DK0790236T3 - Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on - Google Patents
Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-onInfo
- Publication number
- DK0790236T3 DK0790236T3 DK97200175T DK97200175T DK0790236T3 DK 0790236 T3 DK0790236 T3 DK 0790236T3 DK 97200175 T DK97200175 T DK 97200175T DK 97200175 T DK97200175 T DK 97200175T DK 0790236 T3 DK0790236 T3 DK 0790236T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzisothiazol
- indol
- prodrugs
- piperazinyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1156896P | 1996-02-13 | 1996-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0790236T3 true DK0790236T3 (da) | 2004-02-23 |
Family
ID=21750970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97200175T DK0790236T3 (da) | 1996-02-13 | 1997-01-21 | Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on |
Country Status (10)
Country | Link |
---|---|
US (1) | US5935960A (de) |
EP (1) | EP0790236B1 (de) |
JP (1) | JP2911032B2 (de) |
AT (1) | ATE254600T1 (de) |
CA (1) | CA2197272C (de) |
DE (1) | DE69726206T2 (de) |
DK (1) | DK0790236T3 (de) |
ES (1) | ES2210450T3 (de) |
MX (1) | MX9701116A (de) |
PT (1) | PT790236E (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0790236T3 (da) * | 1996-02-13 | 2004-02-23 | Pfizer | Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on |
IL127497A (en) * | 1997-12-18 | 2002-07-25 | Pfizer Prod Inc | Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders |
US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
US6616270B1 (en) | 1998-08-21 | 2003-09-09 | Seiko Epson Corporation | Ink jet recording head and ink jet recording apparatus comprising the same |
US7030142B1 (en) | 1999-04-06 | 2006-04-18 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using ziprasidone metabolites |
JP2002541098A (ja) * | 1999-04-06 | 2002-12-03 | セプラコア インコーポレーテッド | ジプラシドン代謝産物を用いる神経弛緩薬性障害および関連障害を治療するための方法および組成物 |
DK1556378T3 (da) * | 2002-10-24 | 2008-03-17 | Pfizer Prod Inc | Acylderivater af 5-(2-(4-(1,2 benzisothiazol-3-yl)-1piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indo-2-on med neuroleptisk aktivitet |
CA2467538C (en) * | 2004-05-14 | 2010-08-24 | Apotex Pharmachem Inc. | New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same |
CA2471219A1 (en) * | 2004-06-14 | 2005-12-14 | Apotex Pharmachem Inc. | Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) |
CA2500667C (en) * | 2005-03-11 | 2013-01-15 | Apotex Pharmachem Inc. | Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions |
CN101677568A (zh) * | 2007-05-18 | 2010-03-24 | 赛多斯有限责任公司 | 齐拉西酮制剂 |
PL391810A1 (pl) | 2010-07-14 | 2012-01-16 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Nowe sole ziprasidonu oraz sposoby ich otrzymywania |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
WO1990002552A1 (en) * | 1988-09-16 | 1990-03-22 | Pfizer Inc. | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
US5087627A (en) * | 1989-03-15 | 1992-02-11 | Santen Pharmaceutical Co., Ltd. | Agent for treatment of disorders of the cerebro-neural transmission system |
US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
US5359068A (en) * | 1993-06-28 | 1994-10-25 | Pfizer Inc. | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
DK0790236T3 (da) * | 1996-02-13 | 2004-02-23 | Pfizer | Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on |
-
1997
- 1997-01-21 DK DK97200175T patent/DK0790236T3/da active
- 1997-01-21 ES ES97200175T patent/ES2210450T3/es not_active Expired - Lifetime
- 1997-01-21 AT AT97200175T patent/ATE254600T1/de not_active IP Right Cessation
- 1997-01-21 PT PT97200175T patent/PT790236E/pt unknown
- 1997-01-21 EP EP97200175A patent/EP0790236B1/de not_active Expired - Lifetime
- 1997-01-21 DE DE69726206T patent/DE69726206T2/de not_active Expired - Fee Related
- 1997-02-07 US US08/798,395 patent/US5935960A/en not_active Expired - Fee Related
- 1997-02-11 CA CA002197272A patent/CA2197272C/en not_active Expired - Fee Related
- 1997-02-12 MX MX9701116A patent/MX9701116A/es unknown
- 1997-02-13 JP JP9028993A patent/JP2911032B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0790236B1 (de) | 2003-11-19 |
US5935960A (en) | 1999-08-10 |
MX9701116A (es) | 1998-04-30 |
DE69726206D1 (de) | 2003-12-24 |
DE69726206T2 (de) | 2004-04-15 |
CA2197272C (en) | 2001-01-23 |
ATE254600T1 (de) | 2003-12-15 |
PT790236E (pt) | 2004-04-30 |
JPH09227516A (ja) | 1997-09-02 |
EP0790236A1 (de) | 1997-08-20 |
ES2210450T3 (es) | 2004-07-01 |
CA2197272A1 (en) | 1997-08-14 |
JP2911032B2 (ja) | 1999-06-23 |
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