DK0721343T3 - Farmaceutiske formuleringer omfattende en nervevækstfaktor - Google Patents

Farmaceutiske formuleringer omfattende en nervevækstfaktor

Info

Publication number: DK0721343T3
Authority: DK; Denmark
Prior art keywords: growth factor; nerve growth; pharmaceutical formulations; lyophilization; admixed
Prior art date: 1993-08-20

Application number

DK94925903T

Other languages

English (en)

Inventor

Leo Gu

Victoria M Knepp

Deborah M Lidgate

Richard Maskiewicz

Original Assignee

Syntex Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-20

Filing date

1994-08-16

Publication date

2003-02-17

1994-08-16 Application filed by Syntex Llc filed Critical Syntex Llc

2003-02-17 Application granted granted Critical

2003-02-17 Publication of DK0721343T3 publication Critical patent/DK0721343T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK94925903T 1993-08-20 1994-08-16 Farmaceutiske formuleringer omfattende en nervevækstfaktor DK0721343T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/109,798 US6277828B1 (en)	1993-08-20	1993-08-20	Pharmaceutical formulations of nerve growth factor
PCT/US1994/009245 WO1995005845A1 (en)	1993-08-20	1994-08-16	Pharmaceutical formulations of nerve growth factor

Publications (1)

Publication Number	Publication Date
DK0721343T3 true DK0721343T3 (da)	2003-02-17

Family

ID=22329623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94925903T DK0721343T3 (da)	1993-08-20	1994-08-16	Farmaceutiske formuleringer omfattende en nervevækstfaktor

Country Status (32)

