ES8306183A1 - Mejoras en un procedimiento para la preparacion de penici- linas y derivados de penicilinas. - Google Patents

Mejoras en un procedimiento para la preparacion de penici- linas y derivados de penicilinas.

Info

Publication number
ES8306183A1
ES8306183A1 ES506854A ES506854A ES8306183A1 ES 8306183 A1 ES8306183 A1 ES 8306183A1 ES 506854 A ES506854 A ES 506854A ES 506854 A ES506854 A ES 506854A ES 8306183 A1 ES8306183 A1 ES 8306183A1
Authority
ES
Spain
Prior art keywords
formula
preparation
radical
penicillins
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506854A
Other languages
English (en)
Other versions
ES506854A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8306183A1 publication Critical patent/ES8306183A1/es
Publication of ES506854A0 publication Critical patent/ES506854A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PENICILINAS Y DERIVADOS DE PENICILINAS DE FORMULA (I), EN LA QUE R ES UN GRUPO ACILO; Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS, CATALIZADA POR UNA SERINA PROTEINASA MICROBIANA ALCALINA, TAL COMO SUBTILISINA, DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y R ES BENCILO O BENCILO SUSTITUIDO. LA SERINA PROTEINASA MICROBIANA ESTA UNIDA A UN SOPORTE INSOLUBLE, PARA PODERLA SEPARAR DEL MEDIO ACUOSO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS.
ES506854A 1980-11-05 1981-11-04 Mejoras en un procedimiento para la preparacion de penici- linas y derivados de penicilinas. Granted ES506854A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8035454 1980-11-05

Publications (2)

Publication Number Publication Date
ES8306183A1 true ES8306183A1 (es) 1982-08-16
ES506854A0 ES506854A0 (es) 1982-08-16

Family

ID=10517087

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506854A Granted ES506854A0 (es) 1980-11-05 1981-11-04 Mejoras en un procedimiento para la preparacion de penici- linas y derivados de penicilinas.

Country Status (11)

Country Link
US (1) US4413056A (es)
EP (1) EP0051481B1 (es)
JP (1) JPS57105196A (es)
AU (1) AU7712881A (es)
DE (1) DE3165269D1 (es)
DK (1) DK489281A (es)
ES (1) ES506854A0 (es)
GB (1) GB2086897B (es)
GR (1) GR76291B (es)
PT (1) PT73914B (es)
ZA (1) ZA817317B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215891A (en) * 1986-10-15 1993-06-01 Farmitalia Carlo Erba Process for preparing penems
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
IT1224252B (it) * 1988-04-08 1990-09-26 Sclavo Spa Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1160211A (en) * 1966-12-15 1969-08-06 Beecham Group Ltd Penicillins
GB1217143A (en) * 1967-02-13 1970-12-31 Beecham Group Ltd Penicillins
US3528965A (en) * 1968-02-09 1970-09-15 Beecham Group Ltd Penicillin ester process and products
US3972774A (en) * 1975-07-28 1976-08-03 Eli Lilly And Company Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters
ZA802445B (en) * 1979-05-15 1981-04-29 Beecham Group Ltd Process for the preparation of penicillin derivatives
ZA802446B (en) * 1979-05-15 1981-04-29 Beecham Group Ltd Process for the preparation of penicillin derivatives

Also Published As

Publication number Publication date
EP0051481B1 (en) 1984-08-01
GB2086897B (en) 1984-08-08
EP0051481A1 (en) 1982-05-12
GR76291B (es) 1984-08-04
AU7712881A (en) 1982-05-13
DE3165269D1 (en) 1984-09-06
ES506854A0 (es) 1982-08-16
GB2086897A (en) 1982-05-19
ZA817317B (en) 1982-09-29
PT73914B (en) 1983-01-25
PT73914A (en) 1981-11-01
DK489281A (da) 1982-05-06
US4413056A (en) 1983-11-01
JPS57105196A (en) 1982-06-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405