DK0970099T3 - Fremgangsmåde til fremstilling af erythromycin A-oxim - Google Patents

Fremgangsmåde til fremstilling af erythromycin A-oxim

Info

Publication number: DK0970099T3
Authority: DK; Denmark
Prior art keywords: erythromycin; oxime; preparation; isopropanol; acetic acid
Prior art date: 1996-04-10

Application number

DK97907949T

Other languages

English (en)

Inventor

Sou-Jen Chang

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-10

Filing date

1997-02-27

Publication date

2003-05-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24526649&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0970099(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-02-27 Application filed by Abbott Lab filed Critical Abbott Lab

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK0970099T3 publication Critical patent/DK0970099T3/da

Links

KYTWXIARANQMCA-PGYIPVOXSA-N (3r,4s,5s,6r,7r,9r,10z,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradec Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\O)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 KYTWXIARANQMCA-PGYIPVOXSA-N 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 3
229930006677 Erythromycin A Natural products 0.000 abstract 3
229960003276 erythromycin Drugs 0.000 abstract 3
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK97907949T 1996-04-10 1997-02-27 Fremgangsmåde til fremstilling af erythromycin A-oxim DK0970099T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/630,306 US5808017A (en)	1996-04-10	1996-04-10	Process for preparing erythromycin A oxime
PCT/US1997/003177 WO1997038000A1 (en)	1996-04-10	1997-02-27	Process for preparing erythromycin a oxime

Publications (1)

Publication Number	Publication Date
DK0970099T3 true DK0970099T3 (da)	2003-05-26

Family

ID=24526649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97907949T DK0970099T3 (da)	1996-04-10	1997-02-27	Fremgangsmåde til fremstilling af erythromycin A-oxim

Country Status (8)

Country	Link
US (1)	US5808017A (da)
EP (1)	EP0970099B1 (da)
JP (1)	JP4004068B2 (da)
AT (1)	ATE232210T1 (da)
DE (1)	DE69718942T2 (da)
DK (1)	DK0970099T3 (da)
ES (1)	ES2191821T3 (da)
WO (1)	WO1997038000A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE269350T1 (de) *	1997-07-08	2004-07-15	Biochemie Sa	Solvate von erythromycin a oxim
CA2245398C (en) *	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IN190782B (da) *	1998-09-30	2003-08-23	Max India Ltd
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
RU2002116232A (ru) *	1999-12-16	2004-01-10	Тева Фамэситикл Индастрис Лтд. (Il)	Способ получения полиморфных модификаций кларитромицина и новой полиморфной модификации IV
FR2802534B1 (fr) *	1999-12-20	2002-02-01	Merial Sas	Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
US6590084B2 (en)	1999-12-20	2003-07-08	Merial	Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
IL150698A0 (en) *	2000-01-11	2003-02-12	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
JP2004509062A (ja)	2000-02-29	2004-03-25	テバ　ファーマシューティカル　インダストリーズ　リミティド	クラリスロマイシンおよびクラリスロマイシン中間体、本質的にオキシムを含まないクラリスロマイシン、およびそれを含んで成る医薬組成物を調製するための方法
KR20030011797A (ko) *	2000-03-28	2003-02-11	바이오케미 게젤샤프트 엠베하	맛이 차폐된 과립형 입자
DE60114028T2 (de) *	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
WO2003040162A1 (de) *	2001-11-07	2003-05-15	Aventis Pharma Deutschland Gmbh	Verfahren zur herstellung von desclarithromycin, sowie zwischenprodukte
EP1648415A4 (en)	2003-07-21	2011-11-16	Middlebrook Pharmaceuticals Inc	ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
US8313775B2 (en)	2003-07-21	2012-11-20	Shionogi Inc.	Antibiotic product, use and formulation thereof
EP1648418A4 (en)	2003-07-21	2011-11-16	Middlebrook Pharmaceuticals Inc	ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
EP1653925A1 (en)	2003-08-11	2006-05-10	Advancis Pharmaceutical Corporation	Robust pellet
AU2004264356B2 (en)	2003-08-12	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
WO2005023184A2 (en) *	2003-08-29	2005-03-17	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
JP2007513869A (ja)	2003-09-15	2007-05-31	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
CA2572292A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin
CN101362783B (zh) *	2008-10-06	2011-12-07	浙江国邦药业有限公司	一种红霉素a(e)肟的制备方法
CN102911225A (zh) *	2011-08-04	2013-02-06	山东方明药业集团股份有限公司	红霉素a肟的清洁化合成方法及其特别组合的反应设备
CN103897002A (zh) *	2012-12-31	2014-07-02	菏泽市方明制药有限公司	一种粗品硫氰酸红霉素制备红霉素a9-肟的方法
CN103923142B (zh) *	2014-04-30	2017-01-11	浙江震元制药有限公司	一种罗红霉素中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4150220A (en) *	1977-02-04	1979-04-17	Pfizer Inc.	Semi-synthetic 4"-erythromycin A derivatives
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法

