DE69417252T2 - Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17 - Google Patents

Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17

Info

Publication number: DE69417252T2
Authority: DE; Germany
Prior art keywords: pro; against human; immunogenic composition; composition against; glu
Prior art date: 1993-11-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69417252T

Other languages

English (en)

Other versions

DE69417252D1 (de

Inventor

Philip Gevas

Stephen Grimes

Stephen Karr

Dov Michaeli

Robert Scibienski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Receptor Biologix Inc

Original Assignee

Aphton Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1994-11-10

Publication date

1999-07-08

1994-11-10 Application filed by Aphton Corp filed Critical Aphton Corp

1999-04-22 Publication of DE69417252D1 publication Critical patent/DE69417252D1/de

1999-07-08 Application granted granted Critical

1999-07-08 Publication of DE69417252T2 publication Critical patent/DE69417252T2/de

2014-11-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000002163 immunogen Effects 0.000 title abstract 3
102400000921 Gastrin Human genes 0.000 title abstract 2
101001002317 Homo sapiens Gastrin Proteins 0.000 title abstract 2
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

DE69417252T 1993-11-12 1994-11-10 Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17 Expired - Lifetime DE69417252T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/151,219 US5468494A (en)	1993-11-12	1993-11-12	Immunogenic compositions against human gastrin 17
PCT/US1994/013205 WO1995013297A2 (en)	1993-11-12	1994-11-10	Improved immunogenic compositions against human gastrin 17

Publications (2)

Publication Number	Publication Date
DE69417252D1 DE69417252D1 (de)	1999-04-22
DE69417252T2 true DE69417252T2 (de)	1999-07-08

Family

ID=22537815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69417252T Expired - Lifetime DE69417252T2 (de)	1993-11-12	1994-11-10	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17

Country Status (10)

