DK0669919T3 - Anvendelse af dimethylbenzofuraner og dimethylbenzopyraner som 5-HT3-antagonister - Google Patents

Anvendelse af dimethylbenzofuraner og dimethylbenzopyraner som 5-HT3-antagonister

Info

Publication number: DK0669919T3
Authority: DK; Denmark
Prior art keywords: pct; date jun; represents hydrogen; sec; formula
Prior art date: 1992-11-20

Application number

DK94900151T

Other languages

English (en)

Inventor

Jean-Paul Rene Marie A Bosmans

Daele Georges Henri Paul Van

Laerhoven Willy Joannes Ca Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-20

Filing date

1993-11-15

Publication date

1999-09-13

1993-11-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1999-09-13 Application granted granted Critical

1999-09-13 Publication of DK0669919T3 publication Critical patent/DK0669919T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Dental Preparations (AREA)

DK94900151T 1992-11-20 1993-11-15 Anvendelse af dimethylbenzofuraner og dimethylbenzopyraner som 5-HT3-antagonister DK0669919T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97901392A	1992-11-20	1992-11-20
PCT/EP1993/003206 WO1994012494A1 (en)	1992-11-20	1993-11-15	Use of dimethylbenzofurans and dimethylbenzopyrans as 5-ht3 antagonists

Publications (1)

Publication Number	Publication Date
DK0669919T3 true DK0669919T3 (da)	1999-09-13

Family

ID=25526607

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94900151T DK0669919T3 (da)	1992-11-20	1993-11-15	Anvendelse af dimethylbenzofuraner og dimethylbenzopyraner som 5-HT3-antagonister

Country Status (31)

Country	Link
US (2)	US5674868A (da)
EP (1)	EP0669919B1 (da)
JP (1)	JP2830952B2 (da)
KR (1)	KR0166661B1 (da)
AT (1)	ATE176232T1 (da)
AU (1)	AU680640B2 (da)
BG (1)	BG62489B1 (da)
BR (1)	BR9307477A (da)
CA (1)	CA2149044C (da)
CZ (1)	CZ287262B6 (da)
DE (1)	DE69323322T2 (da)
DK (1)	DK0669919T3 (da)
ES (1)	ES2129615T3 (da)
FI (1)	FI952458A (da)
GR (1)	GR3029831T3 (da)
HU (2)	HUT72740A (da)
IL (3)	IL119273A (da)
LV (1)	LV10956B (da)
MX (1)	MX9307257A (da)
NO (2)	NO307690B1 (da)
NZ (1)	NZ257854A (da)
OA (1)	OA10158A (da)
PL (1)	PL176051B1 (da)
RO (1)	RO115160B1 (da)
RU (1)	RU2116072C1 (da)
SG (1)	SG47488A1 (da)
SK (1)	SK282378B6 (da)
TW (1)	TW294595B (da)
UA (1)	UA49792C2 (da)
WO (1)	WO1994012494A1 (da)
ZA (1)	ZA938676B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
CA2286076C (en)	1997-04-18	2006-12-12	Janssen Pharmaceutica N.V.	Use of 5ht3 antagonists for promoting intestinal lavage
JP3529102B2 (ja) *	1997-07-11	2004-05-24	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	５−ｈｔ３および５−ｈｔ４介在性障害に有用な（＋）−ノルシサプリド
US6239122B1 (en) *	2000-01-05	2001-05-29	Joy Ann Steele	Method of treatment of nausea, vomiting, and other disorders using estrogens
WO2004111014A1 (en) *	2003-06-06	2004-12-23	Vertex Pharmaceuticals Incorporated	Pyrimidine derivatives as modulators of atp-binding cassette transporters
WO2005054201A1 (en)	2003-11-20	2005-06-16	Janssen Pharmaceutica N.V.	6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
CN1882549B (zh)	2003-11-20	2011-02-23	詹森药业有限公司	用作聚(adp-核糖)聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮
BRPI0512902A (pt)	2004-06-30	2008-04-15	Janssen Pharmaceutica Nv	derivados de ftalazina como inibidores de parp
JP5100376B2 (ja)	2004-06-30	2012-12-19	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体
EA012416B1 (ru)	2004-06-30	2009-10-30	Янссен Фармацевтика Н.В.	Производные замещенного 2-алкилхиназолинона как ингибиторы parp
ES2381446T3 (es)	2007-03-08	2012-05-28	Janssen Pharmaceutica, N.V.	Derivado de quinolinona como inhibidores de PARP y TANK
ES2448870T3 (es)	2007-10-26	2014-03-17	Janssen Pharmaceutica, N.V.	Derivados de quinolina como inhibidores de PARP
ES2367760T3 (es)	2008-03-27	2011-11-08	Janssen Pharmaceutica, N.V.	Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
DK2271626T3 (da)	2008-03-27	2015-02-23	Janssen Pharmaceutica Nv	Tetrahydrophenanthridinoner og tetrahydrocyclopentaquinolinoner som inhibitorer af polymerisering af parp og tubulin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1183847A (en) *	1981-10-01	1985-03-12	Georges Van Daele	N-(3-hydroxy-4-piperidinyl)benzamide derivatives
ZW12187A1 (en) *	1986-07-03	1989-02-01	Janssen Pharmaceutica Nv	4-(aroylamino)piperidinebutanamide derivatives
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) *	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