1996
- 1996-04-10 US US08/630,306 patent/US5808017A/en not_active Expired - Lifetime
1997
- 1997-02-27 EP EP97907949A patent/EP0970099B1/en not_active Expired - Lifetime
- 1997-02-27 AT AT97907949T patent/ATE232210T1/de not_active IP Right Cessation
- 1997-02-27 JP JP53618597A patent/JP4004068B2/ja not_active Expired - Fee Related
- 1997-02-27 WO PCT/US1997/003177 patent/WO1997038000A1/en active IP Right Grant
- 1997-02-27 DE DE69718942T patent/DE69718942T2/de not_active Expired - Fee Related
- 1997-02-27 DK DK97907949T patent/DK0970099T3/da active
- 1997-02-27 ES ES97907949T patent/ES2191821T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1997038000A1 (en)	1997-10-16
ES2191821T3 (es)	2003-09-16
ATE232210T1 (de)	2003-02-15
JP4004068B2 (ja)	2007-11-07
DE69718942T2 (de)	2003-12-11
JP2000508311A (ja)	2000-07-04
DE69718942D1 (de)	2003-03-13
US5808017A (en)	1998-09-15
EP0970099B1 (en)	2003-02-05
EP0970099A1 (en)	2000-01-12

Publication	Publication Date	Title
DK0970099T3 (da)	2003-05-26	Fremgangsmåde til fremstilling af erythromycin A-oxim
ID24755A (id)	2000-08-03	Proses ekstruksi untuk meningkatkan kekuatan leleh polipropilena
RU95102329A (ru)	1997-01-10	Способ и стабилизированная каталитическая система для получения олефинов
MX9205462A (es)	1993-05-01	Proceso y equipo para teñido de cabello
IE44749L (en)	1977-05-04	Cyclopeptide
BR9809109A (pt)	2000-08-01	Composição aglutinante de tinta em pó
EA199800811A1 (ru)	1999-02-25	Способ получения нитробифенилов
DK0749305T3 (da)	2002-06-17	Fremgangsmåde til fremstilling af avermectin/zein-sammensætninger
DK0935647T3 (da)	2002-09-09	Koncentrerede enfasede vandige opløsninger af tetrahydroiso-alfa-syrer og fremgangsmåder til fremstilling af samme
CA2204184A1 (en)	1997-03-27	End sections of connections for mineral wool conduits of the "climaver plus" type
SE9600086D0 (sv)	1996-01-10	New manufacturing process
JPS53121710A (en)	1978-10-24	Preparation of isomerized chlorofluorohydrocarbon containing hydrogne
ID27440A (id)	2001-04-12	Proses untuk menyiapkan penengah-penengah
JPS529757A (en)	1977-01-25	Clamping method of bolt and its washer
EP0669304A4 (en)	1995-12-20	PROCESS FOR THE PRODUCTION OF DIFLUOROMETHANE.
ES2138215T3 (es)	2000-01-01	Metodo para eliminar un color no deseado de acido clorhidrico.
ES439296A1 (es)	1977-03-01	Procedimiento para la preparacion de anhidrido maleico, a partir de acido maleico.
BR9807726A (pt)	2000-02-15	Processo para a preparação de um composto
JPS5386094A (en)	1978-07-29	Preparation of 7-amino-cephem derivatives
JPS5254083A (en)	1977-05-02	Microbial productio of glicolipids
JPS51120637A (en)	1976-10-22	Signal transmission system
JPS52153915A (en)	1977-12-21	Preparation of alpha-amino-delta-hydroxyvaleric acid
JPS5377098A (en)	1978-07-08	Preparation of indoloisoquinoline derivative
MX9704608A (es)	1998-07-31	Acidos fluoroalquilglicosiduronicos y 6(3)-lactonas correspondientes, preparacion y usos.
JPS548894A (en)	1979-01-23	Cable installation method