DK0801564T3 - Anvendelse af nebivolol som et antiatherogent middel - Google Patents

Anvendelse af nebivolol som et antiatherogent middel

Info

Publication number: DK0801564T3
Authority: DK; Denmark
Prior art keywords: nebivolol; alpha; antiatherogenic; agent; antiatherogenic agent
Prior art date: 1994-12-28

Application number

DK95942209T

Other languages

English (en)

Inventor

Chaffoy De Courcelles Didie De

Anne Simone Josephine Lesage

Josepha Eduarda Maria F Leysen

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-28

Filing date

1995-12-21

Publication date

2002-07-15

1995-12-21 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2002-07-15 Application granted granted Critical

2002-07-15 Publication of DK0801564T3 publication Critical patent/DK0801564T3/da

Links

KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title 1
230000000489 anti-atherogenic effect Effects 0.000 title 1
229960000619 nebivolol Drugs 0.000 title 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
210000000653 nervous system Anatomy 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
230000036542 oxidative stress Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)

DK95942209T 1994-12-28 1995-12-21 Anvendelse af nebivolol som et antiatherogent middel DK0801564T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94203775		1994-12-28
PCT/EP1995/005174 WO1996019987A1 (en)	1994-12-28	1995-12-21	Use of nebivolol as an anti-atherogenic

Publications (1)

Publication Number	Publication Date
DK0801564T3 true DK0801564T3 (da)	2002-07-15

Family

ID=8217503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95942209T DK0801564T3 (da)	1994-12-28	1995-12-21	Anvendelse af nebivolol som et antiatherogent middel

Country Status (20)

Country	Link
US (2)	US5874461A (da)
EP (1)	EP0801564B1 (da)
JP (1)	JPH10511655A (da)
KR (1)	KR100264348B1 (da)
CN (1)	CN1167418C (da)
AT (1)	ATE214924T1 (da)
AU (1)	AU700364B2 (da)
CA (1)	CA2207333C (da)
CZ (1)	CZ287513B6 (da)
DE (1)	DE69526120T2 (da)
DK (1)	DK0801564T3 (da)
ES (1)	ES2176354T3 (da)
FI (1)	FI118884B (da)
HU (1)	HU226208B1 (da)
NO (1)	NO315687B1 (da)
NZ (1)	NZ298074A (da)
PT (1)	PT801564E (da)
SI (1)	SI0801564T1 (da)
SK (1)	SK282144B6 (da)
WO (1)	WO1996019987A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU226208B1 (en) *	1994-12-28	2008-06-30	Janssen Pharmaceutica Nv	Use of nebivolol for producing anti-atherogenic pharmaceuticals
DE19716120A1 (de) *	1997-04-17	1998-10-22	Europ Lab Molekularbiolog	Verwendung von cholesterinsenkenden Mitteln
US6541669B1 (en)	1998-06-08	2003-04-01	Theravance, Inc.	β2-adrenergic receptor agonists
US6713651B1 (en)	1999-06-07	2004-03-30	Theravance, Inc.	β2-adrenergic receptor agonists
JP2000207219A (ja) *	1999-01-18	2000-07-28	Fujitsu Ten Ltd	車載端末とセンタ―との間の通信システム、及び、通信システムに使用する車載端末
US6593497B1 (en)	1999-06-02	2003-07-15	Theravance, Inc.	β2-adrenergic receptor agonists
US6683115B2 (en)	1999-06-02	2004-01-27	Theravance, Inc.	β2-adrenergic receptor agonists
UA73965C2 (en)	1999-12-08	2005-10-17	Theravance Inc	b2 ADRENERGIC RECEPTOR ANTAGONISTS
ATE437637T1 (de) *	2001-05-02	2009-08-15	Nitromed Inc	Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
AU2003287250B9 (en) *	2002-10-30	2010-01-28	Ptc Therapeutics, Inc.	Identifying therapeutic compounds based on their physical-chemical properties
ITTO20030140U1 (it) *	2003-09-16	2005-03-17	Interfila Srl	Matita cosmetica
US7470798B2 (en) *	2003-09-19	2008-12-30	Edison Pharmaceuticals, Inc.	7,8-bicycloalkyl-chroman derivatives
US7803838B2 (en)	2004-06-04	2010-09-28	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
US7838552B2 (en)	2004-06-04	2010-11-23	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
RU2378272C2 (ru)	2004-07-30	2010-01-10	Торрент Фармасьютикалз Лимитед	Небиволол и его фармацевтически приемлемые соли, способ их получения и фармацевтические композиции небиволола
EP1848424B1 (en) *	2005-01-31	2017-04-05	Mylan Laboratories, Inc	Pharmaceutical composition comprising hydroxylated nebivolol
MX359292B (es)	2005-06-01	2018-09-24	Bioelectron Tech Corp	Sustancias terapeuticas activas redox para el tratamiento de enfermedades mitocondriales y otras condiciones y modulacion de biomarcadores de energia.
CA2635280C (en)	2006-02-22	2017-12-12	Edison Pharmaceuticals, Inc.	Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
PL2220030T3 (pl)	2007-11-06	2016-07-29	Bioelectron Tech Corp	Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
US20090181975A1 (en) *	2008-01-15	2009-07-16	Forest Laboratories Holdings Limited	Nebivolol in the treatment of sexual dysfunction
EP2262508B1 (en)	2008-03-05	2018-10-03	BioElectron Technology Corporation	SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
LT3827815T (lt)	2008-09-10	2023-10-10	Ptc Therapeutics, Inc.	Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais
EP2362726B1 (en)	2008-10-14	2018-08-08	Bioelectron Technology Corporation	Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
AU2009327411A1 (en) *	2008-12-19	2010-06-24	Merck Sharp & Dohme Corp.	Feed supplement for mammalian cell culture and methods of use
MX336800B (es)	2009-04-28	2016-02-02	Edison Pharmaceuticals Inc	Tratamiento de neuropatia optica hereditaria de leber y atrofia optica dominante con tocotrienol quinonas.
US20130065910A1 (en) *	2010-06-04	2013-03-14	Comprehensive Drug Enterprises Ltd.	Oral meclizine aqueous formulations with taste flavoring agent
US9296712B2 (en)	2013-03-15	2016-03-29	Edison Pharmaceuticals, Inc.	Resorufin derivatives for treatment of oxidative stress disorders
US9670170B2 (en)	2013-03-15	2017-06-06	Bioelectron Technology Corporation	Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en)	2013-03-15	2018-01-16	Bioelectron Technology Corporation	Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
DE102014107132A1 (de)	2014-05-20	2015-11-26	Corden Pharma International Gmbh	Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
TWI663984B (zh) *	2014-10-24	2019-07-01	朗齊生物醫學股份有限公司	神經疾病用藥臨床新應用
CA2971252A1 (en)	2014-12-16	2016-06-23	Bioelectron Technology Corporation	Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
US10703701B2 (en)	2015-12-17	2020-07-07	Ptc Therapeutics, Inc.	Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1337432C (en) *	1988-03-23	1995-10-24	Raymond M. Xhonneux	Method of lowering the blood pressure
TW355683B (en) *	1994-02-17	1999-04-11	Janssen Pharmaceutica Nv	Composition containing micronized nebivolol
HU226208B1 (en) *	1994-12-28	2008-06-30	Janssen Pharmaceutica Nv	Use of nebivolol for producing anti-atherogenic pharmaceuticals

