DE69932813D1 - Nukleinsäurebindungsproteine - Google Patents

Nukleinsäurebindungsproteine

Info

Publication number
DE69932813D1
DE69932813D1 DE69932813T DE69932813T DE69932813D1 DE 69932813 D1 DE69932813 D1 DE 69932813D1 DE 69932813 T DE69932813 T DE 69932813T DE 69932813 T DE69932813 T DE 69932813T DE 69932813 D1 DE69932813 D1 DE 69932813D1
Authority
DE
Germany
Prior art keywords
binding protein
nucleic binding
sequence containing
nucleic
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69932813T
Other languages
English (en)
Inventor
Yen Choo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gendaq Ltd
Original Assignee
Gendaq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9805576.7A external-priority patent/GB9805576D0/en
Priority claimed from GBGB9806895.0A external-priority patent/GB9806895D0/en
Priority claimed from GBGB9807246.5A external-priority patent/GB9807246D0/en
Application filed by Gendaq Ltd filed Critical Gendaq Ltd
Application granted granted Critical
Publication of DE69932813D1 publication Critical patent/DE69932813D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69932813T 1998-03-17 1999-03-17 Nukleinsäurebindungsproteine Expired - Lifetime DE69932813D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9805576.7A GB9805576D0 (en) 1998-03-17 1998-03-17 Proteins
GBGB9806895.0A GB9806895D0 (en) 1998-03-31 1998-03-31 Nucleic acid binding proteins
GBGB9807246.5A GB9807246D0 (en) 1998-04-03 1998-04-03 Nucleic acid binding proteins
PCT/GB1999/000816 WO1999047656A2 (en) 1998-03-17 1999-03-17 Nucleic acid binding proteins

Publications (1)

Publication Number Publication Date
DE69932813D1 true DE69932813D1 (de) 2006-09-28

Family

ID=27269244

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69932813T Expired - Lifetime DE69932813D1 (de) 1998-03-17 1999-03-17 Nukleinsäurebindungsproteine

Country Status (9)

Country Link
US (1) US6977154B1 (de)
EP (1) EP1064369B1 (de)
JP (1) JP2002506640A (de)
AT (1) ATE336578T1 (de)
AU (1) AU751487B2 (de)
CA (1) CA2323064C (de)
DE (1) DE69932813D1 (de)
NZ (1) NZ506987A (de)
WO (1) WO1999047656A2 (de)

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US6007988A (en) 1994-08-20 1999-12-28 Medical Research Council Binding proteins for recognition of DNA
US7285416B2 (en) 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
GB9824544D0 (en) * 1998-11-09 1999-01-06 Medical Res Council Screening system
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
AU746454B2 (en) 1998-03-02 2002-05-02 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
JP2002506640A (ja) 1998-03-17 2002-03-05 ジェンダック・リミテッド 核酸結合タンパク質
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
IL150069A0 (en) 1999-12-06 2002-12-01 Sangamo Biosciences Inc Methods of using randomized libraries of zinc finger proteins for the identification of gene function
ATE355368T1 (de) * 2000-01-24 2006-03-15 Gendaq Ltd Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne
CN1307027A (zh) * 2000-01-26 2001-08-08 上海博道基因技术有限公司 一种新的多肽——人含tfiis特征性序列片段的锌指蛋白43和编码这种多肽的多核苷酸
EP1254369B1 (de) 2000-02-08 2010-10-06 Sangamo BioSciences, Inc. Zellen zur entdeckung von medikamenten
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
WO2001084148A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
GB2365011A (en) 2000-04-28 2002-02-13 Sangamo Biosciences Inc Methods for the characterisation of regulatory DNA sequences
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
AU7254401A (en) * 2000-07-18 2002-01-30 Novartis Ag Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
WO2002008286A2 (en) * 2000-07-21 2002-01-31 Syngenta Participations Ag Zinc finger domain recognition code and uses thereof
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
AU2884102A (en) 2000-12-07 2002-06-18 Sangamo Biosciences Inc Regulation of angiogenesis with zinc finger proteins
US7273923B2 (en) 2001-01-22 2007-09-25 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
AU2002225187A1 (en) * 2001-01-22 2002-07-30 Sangamo Biosciences, Inc. Zinc finger polypeptides and their use
DE10146129A1 (de) * 2001-09-19 2003-04-03 Ina Schaeffler Kg Schaltelement für einen Ventiltrieb einer Brennkraftmaschine
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
AU2008305568B2 (en) 2007-09-27 2013-11-21 Corteva Agriscience Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
DE102008057830A1 (de) 2007-11-21 2009-05-28 Schaeffler Kg Abschaltbarer Stößel
EP2130836B1 (de) * 2008-06-03 2013-02-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mittel und Verfahren zur Herstellung von Zinkfingern und Konkatemere daraus
MY160435A (en) * 2008-06-12 2017-03-15 Univ Putra Malaysia A novel antiviral peptide against avian influenza virus h9n2
JP5854464B2 (ja) * 2009-10-16 2016-02-09 国立研究開発法人理化学研究所 メチル化ｄｎａ結合ペプチド
WO2020159445A1 (en) 2019-01-31 2020-08-06 Agency For Science, Technology And Research Cnx/erp57 inhibitor for use in the treatment or prevention of cancer

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Also Published As

Publication number Publication date
WO1999047656A2 (en) 1999-09-23
US6977154B1 (en) 2005-12-20
JP2002506640A (ja) 2002-03-05
EP1064369A2 (de) 2001-01-03
AU2944999A (en) 1999-10-11
NZ506987A (en) 2003-01-31
EP1064369B1 (de) 2006-08-16
CA2323064A1 (en) 1999-09-23
AU751487B2 (en) 2002-08-15
ATE336578T1 (de) 2006-09-15
WO1999047656A3 (en) 1999-11-25
CA2323064C (en) 2011-05-31

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Legal Events

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8332 No legal effect for de