Country	Link
US (1)	US5468494A (de)
EP (1)	EP0728148B1 (de)
JP (1)	JP3694893B2 (de)
AT (1)	ATE177757T1 (de)
AU (1)	AU1179795A (de)
DE (1)	DE69417252T2 (de)
DK (1)	DK0728148T3 (de)
ES (1)	ES2130575T3 (de)
GR (1)	GR3029791T3 (de)
WO (1)	WO1995013297A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6861510B1 (en) *	1989-01-24	2005-03-01	Aphton Corporation	Immunogenic compositions against gastrin peptides
EP0380230B1 (de) *	1989-01-24	1994-11-17	Aphton Corporation	Immunogenische Zusammensetzungen gegen Gastrin-Peptide
CA2261433A1 (en) *	1993-12-09	1995-06-10	Belinda Sanchez Ramirez	Composition comprising autologous epidermal growth factor
US5688506A (en) *	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
PT889735E (pt) *	1996-02-08	2011-07-19	Cancer Advances Inc	Métodos imunológicos para o tratamento do cancro gastrointestinal
ES2227833T3 (es) *	1997-05-12	2005-04-01	Aphton Corporation	Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores.
US20040001842A1 (en) *	1997-05-12	2004-01-01	Dov Michaeli	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
PT1077721E (pt) *	1998-05-15	2007-06-21	Receptor Biologix Inc	Prevenção e tratamento da hipergastrinemia.
WO1999059612A1 (en) *	1998-05-15	1999-11-25	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
US20030068326A1 (en) *	1998-05-15	2003-04-10	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
JP2002515457A (ja) *	1998-05-15	2002-05-28	アフトンコーポレーション	腫瘍治療のための併用療法
AU770475B2 (en) *	1999-12-23	2004-02-19	Aphton Corporation	A stable immunogenic composition for frozen storage
EP1303533A2 (de) *	2000-05-05	2003-04-23	Aphton Corporation	Chimäre peptidimmunogene,deren herstellung und verwendung
WO2002076499A2 (en) *	2001-03-23	2002-10-03	Aphton Corporation	Combination treatment of pancreatic cancer
CU22999A1 (es) *	2001-12-04	2004-10-12	Centro Inmunologia Molecular	Método de tratamiento de enfermedades malignas e infecciosas crónicas
US20090191232A1 (en) *	2001-05-04	2009-07-30	Gevas Philip C	Combination therapy for the treatment of tumors
CN1525868A (zh) *	2001-07-09	2004-09-01	埃弗顿有限公司	治疗和预防肝脏、肺脏和食道的癌症和癌症前期症状
US20040247661A1 (en) *	2002-07-03	2004-12-09	Dov Michaeli	Liposomal vaccine
US20050169979A1 (en) *	2002-07-03	2005-08-04	Dov Michaeli	Liposomal vaccine
EP1528915A2 (de) *	2002-07-03	2005-05-11	Aphton Corporation	Liposomaler impfstoff
AU2004225437B2 (en)	2003-03-28	2010-05-13	Cancer Advances, Inc.	Gastrin hormone immunoassays
EP2567974A3 (de)	2004-09-22	2013-05-22	Cancer Advances, Inc.,	Monoklonale Antikörper gegen Progastrin
EP2049524A2 (de) *	2006-07-24	2009-04-22	Tetralogic Pharmaceuticals Corporation	Iap-hemmer
WO2009054091A1 (ja) *	2007-10-26	2009-04-30	Advanced Life Science Institute, Inc.	ガストリン放出ペプチド前駆体に対する抗体及びその使用
JP5559789B2 (ja)	2008-08-07	2014-07-23	マーシア・ファーマ・インコーポレイテッド	アルツハイマー病の処置のための免疫治療組成物
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
US8674064B2 (en) *	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
CN101797382B (zh) *	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
GB201121571D0 (en)	2011-12-15	2012-01-25	Astrimmune Ltd	Compounds and uses thereof
CN105407919B (zh) *	2013-05-21	2019-08-06	Tyg肿瘤学有限公司	胃泌素肽免疫原性组合物
US11583576B2 (en)	2017-06-15	2023-02-21	Cancer Advances Inc.	Compositions and methods for inducing humoral and cellular immunities against tumors and cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4384995A (en) *	1980-01-16	1983-05-24	The Ohio State University	Antigenic modification of polypeptides
US4201770A (en) *	1973-05-07	1980-05-06	The Ohio State University	Antigenic modification of polypeptides
US4526716A (en) *	1981-11-20	1985-07-02	The Ohio State University	Antigenic modification of polypeptides
US4691006A (en) *	1983-03-04	1987-09-01	Ohio State University	Antigenic modification of polypeptides
US4069313A (en) *	1974-11-19	1978-01-17	Merck & Co., Inc.	Water-in-oil adjuvant composition
US4894443A (en) *	1984-02-08	1990-01-16	Cetus Corporation	Toxin conjugates
US5023077A (en) *	1989-01-24	1991-06-11	Aphton Corporation	Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
EP0380230B1 (de) *	1989-01-24	1994-11-17	Aphton Corporation	Immunogenische Zusammensetzungen gegen Gastrin-Peptide
US5120829A (en) *	1989-03-20	1992-06-09	La Jolla Cancer Research Foundation	Hydrophobic attachment site for adhesion peptides
US5256542A (en) *	1992-03-09	1993-10-26	Tanox Biosystems, Inc.	Selecting low frequency antigen-specific single B lymphocytes with correction for background noise

1993
- 1993-11-12 US US08/151,219 patent/US5468494A/en not_active Expired - Lifetime
1994
- 1994-11-10 JP JP51407395A patent/JP3694893B2/ja not_active Expired - Lifetime
- 1994-11-10 ES ES95902570T patent/ES2130575T3/es not_active Expired - Lifetime
- 1994-11-10 WO PCT/US1994/013205 patent/WO1995013297A2/en active IP Right Grant
- 1994-11-10 AU AU11797/95A patent/AU1179795A/en not_active Abandoned
- 1994-11-10 DK DK95902570T patent/DK0728148T3/da active
- 1994-11-10 DE DE69417252T patent/DE69417252T2/de not_active Expired - Lifetime
- 1994-11-10 AT AT95902570T patent/ATE177757T1/de active
- 1994-11-10 EP EP95902570A patent/EP0728148B1/de not_active Expired - Lifetime
1999
- 1999-03-23 GR GR990400879T patent/GR3029791T3/el unknown

