DE69942185D1 - BODIPY Aminoacetaldehyd Diethyl Acetal - Google Patents

BODIPY Aminoacetaldehyd Diethyl Acetal

Info

Publication number
DE69942185D1
DE69942185D1 DE69942185T DE69942185T DE69942185D1 DE 69942185 D1 DE69942185 D1 DE 69942185D1 DE 69942185 T DE69942185 T DE 69942185T DE 69942185 T DE69942185 T DE 69942185T DE 69942185 D1 DE69942185 D1 DE 69942185D1
Authority
DE
Germany
Prior art keywords
diethyl acetal
aminoacetaldehyde diethyl
bodipy aminoacetaldehyde
bodipy
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69942185T
Other languages
English (en)
Inventor
Clayton A Smith
Michael Colvin
Robert W Storms
Susan M Ludeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Application granted granted Critical
Publication of DE69942185D1 publication Critical patent/DE69942185D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69942185T 1998-12-07 1999-12-07 BODIPY Aminoacetaldehyd Diethyl Acetal Expired - Lifetime DE69942185D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11119598P 1998-12-07 1998-12-07

Publications (1)

Publication Number Publication Date
DE69942185D1 true DE69942185D1 (de) 2010-05-06

Family

ID=22337091

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69942185T Expired - Lifetime DE69942185D1 (de) 1998-12-07 1999-12-07 BODIPY Aminoacetaldehyd Diethyl Acetal
DE69939945T Expired - Lifetime DE69939945D1 (de) 1998-12-07 1999-12-07 Verfahren zur isolierung von stammzellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69939945T Expired - Lifetime DE69939945D1 (de) 1998-12-07 1999-12-07 Verfahren zur isolierung von stammzellen

Country Status (12)

Country Link
US (3) US6627759B1 (de)
EP (2) EP1137798B1 (de)
JP (1) JP4498614B2 (de)
AT (2) ATE414783T1 (de)
AU (1) AU774566B2 (de)
CA (1) CA2353701C (de)
CY (2) CY1111042T1 (de)
DE (2) DE69942185D1 (de)
DK (2) DK1137798T3 (de)
ES (2) ES2343222T3 (de)
PT (2) PT1975243E (de)
WO (1) WO2000034507A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03008882A (es) * 2001-03-27 2003-12-08 Vertex Pharma Composiciones y metodos utiles para la infeccion por hcv.
US20030049836A1 (en) * 2001-08-15 2003-03-13 Phi-Wilson Janette T. Cell separation system
WO2004005496A1 (ja) * 2002-07-05 2004-01-15 Kirin Beer Kabushiki Kaisha 臍帯血、骨髄、末梢血等に含まれる新規な未分化幹細胞集団
AU2004316477B2 (en) * 2004-02-11 2010-10-07 Aldagen, Inc. Stem cell populations and methods of use
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US8765119B2 (en) * 2004-05-06 2014-07-01 University Of South Florida Treating amyotrophic lateral sclerosis (ALS)with isolated aldehyde dehydrogenase-positive umbilical cord blood cells
JP2006349658A (ja) * 2005-02-21 2006-12-28 Hisamitsu Pharmaceut Co Inc 神経系癌幹細胞の検出試薬、神経系癌幹細胞を分離する方法、神経系癌幹細胞、及び神経芽腫の予後診断薬。
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
WO2007033330A2 (en) * 2005-09-14 2007-03-22 Duke University Stem cells
US20100034778A1 (en) * 2005-09-14 2010-02-11 Duke University Stem cells
WO2007065167A1 (en) * 2005-12-02 2007-06-07 The Johns Hopkins University Use of high-dose oxazaphosphorine drugs for treating immune disorders
EP2019858B1 (de) * 2006-04-17 2012-06-13 BioE LLC Differenzierung von vorläuferzellen mit mehreren abstammungslinien in respiratorischen epithelzellen
US9255249B2 (en) * 2006-05-17 2016-02-09 Cognate Bioservices, Inc. Isolation and purification of hematopoietic stem cells from post-liposuction lipoaspirates
WO2008034076A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclophosphamide in combination with immune therapeutics
WO2008034074A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclosphosphamide in combination with anti-idiotypic vaccines
WO2008034071A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Method of identifying patients suitable for high-dose cyclophosphamide treatment
US20080187938A1 (en) * 2006-09-22 2008-08-07 The Regents Of The University Of Michigan ALDH1 As A Cancer Stem Cell Marker
US20080226608A1 (en) * 2007-01-15 2008-09-18 Washington University Methods of Isolating and Using Enriched Subpopulations of Bone Marrow Progenitors for the Treatment of Diabetes
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞
US9026372B2 (en) * 2007-11-21 2015-05-05 Accentia Biopharmaceuticals, Inc. Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen
WO2009067690A2 (en) * 2007-11-21 2009-05-28 Accentia Biopharmaceuticals, Inc. Methods for safe and effective treatment using oxazaphosphorine drugs
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
EP2582793B1 (de) 2010-06-15 2017-09-06 Cellular Dynamics International, Inc. Kompendium aus fertig gebauten stammzellmodellen zur abfrage biologischer reaktionen
WO2012006440A2 (en) 2010-07-07 2012-01-12 Cellular Dynamics International, Inc. Endothelial cell production by programming
WO2012071012A2 (en) 2010-11-24 2012-05-31 National University Of Singapore Bodipy structure fluorescence dye for neural stem cell probe
EP2673358B1 (de) 2011-02-08 2019-01-09 FUJIFILM Cellular Dynamics, Inc. Herstellung blutbildender vorläuferzellen durch programmierung
CN103193841A (zh) 2012-01-06 2013-07-10 维瑞斯特姆有限公司 治疗性化合物及相关使用方法
US8715529B1 (en) 2012-01-23 2014-05-06 Arrowhead Center, Inc. Synthesis and applications of triazaborolopyridinium compounds and substituted triazaborolopyridinium compounds and methods of use
EP2958891B1 (de) 2013-02-21 2020-06-17 The Johns Hopkins University Rotes fluoreszierendes aldehyd-dehydrogenase (aldh)-substrat
US20140242595A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
WO2014145493A1 (en) * 2013-03-15 2014-09-18 The Johns Hopkins University Radioactive substrates for aldehyde dehydrogenase
EP2981605B1 (de) 2013-04-03 2019-06-19 FUJIFILM Cellular Dynamics, Inc. Verfahren und zusammensetzungen zur kultivierung von endoderm-vorläuferzellen in einer suspension
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
FR3054564B1 (fr) * 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN109916866B (zh) * 2019-03-04 2021-06-29 三峡大学 一种七元氟硼荧光染料的新用途
CN111172109A (zh) * 2019-12-20 2020-05-19 广州海润康华生物科技有限公司 一种免疫细胞培养方法及其应用
WO2022235586A1 (en) 2021-05-03 2022-11-10 Astellas Institute For Regenerative Medicine Methods of generating mature corneal endothelial cells
AU2022270117A1 (en) 2021-05-07 2023-11-02 Astellas Institute For Regenerative Medicine Methods of generating mature hepatocytes
WO2024044134A1 (en) 2022-08-23 2024-02-29 Astellas Institute For Regenerative Medicine Photoreceptor rescue cell (prc) compositions and methods for treatment of ocular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5274113A (en) * 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5876956A (en) 1995-05-15 1999-03-02 Johns Hopkins University School Of Medicine Methods for identification or purification of cells containing an enzymatic intracellular marker

