DK0832229T3 - CD40L-mutein - Google Patents
CD40L-muteinInfo
- Publication number
- DK0832229T3 DK0832229T3 DK96921405T DK96921405T DK0832229T3 DK 0832229 T3 DK0832229 T3 DK 0832229T3 DK 96921405 T DK96921405 T DK 96921405T DK 96921405 T DK96921405 T DK 96921405T DK 0832229 T3 DK0832229 T3 DK 0832229T3
- Authority
- DK
- Denmark
- Prior art keywords
- cd40l
- mutein
- cd40l mutein
- muteins
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Amplifiers (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Reverberation, Karaoke And Other Acoustics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/477,733 US5981724A (en) | 1991-10-25 | 1995-06-07 | DNA encoding CD40 ligand, a cytokine that binds CD40 |
| US08/484,624 US5962406A (en) | 1991-10-25 | 1995-06-07 | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| PCT/US1996/009632 WO1996040918A2 (en) | 1995-06-07 | 1996-06-06 | Novel cd40l mutein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0832229T3 true DK0832229T3 (da) | 2004-05-03 |
Family
ID=27045653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96921405T DK0832229T3 (da) | 1995-06-07 | 1996-06-06 | CD40L-mutein |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0832229B1 (no) |
| JP (1) | JP3279573B2 (no) |
| KR (1) | KR100453314B1 (no) |
| AT (1) | ATE257858T1 (no) |
| AU (1) | AU693713B2 (no) |
| CA (1) | CA2222914C (no) |
| DE (1) | DE69631331T2 (no) |
| DK (1) | DK0832229T3 (no) |
| ES (1) | ES2214541T3 (no) |
| IL (1) | IL122174A (no) |
| MX (1) | MX9709447A (no) |
| NO (1) | NO317735B1 (no) |
| NZ (1) | NZ311335A (no) |
| PT (1) | PT832229E (no) |
| WO (1) | WO1996040918A2 (no) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405270B2 (en) | 1991-10-25 | 2008-07-29 | Immunex Corporation | CD40-Ligand lacking native-pattern glycosylation |
| AU705647B2 (en) * | 1996-07-10 | 1999-05-27 | Immunex Corporation | Method of activating dendritic cells |
| EP2314695A3 (en) | 1996-12-23 | 2011-12-21 | Immunex Corporation | Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily |
| DE69939822D1 (de) | 1998-05-14 | 2008-12-11 | Immunex Corp | Verfahren zur hemmung der wirkung der osteoklasten |
| AU2001251612A1 (en) | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Roles of jak/stat family members in tolerance induction |
| US20040053249A1 (en) * | 2000-05-26 | 2004-03-18 | Junko Tohma | Fas ligand-fused proteins |
| LT1434871T (lt) | 2001-09-20 | 2017-04-10 | Immunex Corporation | Heteromerinius polipeptidus ekspresuojančių ląstelių atranka |
| KR20050101554A (ko) | 2003-02-14 | 2005-10-24 | 바이오겐 아이덱 엠에이 인코포레이티드 | 외인성 분자를 일시적으로 또는 안정하게 발현하기 위한발현 카세트 및 발현 벡터 |
| JP3936673B2 (ja) * | 2003-06-02 | 2007-06-27 | 国立大学法人群馬大学 | Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体 |
| EP1673389A2 (en) * | 2003-10-10 | 2006-06-28 | Xencor Inc. | Novel variants of cd40l protein |
| NZ554520A (en) | 2004-10-22 | 2010-03-26 | Amgen Inc | Methods for refolding of recombinant antibodies |
| CN101663390B (zh) | 2006-09-13 | 2013-10-23 | Abbvie公司 | 使用非动物源水解产物的分批补料细胞培养方法 |
| EP2500414A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| MY183797A (en) | 2006-09-18 | 2021-03-16 | Univ Arkansas | Compositions and methods of enhancing immune responses |
| US8222016B2 (en) | 2007-06-29 | 2012-07-17 | Daiichi Sankyo Company, Limited | Recombinant C-terminal α-amidating enzyme derivative |
| CA2698809C (en) | 2007-09-14 | 2023-10-17 | Amgen Inc. | Homogeneous antibody populations |
| EP2214840B1 (en) | 2007-10-30 | 2015-05-06 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to flagellated bacterium |
| DK2214701T3 (en) | 2007-11-01 | 2016-12-12 | Univ Arkansas | CONFIGURATIONS AND METHODS FOR IMPROVING THE IMMUNE RESPONSES TO Eimeria |
| BRPI0906490A2 (pt) | 2008-01-15 | 2015-07-14 | Abbott Lab | Vetores de expressão de mamífero melhorados e uso dos mesmos |