1995
- 1995-12-21 HU HU9800675A patent/HU226208B1/hu unknown
- 1995-12-21 KR KR1019970703648A patent/KR100264348B1/ko not_active IP Right Cessation
- 1995-12-21 CA CA002207333A patent/CA2207333C/en not_active Expired - Fee Related
- 1995-12-21 SK SK856-97A patent/SK282144B6/sk not_active IP Right Cessation
- 1995-12-21 NZ NZ298074A patent/NZ298074A/xx not_active IP Right Cessation
- 1995-12-21 ES ES95942209T patent/ES2176354T3/es not_active Expired - Lifetime
- 1995-12-21 CN CNB951971492A patent/CN1167418C/zh not_active Expired - Lifetime
- 1995-12-21 AU AU43477/96A patent/AU700364B2/en not_active Expired
- 1995-12-21 CZ CZ19971919A patent/CZ287513B6/cs not_active IP Right Cessation
- 1995-12-21 AT AT95942209T patent/ATE214924T1/de active
- 1995-12-21 SI SI9530591T patent/SI0801564T1/xx unknown
- 1995-12-21 WO PCT/EP1995/005174 patent/WO1996019987A1/en active IP Right Grant
- 1995-12-21 DE DE69526120T patent/DE69526120T2/de not_active Expired - Lifetime
- 1995-12-21 PT PT95942209T patent/PT801564E/pt unknown
- 1995-12-21 JP JP8520223A patent/JPH10511655A/ja active Pending
- 1995-12-21 US US08/860,238 patent/US5874461A/en not_active Expired - Lifetime
- 1995-12-21 EP EP95942209A patent/EP0801564B1/en not_active Expired - Lifetime
- 1995-12-21 DK DK95942209T patent/DK0801564T3/da active
1997
- 1997-06-26 NO NO19972980A patent/NO315687B1/no not_active IP Right Cessation
- 1997-06-27 FI FI972793A patent/FI118884B/fi not_active IP Right Cessation
1998
- 1998-12-21 US US09/217,728 patent/US6075046A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU226208B1 (en)	2008-06-30
AU4347796A (en)	1996-07-19
WO1996019987A1 (en)	1996-07-04
FI972793A (fi)	1997-06-27
SK282144B6 (sk)	2001-11-06
EP0801564B1 (en)	2002-03-27
CN1167418C (zh)	2004-09-22
HUT77927A (hu)	1998-11-30
NZ298074A (en)	2001-01-26
CA2207333A1 (en)	1996-07-04
DE69526120D1 (de)	2002-05-02
EP0801564A1 (en)	1997-10-22
FI972793A0 (fi)	1997-06-27
FI118884B (fi)	2008-04-30
US6075046A (en)	2000-06-13
JPH10511655A (ja)	1998-11-10
CA2207333C (en)	2006-10-17
CZ287513B6 (en)	2000-12-13
NO315687B1 (no)	2003-10-13
NO972980D0 (no)	1997-06-26
US5874461A (en)	1999-02-23
NO972980L (no)	1997-06-26
SK85697A3 (en)	2000-04-10
PT801564E (pt)	2002-09-30
CZ191997A3 (cs)	1999-01-13
KR100264348B1 (ko)	2000-08-16
ATE214924T1 (de)	2002-04-15
SI0801564T1 (en)	2002-08-31
CN1171739A (zh)	1998-01-28
AU700364B2 (en)	1999-01-07
DE69526120T2 (de)	2002-11-28
MX9704669A (es)	1997-09-30
ES2176354T3 (es)	2002-12-01

