DK0741741T3 - Modificerede oligonucleotider - Google Patents
Modificerede oligonucleotiderInfo
- Publication number
- DK0741741T3 DK0741741T3 DK95906958T DK95906958T DK0741741T3 DK 0741741 T3 DK0741741 T3 DK 0741741T3 DK 95906958 T DK95906958 T DK 95906958T DK 95906958 T DK95906958 T DK 95906958T DK 0741741 T3 DK0741741 T3 DK 0741741T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- nucleotides
- sec
- modified oligonucleotides
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9401446A GB9401446D0 (en) | 1994-01-26 | 1994-01-26 | Modified oligonucleotides |
GB9412526A GB9412526D0 (en) | 1994-06-22 | 1994-06-22 | Modified oligonucleotides |
PCT/EP1995/000156 WO1995020597A1 (en) | 1994-01-26 | 1995-01-17 | Modified oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0741741T3 true DK0741741T3 (da) | 2002-12-23 |
Family
ID=26304218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95906958T DK0741741T3 (da) | 1994-01-26 | 1995-01-17 | Modificerede oligonucleotider |
Country Status (13)
Country | Link |
---|---|
US (1) | US6066447A (ja) |
EP (1) | EP0741741B1 (ja) |
JP (1) | JPH09508134A (ja) |
AT (1) | ATE222921T1 (ja) |
AU (1) | AU697134B2 (ja) |
CA (1) | CA2180727A1 (ja) |
DE (1) | DE69527942T2 (ja) |
DK (1) | DK0741741T3 (ja) |
FI (1) | FI116677B (ja) |
HU (1) | HU220423B (ja) |
IL (1) | IL112424A0 (ja) |
NO (1) | NO316902B1 (ja) |
WO (1) | WO1995020597A1 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0734433B2 (en) * | 1993-12-13 | 2004-03-24 | The Procter & Gamble Company | Viscosity stable concentrated liquid fabric softener compositions |
AU5359496A (en) | 1995-03-06 | 1996-09-23 | Isis Pharmaceuticals, Inc. | Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom |
US6166197A (en) * | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
WO1997014709A1 (en) * | 1995-10-13 | 1997-04-24 | F. Hoffmann-La Roche Ag | Antisense oligomers |
US5808035A (en) * | 1995-12-08 | 1998-09-15 | Usher; David A. | Protected nucleoside and method for its synthesis |
AU3340797A (en) * | 1996-06-28 | 1998-01-21 | Novartis Ag | Modified oligonucleotides |
JP2002507996A (ja) * | 1997-07-03 | 2002-03-12 | デュポン ファーマシューティカルズ カンパニー | 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類 |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
AR020590A1 (es) | 1998-06-02 | 2002-05-22 | Cadus Pharmaceutical Corp | 7-diazapurina-n-6 sustituida, un metodo para su preparacion, composiciones farmaceuticas que la comprenden |
US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
CA2468673C (en) | 2001-11-30 | 2011-01-25 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine a1 and a3 receptors and uses thereof |
KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 a₂b 선택성 길항 화합물, 그의 합성 방법 및용도 |
US20030229067A1 (en) | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
KR100649352B1 (ko) * | 2005-04-30 | 2006-11-27 | 주식회사 하이닉스반도체 | 반도체소자의 제조 방법 |
US7820810B2 (en) | 2007-03-19 | 2010-10-26 | Isis Pharmaceuticals, Inc. | Process for the synthesis of 2′-O-substituted purine nulceosides |
MX2011010050A (es) | 2009-03-25 | 2011-12-14 | Univ Texas | Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos. |
WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
KR20180030699A (ko) * | 2015-07-30 | 2018-03-23 | 호리즌 오펀 엘엘씨 | 푸코시다제 억제제 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
EP0266099A3 (en) * | 1986-10-28 | 1990-09-19 | The Johns Hopkins University | Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids |
WO1989008146A1 (en) * | 1988-02-26 | 1989-09-08 | Worcester Foundation For Experimental Biology | Inhibition of htlv-iii by exogenous oligonucleotides |
DK0497875T3 (da) * | 1989-10-24 | 2000-07-03 | Gilead Sciences Inc | 2'-modificerede oligonukleotider |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
HU217036B (hu) * | 1990-08-03 | 1999-11-29 | Sanofi | Eljárás génexpresszió gátlására alkalmas vegyületek előállítására |
CA2092002A1 (en) * | 1990-09-20 | 1992-03-21 | Mark Matteucci | Modified internucleoside linkages |
-
1995
- 1995-01-17 DK DK95906958T patent/DK0741741T3/da active
- 1995-01-17 AU AU15347/95A patent/AU697134B2/en not_active Ceased
- 1995-01-17 WO PCT/EP1995/000156 patent/WO1995020597A1/en active IP Right Grant
- 1995-01-17 EP EP95906958A patent/EP0741741B1/en not_active Expired - Lifetime
- 1995-01-17 JP JP7519861A patent/JPH09508134A/ja active Pending
- 1995-01-17 HU HU9602040A patent/HU220423B/hu not_active IP Right Cessation
- 1995-01-17 CA CA002180727A patent/CA2180727A1/en not_active Abandoned
- 1995-01-17 AT AT95906958T patent/ATE222921T1/de not_active IP Right Cessation
- 1995-01-17 US US08/687,456 patent/US6066447A/en not_active Expired - Fee Related
- 1995-01-17 DE DE69527942T patent/DE69527942T2/de not_active Expired - Fee Related
- 1995-01-24 IL IL11242495A patent/IL112424A0/xx unknown
-
1996
- 1996-07-24 NO NO19963092A patent/NO316902B1/no unknown
- 1996-07-26 FI FI962980A patent/FI116677B/fi active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
HUT75704A (en) | 1997-05-28 |
FI962980A (fi) | 1996-07-26 |
IL112424A0 (en) | 1995-03-30 |
DE69527942D1 (de) | 2002-10-02 |
CA2180727A1 (en) | 1995-08-03 |
FI116677B (fi) | 2006-01-31 |
JPH09508134A (ja) | 1997-08-19 |
NO316902B1 (no) | 2004-06-21 |
EP0741741B1 (en) | 2002-08-28 |
NO963092L (no) | 1996-09-16 |
EP0741741A1 (en) | 1996-11-13 |
DE69527942T2 (de) | 2003-03-27 |
AU697134B2 (en) | 1998-09-24 |
HU9602040D0 (en) | 1996-09-30 |
AU1534795A (en) | 1995-08-15 |
FI962980A0 (fi) | 1996-07-26 |
NO963092D0 (no) | 1996-07-24 |
ATE222921T1 (de) | 2002-09-15 |
US6066447A (en) | 2000-05-23 |
HU220423B (hu) | 2002-01-28 |
WO1995020597A1 (en) | 1995-08-03 |
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