DE69806470D1 - Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure - Google Patents

Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure

Info

Publication number: DE69806470D1
Authority: DE; Germany
Prior art keywords: amino; hydroxybutyliden; producing; acid; biphosphonic acid
Prior art date: 1997-02-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69806470T

Other languages

English (en)

Other versions

DE69806470T2 (de

Inventor

Rudolf Kubela

Yong Tao

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Apotex Inc

Original Assignee

Apotex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-11

Filing date

1998-02-06

Publication date

2002-08-14

1998-02-06 Application filed by Apotex Inc filed Critical Apotex Inc

2002-08-14 Application granted granted Critical

2002-08-14 Publication of DE69806470D1 publication Critical patent/DE69806470D1/de

2003-02-20 Publication of DE69806470T2 publication Critical patent/DE69806470T2/de

2018-02-07 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000002253 acid Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
229920001515 polyalkylene glycol Polymers 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69806470T 1997-02-11 1998-02-06 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure Expired - Fee Related DE69806470T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002197267A CA2197267C (en)	1997-02-11	1997-02-11	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en)	1997-02-11	1998-02-06	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (2)

Publication Number	Publication Date
DE69806470D1 true DE69806470D1 (de)	2002-08-14
DE69806470T2 DE69806470T2 (de)	2003-02-20

Family

ID=4159900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69806470T Expired - Fee Related DE69806470T2 (de)	1997-02-11	1998-02-06	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure

Country Status (12)

Country	Link
US (1)	US5908959A (de)
EP (1)	EP0971938B1 (de)
AT (1)	ATE220404T1 (de)
AU (1)	AU728164B2 (de)
BR (1)	BR9807568A (de)
CA (1)	CA2197267C (de)
DE (1)	DE69806470T2 (de)
DK (1)	DK0971938T3 (de)
ES (1)	ES2180141T3 (de)
PL (1)	PL335053A1 (de)
PT (1)	PT971938E (de)
WO (1)	WO1998034940A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL144941A0 (en) *	1999-02-17	2002-06-30	Teva Pharma	Novel process for preparing alendronic acid
ES2153794B1 (es)	1999-08-06	2001-10-16	Medichem Sa	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en)	2000-02-01	2003-05-13	The Procter & Gamble Company	Process for making geminal bisphosphonates
TR200101250A2 (tr) *	2001-05-10	2003-04-21	E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) *	2001-06-28	2001-08-22	Rhodia Cons Spec Ltd	Improved solvent systems
KR100897837B1 (ko) *	2001-12-24	2009-05-15	테바 파마슈티컬 인더스트리즈 리미티드	분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
ITMI20020908A1 (it)	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
WO2003097655A1 (en) *	2002-05-17	2003-11-27	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids
US20040138180A1 (en) *	2002-10-03	2004-07-15	Barr Laboratories, Inc.	Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu)	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) *	2003-04-23	2004-10-28	Courtney Douglas L.	Spray booth and filter system
PL1656386T3 (pl)	2003-08-21	2010-05-31	Sun Pharmaceuticals Ind Ltd	Proces wytwarzania związków kwasu difosfonowego
US7361761B2 (en) *	2004-09-28	2008-04-22	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of bisphosphonic acid
EP1891081B1 (de) *	2005-06-13	2014-08-20	Jubilant Organosys Limited	Verfahren zur herstellung von bisphosphonsäuren und formen davon
US8003820B2 (en)	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
AR058168A1 (es) *	2005-11-07	2008-01-23	Merck & Co Inc	Sintesis del alendronato de sodio trihidratado
ES2323728T3 (es)	2005-12-27	2009-07-23	Ipca Laboratories Limited	Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
CN101443341A (zh) *	2006-03-21	2009-05-27	雅宝公司	制造二膦酸的方法
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
US8076483B2 (en)	2006-05-11	2011-12-13	M/S. Ind Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
CA2656053A1 (en) *	2006-07-03	2008-01-10	Generics [Uk] Limited	Novel process for the preparation of bisphosphonic acids
CA2570949A1 (en) *	2006-12-12	2008-06-12	Apotex Pharmachem Inc.	Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
CA2689504A1 (en) *	2007-06-19	2008-12-24	Albemarle Corporation	Processes for manufacturing bisphosphonic acids
CN102124016A (zh) *	2008-07-11	2011-07-13	斯索恩有限公司	制备1-羟基亚烷基-1，1-双膦酸的方法
US20100130746A1 (en) *	2008-11-26	2010-05-27	Martin Kas	Process for Making Zoledronic Acid
WO2010060619A1 (en) *	2008-11-26	2010-06-03	Synthon B.V.	Process for making zoledronic acid
EP2192126B1 (de)	2008-11-26	2013-03-27	Synthon B.V.	Verfahren zur Herstellung von Zoledronsäure
EP2470549B1 (de)	2009-08-28	2014-07-16	Synthon B.V.	Verfahren zur herstellung von hydroxyalkyliden-1,1-biphosphonsäuren
US8779135B2 (en)	2009-10-02	2014-07-15	Straitmark Holding Ag	Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4163733A (en) *	1977-10-25	1979-08-07	Buckman Laboratories, Inc.	Synergistic compositions for corrosion and scale control
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) *	1980-10-16	1981-12-08	Vysoka Skola Chemicko-Technologicka	6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) *	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) *	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) *	1993-08-25	1996-04-23	Merck & Co., Inc.	Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

