DE573603T1 - Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g. - Google Patents
Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g.Info
- Publication number
- DE573603T1 DE573603T1 DE0573603T DE92908481T DE573603T1 DE 573603 T1 DE573603 T1 DE 573603T1 DE 0573603 T DE0573603 T DE 0573603T DE 92908481 T DE92908481 T DE 92908481T DE 573603 T1 DE573603 T1 DE 573603T1
- Authority
- DE
- Germany
- Prior art keywords
- human
- proteins
- inhibitors
- neutrophile elastase
- cathepsin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Insects & Arthropods (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/664,989 US5223409A (en) | 1988-09-02 | 1991-03-01 | Directed evolution of novel binding proteins |
US71583491A | 1991-06-17 | 1991-06-17 | |
PCT/US1992/001501 WO1992015605A2 (en) | 1991-03-01 | 1992-02-28 | Inhibitors of human neutrophil elastase and human cathepsin g |
Publications (1)
Publication Number | Publication Date |
---|---|
DE573603T1 true DE573603T1 (de) | 1999-05-06 |
Family
ID=27099103
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233760T Expired - Fee Related DE69233760D1 (de) | 1991-03-01 | 1992-02-28 | Inhibitoren der menschlichen Elastase von Neutrophilen |
DE69233108T Expired - Lifetime DE69233108T2 (de) | 1991-03-01 | 1992-02-28 | Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g |
DE0573603T Pending DE573603T1 (de) | 1991-03-01 | 1992-02-28 | Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233760T Expired - Fee Related DE69233760D1 (de) | 1991-03-01 | 1992-02-28 | Inhibitoren der menschlichen Elastase von Neutrophilen |
DE69233108T Expired - Lifetime DE69233108T2 (de) | 1991-03-01 | 1992-02-28 | Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP1325931B1 (de) |
JP (1) | JP3819931B2 (de) |
AT (2) | ATE431364T1 (de) |
AU (1) | AU1581692A (de) |
CA (1) | CA2105304C (de) |
DE (3) | DE69233760D1 (de) |
DK (1) | DK0573603T3 (de) |
ES (1) | ES2124203T3 (de) |
WO (1) | WO1992015605A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7078383B2 (en) * | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
EP0575485A1 (de) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Verfahren zur entwicklung bindender miniproteine |
US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
JP2769083B2 (ja) * | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
HU221310B1 (en) * | 1994-06-02 | 2002-09-28 | Merrell Pharma Inc | Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof |
CA2189526C (en) * | 1994-06-02 | 2001-02-27 | William A. Metz, Jr. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
EP0699750A1 (de) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Eine Sammling an Phagemiden, eine Sammling von Escherichia coli Zellen die diese Phagemide tragen, eine Sammling an Phagemid-Partikeln die daraus hergestellt würden und Phagemid-Partikel die durch dieses Verfahren erhalten würden |
EP0789783B1 (de) * | 1994-09-21 | 2002-05-08 | Cytogen Corporation | Antigen bindende peptide (abtides) aus peptidbibliotheken |
US5885577A (en) * | 1994-09-21 | 1999-03-23 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
IL126115A (en) | 1996-03-11 | 2007-03-08 | Aerovance Inc | Significantly purified protein with suppressive activity for sirin protease and its pharmaceutical preparations |
DE69939559D1 (de) * | 1998-12-22 | 2008-10-23 | Bayer Ag | Methode zur Beschleunigung der Schleimauflöserate |
