WO PCT/CA1998/000091 patent/WO1998034940A1/en active IP Right Grant
- 1998-02-06 AT AT98902890T patent/ATE220404T1/de not_active IP Right Cessation
- 1998-02-06 PL PL98335053A patent/PL335053A1/xx unknown
- 1998-02-06 PT PT98902890T patent/PT971938E/pt unknown
- 1998-02-06 BR BR9807568A patent/BR9807568A/pt not_active Application Discontinuation
- 1998-02-06 AU AU59772/98A patent/AU728164B2/en not_active Ceased

Also Published As

Publication number	Publication date
DE69806470D1 (de)	2002-08-14
ES2180141T3 (es)	2003-02-01
PL335053A1 (en)	2000-03-27
BR9807568A (pt)	2000-03-21
EP0971938B1 (en)	2002-07-10
PT971938E (pt)	2002-11-29
AU5977298A (en)	1998-08-26
MX9801171A (es)	1998-12-31
CA2197267A1 (en)	1998-08-11
ATE220404T1 (de)	2002-07-15
DE69806470T2 (de)	2003-02-20
EP0971938A1 (en)	2000-01-19
CA2197267C (en)	2000-02-08
AU728164B2 (en)	2001-01-04
WO1998034940A1 (en)	1998-08-13
US5908959A (en)	1999-06-01

Publication	Publication Date	Title
DK0971938T3 (da)	2002-10-14	Fremgangsmåde til produktion af 4-amino-1-hydroxybutyldien-1,1-biphosphonsyre eller salte deraf
DK0402152T3 (da)	1995-12-04	Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1,1-bisphosphonsyre eller salte deraf
DK0462663T3 (da)	1996-01-29	Forbedret fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1,1-bisphosphonsyre (ABP) eller salte deraf
DE3777589D1 (de)	1992-04-23	Verfahren zur produktion von halbleiteranordnungen.
DE3782768D1 (de)	1993-01-07	Verfahren fuer die produktion von im wesentlichen reinem albumin.
ATE312836T1 (de)	2005-12-15	Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure
DK1097130T3 (da)	2006-09-25	Fremgangsmåde til fremstilling af hydroxymethylthiosmörsyre
ATE273316T1 (de)	2004-08-15	Verfahren zur herstellung von alkenylphosphonsäure-derivaten
NO953992L (no)	1995-10-06	Fremgangsmåte for fremstilling av aminometanfosforsyre
DK375688D0 (da)	1988-07-06	Fremgangsmaade til fremstilling af aminomethylenphosphonalkylphosphinatforbindelser
DK0682018T3 (da)	1998-10-07	Fremgangsmåde til fremstilling af 2-amino-4,6-dichlorpyrimidin
PT1090137E (pt)	2002-08-30	Producao de polimeros a partir de componentes nucleot´dicos e/ou nao nucleotidicos por via enzimatica
HUP0000120A2 (hu)	2000-06-28	N-(foszfono-metil)-glicin és sói előállítására szolgáló eljárás
RU96104412A (ru)	1998-06-10	Способ получения о-полигалоидалкил-о-(полигалоидалкоксикарбониларил)-фосфитов