DE69921138D1 - Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittel - Google Patents
Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittelInfo
- Publication number
- DE69921138D1 DE69921138D1 DE1999621138 DE69921138T DE69921138D1 DE 69921138 D1 DE69921138 D1 DE 69921138D1 DE 1999621138 DE1999621138 DE 1999621138 DE 69921138 T DE69921138 T DE 69921138T DE 69921138 D1 DE69921138 D1 DE 69921138D1
- Authority
- DE
- Germany
- Prior art keywords
- cytotoxic
- system containing
- antineoplastic agent
- releasing system
- homeobox peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Refuse Collection And Transfer (AREA)
- Threshing Machine Elements (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9814527.9A GB9814527D0 (en) | 1998-07-03 | 1998-07-03 | Delivery system |
GB9814527 | 1998-07-03 | ||
PCT/GB1999/001957 WO2000001417A1 (en) | 1998-07-03 | 1999-06-22 | Delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69921138D1 true DE69921138D1 (de) | 2004-11-18 |
DE69921138T2 DE69921138T2 (de) | 2005-11-24 |
Family
ID=10834959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69921138T Expired - Fee Related DE69921138T2 (de) | 1998-07-03 | 1999-06-22 | Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittel |
Country Status (13)
Country | Link |
---|---|
US (2) | US6472507B1 (de) |
EP (1) | EP1093383B1 (de) |
JP (1) | JP2002519392A (de) |
AT (1) | ATE279210T1 (de) |
AU (1) | AU756014B2 (de) |
CA (1) | CA2333145C (de) |
DE (1) | DE69921138T2 (de) |
DK (1) | DK1093383T3 (de) |
ES (1) | ES2230860T3 (de) |
GB (2) | GB9814527D0 (de) |
HU (1) | HUP0300246A3 (de) |
IL (1) | IL140650A0 (de) |
WO (1) | WO2000001417A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
ATE419273T1 (de) * | 1998-11-13 | 2009-01-15 | Cyclacel Ltd | Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 |
WO2000038733A1 (en) | 1998-12-24 | 2000-07-06 | Ucb S.A. | Peptidic product, process and composition |
GB9903547D0 (en) * | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
US6864355B1 (en) * | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
US7049395B2 (en) | 2000-05-02 | 2006-05-23 | Yale University | Anti-inflammatory compounds and uses thereof |
GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
FR2816845B1 (fr) | 2000-11-20 | 2006-10-20 | Centre Nat Rech Scient | Vecteurs de transport a travers un epithelium a jonctions serrees |
DE60239097D1 (de) | 2001-03-02 | 2011-03-17 | Gpc Biotech Ag | Drei-hybrid-assaysystem |
US20050181474A1 (en) * | 2002-01-30 | 2005-08-18 | Frank J. Giordano | Transport peptides and uses therefor |
PT1583562E (pt) | 2003-01-06 | 2011-09-19 | Angiochem Inc | Angiopep-1, compostos relacionados, e suas utilizações |
FR2849603B1 (fr) * | 2003-01-07 | 2006-09-08 | Centre Nat Rech Scient | Composition pour le transport intracellulaire de macromolecules ou particules biologiques |
US20060178297A1 (en) * | 2003-01-28 | 2006-08-10 | Troy Carol M | Systems and methods for silencing expression of a gene in a cell and uses thereof |
EP2662087A1 (de) * | 2003-04-22 | 2013-11-13 | Ipsen Pharma | Somatostatin-vektoren |
JP2007531705A (ja) * | 2003-05-20 | 2007-11-08 | セルペップ ソシエテ アノニム | 増大した活性および細胞膜親和性を有する修飾抗ウイルス性ペプチド |
US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
US7342114B2 (en) | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
US7790150B2 (en) * | 2003-09-05 | 2010-09-07 | The General Hospital Corporation | Dual phase drug release system |
US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
WO2005040193A2 (en) * | 2003-10-20 | 2005-05-06 | The Regent Of The University Of California | Synthetic peptides that cause f-actin bundling and block actin depolymerization |
US20050209147A1 (en) * | 2004-01-16 | 2005-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of RhoA signaling |
US8034762B2 (en) * | 2004-09-02 | 2011-10-11 | Cognosci, Inc. | Treatment of subarachnoid hemorrhage with Apo E analogs |
EP1796708A4 (de) | 2004-09-02 | 2009-07-08 | Cognosci Inc | Verbesserte apo-e-analoge und verwendungsverfahren dafür |
US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
DK1842557T3 (da) | 2004-12-22 | 2013-12-02 | Nitto Denko Corp | Lægemiddelbærer og lægemiddelbærerkit til inhibition af fibrose |
CA2597958C (en) | 2005-02-18 | 2019-01-15 | Angiochem Inc. | Molecules for transporting a compound across the blood-brain barrier |
