DK0767800T3 - Histidin- og homohistidinderivater som inhibitorer af protein farnesyltransferase - Google Patents

Histidin- og homohistidinderivater som inhibitorer af protein farnesyltransferase

Info

Publication number
DK0767800T3
DK0767800T3 DK95921421T DK95921421T DK0767800T3 DK 0767800 T3 DK0767800 T3 DK 0767800T3 DK 95921421 T DK95921421 T DK 95921421T DK 95921421 T DK95921421 T DK 95921421T DK 0767800 T3 DK0767800 T3 DK 0767800T3
Authority
DK
Denmark
Prior art keywords
inhibitors
homohistidine
histidine
derivatives
farnesyl transferase
Prior art date
Application number
DK95921421T
Other languages
Danish (da)
English (en)
Inventor
Gary Louis Bolton
John Cooke Hodges
Michael William Wilson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0767800T3 publication Critical patent/DK0767800T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95921421T 1994-06-30 1995-05-30 Histidin- og homohistidinderivater som inhibitorer af protein farnesyltransferase DK0767800T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/268,364 US5571792A (en) 1994-06-30 1994-06-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
PCT/US1995/006660 WO1996000736A1 (en) 1994-06-30 1995-05-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Publications (1)

Publication Number Publication Date
DK0767800T3 true DK0767800T3 (da) 2001-06-18

Family

ID=23022659

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95921421T DK0767800T3 (da) 1994-06-30 1995-05-30 Histidin- og homohistidinderivater som inhibitorer af protein farnesyltransferase

Country Status (17)

Country Link
US (1) US5571792A (de)
EP (1) EP0767800B1 (de)
JP (1) JPH10502078A (de)
AT (1) ATE200085T1 (de)
AU (1) AU699629B2 (de)
CA (1) CA2190977A1 (de)
DE (1) DE69520499T2 (de)
DK (1) DK0767800T3 (de)
ES (1) ES2158115T3 (de)
GR (1) GR3035936T3 (de)
HR (1) HRP950337B1 (de)
MX (1) MX9605945A (de)
NO (1) NO315427B1 (de)
NZ (1) NZ287696A (de)
PT (1) PT767800E (de)
WO (1) WO1996000736A1 (de)
ZA (1) ZA955411B (de)

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EP0840605A4 (de) * 1995-07-13 2000-05-10 Univ Cincinnati Verbindungen zur verwendung in der behandlung von neurofibromatose
US6008372A (en) * 1996-01-16 1999-12-28 Warner-Lambert Company Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase
US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027852A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000505797A (ja) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
EP1011669A4 (de) * 1996-01-30 2001-09-12 Merck & Co Inc Farnesyl-protein transferase inhibitoren
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5922883A (en) * 1996-04-03 1999-07-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250937A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
SK161098A3 (en) * 1996-05-22 2000-06-12 Warner Lambert Co Inhibitors of protein farnesyl transferase
US6300501B1 (en) * 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
ATE277907T1 (de) * 1996-07-01 2004-10-15 Lilly Co Eli Blutzuckersenkende und lipidsenkende verbindungen
US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US6737410B1 (en) 1997-04-11 2004-05-18 Warner-Lambert Company Inhibitors of protein farnesyl transferase
WO1998046625A1 (en) * 1997-04-11 1998-10-22 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
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AU759492B2 (en) 1998-04-27 2003-04-17 Warner-Lambert Company Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
US6492410B1 (en) 1998-05-12 2002-12-10 Warner-Lambert Company Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer
US6458935B1 (en) 1999-06-23 2002-10-01 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
EP1090909A1 (de) * 1999-09-28 2001-04-11 Rijksuniversiteit Leiden Hemmer für Enzyme, die Prenylpyrophosphate umsetzen
JP2001158799A (ja) 1999-09-28 2001-06-12 Rijksuniv Leiden プレニル化ピロリン酸消費酵素の新規な阻害剤
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CA2524222C (en) * 2003-04-29 2012-02-07 Roger Alberto N.epsilon. and/or n.alpha. derivatized, metal and organic protected l-histidine for coupling to biomolecules for highly efficient labeling with [m(oh2)3(co)3]+ by fac coordination
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Also Published As

Publication number Publication date
NO315427B1 (no) 2003-09-01
DE69520499T2 (de) 2001-07-26
AU699629B2 (en) 1998-12-10
HRP950337B1 (en) 2001-12-31
ATE200085T1 (de) 2001-04-15
WO1996000736A1 (en) 1996-01-11
EP0767800B1 (de) 2001-03-28
ES2158115T3 (es) 2001-09-01
NO965604D0 (no) 1996-12-27
PT767800E (pt) 2001-08-30
NO965604L (no) 1997-02-25
MX9605945A (es) 1997-12-31
CA2190977A1 (en) 1996-01-11
EP0767800A1 (de) 1997-04-16
AU2650495A (en) 1996-01-25
JPH10502078A (ja) 1998-02-24
US5571792A (en) 1996-11-05
DE69520499D1 (de) 2001-05-03
ZA955411B (en) 1996-02-05
NZ287696A (en) 1997-12-19
HRP950337A2 (en) 1997-08-31
GR3035936T3 (en) 2001-08-31

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