DK0717042T3 - Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater - Google Patents

Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater

Info

Publication number
DK0717042T3
DK0717042T3 DK95119485T DK95119485T DK0717042T3 DK 0717042 T3 DK0717042 T3 DK 0717042T3 DK 95119485 T DK95119485 T DK 95119485T DK 95119485 T DK95119485 T DK 95119485T DK 0717042 T3 DK0717042 T3 DK 0717042T3
Authority
DK
Denmark
Prior art keywords
azetidine
thiazolyl
dihydro
preparation
thiol derivatives
Prior art date
Application number
DK95119485T
Other languages
English (en)
Inventor
Kazuhiko Hayashi
Chisato Sato
Satoshi Tamai
Original Assignee
Wyeth Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Lederle Japan Ltd filed Critical Wyeth Lederle Japan Ltd
Application granted granted Critical
Publication of DK0717042T3 publication Critical patent/DK0717042T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Processing Of Solid Wastes (AREA)
  • Saccharide Compounds (AREA)
  • Chemical Vapour Deposition (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK95119485T 1994-12-12 1995-12-11 Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater DK0717042T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33142394 1994-12-12
JP25728195 1995-09-11

Publications (1)

Publication Number Publication Date
DK0717042T3 true DK0717042T3 (da) 2001-08-06

Family

ID=26543132

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95119485T DK0717042T3 (da) 1994-12-12 1995-12-11 Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater

Country Status (15)

Country Link
US (1) US5659043A (da)
EP (1) EP0717042B1 (da)
KR (1) KR100337053B1 (da)
AT (1) ATE201410T1 (da)
AU (1) AU703119B2 (da)
CA (1) CA2164918C (da)
DE (1) DE69521012T2 (da)
DK (1) DK0717042T3 (da)
ES (1) ES2156917T3 (da)
FI (1) FI120402B (da)
GR (1) GR3035925T3 (da)
HU (4) HU223536B1 (da)
IL (1) IL116331A (da)
NO (1) NO955007L (da)
PT (1) PT717042E (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
KR100621782B1 (ko) * 2004-06-14 2006-09-19 한국과학기술연구원 1-베타메틸카바페넴 유도체 및 이의 제조방법
CN102532139A (zh) * 2010-12-07 2012-07-04 重庆医药工业研究院有限责任公司 一种替比培南的制备方法
CN102731502B (zh) * 2011-04-13 2016-08-03 石药集团中奇制药技术(石家庄)有限公司 一种碳青霉烯抗生素的制备方法
CN102731503B (zh) * 2011-04-13 2016-02-03 石药集团中奇制药技术(石家庄)有限公司 一种泰比培南的制备方法
CN102250080B (zh) * 2011-04-26 2015-06-03 广州白云山制药股份有限公司广州白云山制药总厂 一种1-(4,5-二氢-2-噻唑啉基)-3-巯基吖丁叮盐酸盐的制备方法
CN102757430B (zh) * 2011-04-29 2016-04-13 上海医药工业研究院 一种替比培南的制备方法
CN104292222B (zh) * 2013-07-17 2017-05-10 常州锐博生物科技有限公司 一种替比培南匹伏酯侧链的新的合成方法
MX2018000202A (es) 2015-07-02 2018-06-27 Horizon Orphan Llc Analogos de cisteamina resistentes a la ado y sus usos.
CN112321582B (zh) * 2020-11-03 2021-12-03 江西富祥药业股份有限公司 一种泰比培南侧链的合成及中间体的精制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU682510B2 (en) * 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives

Also Published As

Publication number Publication date
CA2164918A1 (en) 1996-06-13
HU223472B1 (hu) 2004-07-28
AU703119B2 (en) 1999-03-18
IL116331A0 (en) 1996-03-31
US5659043A (en) 1997-08-19
ES2156917T3 (es) 2001-08-01
HU0203892D0 (en) 2003-01-28
NO955007L (no) 1996-06-13
FI955954A (fi) 1996-06-13
HU0203891D0 (en) 2003-01-28
HU223477B1 (hu) 2004-07-28
HU223536B1 (hu) 2004-08-30
FI120402B (fi) 2009-10-15
DE69521012T2 (de) 2001-09-06
EP0717042B1 (en) 2001-05-23
NO955007D0 (no) 1995-12-11
PT717042E (pt) 2001-08-30
GR3035925T3 (en) 2001-08-31
HUT75098A (en) 1997-04-28
KR100337053B1 (ko) 2002-11-07
EP0717042A1 (en) 1996-06-19
KR960022512A (ko) 1996-07-18
AU4035995A (en) 1996-06-20
HU0203890D0 (en) 2003-01-28
HU9503548D0 (en) 1996-02-28
FI955954A0 (fi) 1995-12-12
DE69521012D1 (de) 2001-06-28
IL116331A (en) 2000-02-17
CA2164918C (en) 2007-09-25
ATE201410T1 (de) 2001-06-15
HU223476B1 (hu) 2004-07-28

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