DK0549967T3 - Polymerer og oligomerer af galdesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Polymerer og oligomerer af galdesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number: DK0549967T3
Authority: DK; Denmark
Prior art keywords: pharmaceuticals; esters; copolymerisation; atoms; oligomers
Prior art date: 1991-12-20

Application number

DK92121459.9T

Other languages

English (en)

Inventor

Stefan Dr Muellner

Werner Dr Dr Kramer

Matthias Dr Gutweiler

Matthias Dr Kroggel

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-17

Publication date

1996-07-22

1992-12-17 Application filed by Hoechst Ag filed Critical Hoechst Ag

1996-07-22 Application granted granted Critical

1996-07-22 Publication of DK0549967T3 publication Critical patent/DK0549967T3/da

Links

239000003814 drug Substances 0.000 title abstract 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
229920000642 polymer Polymers 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
239000003613 bile acid Substances 0.000 abstract 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
150000005690 diesters Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000002778 food additive Substances 0.000 abstract 1
235000013373 food additive Nutrition 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F12/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F12/02—Monomers containing only one unsaturated aliphatic radical
- C08F12/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F12/14—Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing heteroatoms
- C08F12/26—Nitrogen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/52—Amides or imides
- C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Polymers & Plastics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Detergent Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicinal Preparation (AREA)
Lubricants (AREA)
Cephalosporin Compounds (AREA)
Polyesters Or Polycarbonates (AREA)

DK92121459.9T 1991-12-20 1992-12-17 Polymerer og oligomerer af galdesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0549967T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4142379		1991-12-20

Publications (1)

Publication Number	Publication Date
DK0549967T3 true DK0549967T3 (da)	1996-07-22

Family

ID=6447759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92121459.9T DK0549967T3 (da)	1991-12-20	1992-12-17	Polymerer og oligomerer af galdesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (17)

Country	Link
US (1)	US5430116A (da)
EP (1)	EP0549967B1 (da)
JP (1)	JP3292318B2 (da)
AT (1)	ATE135380T1 (da)
AU (1)	AU653658B2 (da)
CA (1)	CA2085831C (da)
DE (1)	DE59205695D1 (da)
DK (1)	DK0549967T3 (da)
ES (1)	ES2087422T3 (da)
FI (1)	FI108451B (da)
GR (1)	GR3019564T3 (da)
HU (1)	HUT63434A (da)
IL (1)	IL104166A (da)
NO (1)	NO301889B1 (da)
NZ (1)	NZ245503A (da)
TW (1)	TW255898B (da)
ZA (1)	ZA929827B (da)