1993
- 1993-11-03 TW TW082109153A patent/TW294595B/zh active
- 1993-11-15 SK SK675-95A patent/SK282378B6/sk unknown
- 1993-11-15 DK DK94900151T patent/DK0669919T3/da active
- 1993-11-15 HU HU9501476A patent/HUT72740A/hu unknown
- 1993-11-15 BR BR9307477A patent/BR9307477A/pt not_active Application Discontinuation
- 1993-11-15 SG SG1996002238A patent/SG47488A1/en unknown
- 1993-11-15 CA CA002149044A patent/CA2149044C/en not_active Expired - Fee Related
- 1993-11-15 WO PCT/EP1993/003206 patent/WO1994012494A1/en active IP Right Grant
- 1993-11-15 UA UA95048357A patent/UA49792C2/uk unknown
- 1993-11-15 RO RO95-00941A patent/RO115160B1/ro unknown
- 1993-11-15 ES ES94900151T patent/ES2129615T3/es not_active Expired - Lifetime
- 1993-11-15 KR KR1019950701615A patent/KR0166661B1/ko not_active IP Right Cessation
- 1993-11-15 US US08/416,914 patent/US5674868A/en not_active Expired - Fee Related
- 1993-11-15 AT AT94900151T patent/ATE176232T1/de not_active IP Right Cessation
- 1993-11-15 EP EP94900151A patent/EP0669919B1/en not_active Expired - Lifetime
- 1993-11-15 NZ NZ257854A patent/NZ257854A/en unknown
- 1993-11-15 AU AU54659/94A patent/AU680640B2/en not_active Ceased
- 1993-11-15 JP JP6512708A patent/JP2830952B2/ja not_active Expired - Fee Related
- 1993-11-15 DE DE69323322T patent/DE69323322T2/de not_active Expired - Fee Related
- 1993-11-15 PL PL93309045A patent/PL176051B1/pl not_active IP Right Cessation
- 1993-11-15 RU RU95113434A patent/RU2116072C1/ru not_active IP Right Cessation
- 1993-11-15 CZ CZ19951258A patent/CZ287262B6/cs not_active IP Right Cessation
- 1993-11-18 IL IL11927393A patent/IL119273A/xx not_active IP Right Cessation
- 1993-11-18 IL IL11927396A patent/IL119273A0/xx unknown
- 1993-11-18 IL IL107654A patent/IL107654A/en not_active IP Right Cessation
- 1993-11-19 MX MX9307257A patent/MX9307257A/es unknown
- 1993-11-19 ZA ZA938676A patent/ZA938676B/xx unknown
1995
- 1995-04-20 BG BG99593A patent/BG62489B1/bg unknown
- 1995-05-19 OA OA60663A patent/OA10158A/en unknown
- 1995-05-19 FI FI952458A patent/FI952458A/fi unknown
- 1995-05-19 NO NO951980A patent/NO307690B1/no unknown
- 1995-06-20 LV LVP-95-184A patent/LV10956B/en unknown
- 1995-06-30 HU HU95P/P00699P patent/HU211546A9/hu unknown
1997
- 1997-05-01 US US08/848,777 patent/US5863923A/en not_active Expired - Fee Related
1999
- 1999-03-31 GR GR990400922T patent/GR3029831T3/el unknown
- 1999-11-24 NO NO995762A patent/NO308530B1/no unknown

