DK0573603T3 - Inhibitorer af human neutrofil elastase og human cathepsin G - Google Patents
Inhibitorer af human neutrofil elastase og human cathepsin GInfo
- Publication number
- DK0573603T3 DK0573603T3 DK92908481T DK92908481T DK0573603T3 DK 0573603 T3 DK0573603 T3 DK 0573603T3 DK 92908481 T DK92908481 T DK 92908481T DK 92908481 T DK92908481 T DK 92908481T DK 0573603 T3 DK0573603 T3 DK 0573603T3
- Authority
- DK
- Denmark
- Prior art keywords
- human
- proteins
- inhibitors
- neutrophil elastase
- cathepsin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/664,989 US5223409A (en) | 1988-09-02 | 1991-03-01 | Directed evolution of novel binding proteins |
US71583491A | 1991-06-17 | 1991-06-17 | |
PCT/US1992/001501 WO1992015605A2 (en) | 1991-03-01 | 1992-02-28 | Inhibitors of human neutrophil elastase and human cathepsin g |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0573603T3 true DK0573603T3 (da) | 2003-10-20 |
Family
ID=27099103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92908481T DK0573603T3 (da) | 1991-03-01 | 1992-02-28 | Inhibitorer af human neutrofil elastase og human cathepsin G |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP0573603B1 (de) |
JP (1) | JP3819931B2 (de) |
AT (2) | ATE431364T1 (de) |
AU (1) | AU1581692A (de) |
CA (1) | CA2105304C (de) |
DE (3) | DE69233108T2 (de) |
DK (1) | DK0573603T3 (de) |
ES (1) | ES2124203T3 (de) |
WO (1) | WO1992015605A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US7078383B2 (en) * | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
ES2287206T3 (es) | 1991-03-01 | 2007-12-16 | Dyax Corporation | Proceso para el desarrollo de mini-proteinas de union. |
US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
JP2769083B2 (ja) * | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
PT762887E (pt) * | 1994-06-02 | 2002-01-30 | Merrell Pharma Inc | Derivados do enol acetilado como pro-farmacos de inibidores de elastase |
NZ284766A (en) * | 1994-06-02 | 1998-06-26 | Merrell Pharma Inc | Perfluoro amino ketones; medicaments as elastase inhibitors |
EP0699750A1 (de) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Eine Sammling an Phagemiden, eine Sammling von Escherichia coli Zellen die diese Phagemide tragen, eine Sammling an Phagemid-Partikeln die daraus hergestellt würden und Phagemid-Partikel die durch dieses Verfahren erhalten würden |
WO1996009411A1 (en) * | 1994-09-21 | 1996-03-28 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
US5885577A (en) * | 1994-09-21 | 1999-03-23 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
HU226419B1 (en) | 1996-03-11 | 2008-12-29 | Aerovance | Human bikunin |
DK1374891T3 (da) * | 1998-12-22 | 2009-01-26 | Bayer Ag | Fremgangsmåde til fremskyndelse af hastigheden af mucociliær clearance |
GB9908195D0 (en) | 1999-04-09 | 1999-06-02 | Microbiological Res Authority | Treatment of intracellular infection |
EP1201249A1 (de) * | 2000-10-31 | 2002-05-02 | Debiopharm S.A. | Suspension von EPI-HNE-4, daraus hergestelltes Trockenpulveraerosol, Herstellungsverfahren und Arzneimittel enthaltend diese Suspension- oder Aerosolzubereitung und ihre Verwendung |
AU2002217014B2 (en) * | 2000-10-31 | 2006-11-02 | Debiopharm S.A. | Suspension of an EPI-hNE protein, process of preparation thereof, dry powder aerosol derived therefrom, pharmaceutical compositions containing said suspension or aerosol, and their uses |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
WO2006017355A2 (en) * | 2004-07-13 | 2006-02-16 | Bayer Pharmaceuticals Corporation | Improved aprotinin variants |
WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
MX2011006483A (es) | 2008-12-16 | 2011-07-13 | Novartis Ag | Sistemas de despliegue en levadura. |
CN110055221B (zh) * | 2019-04-16 | 2021-10-08 | 清华大学 | 一种基于细胞三维打印技术的类脑疾病治疗组织模型及其制备方法与应用 |
US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
EP4252850A3 (de) | 2020-04-16 | 2023-11-15 | Mereo Biopharma 4 Limited | Methoden beinhaltend neutrophile elastase inhibitor alvelestat zur behandlung von atemwegserkrankung aufgrund von alpha-1 antitrypsin mangel |
WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
AU600226B2 (en) * | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
IL91501A (en) * | 1988-09-02 | 1998-03-10 | Dyax Corp | Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity |
ATE114332T1 (de) * | 1989-05-13 | 1994-12-15 | Bayer Ag | Proteinaseninhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel. |
-
1992
- 1992-02-28 AT AT03000399T patent/ATE431364T1/de not_active IP Right Cessation
- 1992-02-28 CA CA002105304A patent/CA2105304C/en not_active Expired - Lifetime
- 1992-02-28 AU AU15816/92A patent/AU1581692A/en not_active Abandoned
- 1992-02-28 DE DE69233108T patent/DE69233108T2/de not_active Expired - Lifetime
- 1992-02-28 AT AT92908481T patent/ATE243710T1/de not_active IP Right Cessation
- 1992-02-28 JP JP50820492A patent/JP3819931B2/ja not_active Expired - Fee Related
- 1992-02-28 DE DE69233760T patent/DE69233760D1/de not_active Expired - Fee Related
- 1992-02-28 ES ES92908481T patent/ES2124203T3/es not_active Expired - Lifetime
- 1992-02-28 DK DK92908481T patent/DK0573603T3/da active
- 1992-02-28 EP EP92908481A patent/EP0573603B1/de not_active Expired - Lifetime
- 1992-02-28 EP EP03000399A patent/EP1325931B1/de not_active Expired - Lifetime
- 1992-02-28 WO PCT/US1992/001501 patent/WO1992015605A2/en active IP Right Grant
- 1992-02-28 DE DE0573603T patent/DE573603T1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH06510522A (ja) | 1994-11-24 |
EP0573603B1 (de) | 2003-06-25 |
ES2124203T1 (es) | 1999-02-01 |
AU1581692A (en) | 1992-10-06 |
EP0573603A1 (de) | 1993-12-15 |
EP1325931A1 (de) | 2003-07-09 |
DE69233108D1 (de) | 2003-07-31 |
CA2105304C (en) | 2005-10-04 |
WO1992015605A2 (en) | 1992-09-17 |
EP1325931B1 (de) | 2009-05-13 |
CA2105304A1 (en) | 1992-09-02 |
ATE431364T1 (de) | 2009-05-15 |
ATE243710T1 (de) | 2003-07-15 |
WO1992015605A3 (en) | 1992-12-23 |
DE69233108T2 (de) | 2004-04-29 |
DE573603T1 (de) | 1999-05-06 |
ES2124203T3 (es) | 2004-04-16 |
JP3819931B2 (ja) | 2006-09-13 |
DE69233760D1 (de) | 2009-06-25 |
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