1997
- 1997-02-11 CA CA002197267A patent/CA2197267C/en not_active Expired - Fee Related
1998
- 1998-02-06 WO PCT/CA1998/000091 patent/WO1998034940A1/en active IP Right Grant
- 1998-02-06 PL PL98335053A patent/PL335053A1/xx unknown
- 1998-02-06 US US09/019,806 patent/US5908959A/en not_active Expired - Fee Related
- 1998-02-06 DE DE69806470T patent/DE69806470T2/de not_active Expired - Fee Related
- 1998-02-06 BR BR9807568A patent/BR9807568A/pt not_active Application Discontinuation
- 1998-02-06 AU AU59772/98A patent/AU728164B2/en not_active Ceased
- 1998-02-06 AT AT98902890T patent/ATE220404T1/de not_active IP Right Cessation
- 1998-02-06 ES ES98902890T patent/ES2180141T3/es not_active Expired - Lifetime
- 1998-02-06 PT PT98902890T patent/PT971938E/pt unknown
- 1998-02-06 DK DK98902890T patent/DK0971938T3/da active
- 1998-02-06 EP EP98902890A patent/EP0971938B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1998034940A1 (en)	1998-08-13
PL335053A1 (en)	2000-03-27
MX9801171A (es)	1998-12-31
DE69806470T2 (de)	2003-02-20
ATE220404T1 (de)	2002-07-15
AU728164B2 (en)	2001-01-04
CA2197267A1 (en)	1998-08-11
AU5977298A (en)	1998-08-26
PT971938E (pt)	2002-11-29
US5908959A (en)	1999-06-01
BR9807568A (pt)	2000-03-21
ES2180141T3 (es)	2003-02-01
EP0971938A1 (de)	2000-01-19
DK0971938T3 (da)	2002-10-14
EP0971938B1 (de)	2002-07-10
CA2197267C (en)	2000-02-08

Legal Events

Date	Code	Title	Description
2003-08-07	8364	No opposition during term of opposition
2010-12-16	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69806470D1 (de)	2002-08-14	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure
ATE128470T1 (de)	1995-10-15	Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure.
FI902845A0 (fi)	1990-06-07	Menetelmä 4-amino-1-hydroksibutylideeni-1,1-bisfosfonihapon tai sen suolojen valmistamiseksi
ATE160352T1 (de)	1997-12-15	Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren
DE69619237D1 (de)	2002-03-21	Verfahren zur herstellung von n-phosphonomethyliminodiessigesäure.
ATE312836T1 (de)	2005-12-15	Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure
ATE273316T1 (de)	2004-08-15	Verfahren zur herstellung von alkenylphosphonsäure-derivaten
ATE155789T1 (de)	1997-08-15	Verfahren zur herstellung von aminomethanphosphonsäure
DE69916067D1 (de)	2004-05-06	Verfahren zur herstellung von n-phosphonomethyl iminodiessigsäure
DE3864927D1 (de)	1991-10-24	Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten.
ATE235461T1 (de)	2003-04-15	Verfahren zur herstellung von 3-cyano-2,4- dihalogen-5-fluor-benzoesäuren
DE58901876D1 (de)	1992-08-27	Verfahren zur herstellung von aminoalkylenphosphonsaeuregruppen aufweisenden ionenaustauscherharzen.
DE3765505D1 (de)	1990-11-15	Verfahren zur herstellung von vinylphosphonsaeuredichlorid.
ATE256689T1 (de)	2004-01-15	Verfahren zur herstellung von ascorbinsaüre-2- monophosphat salz