Also Published As

Publication number	Publication date
ATE176232T1 (de)	1999-02-15
SK67595A3 (en)	1995-11-08
DE69323322T2 (de)	1999-09-09
DE69323322D1 (de)	1999-03-11
NO951980L (no)	1995-05-19
KR0166661B1 (ko)	1999-01-15
NO995762D0 (no)	1999-11-24
NZ257854A (en)	1997-04-24
UA49792C2 (uk)	2002-10-15
FI952458A0 (fi)	1995-05-19
RU2116072C1 (ru)	1998-07-27
JPH08505840A (ja)	1996-06-25
CZ125895A3 (en)	1995-10-18
EP0669919A1 (en)	1995-09-06
LV10956B (en)	1996-10-20
BG62489B1 (bg)	1999-12-30
IL107654A0 (en)	1994-02-27
NO308530B1 (no)	2000-09-25
TW294595B (da)	1997-01-01
SK282378B6 (sk)	2002-01-07
RO115160B1 (ro)	1999-11-30
PL176051B1 (pl)	1999-03-31
WO1994012494A1 (en)	1994-06-09
BR9307477A (pt)	1999-06-29
RU95113434A (ru)	1997-03-10
NO951980D0 (no)	1995-05-19
HUT72740A (en)	1996-05-28
CA2149044C (en)	2007-04-03
CA2149044A1 (en)	1994-06-09
IL119273A0 (en)	1996-12-05
BG99593A (en)	1995-12-29
ES2129615T3 (es)	1999-06-16
US5863923A (en)	1999-01-26
NO307690B1 (no)	2000-05-15
GR3029831T3 (en)	1999-06-30
AU680640B2 (en)	1997-08-07
NO995762L (no)	1995-05-19
ZA938676B (en)	1995-05-19
AU5465994A (en)	1994-06-22
CZ287262B6 (en)	2000-10-11
PL309045A1 (en)	1995-09-18
IL119273A (en)	2000-07-16
MX9307257A (es)	1994-05-31
FI952458A (fi)	1995-05-19
SG47488A1 (en)	1998-04-17
OA10158A (en)	1996-12-18
JP2830952B2 (ja)	1998-12-02
IL107654A (en)	1998-01-04
HU9501476D0 (en)	1995-07-28
HU211546A9 (en)	1995-12-28
EP0669919B1 (en)	1999-01-27
LV10956A (lv)	1995-12-20
US5674868A (en)	1997-10-07

Publication	Publication Date	Title
DK0669919T3 (da)	1999-09-13	Anvendelse af dimethylbenzofuraner og dimethylbenzopyraner som 5-HT3-antagonister
GR3034769T3 (en)	2001-02-28	Triazole antifungal agents.
FI943931A (fi)	1994-08-26	Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
DK0871626T3 (da)	2002-02-25	Triazoloner som apolipoprotein-B syntheseinhibitorer
NO964216D0 (no)	1996-10-04	Ester- og karbamatderivater av azoloner som er kraftige midler mot Helicobacter
DE69304930T2 (de)	1997-02-27	4-chinolinyl derivate mit anti-helicobacter wirkung
LV11545A (lv)	1996-10-20	Pozitivas inotropas un lusitropas iedarbibas pirolohinolinona atvasinajumi