Also Published As

Publication number	Publication date
WO1995013297A2 (en)	1995-05-18
GR3029791T3 (en)	1999-06-30
DK0728148T3 (da)	1999-09-27
EP0728148A1 (de)	1996-08-28
ES2130575T3 (es)	1999-07-01
JP3694893B2 (ja)	2005-09-14
US5468494A (en)	1995-11-21
JPH09505056A (ja)	1997-05-20
EP0728148B1 (de)	1999-03-17
AU1179795A (en)	1995-05-29
DE69417252D1 (de)	1999-04-22
ATE177757T1 (de)	1999-04-15
WO1995013297A3 (en)	1995-06-15

Legal Events

Date	Code	Title	Description
2007-08-09	8327	Change in the person/name/address of the patent owner	Owner name: RECEPTOR BIOLOGIX, INC. (N.D.GES.D. STAATES DE, US
2008-09-11	8339	Ceased/non-payment of the annual fee
2009-01-22	8370	Indication related to discontinuation of the patent is to be deleted

Publication	Publication Date	Title
DE69417252D1 (de)	1999-04-22	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
IL113812A0 (en)	1995-08-31	Copolymer-1, pharmaceutical compositions containing it and its use
GR3023233T3 (en)	1997-07-30	Inhibitors of dipeptidyl-aminopeptidase type iv
HK1043475A1 (en)	2002-09-13	Compositions and methods for treating infections using analogues of indolicidin
JO2034B1 (en)	1999-05-15	Isotopes of the hormone peptide its uses and the chemical compounds it contains
GR3026758T3 (en)	1998-07-31	Lactobacillus strains of human origin, their compositions and uses thereof
GB9108652D0 (en)	1991-06-12	Immunoreactive compounds
ZA975470B (en)	1997-12-22	Insulin preparations containing naci.
SE9101838D0 (sv)	1991-06-14	Novel peptides and their use
ITMI911155A1 (it)	1992-10-26	Perfluoropolieteri ad elevata viscosita' e basso contenuto di ossigeno perossidico, e procedimento per la loro preparazione
BG103677A (en)	2000-06-30	Solid mixtures based on sulphonylcarbamides and adjuvants
AU1751892A (en)	1992-11-02	Novel peptide compositions and uses therefor
MY106352A (en)	1995-05-30	Hemoregulatory peptides.
ITRM910430A1 (it)	1992-12-17	Composizioni farmaceutiche di somatostatina con assorbimento migliorato, loro preparazione e loro impiego
MD970269A (en)	1999-05-31	Clavulanates
IL139604A0 (en)	2002-02-10	Novel peptides
AU2001248822A1 (en)	2001-11-07	Gd3-mimetic peptides
AU8375891A (en)	1992-03-19	Antioxidant system based on a basic amino acid in combination with a tocopherol or derivative thereof and a nonthiolated polypeptide, and compositions containing the same
ZA9710254B (en)	1998-05-28	LH-RH peptide analogues, their uses and pharmaceutical composition containing them.
EP0717618A4 (de)	1997-06-04	Stabilisierte tablettenformulierung
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use
ES2013025A6 (es)	1990-04-16	Un metodo para preparar 24r-escimnol.
DE69400945D1 (de)	1997-01-02	Herstellung von Siliziumnitrid-Pulver mit hohem Alpha-Gehalt
HU9500619D0 (en)	1995-04-28	Cloning and expression of b-app-c100 receptor
GB9604518D0 (en)	1996-05-01	Novel compounds