DK0387231T3 - Hidtil ukendte inhibitorer for retroviral protease - Google Patents

Hidtil ukendte inhibitorer for retroviral protease

Info

Publication number
DK0387231T3
DK0387231T3 DK90870034.7T DK90870034T DK0387231T3 DK 0387231 T3 DK0387231 T3 DK 0387231T3 DK 90870034 T DK90870034 T DK 90870034T DK 0387231 T3 DK0387231 T3 DK 0387231T3
Authority
DK
Denmark
Prior art keywords
novel inhibitors
retroviral protease
protease
retroviral
peptides
Prior art date
Application number
DK90870034.7T
Other languages
English (en)
Inventor
Garland Rose Marshall
Mihaly Vadkerti Toth
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0387231T3 publication Critical patent/DK0387231T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK90870034.7T 1989-03-08 1990-03-07 Hidtil ukendte inhibitorer for retroviral protease DK0387231T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/320,742 US5342922A (en) 1989-03-08 1989-03-08 Inhibitors of retroviral protease

Publications (1)

Publication Number Publication Date
DK0387231T3 true DK0387231T3 (da) 1995-07-03

Family

ID=23247697

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90870034.7T DK0387231T3 (da) 1989-03-08 1990-03-07 Hidtil ukendte inhibitorer for retroviral protease

Country Status (6)

Country Link
US (2) US5342922A (da)
EP (1) EP0387231B1 (da)
AT (1) ATE120468T1 (da)
DE (1) DE69018113T2 (da)
DK (1) DK0387231T3 (da)
ES (1) ES2070309T3 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086165A (en) * 1989-03-08 1992-02-04 Washington University Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
US5212157A (en) * 1989-06-06 1993-05-18 Bio-Mega, Inc. Enzyme inhibitors
US6313094B1 (en) 1990-12-11 2001-11-06 Japan Energy Corporation β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
BR9306058A (pt) 1992-03-11 1997-11-18 Narhex Ltd Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
DE69414279T2 (de) * 1993-02-09 1999-04-08 Bayer Corp., Pittsburgh, Pa. Sulfonamidaminomethylenderivate als Immunsuppressiva
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
IL111991A (en) * 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
DE4412174A1 (de) * 1994-04-08 1995-10-19 Schramm Wolfgang Prof Dr Peptide, Verfahren zu ihrer Herstellung und ihre Verwendung
US6222043B1 (en) 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
CA2179935C (en) * 1995-06-30 2010-09-07 Ryohei Kato Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
JP3098401B2 (ja) * 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
US5872210A (en) * 1995-10-05 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Transframe peptide inhibitor of viral protease
US5747526A (en) * 1996-01-25 1998-05-05 Hollinshead; Ariel C. Anti-HIV /Aids Chemo(C)-, immuno(I)-, or ci-therapy using tur (or related compounds) and/or NVA (or EPV)
JP3020141B2 (ja) * 1996-10-07 2000-03-15 株式会社富士薬品 経鼻投与用製剤
EP0900566A4 (en) 1996-12-27 2001-04-25 Japan Energy Corp NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS
EP1068568A4 (en) * 1998-04-03 2004-10-27 Triangle Pharmaceuticals Inc SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS TO GUIDE THE SELECTION OF THERAPEUTIC SCHEMES $ i ()
US7141593B1 (en) * 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
US7447643B1 (en) 2000-09-21 2008-11-04 Theradoc.Com, Inc. Systems and methods for communicating between a decision-support system and one or more mobile information devices
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
WO2005016364A1 (en) * 2003-08-14 2005-02-24 Guthy-Renker Corporation Skin care composition including hexapeptide complexes and methods of their manufacture
US20090291884A1 (en) * 2006-11-02 2009-11-26 Michael Agadjanyan Proteins for use in diagnosing and treating infection and disease
FR2959992A1 (fr) * 2010-05-11 2011-11-18 Univ Claude Bernard Lyon Peptides a activite antiproteasique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880779A (en) * 1987-07-31 1989-11-14 Research Corporation Technologies, Inc. Method of prevention or treatment of AIDS by inhibition of human immunodeficiency virus
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides

Also Published As

Publication number Publication date
ATE120468T1 (de) 1995-04-15
DE69018113D1 (de) 1995-05-04
US6121417A (en) 2000-09-19
ES2070309T3 (es) 1995-06-01
DE69018113T2 (de) 1995-09-28
EP0387231B1 (en) 1995-03-29
US5342922A (en) 1994-08-30
EP0387231A2 (en) 1990-09-12
EP0387231A3 (en) 1991-05-02

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