DK0833620T3 - FGFR3, en markør for mesenkymale progenitorceller - Google Patents

FGFR3, en markør for mesenkymale progenitorceller

Info

Publication number
DK0833620T3
DK0833620T3 DK96917640T DK96917640T DK0833620T3 DK 0833620 T3 DK0833620 T3 DK 0833620T3 DK 96917640 T DK96917640 T DK 96917640T DK 96917640 T DK96917640 T DK 96917640T DK 0833620 T3 DK0833620 T3 DK 0833620T3
Authority
DK
Denmark
Prior art keywords
fgfr3
progenitor cells
bone
marker
skeletal progenitor
Prior art date
Application number
DK96917640T
Other languages
Danish (da)
English (en)
Inventor
Avner Yayon
Zvi Nevo
Original Assignee
Yeda Res & Dev
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Univ Ramot filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK0833620T3 publication Critical patent/DK0833620T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96917640T 1995-06-12 1996-06-12 FGFR3, en markør for mesenkymale progenitorceller DK0833620T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13795P 1995-06-12 1995-06-12
PCT/IL1996/000010 WO1996041620A1 (fr) 1995-06-12 1996-06-12 Fgfr3 utilise en qualite de marqueur de cellules progenitrices mesenchymateuses du squelette

Publications (1)

Publication Number Publication Date
DK0833620T3 true DK0833620T3 (da) 2003-01-13

Family

ID=21690089

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96917640T DK0833620T3 (da) 1995-06-12 1996-06-12 FGFR3, en markør for mesenkymale progenitorceller
DK96917641T DK0836380T3 (da) 1995-06-12 1996-06-12 FGF9 som en specifik ligand for FGFR3

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96917641T DK0836380T3 (da) 1995-06-12 1996-06-12 FGF9 som en specifik ligand for FGFR3

Country Status (12)

