DK0506853T3 - Anvendelse af GABA-B selektive agonister som antitussive midler - Google Patents

Anvendelse af GABA-B selektive agonister som antitussive midler

Info

Publication number
DK0506853T3
DK0506853T3 DK91902534.6T DK91902534T DK0506853T3 DK 0506853 T3 DK0506853 T3 DK 0506853T3 DK 91902534 T DK91902534 T DK 91902534T DK 0506853 T3 DK0506853 T3 DK 0506853T3
Authority
DK
Denmark
Prior art keywords
gaba
selective agonists
antitussive agents
mammal
antitussive
Prior art date
Application number
DK91902534.6T
Other languages
English (en)
Inventor
William Kreutner
Donald Bolser
Richard Chapman
Sultan Aziz
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0506853T3 publication Critical patent/DK0506853T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DK91902534.6T 1989-12-20 1990-12-18 Anvendelse af GABA-B selektive agonister som antitussive midler DK0506853T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/454,786 US5006560A (en) 1989-12-20 1989-12-20 Use of GABA-B selective agonists as anti-tussive agents

Publications (1)

Publication Number Publication Date
DK0506853T3 true DK0506853T3 (da) 1994-08-01

Family

ID=23806078

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902534.6T DK0506853T3 (da) 1989-12-20 1990-12-18 Anvendelse af GABA-B selektive agonister som antitussive midler

Country Status (14)

Country Link
US (1) US5006560A (da)
EP (1) EP0506853B1 (da)
JP (1) JPH06102630B2 (da)
KR (1) KR950007208B1 (da)
AT (1) ATE106725T1 (da)
AU (1) AU642969B2 (da)
CA (1) CA2071981C (da)
DE (1) DE69009778T2 (da)
DK (1) DK0506853T3 (da)
ES (1) ES2055587T3 (da)
FI (1) FI922798A0 (da)
HU (1) HU212271B (da)
OA (1) OA09702A (da)
WO (1) WO1991008740A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214054A (en) * 1988-05-18 1993-05-25 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
US5229404A (en) * 1988-05-18 1993-07-20 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
US5231106A (en) * 1988-05-18 1993-07-27 Novo Nordisk A/S Azacyclic carboxylic acid derivatives and their preparation and use
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
US5182266A (en) * 1990-01-31 1993-01-26 Abbott Laboratories Method for treating renal disease
FR2662354B1 (fr) * 1990-05-23 1994-10-07 Adir Utilisation du baclofene pour l'obtention de medicaments destines au traitement de l'angine de poitrine.
GB9117716D0 (en) * 1991-08-16 1991-10-02 Lynxvale Ltd Gaba derivatives and their therapeutic application
US6194460B1 (en) * 1995-05-31 2001-02-27 Montefiore Medical Center Composition for treating cough induced by angiotensin converting enzyme inhibitors
US6121290A (en) * 1996-05-24 2000-09-19 Smithkline Beecham Corporation Use of GABA uptake inhibitors as anti-tussive agents
EP1077692B1 (en) * 1998-05-15 2004-07-28 Warner-Lambert Company LLC Amino acid stabilized gabapentin and pregabalin preparations and process for preparing the same
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
MXPA06001876A (es) * 2003-08-20 2006-05-17 Xenoport Inc Prodrogas de aciloxialquil carbamato, metodos de sintesis y uso.
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US20060160777A1 (en) * 2004-12-27 2006-07-20 Anders Lehmann New use of GABAbeta receptor agonists
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
ES2365574T3 (es) * 2007-01-11 2011-10-07 Xenoport, Inc. Formas de dosificación oral para liberación continua de un profármaco de r-baclofeno y procedimientos de tratamiento.
WO2009061934A1 (en) * 2007-11-06 2009-05-14 Xenoport, Inc. Use of prodrugs of gaba b agonists for treating neuropathic and musculoskeletal pain
WO2009094563A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
US8062870B2 (en) * 2008-01-25 2011-11-22 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
EP2309858A4 (en) 2008-07-31 2011-09-14 Dekel Pharmaceuticals Ltd COMPOSITIONS AND METHOD FOR THE TREATMENT OF INFLAMMATORY DISEASES
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
WO2010017498A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing n-hydroxysuccinimidyl carbonates
KR20110117216A (ko) 2009-03-03 2011-10-26 제노포트 인코포레이티드 Ｒ-바클로펜 전구약물의 서방형 경구 투약 형태
WO2010120370A2 (en) * 2009-04-17 2010-10-21 Xenoport, Inc. Gamma-amino-butyric acid derivatives as gabab receptor ligands
WO2013023155A1 (en) 2011-08-11 2013-02-14 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH449645A (de) * 1963-07-09 1968-01-15 Ciba Geigy Verfahren zur Herstellung neuer Aminosäuren

Also Published As

Publication number Publication date
ES2055587T3 (es) 1994-08-16
FI922798A (fi) 1992-06-17
KR920703043A (ko) 1992-12-17
WO1991008740A1 (en) 1991-06-27
DE69009778T2 (de) 1994-09-22
CA2071981C (en) 2002-06-25
US5006560A (en) 1991-04-09
HUT61194A (en) 1992-12-28
EP0506853A1 (en) 1992-10-07
ATE106725T1 (de) 1994-06-15
OA09702A (en) 1993-08-30
AU642969B2 (en) 1993-11-04
EP0506853B1 (en) 1994-06-08
HU9202077D0 (en) 1992-09-28
DE69009778D1 (de) 1994-07-14
CA2071981A1 (en) 1991-06-21
HU212271B (en) 1996-04-29
AU7174591A (en) 1991-07-18
JPH06102630B2 (ja) 1994-12-14
JPH05504764A (ja) 1993-07-22
KR950007208B1 (ko) 1995-07-04
FI922798A0 (fi) 1992-06-17

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