Also Published As

Publication number Publication date
EP1137798A1 (de) 2001-10-04
DE69939945D1 (de) 2009-01-02
CY1111098T1 (el) 2015-06-11
ES2343222T3 (es) 2010-07-26
US6991897B2 (en) 2006-01-31
EP1975243A1 (de) 2008-10-01
AU774566B2 (en) 2004-07-01
JP2002531139A (ja) 2002-09-24
AU2165200A (en) 2000-06-26
PT1975243E (pt) 2010-06-24
EP1975243B1 (de) 2010-03-24
EP1137798B1 (de) 2008-11-19
CY1111042T1 (el) 2015-06-11
US20040023318A1 (en) 2004-02-05
ATE462014T1 (de) 2010-04-15
CA2353701A1 (en) 2000-06-15
DK1137798T3 (da) 2009-04-14
EP1137798A4 (de) 2003-06-25
US20060051833A1 (en) 2006-03-09
ATE414783T1 (de) 2008-12-15
US7754480B2 (en) 2010-07-13
ES2317707T3 (es) 2009-04-16
PT1137798E (pt) 2009-02-20
WO2000034507A1 (en) 2000-06-15
CA2353701C (en) 2014-06-03
JP4498614B2 (ja) 2010-07-07
US6627759B1 (en) 2003-09-30
DK1975243T3 (da) 2010-06-28

Similar Documents

Publication Publication Date Title
DE69942185D1 (de) BODIPY Aminoacetaldehyd Diethyl Acetal
PT900279E (pt) Processo melhorado de transformacao de plantas
PT2280283E (pt) Células marcadas para uso como controlo funcional interno em ensaios de deteção de células raras
WO2000001845A3 (de) Verfahren zur frühen diagnose von carcinomen
WO2002052436A3 (en) Method and system for automatically updating contact information within a database
WO2004074426A3 (de) Verfahren und vorrichtungen zur verletzungsfreien bewegung einer sonde durch biologisches zellmaterial
DK1073722T3 (da) Pyruvat-carboxylase-overekspression til øget produktion af biokemikalier, der er afledt af oxaloacetat, i mikrobielle celler
IS2614B (is) Aðferð til stýringar á síalsýrumagni prótína sem framleidd eru í spendýrafrumurækt
PT799058E (pt) Melhoramentos na funcao endometrica ou com ela relacionados
DE59800215D1 (de) Mikroinjektionsverfahren zum Einbringen eines Injektionsstoffes, insbes. fremdes, genetisches Material, in Prokaryoten-und Eukaryotenzellen, sowie Zellkompartimente von letzteren (Plastiden, Zellkerne), sowie Nanopipette hierzu
EP1225228A3 (de) Verfahren zur Einbringung von Fremdmaterial In höhere Zellen unter Verwendung eines Laserstrahls
BR0315435A (pt) Distribuição de vegf com base na célula
EP1325953A4 (de) Methode zur kultivierung von mesenchymalen stammzellen
WO2002010337A3 (en) Method of cloning porcine animals
DK0763057T3 (da) Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
WO2002068635A3 (en) Methods of inhibiting expression of a target gene in mammalian cells
WO2005030939A3 (en) Method and composition for regulating expansion of stem cells
TR200001046T2 (tr) Homolog rekombinasyonda pozitif-negatif seçimi.
AU2002242858A1 (en) Patch-clamping and its use in analysing subcellular features
NO20015494D0 (no) Fremgangsmåte for dyrking av celler
IL161773A0 (en) Method for selecting genetically transformed cells
ATE447616T1 (de) Selektionsverfahren
WO2002052272A3 (de) Screening-verfahren zum nachweis von reversiblen protein-protein wechselwirkungen
NO20010246L (no) Fremgangsmåte for fremstilling av proteiner i transformerte gjærceller
WO2002099100A3 (en) Method of production of a protein in cells which inducibly express the cell cycle inhibitor protein, p21

Legal Events

Date Code Title Description
8364 No opposition during term of opposition