Country	Link
US (2)	US6277828B1 (da)
EP (1)	EP0721343B1 (da)
JP (2)	JP4592830B2 (da)
KR (1)	KR100341193B1 (da)
CN (1)	CN1163265C (da)
AT (1)	ATE226085T1 (da)
AU (1)	AU677699B2 (da)
BG (1)	BG62951B1 (da)
BR (1)	BR9407278A (da)
CA (1)	CA2169834C (da)
CZ (1)	CZ292422B6 (da)
DE (1)	DE69431562T2 (da)
DK (1)	DK0721343T3 (da)
ES (1)	ES2181723T3 (da)
FI (1)	FI113241B (da)
HK (1)	HK1012990A1 (da)
HU (1)	HU228152B1 (da)
IL (3)	IL124941A (da)
LT (1)	LT4051B (da)
LV (1)	LV11279B (da)
NO (1)	NO317627B1 (da)
NZ (1)	NZ271873A (da)
PL (1)	PL176387B1 (da)
PT (1)	PT721343E (da)
RO (1)	RO114742B1 (da)
RU (1)	RU2126265C1 (da)
SI (1)	SI9420048B (da)
SK (1)	SK284064B6 (da)
TW (1)	TW427905B (da)
UA (1)	UA43348C2 (da)
WO (1)	WO1995005845A1 (da)
ZA (1)	ZA946333B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5981485A (en)	1997-07-14	1999-11-09	Genentech, Inc.	Human growth hormone aqueous formulation
WO1996035446A1 (en) *	1995-05-12	1996-11-14	The Rockefeller University	Treatment of alzheimer disease by modulation of synapsins
JP4057058B2 (ja) *	1995-11-07	2008-03-05	ジェネンテックインコーポレーテッド	Ｎｇｆの安定化処方
US6964947B1 (en) *	1995-11-07	2005-11-15	Genentech, Inc.	Stabilizing formulation for NGF
US6090781A (en) *	1996-11-06	2000-07-18	Genentech, Inc.	Stabilizing formulation for NGF
EP1015826A2 (en) *	1996-05-29	2000-07-05	Universal Preservation Technologies, Inc.	Long-term shelf preservation by vitrification
CN1059597C (zh) *	1996-08-08	2000-12-20	陈素兰	神经损伤修复制剂
DE69836543T2 (de) *	1997-05-01	2007-09-20	Protechtion Unlimited, Inc., Wilmington	Nervenwachstumsfaktor als impfstoffadjuvans
US6313089B1 (en)	1997-08-20	2001-11-06	Duke University	Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use
AU9676598A (en) *	1997-09-30	1999-04-23	Duke University	Apolipoprotein e/growth factor complexes and methods of use
US6979442B1 (en)	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
AU2002351756A1 (en)	2001-12-21	2003-07-15	Novo Nordisk Health Care Ag	Liquid composition of factor vii polypeptides
KR20040065278A (ko) *	2001-12-21	2004-07-21	노보 노르디스크 에이/에스	변경된 인자 ⅶ 폴리펩티드의 액체 조성물
US20040009918A1 (en) *	2002-05-03	2004-01-15	Hanne Nedergaard	Stabilised solid compositions of modified factor VII
AU2003240438A1 (en)	2002-06-21	2004-01-06	Novo Nordisk A/S	Stabilised solid compositions of factor vii polypeptides
WO2004082708A2 (en) *	2003-03-18	2004-09-30	Novo Nordisk Health Care Ag	Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides
US7897734B2 (en) *	2003-03-26	2011-03-01	Novo Nordisk Healthcare Ag	Method for the production of proteins
EP1628677B1 (en) *	2003-05-23	2010-01-13	Novo Nordisk Health Care AG	Protein stabilization in solution
CN1318087C (zh) *	2003-06-06	2007-05-30	北京三诺佳邑生物技术有限责任公司	去白蛋白神经生长因子制剂
ATE547114T1 (de) *	2003-06-25	2012-03-15	Novo Nordisk Healthcare Ag	Flüssige zusammensetzungen von factor vii polypeptiden
ATE446768T1 (de) *	2003-07-01	2009-11-15	Novo Nordisk Healthcare Ag	Flüssige wässrige pharmazeutische zusammnesetzung von factor vii polypeptiden
KR101293503B1 (ko)	2003-08-14	2013-08-07	노보 노르디스크 헬스 케어 악티엔게젤샤프트	인자 ｖｉｉ 폴리펩티드의 액상 수성 약학적 조성물
PL2298287T3 (pl) *	2003-12-19	2019-02-28	Novo Nordisk Health Care Ag	Stabilizowane kompozycje polipeptydów czynnika VII
US8017151B2 (en) *	2004-09-07	2011-09-13	Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center	Amphiphilic polymer-protein conjugates and methods of use thereof
US8168222B2 (en)	2004-09-07	2012-05-01	Board Of Regents Of The University Of Nebraska	Amphiphilic polymer-protein conjugates and methods of use thereof
WO2008020584A1 (fr) *	2006-08-14	2008-02-21	Eisai R & D Management Co., Ltd.	Préparation lyophilisée stable
ES2407413T3 (es) *	2006-11-08	2013-06-12	P Mind Co., Ltd	Aparato para acelerar la producción de factor neurotrófico
EP1958618A1 (de)	2007-02-15	2008-08-20	Octapharma AG	Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
CN102196822A (zh) *	2008-09-26	2011-09-21	阿道恰公司	由多糖和hbp构成的复合物
CN102232932B (zh) *	2010-04-27	2013-06-05	重庆莱美药业股份有限公司	果胶-阿霉素轭合物的冻干制剂及制备方法
DK2694094T3 (da)	2011-04-07	2017-11-13	Neovacs	FREMGANGSMÅDE TIL BEHANDLING AF IFN-alpha-RELATEREDE TILSTANDE
US20150005236A1 (en) *	2012-02-08	2015-01-01	Institut National De La Recherche Agronomique	Use of beta-nerve growth factor for inducing ovulation in mammals
WO2016169453A1 (zh) *	2015-04-21	2016-10-27	舒泰神（北京）生物制药股份有限公司	神经生长因子组合物及注射粉剂
ES2882106T3 (es) *	2015-04-21	2021-12-01	Staidson Beijing Biopharmaceuticals Co Ltd	Composición de factor de crecimiento nervioso y polvo para inyección
ES2893952T3 (es) *	2015-04-21	2022-02-10	Staidson Beijing Biopharmaceuticals Co Ltd	Composición de factor de crecimiento nervioso y polvo para inyección
US9868828B2 (en) *	2015-06-23	2018-01-16	Amolifescience Co., Ltd.	Defined three-dimensional microenvironment for stem cell
WO2017164349A1 (ja)	2016-03-25	2017-09-28	アステラス製薬株式会社	ＰＥＧ化抗ヒトＮＧＦ抗体Ｆａｂ'フラグメント含有医薬組成物
DK3463308T3 (da) *	2016-06-01	2022-01-31	Servier Ip Uk Ltd	Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf
CN109260147B (zh) *	2018-10-15	2019-09-13	珠海亿胜生物制药有限公司	一种用于治疗或预防神经损伤的重组人碱性成纤维细胞生长因子注射剂
US11767504B2 (en)	2020-08-14	2023-09-26	Albcura Corporation	Albumin compositions and methods of producing and using same
IL302317A (en)	2020-10-28	2023-06-01	Dompe Farm Spa	Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ235556A (en)	1986-11-05	1991-06-25	Ethicon Inc	Breast milk substitute containing recombinant human egf
NZ226170A (en) *	1987-09-18	1990-07-26	Ethicon Inc	Stable freeze-dried pharmaceutical composition containing epidermal growth factor
IT1219874B (it) *	1988-03-18	1990-05-24	Fidia Farmaceutici	Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US5096885A (en)	1988-04-15	1992-03-17	Genentech, Inc.	Human growth hormone formulation
JPH0418031A (ja) *	1989-02-16	1992-01-22	Hiroshi Saito	損傷治癒促進剤
JP3283288B2 (ja) *	1991-03-08	2002-05-20	電気化学工業株式会社	生理活性ペプチド製剤
JP2818834B2 (ja) *	1991-08-12	1998-10-30	大塚製薬株式会社	ＩＬ−１α安定化医薬製剤