Country Link
US (2) US6447783B1 (fr)
EP (3) EP0833620B1 (fr)
JP (3) JPH11507828A (fr)
CN (1) CN1195982A (fr)
AT (2) ATE225652T1 (fr)
AU (2) AU715996B2 (fr)
CA (2) CA2223701C (fr)
DE (2) DE69619526T2 (fr)
DK (2) DK0833620T3 (fr)
ES (2) ES2183957T3 (fr)
IL (2) IL122472A (fr)
WO (2) WO1996041620A1 (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US7799077B2 (en) 2002-10-07 2010-09-21 Conformis, Inc. Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces
US7618451B2 (en) 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US10085839B2 (en) 2004-01-05 2018-10-02 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US6136040A (en) * 1998-03-05 2000-10-24 Washington University Animal model with disrupted FGF-9 gene
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
JP2002532126A (ja) 1998-09-14 2002-10-02 スタンフォード ユニバーシティ 関節状態の評価及び損傷防止装置
US20020058036A1 (en) * 1999-07-27 2002-05-16 Michael Jeffers Novel fibroblast growth factor and nucleic acids encoding same
US7482114B2 (en) 1999-10-06 2009-01-27 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation
AU7634400A (en) 1999-10-06 2001-05-10 Tigenix N.V. Isolation of precursor cells and their use for tissue repair
AU7764200A (en) 1999-10-06 2001-05-10 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cellpopulations, and selecting cell populations for autologous transplantation
US20030149238A1 (en) * 2000-02-14 2003-08-07 Pankaj Agarwal Novel compounds
AU2001240149A1 (en) 2000-03-13 2001-09-24 Amgen Inc Fibroblast growth factor-like molecules and uses thereof
WO2002022013A1 (fr) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Evaluation de l'etat d'une articulation et d'une perte de cartilage
WO2002022014A1 (fr) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Évaluation de l'état d'une articulation et traitement afférent
WO2002063037A2 (fr) * 2001-02-02 2002-08-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Procede d'identification d'acides nucleiques fonctionnels
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
WO2002096268A2 (fr) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methodes et compositions d'arthroplastie
US8951260B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Surgical cutting guide
AU2002314495A1 (en) 2001-06-20 2003-01-02 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
WO2003076467A1 (fr) * 2002-03-14 2003-09-18 Yeda Research And Development Co. Ltd. Compositions et procedes visant a induire et a reguler la formation osseuse
WO2004022095A1 (fr) * 2002-09-04 2004-03-18 Abtech Anticorps anti-idiotypiques utiles en tant qu'agonistes d'un recepteur vegf ou fgf pour la therapie osseuse
US8932363B2 (en) 2002-11-07 2015-01-13 Conformis, Inc. Methods for determining meniscal size and shape and for devising treatment
EP2453024B1 (fr) 2004-06-21 2017-12-06 The Board of Trustees of The Leland Stanford Junior University Gènes et voies exprimés différemment dans le trouble bipolaire et/ou le trouble dépressif majeur
AU2011211453B2 (en) * 2004-06-21 2015-01-15 The Board Of Trustees Of The Leland Stanford Junior University Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
CN101506355B (zh) * 2004-09-24 2012-06-27 成血管细胞***公司 多能扩增间充质前体细胞子代（memp）及其应用
US7391676B2 (en) * 2004-12-22 2008-06-24 Asml Netherlands B.V. Ultrasonic distance sensors
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
US20070049739A1 (en) * 2005-08-30 2007-03-01 Biomet Manufacturing Corp. Method and system for extracting blood-derived growth factors
CN102599960B (zh) 2006-02-06 2015-08-12 康复米斯公司 患者可选择的关节成形术装置和手术器具
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
JP4748222B2 (ja) * 2007-01-23 2011-08-17 公立大学法人横浜市立大学 軟骨細胞調製方法
EP2591756A1 (fr) 2007-02-14 2013-05-15 Conformis, Inc. Dispositif d'implant et procédé de fabrication
WO2009111626A2 (fr) 2008-03-05 2009-09-11 Conformis, Inc. Implants pour modifier des modèles d’usure de surfaces articulaires
JP2011519713A (ja) 2008-05-12 2011-07-14 コンフォーミス・インコーポレイテッド 面関節および他の関節の治療のためのデバイスならびに方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
EP2405865B1 (fr) 2009-02-24 2019-04-17 ConforMIS, Inc. Systèmes automatisés four la fabrication des implants et instruments adaptés individuellement au patient
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
BRPI1006448B1 (pt) 2009-03-25 2021-08-17 Genentech, Inc Anticorpo antagonista anti-fgfr3, anticorpo monoclonal, polinucleotídeo, vetor, micro­organismo transgênico, método para produção de um anticorpo anti-fgfr3, formulação farmacêutica e usos do anticorpo antagonista anti-fgfr3
SG175229A1 (en) 2009-04-16 2011-11-28 Conformis Inc Patient-specific joint arthroplasty devices for ligament repair
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
SG193484A1 (en) 2011-02-15 2013-10-30 Conformis Inc Patent-adapted and improved articular implants, designs, surgical procedures and related guide tools
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
AU2013373679A1 (en) * 2013-01-16 2015-08-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
KR20150124941A (ko) 2013-03-10 2015-11-06 고쿠리츠 다이가쿠 호우징 나고야 다이가쿠 골 계통 질환 치료약 및 그 용도
KR102432192B1 (ko) 2016-07-07 2022-08-12 화이자 인코포레이티드 가용성 섬유아세포 성장 인자 수용체 3(sfgfr3) 폴리펩티드 및 이의 용도
JP2020015733A (ja) * 2019-08-19 2020-01-30 アンセルムＩｎｓｅｒｍ 骨格成長遅延障害の予防または処置における使用のための、可溶性線維芽細胞増殖因子受容体３（ｆｇｒ３）ポリペプチド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5270197A (en) * 1990-12-20 1993-12-14 The Children's Medical Center Corporation Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
JP3385040B2 (ja) * 1991-02-14 2003-03-10 武田薬品工業株式会社 グリア活性化因子およびその製造法
EP0608546A3 (en) 1992-12-22 1995-09-27 Takeda Chemical Industries Ltd Glia activating factor (gaf), antibodies against it and their uses.
WO1994021813A1 (fr) * 1993-03-17 1994-09-29 The Whittier Institute For Diabetes And Endocrinology Anticorps monoclonaux specifiques des recepteurs de facteur de croissance de fibroblaste, immunotoxines, et utilisation

