DK0541322T3 - 1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet - Google Patents

1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet

Info

Publication number: DK0541322T3
Authority: DK; Denmark
Prior art keywords: alkyl; acyl; disulfonylhydrazines; antineoplastic activity; antineoplastic
Prior art date: 1991-11-08

Application number

DK92310041.6T

Other languages

English (en)

Inventor

Alan C Sartorelli

Philip G Penketh

Krishnamurthy Shyam

Original Assignee

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-08

Filing date

1992-11-02

Publication date

1996-10-14

1992-11-02 Application filed by Univ Yale filed Critical Univ Yale

1996-10-14 Application granted granted Critical

1996-10-14 Publication of DK0541322T3 publication Critical patent/DK0541322T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK92310041.6T 1991-11-08 1992-11-02 1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet DK0541322T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/790,689 US5256820A (en)	1991-11-08	1991-11-08	1-alkyl-2-acyl-1,2-disulfonylhydrazines

Publications (1)

Publication Number	Publication Date
DK0541322T3 true DK0541322T3 (da)	1996-10-14

Family

ID=25151476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92310041.6T DK0541322T3 (da)	1991-11-08	1992-11-02	1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet

Country Status (9)

Country	Link
US (1)	US5256820A (da)
EP (1)	EP0541322B1 (da)
JP (1)	JP3229039B2 (da)
AT (1)	ATE142620T1 (da)
CA (1)	CA2082037A1 (da)
DE (1)	DE69213656T2 (da)
DK (1)	DK0541322T3 (da)
ES (1)	ES2094885T3 (da)
GR (1)	GR3021045T3 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5637619A (en) *	1995-07-05	1997-06-10	Yale University	Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines
US6040338A (en) *	1997-11-03	2000-03-21	Yale University	N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
WO2004098504A2 (en) *	2003-04-30	2004-11-18	Yale University	Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and methods of treating tumors
US6855695B2 (en) *	2003-06-13	2005-02-15	Vion Pharmaceuticals, Inc.	Water-soluble SHPs as novel alkylating agents
EP1804816B1 (en) *	2004-03-26	2011-12-21	Vion Pharmaceuticals, Inc.	Combination therapy comprising cloretazine(tm)
WO2006034266A2 (en) *	2004-09-21	2006-03-30	Vion Pharmaceuticals, Inc.	Sulfonyl hydrazines as hypoxia-selective antineoplastic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4892887A (en) *	1984-12-20	1990-01-09	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4684747A (en) *	1984-12-20	1987-08-04	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4849563A (en) *	1986-01-21	1989-07-18	Yale University	Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
US5101072A (en) *	1989-09-06	1992-03-31	Yale University	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents

1991
- 1991-11-08 US US07/790,689 patent/US5256820A/en not_active Expired - Lifetime
1992
- 1992-11-02 DE DE69213656T patent/DE69213656T2/de not_active Expired - Fee Related
- 1992-11-02 AT AT92310041T patent/ATE142620T1/de not_active IP Right Cessation
- 1992-11-02 ES ES92310041T patent/ES2094885T3/es not_active Expired - Lifetime
- 1992-11-02 EP EP92310041A patent/EP0541322B1/en not_active Expired - Lifetime
- 1992-11-02 DK DK92310041.6T patent/DK0541322T3/da active
- 1992-11-03 CA CA002082037A patent/CA2082037A1/en not_active Abandoned
- 1992-11-06 JP JP29737492A patent/JP3229039B2/ja not_active Expired - Fee Related
1996
- 1996-09-13 GR GR960402407T patent/GR3021045T3/el unknown

Also Published As

Publication number	Publication date
EP0541322B1 (en)	1996-09-11
CA2082037A1 (en)	1993-05-09
GR3021045T3 (en)	1996-12-31
ATE142620T1 (de)	1996-09-15
JP3229039B2 (ja)	2001-11-12
DE69213656T2 (de)	1997-01-23
JPH0625146A (ja)	1994-02-01
US5256820A (en)	1993-10-26
EP0541322A1 (en)	1993-05-12
DE69213656D1 (de)	1996-10-17
ES2094885T3 (es)	1997-02-01

Publication	Publication Date	Title
ATE116306T1 (de)	1995-01-15	Hypoglykämische oxazolidindion-derivate.
ATE142630T1 (de)	1996-09-15	Triazin-derivate und unkrautvertilgungsmittel daraus
FI914928A0 (fi)	1991-10-18	Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
NO933376D0 (no)	1993-09-22	Morfinan-derivater og medisinsk anvendelse derav
DE69325944D1 (de)	1999-09-16	s-Triazinderivate als Lichtschutzmittel
SG47986A1 (en)	1998-04-17	A pharmaceutical solution
DE3588100D1 (de)	1996-05-23	Carbamidsäureester-Derivate, Mittel und Herstellungsverfahren
DK345989D0 (da)	1989-07-12	Quinolinderivater
DK0382660T3 (da)	1993-06-01	Dioxaphosphorinanforbindelser og dermed stabiliserede polyolefinmaterialer
DK0541322T3 (da)	1996-10-14	1-Alkyl-2-acyl-1,2-disulfonylhydraziner med antineoplastisk aktivitet
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
ATE156486T1 (de)	1997-08-15	Fungizide 3,4-diaryl-(5h)-furan-2-onederivate
ES2035915T3 (es)	1993-05-01	Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
EP0407621A4 (en)	1991-10-02	Benzothiazole derivatives
AU597923B2 (en)	1990-06-14	5-aminoalkyl-beta-carboline derivatives, their production and their use as drugs
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
DE69314573T2 (de)	1998-03-12	2-Thiazolylpyrroleakrylate mit fungizider Wirkung