DK0466730T3 - Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler - Google Patents
Geminale biphosphonsyrer og derivater deraf som anti-arthritismidlerInfo
- Publication number
- DK0466730T3 DK0466730T3 DK90905160.9T DK90905160T DK0466730T3 DK 0466730 T3 DK0466730 T3 DK 0466730T3 DK 90905160 T DK90905160 T DK 90905160T DK 0466730 T3 DK0466730 T3 DK 0466730T3
- Authority
- DK
- Denmark
- Prior art keywords
- geminal
- derivatives
- arthritic agents
- biphosphonic acids
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 229940124346 antiarthritic agent Drugs 0.000 title 1
- 239000003435 antirheumatic agent Substances 0.000 title 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33261889A | 1989-04-03 | 1989-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0466730T3 true DK0466730T3 (da) | 1993-10-18 |
Family
ID=23299047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90905160.9T DK0466730T3 (da) | 1989-04-03 | 1990-03-08 | Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0466730B1 (ja) |
| JP (1) | JPH04505011A (ja) |
| KR (1) | KR920701216A (ja) |
| AT (1) | ATE91689T1 (ja) |
| AU (1) | AU628158B2 (ja) |
| CA (1) | CA2046905A1 (ja) |
| DE (1) | DE69002328T2 (ja) |
| DK (1) | DK0466730T3 (ja) |
| HU (1) | HU207095B (ja) |
| WO (1) | WO1990012017A1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2072015T3 (es) * | 1990-08-21 | 1995-07-01 | Upjohn Co | Derivados del acido bisfosfonico como agente anti-artritico. |
| NZ253541A (en) * | 1992-05-29 | 1997-01-29 | Procter & Gamble Pharma | Cyclic quaternary-n-containing phosphonate derivatives and medicaments |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| CA2188066C (en) * | 1992-05-29 | 2000-12-05 | Susan Mary Kaas | Thio-substituted phosphonate compounds |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| PL175046B1 (pl) * | 1992-05-29 | 1998-10-30 | Procter & Gamble Pharma | Nowe tio-podstawione, zawierające azot heterocykliczne związki fosfonianowe |
| AU4387893A (en) * | 1992-07-16 | 1994-02-14 | Upjohn Company, The | Phosphono derivatives as antiinflammatory and antiarthritic agents |
| AU4848193A (en) * | 1992-09-23 | 1994-04-26 | Upjohn Company, The | Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| HU199151B (en) * | 1987-03-10 | 1990-01-29 | Yamanouchi Pharma Co Ltd | Process for producing bis-phosphonic acid derivatives |
| DE3719513A1 (de) * | 1987-06-11 | 1988-12-22 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1990
- 1990-03-08 DK DK90905160.9T patent/DK0466730T3/da active
- 1990-03-08 WO PCT/US1990/001106 patent/WO1990012017A1/en active IP Right Grant
- 1990-03-08 JP JP2505037A patent/JPH04505011A/ja active Pending
- 1990-03-08 KR KR1019910701244A patent/KR920701216A/ko not_active Application Discontinuation
- 1990-03-08 HU HU902754A patent/HU207095B/hu not_active IP Right Cessation
- 1990-03-08 CA CA002046905A patent/CA2046905A1/en not_active Abandoned
- 1990-03-08 EP EP90905160A patent/EP0466730B1/en not_active Expired - Lifetime
- 1990-03-08 DE DE90905160T patent/DE69002328T2/de not_active Expired - Fee Related
- 1990-03-08 AT AT90905160T patent/ATE91689T1/de not_active IP Right Cessation
- 1990-03-08 AU AU53306/90A patent/AU628158B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU628158B2 (en) | 1992-09-10 |
| KR920701216A (ko) | 1992-08-11 |
| EP0466730B1 (en) | 1993-07-21 |
| AU5330690A (en) | 1990-11-05 |
| DE69002328D1 (de) | 1993-08-26 |
| CA2046905A1 (en) | 1990-10-04 |
| ATE91689T1 (de) | 1993-08-15 |
| DE69002328T2 (de) | 1993-12-09 |
| WO1990012017A1 (en) | 1990-10-18 |
| EP0466730A1 (en) | 1992-01-22 |
| HU207095B (en) | 1993-03-01 |
| HUT58751A (en) | 1992-03-30 |
| HU902754D0 (en) | 1991-12-30 |
| JPH04505011A (ja) | 1992-09-03 |
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