Publication	Publication Date	Title
DK0801564T3 (da)	2002-07-15	Anvendelse af nebivolol som et antiatherogent middel
HUP9700603A1 (hu)	1999-06-28	Gyógyászati készítmény véralvadási zavarok kezelésére
DE69920757D1 (de)	2004-11-04	Immunsuppressive wirkungen von pteridinderivaten
NO986051L (no)	1999-02-23	Anvendelsen av topiramat eller derivater derav for fremstilling av et medikament for behandling av manisk depressive, bipolare forstyrrelser
DK0966447T3 (da)	2003-06-23	Anvendelige små molekyler til behandling af betændelsessygdomme
DK0932398T3 (da)	2006-09-25	Anvendelse af topiramat eller derivater deraf til fremstilling af et lægemiddel til behandling af maniodepressive bipolære forstyrrelser
TR199901174T2 (xx)	1999-08-23	Yeni heterosiklilmetil-ikameli pirazol t�revleri.
UA27911C2 (uk)	2000-10-16	Засіб для лікування або запобігання фізіологічних розладів, які викликані надлишком тахікініну
IL110943A (en)	1997-02-18	Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
DK0888327T3 (da)	2002-09-16	Benzopyranderivater, som har antagonistisk virkning imod leukotriener
BRPI0408889A (pt)	2006-04-11	uso de clusterina para o tratamento e/ou prevenção de doenças neurológicas periféricas
DE59904180D1 (de)	2003-03-06	Cyclopentabenzofuran-derivate und ihre verwendung
BG105264A (en)	2001-11-30	New use of taxoid derivatives
BG102707A (en)	1999-09-30	New triazolopurinpurines, method for their preparation and appplication as medicamentous forms
DE69309790D1 (de)	1997-05-22	Cyclopentanperhydrophenanthren-17-beta-(3-Furyl)-3-Derivate und pharmazeutische Präparate davon, zur Behandlung von Kardiovaskulär-Erkrankungen
EA199700243A1 (ru)	1998-02-26	Производное аминотетралина для лечения сердечно-сосудистых заболеваний
NO990450D0 (no)	1999-01-29	Behandling av sinnslidelser
PT869785E (pt)	2002-12-31	4-hidroxicumarina-3-carboxamidas para o tratamento de diabetes mellitus nao insulinodependente
IT1289154B1 (it)	1998-09-29	Derivati di isoflavone loro preparazione e loro impiego terapeutico
AU1569700A (en)	2000-07-03	Novel therapeutic application of low molecular weight heparin
NO984651L (no)	1998-12-03	Anvendelse av benzonaftalenderivater for fremstilling av medikamenter for behandling av sykdommer i sentralnervesystemet
DE69905489D1 (de)	2003-03-27	Protein c zur behandlung von sichelzellanämie und thalassämie
DE69930419D1 (de)	2006-05-11	Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie
BR9813098A (pt)	2000-08-15	Uso de glicosaminoglicans, preparação farmacêutica, e, combinaçào
MX9706454A (es)	1997-11-29	Uso de benzotiazoles fusionados como neuroproyectores.