1993
- 1993-08-20 US US08/109,798 patent/US6277828B1/en not_active Expired - Lifetime
1994
- 1994-08-16 ES ES94925903T patent/ES2181723T3/es not_active Expired - Lifetime
- 1994-08-16 HU HU9600371A patent/HU228152B1/hu unknown
- 1994-08-16 JP JP50764495A patent/JP4592830B2/ja not_active Expired - Lifetime
- 1994-08-16 WO PCT/US1994/009245 patent/WO1995005845A1/en active IP Right Grant
- 1994-08-16 UA UA96020622A patent/UA43348C2/uk unknown
- 1994-08-16 SI SI9420048A patent/SI9420048B/sl unknown
- 1994-08-16 RO RO96-00301A patent/RO114742B1/ro unknown
- 1994-08-16 CZ CZ1996424A patent/CZ292422B6/cs not_active IP Right Cessation
- 1994-08-16 AT AT94925903T patent/ATE226085T1/de active
- 1994-08-16 DK DK94925903T patent/DK0721343T3/da active
- 1994-08-16 NZ NZ271873A patent/NZ271873A/en not_active IP Right Cessation
- 1994-08-16 KR KR1020017005635A patent/KR100341193B1/ko not_active IP Right Cessation
- 1994-08-16 AU AU75668/94A patent/AU677699B2/en not_active Expired
- 1994-08-16 CN CNB94193148XA patent/CN1163265C/zh not_active Expired - Lifetime
- 1994-08-16 DE DE69431562T patent/DE69431562T2/de not_active Expired - Lifetime
- 1994-08-16 EP EP94925903A patent/EP0721343B1/en not_active Expired - Lifetime
- 1994-08-16 PL PL94313084A patent/PL176387B1/pl unknown
- 1994-08-16 BR BR9407278A patent/BR9407278A/pt not_active Application Discontinuation
- 1994-08-16 SK SK183-96A patent/SK284064B6/sk not_active IP Right Cessation
- 1994-08-16 PT PT94925903T patent/PT721343E/pt unknown
- 1994-08-16 CA CA002169834A patent/CA2169834C/en not_active Expired - Lifetime
- 1994-08-16 RU RU96105951A patent/RU2126265C1/ru active
- 1994-08-19 IL IL124941A patent/IL124941A/en not_active IP Right Cessation
- 1994-08-19 IL IL11072594A patent/IL110725A/en not_active IP Right Cessation
- 1994-08-19 ZA ZA946333A patent/ZA946333B/xx unknown
- 1994-08-30 TW TW083107604A patent/TW427905B/zh not_active IP Right Cessation
1996
- 1996-02-19 LV LVP-96-48A patent/LV11279B/en unknown
- 1996-02-19 FI FI960750A patent/FI113241B/fi not_active IP Right Cessation
- 1996-02-19 NO NO19960651A patent/NO317627B1/no not_active IP Right Cessation
- 1996-02-19 BG BG100371A patent/BG62951B1/bg unknown
- 1996-02-19 LT LT96-011A patent/LT4051B/lt not_active IP Right Cessation
1998
- 1998-06-16 IL IL12494198A patent/IL124941A0/xx active IP Right Grant
- 1998-12-19 HK HK98114132A patent/HK1012990A1/xx not_active IP Right Cessation
2001
- 2001-02-20 US US09/789,855 patent/US7074763B2/en not_active Expired - Fee Related
2007
- 2007-08-08 JP JP2007206876A patent/JP2007314572A/ja active Pending

