DE69923795D1 - Verfahren zur Herstellung biologisch-abbaubarer Polyester - Google Patents

Verfahren zur Herstellung biologisch-abbaubarer Polyester

Info

Publication number
DE69923795D1
DE69923795D1 DE69923795T DE69923795T DE69923795D1 DE 69923795 D1 DE69923795 D1 DE 69923795D1 DE 69923795 T DE69923795 T DE 69923795T DE 69923795 T DE69923795 T DE 69923795T DE 69923795 D1 DE69923795 D1 DE 69923795D1
Authority
DE
Germany
Prior art keywords
carboxyl
polymer
omega
protected carboxyl
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69923795T
Other languages
English (en)
Other versions
DE69923795T2 (de
Inventor
Yoshio Hata
Yasutaka Igari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69923795D1 publication Critical patent/DE69923795D1/de
Publication of DE69923795T2 publication Critical patent/DE69923795T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113Multiple emulsions, e.g. oil-in-water-in-oil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Biological Depolymerization Polymers (AREA)
DE69923795T 1998-12-15 1999-12-14 Verfahren zur Herstellung biologisch-abbaubarer Polyester Expired - Lifetime DE69923795T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP35649798 1998-12-15
JP35649798 1998-12-15
PCT/JP1999/007013 WO2000035990A1 (fr) 1998-12-15 1999-12-14 Procede de production d'un polymere

Publications (2)

Publication Number Publication Date
DE69923795D1 true DE69923795D1 (de) 2005-03-24
DE69923795T2 DE69923795T2 (de) 2006-03-16

Family

ID=18449318

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69923795T Expired - Lifetime DE69923795T2 (de) 1998-12-15 1999-12-14 Verfahren zur Herstellung biologisch-abbaubarer Polyester

Country Status (11)

Country Link
US (1) US6756472B1 (de)
EP (1) EP1158014B1 (de)
KR (1) KR100584634B1 (de)
CN (1) CN1134479C (de)
AT (1) ATE289205T1 (de)
AU (1) AU1797800A (de)
CA (1) CA2355186C (de)
DE (1) DE69923795T2 (de)
ES (1) ES2234325T3 (de)
PT (1) PT1158014E (de)
WO (1) WO2000035990A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2378714A1 (en) 1999-07-15 2001-01-25 Takeda Chemical Industries, Ltd. Sustained release compositions, methods for producing the same and uses thereof
CA2407472A1 (en) * 2000-06-14 2002-10-23 Takeda Chemical Industries, Ltd. Sustained release compositions
PT1693054T (pt) * 2000-08-07 2016-07-07 Takeda Pharmaceuticals Co Polímero de ácido láctico e processo para a sua produção
FR2821360B1 (fr) 2001-02-27 2003-05-30 Sod Conseils Rech Applic Procede de preparation de polyesters avec des fonctions acides libres intracatenaires
TWI332407B (en) 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
TWI225416B (en) * 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
DE60327737D1 (de) * 2002-01-22 2009-07-09 Biomatera Inc Verfahren zur trocknung von biologisch abbaubaren polymeren
EP1923075B1 (de) * 2004-08-13 2015-11-11 Rutgers, The State University Röntgendichte Polymerstents
ES2791698T3 (es) 2006-12-18 2020-11-05 Takeda Pharmaceuticals Co Composición de liberación sostenida y método para producir la misma
US8282990B2 (en) * 2007-04-19 2012-10-09 Dong-A Pharmaceutical, Co., Ltd. Method for preparing a biodegradable polymer microsphere containing a glucose-regulating peptide
EP2508504B1 (de) * 2009-12-01 2016-04-13 Sumitomo Chemical Co., Ltd Verfahren zur herstellung von cycloalkandicarbonsäuremonoestern
CN103275312B (zh) * 2013-05-16 2015-01-21 湘潭大学 含侧羟基或侧羧基官能团的聚丙交酯及其制备方法
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CA2167920A1 (en) 1993-07-23 1995-02-02 Abraham J. Domb Nonoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
EP0668073B1 (de) * 1994-02-21 1999-04-14 Takeda Chemical Industries, Ltd. Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe
PT839525E (pt) 1996-10-31 2004-10-29 Takeda Chemical Industries Ltd Preparacao de libertacao prolongada
AU758596B2 (en) * 1998-01-16 2003-03-27 Takeda Pharmaceutical Company Limited Sustained release compositions, process for producing the same and utilization thereof
CA2378714A1 (en) * 1999-07-15 2001-01-25 Takeda Chemical Industries, Ltd. Sustained release compositions, methods for producing the same and uses thereof

Also Published As

Publication number Publication date
CA2355186A1 (en) 2000-06-22
EP1158014B1 (de) 2005-02-16
WO2000035990A1 (fr) 2000-06-22
US6756472B1 (en) 2004-06-29
ATE289205T1 (de) 2005-03-15
PT1158014E (pt) 2005-04-29
CN1134479C (zh) 2004-01-14
ES2234325T3 (es) 2005-06-16
DE69923795T2 (de) 2006-03-16
EP1158014A1 (de) 2001-11-28
KR100584634B1 (ko) 2006-05-30
AU1797800A (en) 2000-07-03
EP1158014A4 (de) 2003-01-22
CN1334834A (zh) 2002-02-06
CA2355186C (en) 2008-03-18
KR20010082348A (ko) 2001-08-29

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