DK0741741T3 - Modificerede oligonucleotider - Google Patents

Modificerede oligonucleotider

Info

Publication number
DK0741741T3
DK0741741T3 DK95906958T DK95906958T DK0741741T3 DK 0741741 T3 DK0741741 T3 DK 0741741T3 DK 95906958 T DK95906958 T DK 95906958T DK 95906958 T DK95906958 T DK 95906958T DK 0741741 T3 DK0741741 T3 DK 0741741T3
Authority
DK
Denmark
Prior art keywords
pct
nucleotides
sec
modified oligonucleotides
date
Prior art date
Application number
DK95906958T
Other languages
Danish (da)
English (en)
Inventor
Catherine Lesueur
Mesmaeker Alain De
Adrian Waldner
Jacques Lebreton
Marc-Olivier Bevierre
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9401446A external-priority patent/GB9401446D0/en
Priority claimed from GB9412526A external-priority patent/GB9412526D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0741741T3 publication Critical patent/DK0741741T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95906958T 1994-01-26 1995-01-17 Modificerede oligonucleotider DK0741741T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9401446A GB9401446D0 (en) 1994-01-26 1994-01-26 Modified oligonucleotides
GB9412526A GB9412526D0 (en) 1994-06-22 1994-06-22 Modified oligonucleotides
PCT/EP1995/000156 WO1995020597A1 (en) 1994-01-26 1995-01-17 Modified oligonucleotides

Publications (1)

Publication Number Publication Date
DK0741741T3 true DK0741741T3 (da) 2002-12-23

Family

ID=26304218

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95906958T DK0741741T3 (da) 1994-01-26 1995-01-17 Modificerede oligonucleotider

Country Status (13)

Country Link
US (1) US6066447A (ja)
EP (1) EP0741741B1 (ja)
JP (1) JPH09508134A (ja)
AT (1) ATE222921T1 (ja)
AU (1) AU697134B2 (ja)
CA (1) CA2180727A1 (ja)
DE (1) DE69527942T2 (ja)
DK (1) DK0741741T3 (ja)
FI (1) FI116677B (ja)
HU (1) HU220423B (ja)
IL (1) IL112424A0 (ja)
NO (1) NO316902B1 (ja)
WO (1) WO1995020597A1 (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0734433B2 (en) * 1993-12-13 2004-03-24 The Procter & Gamble Company Viscosity stable concentrated liquid fabric softener compositions
AU5359496A (en) 1995-03-06 1996-09-23 Isis Pharmaceuticals, Inc. Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
US6166197A (en) * 1995-03-06 2000-12-26 Isis Pharmaceuticals, Inc. Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
WO1997014709A1 (en) * 1995-10-13 1997-04-24 F. Hoffmann-La Roche Ag Antisense oligomers
US5808035A (en) * 1995-12-08 1998-09-15 Usher; David A. Protected nucleoside and method for its synthesis
AU3340797A (en) * 1996-06-28 1998-01-21 Novartis Ag Modified oligonucleotides
JP2002507996A (ja) * 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
AR020590A1 (es) 1998-06-02 2002-05-22 Cadus Pharmaceutical Corp 7-diazapurina-n-6 sustituida, un metodo para su preparacion, composiciones farmaceuticas que la comprenden
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
CA2468673C (en) 2001-11-30 2011-01-25 Osi Pharmaceuticals, Inc. Compounds specific to adenosine a1 and a3 receptors and uses thereof
KR20040068317A (ko) 2001-12-20 2004-07-30 오에스아이 파마슈티컬스, 인코포레이티드 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도
US20030229067A1 (en) 2001-12-20 2003-12-11 Arlindo Castelhano Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
KR100649352B1 (ko) * 2005-04-30 2006-11-27 주식회사 하이닉스반도체 반도체소자의 제조 방법
US7820810B2 (en) 2007-03-19 2010-10-26 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted purine nulceosides
MX2011010050A (es) 2009-03-25 2011-12-14 Univ Texas Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos.
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
KR20180030699A (ko) * 2015-07-30 2018-03-23 호리즌 오펀 엘엘씨 푸코시다제 억제제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (en) * 1986-10-28 1990-09-19 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
WO1989008146A1 (en) * 1988-02-26 1989-09-08 Worcester Foundation For Experimental Biology Inhibition of htlv-iii by exogenous oligonucleotides
DK0497875T3 (da) * 1989-10-24 2000-07-03 Gilead Sciences Inc 2'-modificerede oligonukleotider
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
HU217036B (hu) * 1990-08-03 1999-11-29 Sanofi Eljárás génexpresszió gátlására alkalmas vegyületek előállítására
CA2092002A1 (en) * 1990-09-20 1992-03-21 Mark Matteucci Modified internucleoside linkages

Also Published As

Publication number Publication date
HUT75704A (en) 1997-05-28
FI962980A (fi) 1996-07-26
IL112424A0 (en) 1995-03-30
DE69527942D1 (de) 2002-10-02
CA2180727A1 (en) 1995-08-03
FI116677B (fi) 2006-01-31
JPH09508134A (ja) 1997-08-19
NO316902B1 (no) 2004-06-21
EP0741741B1 (en) 2002-08-28
NO963092L (no) 1996-09-16
EP0741741A1 (en) 1996-11-13
DE69527942T2 (de) 2003-03-27
AU697134B2 (en) 1998-09-24
HU9602040D0 (en) 1996-09-30
AU1534795A (en) 1995-08-15
FI962980A0 (fi) 1996-07-26
NO963092D0 (no) 1996-07-24
ATE222921T1 (de) 2002-09-15
US6066447A (en) 2000-05-23
HU220423B (hu) 2002-01-28
WO1995020597A1 (en) 1995-08-03

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