DK0867515T3 - Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre - Google Patents

Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre

Info

Publication number
DK0867515T3
DK0867515T3 DK97104947T DK97104947T DK0867515T3 DK 0867515 T3 DK0867515 T3 DK 0867515T3 DK 97104947 T DK97104947 T DK 97104947T DK 97104947 T DK97104947 T DK 97104947T DK 0867515 T3 DK0867515 T3 DK 0867515T3
Authority
DK
Denmark
Prior art keywords
clavulanic acid
alkali metal
metal salt
pharmaceutically acceptable
water immiscible
Prior art date
Application number
DK97104947T
Other languages
Danish (da)
English (en)
Inventor
Jaoquim P Cardoso
Original Assignee
Cipan Comp Ind Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipan Comp Ind Prod filed Critical Cipan Comp Ind Prod
Application granted granted Critical
Publication of DK0867515T3 publication Critical patent/DK0867515T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97104947T 1997-03-24 1997-03-24 Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre DK0867515T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97104947A EP0867515B1 (de) 1997-03-24 1997-03-24 Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure

Publications (1)

Publication Number Publication Date
DK0867515T3 true DK0867515T3 (da) 2000-06-13

Family

ID=8226629

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97104947T DK0867515T3 (da) 1997-03-24 1997-03-24 Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre

Country Status (12)

Country Link
US (1) US6417352B1 (de)
EP (1) EP0867515B1 (de)
JP (1) JP3474204B2 (de)
AT (1) ATE187498T1 (de)
AU (1) AU740387B2 (de)
DE (1) DE69700903T2 (de)
DK (1) DK0867515T3 (de)
ES (1) ES2142641T3 (de)
GR (1) GR3032882T3 (de)
NZ (1) NZ337476A (de)
PT (1) PT867515E (de)
ZA (1) ZA982437B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
GB0022841D0 (en) * 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
CN101548018A (zh) * 2006-12-01 2009-09-30 帝斯曼知识产权资产管理有限公司 一种用于制备克拉维酸的方法
JP5778161B2 (ja) * 2010-09-24 2015-09-16 第一三共株式会社 置換シクロアルケン誘導体の結晶
CN103833774A (zh) * 2014-03-21 2014-06-04 山东新时代药业有限公司 一种从克拉维酸钾混粉中回收有效成分的方法
CN109535183A (zh) * 2017-09-21 2019-03-29 联邦制药(内蒙古)有限公司 一种制备克拉维酸叔辛胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770590A (en) * 1971-12-01 1973-11-06 Merck & Co Inc Fermentation process
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
GB9521173D0 (en) 1995-10-17 1995-12-20 Univ Southampton Isolation of parasites

Also Published As

Publication number Publication date
US6417352B1 (en) 2002-07-09
JP3474204B2 (ja) 2003-12-08
ZA982437B (en) 1998-09-28
DE69700903T2 (de) 2000-07-06
ATE187498T1 (de) 1999-12-15
ES2142641T3 (es) 2000-04-16
EP0867515B1 (de) 1999-12-08
AU740387B2 (en) 2001-11-01
PT867515E (pt) 2000-05-31
JP2001521393A (ja) 2001-11-06
GR3032882T3 (en) 2000-07-31
AU7038998A (en) 1998-10-20
DE69700903D1 (de) 2000-01-13
EP0867515A1 (de) 1998-09-30
NZ337476A (en) 2001-03-30

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