| PT2501822T (pt) | 2009-11-17 | 2017-10-18 | Squibb & Sons Llc | Métodos para produção de proteínas melhorada |
| JP6242050B2 (ja) | 2010-01-21 | 2017-12-06 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 免疫応答を増強するワクチンベクターおよび方法 |
| BR112012031211A2 (pt) | 2010-06-09 | 2018-01-30 | Univ Arkansas | métodos e vacina para reduzir a infecção causada pelo campylobacter |
| BR112015019283B1 (pt) | 2013-02-14 | 2023-12-19 | The Board Of Trustees Of The University Of Arkansas | Composições e métodos de aprimoramento de respostas imunes à eiméria ou infecção por eiméria limitadora |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| AR095313A1 (es) | 2013-03-15 | 2015-10-07 | Univ Arkansas | Composiciones y métodos para aumentar la respuesta inmune contra patógenos entéricos |
| CN114605549A (zh) | 2015-08-05 | 2022-06-10 | 詹森生物科技公司 | 抗cd154抗体及其使用方法 |
| WO2017083604A1 (en) | 2015-11-12 | 2017-05-18 | Amgen Inc. | Triazine mediated pharmacokinetic enhancement of therapeutics |
| TWI843057B (zh) | 2016-05-03 | 2024-05-21 | 阿肯色州大學董事會 | 包含免疫刺激性及抗原性多肽的酵母菌疫苗載體以及其使用方法 |
| IL300591A (en) | 2016-05-11 | 2023-04-01 | Amgen Inc | Direct selection of cells expressing high levels of heteromeric proteins using intergenic glutamine synthetase complementation vectors |
| MA44993A (fr) * | 2016-05-13 | 2019-03-20 | Medimmune Llc | Polypeptides de fusion cd40l-fc et procédés d'utilisation associés |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2227513T5 (es) * | 1991-10-25 | 2009-04-01 | Immunex Corporation | Citoquina novedosa. |
| US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
| ES2198414T3 (es) * | 1992-10-23 | 2004-02-01 | Immunex Corporation | Procedimientos para preparar proteinas oligomericas solubles. |
-
1996
- 1996-06-06 DE DE1996631331 patent/DE69631331T2/de not_active Expired - Fee Related
- 1996-06-06 KR KR1019970708620A patent/KR100453314B1/ko not_active IP Right Cessation
- 1996-06-06 DK DK96921405T patent/DK0832229T3/da active
- 1996-06-06 EP EP96921405A patent/EP0832229B1/en not_active Expired - Lifetime
- 1996-06-06 IL IL12217496A patent/IL122174A/en not_active IP Right Cessation
- 1996-06-06 AU AU62638/96A patent/AU693713B2/en not_active Ceased
- 1996-06-06 NZ NZ311335A patent/NZ311335A/en unknown
- 1996-06-06 WO PCT/US1996/009632 patent/WO1996040918A2/en active IP Right Grant
- 1996-06-06 MX MX9709447A patent/MX9709447A/es not_active IP Right Cessation
- 1996-06-06 ES ES96921405T patent/ES2214541T3/es not_active Expired - Lifetime
- 1996-06-06 JP JP50191197A patent/JP3279573B2/ja not_active Expired - Fee Related
- 1996-06-06 AT AT96921405T patent/ATE257858T1/de not_active IP Right Cessation
- 1996-06-06 PT PT96921405T patent/PT832229E/pt unknown
- 1996-06-06 CA CA002222914A patent/CA2222914C/en not_active Expired - Fee Related
-
1997
- 1997-11-26 NO NO19975437A patent/NO317735B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69631331T2 (de) | 2004-11-18 |
| CA2222914A1 (en) | 1996-12-19 |
| WO1996040918A3 (en) | 1997-01-23 |
| NZ311335A (en) | 1998-05-27 |
| AU6263896A (en) | 1996-12-30 |
| NO975437D0 (no) | 1997-11-26 |
| IL122174A0 (en) | 1998-04-05 |
| JPH11504819A (ja) | 1999-05-11 |
| JP3279573B2 (ja) | 2002-04-30 |
| AU693713B2 (en) | 1998-07-02 |
| EP0832229A2 (en) | 1998-04-01 |
| PT832229E (pt) | 2004-06-30 |
| NO975437L (no) | 1998-02-06 |
| WO1996040918A2 (en) | 1996-12-19 |
| DE69631331D1 (de) | 2004-02-19 |
| NO317735B1 (no) | 2004-12-13 |
| ATE257858T1 (de) | 2004-01-15 |
| EP0832229B1 (en) | 2004-01-14 |
| KR19990022141A (ko) | 1999-03-25 |
| ES2214541T3 (es) | 2004-09-16 |
| CA2222914C (en) | 2002-04-02 |
| KR100453314B1 (ko) | 2004-12-17 |
| IL122174A (en) | 2004-07-25 |
| MX9709447A (es) | 1998-02-28 |
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