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US6268392B1 (en)	1994-09-13	2001-07-31	G. D. Searle & Co.	Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
DE19633268A1 (de) *	1996-08-19	1998-02-26	Hoechst Ag	Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
KR100313150B1 (ko) *	1997-12-31	2001-12-28	박종섭	리소콜릴에시딜(메타)아크릴레이트 단량체와 그를 도입한 공중합체 수지 및 이 수지를 이용한 포토레지스트
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
US6462091B1 (en)	1998-12-23	2002-10-08	G.D. Searle & Co.	Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
US6458851B1 (en) *	1998-12-23	2002-10-01	G. D. Searle, Llc	Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
BR9916484A (pt)	1998-12-23	2002-01-22	Searle Llc	Combinações de inibidores do transporte de ácido biliar ileal e de agentes sequestrantes de ácido biliar em indicações cardiovasculares
CN1338944A (zh)	1998-12-23	2002-03-06	G.D.瑟尔有限公司	用于心血管适应症的胆固醇酯转移蛋白抑制剂和苯氧异丁酸类衍生物的联合形式
EP1140184B1 (en)	1998-12-23	2003-06-04	G.D. Searle LLC.	Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
KR20010102964A (ko)	1998-12-23	2001-11-17	윌리암스 로저 에이	심장혈관 징후를 위한 회장 담즙산 수송 억제인자 및피브린산 유도체의 조합물
NZ512532A (en) *	1998-12-23	2003-12-19	G	Combinations for treating cardiovascular diseases like hypercholesterolemia and atherosclerosis
DK1140185T3 (da)	1998-12-23	2003-09-29	Searle Llc	Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
EP1286984A2 (en)	2000-03-10	2003-03-05	Pharmacia Corporation	Method for the preparation of tetrahydrobenzothiepines
AU2001247331A1 (en) *	2000-03-10	2001-09-24	Pharmacia Corporation	Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
SE0003766D0 (sv) *	2000-10-18	2000-10-18	Astrazeneca Ab	Novel formulation
US20040077625A1 (en) *	2001-07-25	2004-04-22	Tremont Samuel J.	Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
BR0213501A (pt) *	2001-11-02	2004-08-24	Searle Llc	Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
WO2003061604A2 (en)	2002-01-17	2003-07-31	Pharmacia Corporation	Novel alkyl/aryl hydroxy or keto thiepines.
GB0307918D0 (en)	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
ES2552657T3 (es)	2010-05-26	2015-12-01	Satiogen Pharmaceuticals, Inc.	Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
CN105287604B (zh)	2010-11-08	2019-07-09	阿尔比里奥公司	含ibat抑制剂和胆汁酸结合剂的药物组合
CA2815749C (en)	2010-11-08	2019-12-03	Albireo Ab	Ibat inhibitors for the treatment of liver diseases
US20130108573A1 (en)	2011-10-28	2013-05-02	Lumena Pharmaceuticals, Inc.	Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
EA201891154A1 (ru)	2011-10-28	2019-02-28	ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи	Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей
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JP2016514684A (ja)	2013-03-15	2016-05-23	ルメナファーマシューティカルズエルエルシー	原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤
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CA2952406A1 (en)	2014-06-25	2015-12-30	Ea Pharma Co., Ltd.	Solid formulation and method for preventing or reducing coloration thereof
WO2016045642A1 (en) *	2014-09-28	2016-03-31	National Institute Of Biological Sciences, Beijing	Polymeric bile acid derivatives inhibit hepatitis b and d virus and ntcp transport
EP3012252A1 (en)	2014-10-24	2016-04-27	Ferring BV	Crystal modifications of elobixibat
US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
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US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
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US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
WO2020161216A1 (en)	2019-02-06	2020-08-13	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
JP7504109B2 (ja)	2019-02-06	2024-06-21	アルビレオ・アクチボラグ	ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
JP2022519905A (ja)	2019-02-12	2022-03-25	ミルムファーマシューティカルズインコーポレイテッド	胆汁酸塩排出ポンプ欠損症の患者における遺伝子型およびａｓｂｔｉに対する用量依存的反応
CA3158181A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202134221A (zh)	2019-12-04	2021-09-16	瑞典商艾爾比瑞歐公司	苯并噻二氮呯化合物及其作為膽酸調節劑之用途
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CN114786772B (zh)	2019-12-04	2024-04-09	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
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EP4255565A1 (en)	2020-12-04	2023-10-11	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
US20230398125A1 (en)	2022-06-09	2023-12-14	Albireo Ab	Treating hepatitis
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US20240207286A1 (en)	2022-12-09	2024-06-27	Albireo Ab	Asbt inhibitors in the treatment of renal diseases