Also Published As

Publication number	Publication date
LT4051B (en)	1996-10-25
IL110725A (en)	2004-09-27
LV11279B (en)	1996-10-20
PL313084A1 (en)	1996-05-27
BR9407278A (pt)	1996-10-01
EP0721343B1 (en)	2002-10-16
UA43348C2 (uk)	2001-12-17
HU9600371D0 (en)	1996-04-29
CZ292422B6 (cs)	2003-09-17
JP4592830B2 (ja)	2010-12-08
DE69431562D1 (de)	2002-11-21
DE69431562T2 (de)	2003-06-18
NO317627B1 (no)	2004-11-29
ES2181723T3 (es)	2003-03-01
HU228152B1 (en)	2012-12-28
NZ271873A (en)	1996-10-28
SI9420048B (sl)	2003-12-31
CZ42496A3 (en)	1996-05-15
EP0721343A1 (en)	1996-07-17
ATE226085T1 (de)	2002-11-15
US6277828B1 (en)	2001-08-21
JPH10508000A (ja)	1998-08-04
RO114742B1 (ro)	1999-07-30
HK1012990A1 (en)	1999-08-13
RU2126265C1 (ru)	1999-02-20
US7074763B2 (en)	2006-07-11
IL124941A0 (en)	1999-01-26
NO960651D0 (no)	1996-02-19
AU7566894A (en)	1995-03-21
BG62951B1 (bg)	2000-12-29
US20010007662A1 (en)	2001-07-12
PL176387B1 (pl)	1999-05-31
TW427905B (en)	2001-04-01
CN1133012A (zh)	1996-10-09
BG100371A (bg)	1996-12-31
IL124941A (en)	2006-12-10
NO960651L (no)	1996-02-19
SK284064B6 (sk)	2004-09-08
AU677699B2 (en)	1997-05-01
SK18396A3 (en)	1996-10-02
FI113241B (fi)	2004-03-31
FI960750A (fi)	1996-02-20
CN1163265C (zh)	2004-08-25
CA2169834C (en)	2008-11-04
PT721343E (pt)	2003-01-31
FI960750A0 (fi)	1996-02-19
IL110725A0 (en)	1994-11-11
KR100341193B1 (ko)	2002-06-21
LT96011A (en)	1996-07-25
CA2169834A1 (en)	1995-03-02
WO1995005845A1 (en)	1995-03-02
SI9420048A (en)	1996-10-31
JP2007314572A (ja)	2007-12-06
HUT74728A (en)	1997-02-28
LV11279A (lv)	1996-06-20
ZA946333B (en)	1996-02-19

Publication	Publication Date	Title
DK0721343T3 (da)	2003-02-17	Farmaceutiske formuleringer omfattende en nervevækstfaktor
IT1232827B (it)	1992-03-05	Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
LU90484I2 (fr)	2000-02-21	Novorapid - insuline asparte et ses sels et derives pharmaceutiquement acceptables
MX9203439A (es)	1992-08-01	Una citocina mamifera, il-11
FI875533A (fi)	1987-12-16	Insulinpreparat foer non-parenteral dosering.
NO893678D0 (no)	1989-09-14	Cyklosporinholdige preparater og fremgangsmaate for deres fremstilling.
IT1196484B (it)	1988-11-16	Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe
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