DK0805813T3 - Tricyclic vasopressin antagonists - Google Patents

Tricyclic vasopressin antagonists

Info

Publication number
DK0805813T3
DK0805813T3 DK96902143T DK96902143T DK0805813T3 DK 0805813 T3 DK0805813 T3 DK 0805813T3 DK 96902143 T DK96902143 T DK 96902143T DK 96902143 T DK96902143 T DK 96902143T DK 0805813 T3 DK0805813 T3 DK 0805813T3
Authority
DK
Denmark
Prior art keywords
vasopressin antagonists
tricyclic
tricyclic vasopressin
antagonists
vasopressin
Prior art date
Application number
DK96902143T
Other languages
Danish (da)
English (en)
Inventor
Jay Donald Albright
Aranapakam Mudumbai Venkatesan
George Theodore Grosu
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0805813T3 publication Critical patent/DK0805813T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96902143T 1995-01-17 1996-01-16 Tricyclic vasopressin antagonists DK0805813T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/373,125 US5521173A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists
PCT/US1996/000515 WO1996022292A1 (fr) 1995-01-17 1996-01-16 Antagonistes de vasopressine tricycliques

Publications (1)

Publication Number Publication Date
DK0805813T3 true DK0805813T3 (da) 2002-08-05

Family

ID=23471074

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96902143T DK0805813T3 (da) 1995-01-17 1996-01-16 Tricyclic vasopressin antagonists

Country Status (24)

Country Link
US (2) US5521173A (fr)
EP (1) EP0805813B1 (fr)
JP (2) JP4156664B2 (fr)
CN (1) CN1052725C (fr)
AR (1) AR002021A1 (fr)
AT (1) ATE217625T1 (fr)
AU (1) AU707881B2 (fr)
BR (1) BR9607177A (fr)
CA (1) CA2210708C (fr)
CZ (1) CZ224797A3 (fr)
DE (1) DE69621225T2 (fr)
DK (1) DK0805813T3 (fr)
EA (1) EA000056B1 (fr)
ES (1) ES2175066T3 (fr)
HK (1) HK1003891A1 (fr)
HU (1) HUP9702459A3 (fr)
IL (1) IL116774A (fr)
MX (1) MX9705414A (fr)
NZ (1) NZ301198A (fr)
PT (1) PT805813E (fr)
TW (1) TW472056B (fr)
UA (1) UA48960C2 (fr)
WO (1) WO1996022292A1 (fr)
ZA (1) ZA96303B (fr)

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US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
EP0987266A4 (fr) * 1997-03-31 2000-07-26 Wakamoto Pharma Co Ltd Derives de biphenyle et compositions medicinales
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
RU2213094C2 (ru) * 1997-07-30 2003-09-27 Американ Хоум Продактс Корпорейшн Трициклические соединения, способы их получения, фармацевтическая композиция и способ лечения
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
DE69911259D1 (de) * 1999-01-19 2003-10-16 Ortho Mcneil Pharm Inc Tricyclische benzodiazepine als vasopressin antagonisten
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
US6297234B1 (en) * 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
EP1149103A1 (fr) * 1999-02-04 2001-10-31 American Home Products Corporation Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
CN1391476A (zh) * 1999-09-27 2003-01-15 美国氰胺公司 血管升压素激动剂制剂和方法
ATE394371T1 (de) * 2001-03-20 2008-05-15 Serono Lab Pyrrolidinesterderivate mit oxytocinmodulierender wirkung
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6903087B2 (en) * 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
JP2004526771A (ja) * 2001-04-12 2004-09-02 ワイス シクロヘキシルフェニルバソプレッシンアゴニスト
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US6900200B2 (en) * 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6903091B2 (en) * 2001-04-12 2005-06-07 Wyeth Biphenyl vasopressin agonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7022699B2 (en) * 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
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US7119088B2 (en) * 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
EP2061795B1 (fr) * 2006-08-14 2014-01-15 Council of Scientific & Industrial Research Hybrides pyrrolo[2,1-c][1,4]benzodiazépine et leur procédé de préparation
CN102118968A (zh) 2008-06-10 2011-07-06 雅培制药有限公司 新的三环化合物
JP5567027B2 (ja) 2008-11-13 2014-08-06 エフ.ホフマン−ラ ロシュ アーゲー スピロ−5,6−ジヒドロ−4H−2,3,5,10b−テトラアザ−ベンゾ[e]アズレン
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KR20170118230A (ko) 2009-12-01 2017-10-24 애브비 인코포레이티드 신규한 트리사이클릭 화합물
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
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US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
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US9199976B2 (en) 2010-06-01 2015-12-01 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
CN103288829A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法
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JP2021530554A (ja) 2018-07-26 2021-11-11 スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド 異常なacvr1発現を伴う疾患を処置するための方法およびそこで使用するためのacvr1阻害剤

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Also Published As

Publication number Publication date
EA199700118A1 (ru) 1997-12-30
CA2210708A1 (fr) 1996-07-25
US5521173A (en) 1996-05-28
BR9607177A (pt) 1997-11-11
EP0805813B1 (fr) 2002-05-15
DE69621225D1 (de) 2002-06-20
NZ301198A (en) 1999-08-30
HUP9702459A2 (hu) 1998-05-28
ES2175066T3 (es) 2002-11-16
UA48960C2 (uk) 2002-09-16
AR002021A1 (es) 1998-01-07
CZ224797A3 (cs) 1998-03-18
AU707881B2 (en) 1999-07-22
HK1003891A1 (en) 1998-11-13
TW472056B (en) 2002-01-11
HUP9702459A3 (en) 2000-08-28
JP2008069176A (ja) 2008-03-27
EA000056B1 (ru) 1998-04-30
PT805813E (pt) 2002-10-31
MX9705414A (es) 1997-11-29
ZA96303B (en) 1997-07-15
EP0805813A1 (fr) 1997-11-12
ATE217625T1 (de) 2002-06-15
IL116774A0 (en) 1996-05-14
JPH11500424A (ja) 1999-01-12
CN1052725C (zh) 2000-05-24
DE69621225T2 (de) 2002-11-14
IL116774A (en) 2000-12-06
AU4656696A (en) 1996-08-07
CN1178532A (zh) 1998-04-08
WO1996022292A1 (fr) 1996-07-25
US5780471A (en) 1998-07-14
JP4156664B2 (ja) 2008-09-24
CA2210708C (fr) 2005-05-24

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