ES2035915T3 - Agentes antiarritmicos n-fenetil-aminoalquil-benzamida. - Google Patents

Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.

Info

Publication number
ES2035915T3
ES2035915T3 ES198888302270T ES88302270T ES2035915T3 ES 2035915 T3 ES2035915 T3 ES 2035915T3 ES 198888302270 T ES198888302270 T ES 198888302270T ES 88302270 T ES88302270 T ES 88302270T ES 2035915 T3 ES2035915 T3 ES 2035915T3
Authority
ES
Spain
Prior art keywords
aminoalquil
fenetil
benzamida
antiarrhythmic agents
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302270T
Other languages
English (en)
Inventor
Peter Edward Dr. Cross
John Edmund Dr. Arrowsmith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ES2035915T3 publication Critical patent/ES2035915T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LAS QUE R1 Y R5 SON, INDEPENDIENTEMENTE C1-C4 ALQUILO; R2 Y R3 SON INDEPENDIENTEMENTE, H O C1-C4 ALQUILO; R4 ES H O C1-C4 ALCOXI; Y N ES 2, 3 O 4, SON AGENTES ANTOARRITMIA UTILES PARA EL TRATAMIENTO DE ESTADOS CARDIACOS.
ES198888302270T 1987-03-20 1988-03-16 Agentes antiarritmicos n-fenetil-aminoalquil-benzamida. Expired - Lifetime ES2035915T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878706662A GB8706662D0 (en) 1987-03-20 1987-03-20 Anti-arrhythmia agents

Publications (1)

Publication Number Publication Date
ES2035915T3 true ES2035915T3 (es) 1993-05-01

Family

ID=10614327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302270T Expired - Lifetime ES2035915T3 (es) 1987-03-20 1988-03-16 Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.

Country Status (9)

Country Link
EP (1) EP0285284B1 (es)
JP (1) JPS63255258A (es)
AT (1) ATE63541T1 (es)
DE (1) DE3862791D1 (es)
DK (1) DK148288A (es)
ES (1) ES2035915T3 (es)
GB (1) GB8706662D0 (es)
GR (1) GR3001955T3 (es)
PT (1) PT87005B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544654A (en) * 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
EP0164865B1 (en) * 1984-05-04 1988-12-21 The Upjohn Company N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
CA1241967A (en) * 1984-05-11 1988-09-13 George C. Buzby Jr. Sulfonamides useful as anti-arrhythmic agents
US4569801A (en) * 1984-10-15 1986-02-11 Eli Lilly And Company Alkylsulfonamidophenylalkylamines

Also Published As

Publication number Publication date
EP0285284A3 (en) 1989-03-29
JPS63255258A (ja) 1988-10-21
ATE63541T1 (de) 1991-06-15
GR3001955T3 (en) 1992-11-23
GB8706662D0 (en) 1987-04-23
DE3862791D1 (de) 1991-06-20
PT87005B (pt) 1992-06-30
EP0285284A2 (en) 1988-10-05
DK148288D0 (da) 1988-03-18
PT87005A (pt) 1988-04-01
EP0285284B1 (en) 1991-05-15
DK148288A (da) 1988-12-30

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