Also Published As

Publication number Publication date
JPH11507828A (ja) 1999-07-13
IL122472A0 (en) 1998-06-15
JP2004305221A (ja) 2004-11-04
WO1996041620A1 (fr) 1996-12-27
EP0836380A4 (fr) 1999-03-31
EP0833620B1 (fr) 2002-10-09
ES2183957T3 (es) 2003-04-01
EP1342476A3 (fr) 2003-09-17
DE69624239D1 (de) 2002-11-14
DK0836380T3 (da) 2002-04-22
ES2173289T3 (es) 2002-10-16
US6447783B1 (en) 2002-09-10
ATE225652T1 (de) 2002-10-15
CN1195982A (zh) 1998-10-14
AU715996B2 (en) 2000-02-17
US20020193309A1 (en) 2002-12-19
CA2224229A1 (fr) 1996-12-27
AU6014596A (en) 1997-01-09
DE69619526D1 (de) 2002-04-04
CA2223701C (fr) 2010-02-16
ATE213590T1 (de) 2002-03-15
IL122472A (en) 2003-11-23
EP1342476A2 (fr) 2003-09-10
DE69624239T2 (de) 2003-07-10
EP0836380A1 (fr) 1998-04-22
JP3673281B2 (ja) 2005-07-20
EP0836380B1 (fr) 2002-02-27
IL122473A0 (en) 1998-06-15
JPH11508358A (ja) 1999-07-21
AU721773B2 (en) 2000-07-13
IL122473A (en) 2003-11-23
DE69619526T2 (de) 2002-10-31
AU6014496A (en) 1997-01-09
EP0833620A4 (fr) 1998-05-06
WO1996041523A1 (fr) 1996-12-27
CA2223701A1 (fr) 1996-12-27
EP0833620A1 (fr) 1998-04-08

Similar Documents

Publication Publication Date Title
DK0833620T3 (da) FGFR3, en markør for mesenkymale progenitorceller
DE69221368D1 (de) Osteogenische Wachstumsfaktoren zur Abgabe an Zielorgan
ATE240729T1 (de) Methoden und zusammensetzungen zur lipidisierung hydrophiler moleküle
DE69329903D1 (de) Bioabbaubare polymere zur zelltransplantation
TR200000927T2 (tr) Prostaglandin agonistleri ve kemik bozukluklarının tedavisi
DE69625518T2 (de) Wirkstoff zur behandlung neurodegenerativer störungen
BR0313197A (pt) Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
AU3142597A (en) Dha-pharmaceutical agent conjugates
WO2001068811A3 (fr) Procede permettant de produire in vitro du tissu cartilagineux ou osseux tridimensionnel vivant, et son utilisation comme matiere de greffe
HUT54144A (en) Process for producing 3-desmethylmevalonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
YU7797A (sh) Kombinovana terapija za osteoporozu
DK1007566T3 (da) Terapeutisk anvendelse af SMR1-protein og aktive derivater deraf
EP1080724A4 (fr) Compositions destinees a diminuer l'activite mtp
DE69737455D1 (de) Definierte systeme zur kultivieurng epithelialer zellen und anwendung derselben
DE69714775T2 (de) Verfahren zur Tötung von Zielzellen in geernteten Zellpopulationen mit Hilfe von zwei Immunotoxinen
CA2069638A1 (fr) Amelioration d'une image rmn des os et des tissus apparentes a l'aide de complexes de cations paramagnetiques et de ligands a base de polyphosphonate
PT1017681E (pt) Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios
PL361732A1 (en) Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy
FR2768145B1 (fr) Nouveaux composes derives d'acide alkylene diamine di- ou tri-acetique, leur procede de preparation, leur utilisation dans des compositions cosmetiques et pharmaceutiques, et compositions les comprenant
ATE265234T1 (de) Pharmazeutische zusammensetzung von hydrophob modifizierten hedgehog-proteinen und deren verwendung
WO2002012336A3 (fr) THERAPEUTIQUES DU TGF-β, COMPOSITIONS ET PROCEDES D'UTILISATION
Smart et al. Effect of dietary ascorbate on covalent binding of benzene to bone marrow and hepatic tissue in vivo
IT1247481B (it) Composizioni farmaceutiche a base di collagene