DE806438C - Process for the production of novel pentaerythritol clusters - Google Patents
Process for the production of novel pentaerythritol clustersInfo
- Publication number
- DE806438C DE806438C DEP31383A DEP0031383A DE806438C DE 806438 C DE806438 C DE 806438C DE P31383 A DEP31383 A DE P31383A DE P0031383 A DEP0031383 A DE P0031383A DE 806438 C DE806438 C DE 806438C
- Authority
- DE
- Germany
- Prior art keywords
- pentaerythritol
- production
- clusters
- novel
- nitric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von neuartigen Abkömmlingen des Pentaerythrits Es wurde gefunden, daß man neuartige Abkömmlinge des Pentaerythrits mit wertvollen therapeutischen Eigenschaften erhält, wenn man Bromhydrine des Pentaerythrits nach an sich üblichen Methoden in ihre Salpetersäureester überführt.Process for the production of novel derivatives of pentaerythritol It has been found that novel derivatives of pentaerythritol with valuable therapeutic properties obtained if one after the bromohydrins of the pentaerythritol Conventional methods per se converted into their nitric acid esters.
Es zeigte sich, daß diese bisher noch nicht bekannten Verbindungen wirksame Heilmittel bei Herz- und Gefäßerkrankungen sind und gegenüber vergleichbaren Produkten bei starker Intensität eine wesentlich nachhaltigere Wirkung aufweisen. Beispiel i 12,5 g Pentaerythritmonol>romhydrin werden unter Rühren bei 5 bis io° in 6o ccm Salpetersäure (98 bis iooo/oig) eingetragen. Man rührt dann noch 2 bis 3 Stunden bei io bis 15° und gießt darauf den Kristallbrei auf etwa 70 g zerstoßenes Eis. Nach i bis 2stündigem Stehen saugt man ab, wäscht gut mit Wasser und trocknet bei mäßiger Temperatur. Ausbeute 17,7 g, die aus 5o ccm Methylalkohol umkristallisiert werden. Farblose Kristalle vom Still). 9o bis 92°.It was found that these hitherto unknown compounds are effective remedies for heart and vascular diseases and have a much more lasting effect than comparable products at high intensity. EXAMPLE I 12.5 g of pentaerythritol monol romhydrin are introduced into 60 cc of nitric acid (98 to 100%) with stirring at 5 to 10 °. The mixture is then stirred for a further 2 to 3 hours at 10 to 15 ° and then the crystal slurry is poured onto about 70 g of crushed ice. After standing for 1 to 2 hours, the product is filtered off with suction, washed well with water and dried at a moderate temperature. Yield 17.7 g, which are recrystallized from 50 cc methyl alcohol. Colorless crystals from Still). 9o to 92 °.
Beispiel e Unter den gleichen Bedingungen wie bei Beispiel i -,werden i 5o g Pentaerythritdibromhydrin in 58o ccm Salpetersäure (98 bis iooo/oig) im Verlauf von 2 bis 3 Stunden eingetragen. Die Aufarbeitung ist die gleiche wie bei Beispiel i. Ausbeute 195 g vom Smp. 7o bis 73°. Durch Umkristallisation aus der doppelten Menge Methylalkohol erhält man fast farblose Kristallnädelchen vom Smp. 750.Example e Under the same conditions as in example i -, will 150 g of pentaerythritol dibromohydrin in 58o ccm of nitric acid (98 to 100%) in the course entered from 2 to 3 hours. The work-up is the same as in example i. Yield 195 g with a melting point of 70 ° to 73 °. By recrystallization almost colorless crystal needles are obtained from twice the amount of methyl alcohol from m.p. 750.
Beispiel 3 Unter den gleichen Bedingungen wie bei Beispiel i trägt man i9 g Pentaerythrittribromhydrin in 75 ccm Salpetersäure ein und arbeitet wie bei Beispiel i auf. Ausbeute 21 g vom Smp. 5o bis 54°. Durch Umkristallisation aus der doppelten Menge Methylalkohol erhöht sich der Smp. auf 58 bis 6o°.Example 3 Under the same conditions as in Example i one 19 g of pentaerythritol tribromohydrin in 75 cc of nitric acid and works as in example i. Yield 21 g with a melting point of 50 ° to 54 °. By recrystallization twice the amount of methyl alcohol increases the m.p. to 58 to 60 °.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP31383A DE806438C (en) | 1949-01-11 | 1949-01-12 | Process for the production of novel pentaerythritol clusters |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2853511X | 1949-01-11 | ||
DEP31383A DE806438C (en) | 1949-01-11 | 1949-01-12 | Process for the production of novel pentaerythritol clusters |
Publications (1)
Publication Number | Publication Date |
---|---|
DE806438C true DE806438C (en) | 1951-06-14 |
Family
ID=25990205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEP31383A Expired DE806438C (en) | 1949-01-11 | 1949-01-12 | Process for the production of novel pentaerythritol clusters |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE806438C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2853511A (en) * | 1949-01-11 | 1958-09-23 | Riedelde Haen Ag Fa | Pentaerythritol bromhydrin nitrates |
-
1949
- 1949-01-12 DE DEP31383A patent/DE806438C/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2853511A (en) * | 1949-01-11 | 1958-09-23 | Riedelde Haen Ag Fa | Pentaerythritol bromhydrin nitrates |
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