DK0600992T3 - Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner - Google Patents

Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner

Info

Publication number
DK0600992T3
DK0600992T3 DK92917956T DK92917956T DK0600992T3 DK 0600992 T3 DK0600992 T3 DK 0600992T3 DK 92917956 T DK92917956 T DK 92917956T DK 92917956 T DK92917956 T DK 92917956T DK 0600992 T3 DK0600992 T3 DK 0600992T3
Authority
DK
Denmark
Prior art keywords
gentisic acid
stabilize
proteins
radiolabelled peptides
gentisyl alcohol
Prior art date
Application number
DK92917956T
Other languages
English (en)
Inventor
Edward A Deutsch
Wilhelmus Theodorus Goedemans
Jong Martinus Theodorus De
Kathleen M Miller
James W Brodack
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Application granted granted Critical
Publication of DK0600992T3 publication Critical patent/DK0600992T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK92917956T 1991-08-29 1992-07-31 Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner DK0600992T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75182591A 1991-08-29 1991-08-29
PCT/US1992/006429 WO1993004702A1 (en) 1991-08-29 1992-07-31 Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins

Publications (1)

Publication Number Publication Date
DK0600992T3 true DK0600992T3 (da) 2000-10-09

Family

ID=25023648

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92917956T DK0600992T3 (da) 1991-08-29 1992-07-31 Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner

Country Status (11)

Country Link
US (1) US5384113A (da)
EP (1) EP0600992B1 (da)
JP (1) JP3853354B2 (da)
AT (1) ATE196428T1 (da)
AU (1) AU2462592A (da)
CA (1) CA2113995C (da)
DE (1) DE69231469T2 (da)
DK (1) DK0600992T3 (da)
ES (1) ES2150916T3 (da)
GR (1) GR3035067T3 (da)
WO (1) WO1993004702A1 (da)

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US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
EP0626170A3 (en) * 1993-05-10 1996-03-27 Sandoz Ltd Stabilization of pharmacoligically active compounds in controlled release compositions.
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US20010055563A1 (en) 1999-09-09 2001-12-27 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
WO1997028181A2 (en) * 1996-02-02 1997-08-07 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
US6066309A (en) * 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
WO1997033580A1 (en) * 1996-03-11 1997-09-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Maintaining kidney function during surgery or trauma
US5859043A (en) * 1996-06-11 1999-01-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for maintaining kidney function during surgery or severe trauma under general anesthesia
AUPO066096A0 (en) * 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
US6468971B1 (en) 1997-03-05 2002-10-22 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Maintaining kidney function during surgery or trauma
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
WO2000018440A1 (en) * 1998-09-25 2000-04-06 Mallinckrodt Inc. Somatostatin receptor radioligand with increased uptake
DE60014375T2 (de) * 1999-06-29 2005-12-01 Mallinckrodt, Inc. Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung
EP1311301A2 (en) * 2000-07-06 2003-05-21 Bristol-Myers Squibb Pharma Company Stable radiopharmaceutical compositions and methods for preparation thereof
US6989138B2 (en) 2000-10-24 2006-01-24 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
US6881396B2 (en) * 2000-10-24 2005-04-19 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy-chromans
US6902718B2 (en) * 2000-10-24 2005-06-07 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
MXPA03007595A (es) * 2001-02-26 2003-12-04 Bristol Myers Squibb Pharma Co Analogos de acido ascorbico para metalorradiofarmaceuticos.
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
US7238338B1 (en) 2001-06-22 2007-07-03 Triumf System and method for the large scale labeling of compounds with radiohalogens
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
JP2006505610A (ja) 2002-11-05 2006-02-16 イヨン ベアム アプリカスィヨン エッス．アー． １８−ｆ標識放射性製剤の安定化
US7018614B2 (en) 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
CA2526556C (en) * 2003-07-24 2012-09-25 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US20080193379A1 (en) * 2005-06-14 2008-08-14 Nihon Medi-Physics Co., Ltd. Radioactive Diagnostic Imaging Agent
GB0514087D0 (en) * 2005-07-11 2005-08-17 Ge Healthcare Ltd Stabilised radiopharmaceutical compositions
EP2214722A1 (en) * 2007-11-07 2010-08-11 GE Healthcare BV Stabilization of radiopharmaceuticals
WO2009086062A1 (en) * 2007-12-21 2009-07-09 Lyotropic Therapeutics, Inc. Stabilized formulations of peptides and proteins
CA2967254C (en) 2008-02-29 2019-03-26 Lantheus Medical Imaging, Inc. Contrast agents for applications including imaging cancer
EP2419096B1 (en) 2009-04-15 2019-11-13 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
KR102438133B1 (ko) 2010-02-08 2022-08-31 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
WO2011147762A2 (en) 2010-05-25 2011-12-01 Bayer Pharma Aktiengesellschaft Stabilized radiopharmaceutical composition
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
GB201504064D0 (en) 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
KR102484725B1 (ko) * 2016-11-04 2023-01-06 클라리티 파마슈티컬스 리미티드 방사선 요법 및 진단 영상용 제형
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
CN114835690B (zh) * 2022-07-04 2022-09-27 北京先通国际医药科技股份有限公司 含化合物i的液体组合物的制备方法、及在心肌灌注pet显像中的用途
CN115015441B (zh) * 2022-07-14 2023-08-18 原子高科股份有限公司 一种测定镥[177Lu]氧奥曲肽注射液中稳定剂含量的方法
WO2024036372A1 (en) * 2022-08-16 2024-02-22 Clarity Pharmaceuticals Limited Formulations for radiotherapy and diagnostic imaging and use thereof in treatment, diagnosis and imaging diseases

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* Cited by examiner, † Cited by third party
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US4497744A (en) * 1978-03-31 1985-02-05 Mallinckrodt, Inc. Gentisic acid salts as radiographic scanning agent stabilizers
US4232000A (en) * 1978-06-28 1980-11-04 The Procter & Gamble Company Radioactive scanning agents with stabilizer
US4229427A (en) * 1978-06-28 1980-10-21 The Procter & Gamble Company Radioactive scanning agents with hydroquinone stabilizer
US4232284A (en) * 1979-05-07 1980-11-04 Power Parts, Inc. Ignition coil and electrical connector therefor
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4440738A (en) * 1982-06-10 1984-04-03 Mallinckrodt, Inc. Stable radiographic imaging agents
US4504463A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4707353A (en) * 1982-12-08 1987-11-17 Mallinckrodt, Inc. Radiographic imaging agents
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
JPS59199636A (ja) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk 放射性診断剤
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
GB2239178B (en) * 1987-07-10 1991-11-27 Sandoz Ltd Somatostatin analogues for the treatment of breast cancer
DE3780820D1 (da) * 1987-10-30 1992-09-03 Sorin Biomedica S.P.A., Saluggia, Vercelli, It
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
US5093105A (en) * 1991-04-09 1992-03-03 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats

Also Published As

Publication number Publication date
JP3853354B2 (ja) 2006-12-06
JPH06510539A (ja) 1994-11-24
CA2113995A1 (en) 1993-03-18
EP0600992B1 (en) 2000-09-20
US5384113A (en) 1995-01-24
WO1993004702A1 (en) 1993-03-18
ATE196428T1 (de) 2000-10-15
EP0600992A1 (en) 1994-06-15
DE69231469D1 (de) 2000-10-26
DE69231469T2 (de) 2001-01-25
AU2462592A (en) 1993-04-05
CA2113995C (en) 2003-04-22
GR3035067T3 (en) 2001-03-30
ES2150916T3 (es) 2000-12-16

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