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1992
- 1992-12-17 DK DK92121459.9T patent/DK0549967T3/da active
- 1992-12-17 DE DE59205695T patent/DE59205695D1/de not_active Expired - Lifetime
- 1992-12-17 NZ NZ245503A patent/NZ245503A/en unknown
- 1992-12-17 AT AT92121459T patent/ATE135380T1/de not_active IP Right Cessation
- 1992-12-17 ES ES92121459T patent/ES2087422T3/es not_active Expired - Lifetime
- 1992-12-17 US US07/992,411 patent/US5430116A/en not_active Expired - Lifetime
- 1992-12-17 AU AU30209/92A patent/AU653658B2/en not_active Ceased
- 1992-12-17 FI FI925735A patent/FI108451B/fi active
- 1992-12-17 EP EP92121459A patent/EP0549967B1/de not_active Expired - Lifetime
- 1992-12-18 ZA ZA929827A patent/ZA929827B/xx unknown
- 1992-12-18 JP JP35485792A patent/JP3292318B2/ja not_active Expired - Lifetime
- 1992-12-18 NO NO924922A patent/NO301889B1/no not_active IP Right Cessation
- 1992-12-18 CA CA002085831A patent/CA2085831C/en not_active Expired - Lifetime
- 1992-12-18 IL IL10416692A patent/IL104166A/en not_active IP Right Cessation
- 1992-12-18 HU HU9204020A patent/HUT63434A/hu unknown
- 1992-12-29 TW TW081110422A patent/TW255898B/zh active
1996
- 1996-04-05 GR GR960400949T patent/GR3019564T3/el unknown

Also Published As

Publication number	Publication date
HU9204020D0 (en)	1993-04-28
NO924922D0 (no)	1992-12-18
IL104166A0 (en)	1993-05-13
US5430116A (en)	1995-07-04
CA2085831A1 (en)	1993-06-21
DE59205695D1 (de)	1996-04-18
IL104166A (en)	1999-04-11
FI925735A (fi)	1993-06-21
JPH0625354A (ja)	1994-02-01
EP0549967B1 (de)	1996-03-13
TW255898B (da)	1995-09-01
FI925735A0 (fi)	1992-12-17
NO924922L (no)	1993-06-21
NZ245503A (en)	1995-11-27
FI108451B (fi)	2002-01-31
ZA929827B (en)	1993-06-23
AU3020992A (en)	1993-06-24
ES2087422T3 (es)	1996-07-16
NO301889B1 (no)	1997-12-22
HUT63434A (en)	1993-08-30
GR3019564T3 (en)	1996-07-31
CA2085831C (en)	2006-05-30
EP0549967A1 (de)	1993-07-07
AU653658B2 (en)	1994-10-06
ATE135380T1 (de)	1996-03-15
JP3292318B2 (ja)	2002-06-17

Publication	Publication Date	Title
DK0549967T3 (da)	1996-07-22	Polymerer og oligomerer af galdesyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
NZ333277A (en)	2000-09-29	Polymerization using dithiocarboxylic acid derivatives as chain transfer agents
HU896064D0 (en)	1991-02-28	Acrylate bone cement preparation
TW234132B (da)	1994-11-11
WO1994012571A3 (de)	1994-08-04	Mischungen von ungesättigten carbonsäurepolymerisaten und ihre verwendung
ES2069221T3 (es)	1995-05-01	Preparacion de liberacion prolongada y polimeros para dicha preparacion.
BR9403185A (pt)	1995-04-11	Copolímeros com viscosidade de solução particularmente baixa, processo para a sua preparação, sua aplicação e lacas
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KR880011257A (ko)	1988-10-27	고굴절율 광학물품의 제조용 액체의 중합조성물
ATE20476T1 (de)	1986-07-15	Granulierte detergenszusammensetzungen, welche ein gemischtes polymerzusatzsystem enthalten.
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DE50309410D1 (de)	2008-04-30	Pfropfcolpolymere in kosmetischen formulierungen
DE3587665D1 (de)	1994-01-05	Verfahren zur Herstellung von Copolymerisaten des Ethylens mit (Meth)acrylsäurealkylestern.
Plachetta et al.	1988	Thermoplastic Molding Compositions on the Basis of Polyamides and Copolymers of Ethylene
JPS5493094A (en)	1979-07-23	Preparation of modified polyester
TH36760A (da)	2000-01-14
ATE181739T1 (de)	1999-07-15	Polymethacrylat-giessharze mit besonderer mikrodomänen-struktur
JPS5476691A (en)	1979-06-19	Random pre-copolymer, its preparation, and molding compound containing the same