GB9908195D0 (en) | 1999-04-09 | 1999-06-02 | Microbiological Res Authority | Treatment of intracellular infection |
EP1201249A1 (de) * | 2000-10-31 | 2002-05-02 | Debiopharm S.A. | Suspension von EPI-HNE-4, daraus hergestelltes Trockenpulveraerosol, Herstellungsverfahren und Arzneimittel enthaltend diese Suspension- oder Aerosolzubereitung und ihre Verwendung |
BR0115020A (pt) | 2000-10-31 | 2003-12-23 | Deobiopharm S A | Suspensão de uma proteìna epi-hne, processo de preparação da mesma, aerossol de pó seco derivado da mesma, composições farmacêuticas contendo a suspensão referida ou o aerossol referido, e suas aplicações |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US20090005297A1 (en) * | 2004-07-13 | 2009-01-01 | Kevin Lumb | Aprotinin Variants |
WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
EP2379718B2 (de) | 2008-12-16 | 2020-12-30 | Novartis AG | Hefe-display-systeme |
CN110055221B (zh) * | 2019-04-16 | 2021-10-08 | 清华大学 | 一种基于细胞三维打印技术的类脑疾病治疗组织模型及其制备方法与应用 |
EP4031138A1 (de) | 2019-09-17 | 2022-07-27 | Mereo Biopharma 4 Limited | Alvelestat zur verwendung bei der behandelung von transplantatabstossung, bronchiolitis-obliterans-syndrom und transplantat-gegen-wirtszelle |
MX2022012942A (es) | 2020-04-16 | 2023-01-11 | Mereo Biopharma 4 Ltd | Metodos que involucran el inhibidor de la elastasa de neutrofilo alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina. |
IL312002A (en) | 2021-10-20 | 2024-06-01 | Mereo Biopharma 4 Ltd | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
DE68927933T2 (de) * | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
ES2066033T3 (es) * | 1989-05-13 | 1995-03-01 | Bayer Ag | Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
-
1992
- 1992-02-28 AU AU15816/92A patent/AU1581692A/en not_active Abandoned
- 1992-02-28 CA CA002105304A patent/CA2105304C/en not_active Expired - Lifetime
- 1992-02-28 DE DE69233760T patent/DE69233760D1/de not_active Expired - Fee Related
- 1992-02-28 WO PCT/US1992/001501 patent/WO1992015605A2/en active IP Right Grant
- 1992-02-28 EP EP03000399A patent/EP1325931B1/de not_active Expired - Lifetime
- 1992-02-28 AT AT03000399T patent/ATE431364T1/de not_active IP Right Cessation
- 1992-02-28 JP JP50820492A patent/JP3819931B2/ja not_active Expired - Fee Related
- 1992-02-28 ES ES92908481T patent/ES2124203T3/es not_active Expired - Lifetime
- 1992-02-28 EP EP92908481A patent/EP0573603B1/de not_active Expired - Lifetime
- 1992-02-28 AT AT92908481T patent/ATE243710T1/de not_active IP Right Cessation
- 1992-02-28 DE DE69233108T patent/DE69233108T2/de not_active Expired - Lifetime
- 1992-02-28 DK DK92908481T patent/DK0573603T3/da active
- 1992-02-28 DE DE0573603T patent/DE573603T1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
DK0573603T3 (da) | 2003-10-20 |
DE69233108D1 (de) | 2003-07-31 |
ATE243710T1 (de) | 2003-07-15 |
DE69233760D1 (de) | 2009-06-25 |
EP0573603A1 (de) | 1993-12-15 |
WO1992015605A3 (en) | 1992-12-23 |
EP0573603B1 (de) | 2003-06-25 |
JP3819931B2 (ja) | 2006-09-13 |
ES2124203T1 (es) | 1999-02-01 |
ATE431364T1 (de) | 2009-05-15 |
EP1325931B1 (de) | 2009-05-13 |
JPH06510522A (ja) | 1994-11-24 |
WO1992015605A2 (en) | 1992-09-17 |
CA2105304A1 (en) | 1992-09-02 |
AU1581692A (en) | 1992-10-06 |
EP1325931A1 (de) | 2003-07-09 |
ES2124203T3 (es) | 2004-04-16 |
DE69233108T2 (de) | 2004-04-29 |
CA2105304C (en) | 2005-10-04 |
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