DK2433653T3 (da) | 2005-07-15 | 2019-08-19 | Angiochem Inc | Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
BRPI0709447A2 (pt) * | 2006-03-30 | 2011-07-12 | Diatos Sa | conjugado, composição farmacêutica, uso e composto |
JP5313867B2 (ja) * | 2006-03-30 | 2013-10-09 | ドライス ファーマシューティカルズ,インコーポレイティド | カンプトテシン−細胞透過性ペプチド複合体及びそれを含む医薬組成物 |
TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
EP2207570A2 (de) | 2007-09-14 | 2010-07-21 | Nitto Denko Corporation | Arzneimittelträger |
TW200932274A (en) | 2007-12-18 | 2009-08-01 | Alcon Res Ltd | Interfering RNA delivery system and uses thereof |
GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
EP2252314B1 (de) | 2008-02-27 | 2014-04-09 | Temple University - Of The Commonwealth System of Higher Education | Leptin-agonist und anwendungsverfahren |
KR101585046B1 (ko) * | 2008-02-28 | 2016-01-13 | 도레이 카부시키가이샤 | 경비 투여용 의약 조성물 |
CN102105135B (zh) | 2008-05-23 | 2016-08-24 | 英属哥伦比亚大学 | 用于脂质体纳米颗粒的修饰的药物 |
WO2010033207A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
JP2012505637A (ja) | 2008-10-15 | 2012-03-08 | アンジオケム,インコーポレーテッド | Glp−1アゴニストのコンジュゲート及びその使用 |
CN102307904A (zh) | 2008-12-05 | 2012-01-04 | 安吉奥开米公司 | 神经降压素或神经降压素类似物的缀合物及其用途 |
CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
FR2941230B1 (fr) | 2009-01-19 | 2011-03-18 | Centre Nat Rech Scient | Polypeptides d'adressage specifique a des cellules-cibles d'otx2 |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
WO2010138955A2 (en) | 2009-05-29 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Methods and compositions for treating neoplasia |
RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
GB201001602D0 (en) | 2010-02-01 | 2010-03-17 | Cytovation As | Oligopeptidic compounds and uses therof |
JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ctx1bおよび54−デオキシ−ctx1bを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
WO2013036931A1 (en) * | 2011-09-08 | 2013-03-14 | Western University Of Health Sciences | Targeted liposomes in cancer therapy |
CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
GB201318954D0 (en) * | 2013-10-28 | 2013-12-11 | Cupid Peptide Company Ltd | Cell transport |
EP3288577B1 (de) | 2015-05-01 | 2021-10-27 | Allysta Pharmaceuticals, Inc. | Adiponectin-peptidomimetika zur behandlung von augenerkrankungen |
GB201507722D0 (en) | 2015-05-06 | 2015-06-17 | Norwegian Univ Sci & Tech Ntnu | Anti-bacterial agents and their use in therapy |
ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
US10087194B2 (en) | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
CN106937529B (zh) | 2015-10-27 | 2021-02-05 | 加州太平洋医疗中心 | 鬼臼毒素衍生物及其应用 |
WO2018085836A1 (en) | 2016-11-07 | 2018-05-11 | Colorado State University Research Foundation | Anti-hiv peptides |
CN110563739A (zh) * | 2018-06-05 | 2019-12-13 | 薪火炙药(北京)科技有限公司 | 具有选择性抗肺癌作用的鬼臼毒素类化合物p-x及其制备方法和应用 |
GB201915454D0 (en) | 2019-10-24 | 2019-12-11 | Norwegian Univ Sci & Tech Ntnu | Antibacterial bone cement and uses thereof |
KR102397922B1 (ko) * | 2020-02-19 | 2022-05-13 | 서울대학교 산학협력단 | 신규한 종양-관련 항원 단백질 olfm4 및 이의 용도 |
GB202006699D0 (en) | 2020-05-06 | 2020-06-17 | Therapim Pty Ltd | Dosage regimen |
GB202008888D0 (en) | 2020-06-11 | 2020-07-29 | Norwegian Univ Of Science And Technology (Ntnu) | Peptides for sepsis treatment |
EP4281034A1 (de) | 2021-01-24 | 2023-11-29 | Forrest, Michael, David | Inhibitoren der atp-synthase kosmetische und therapeutische verwendungen |
Family Cites Families (20)
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US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
US5043329A (en) * | 1987-02-17 | 1991-08-27 | Board Of Regents, University Of Texas System | Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract |
DE3836971C1 (de) * | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De | |
US5888762A (en) * | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
FR2662698A1 (fr) | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
DE69126592T2 (de) | 1990-10-15 | 1998-01-08 | Tecnogen Scpa | Nicht-lineare Peptide, die hydropatisch komplementär zu bekannten Aminosäuresequenzen sind, Verfahren zur Herstellung und Verwendung davon |
WO1993022343A1 (en) * | 1992-05-01 | 1993-11-11 | The Rockfeller University | Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom |
US5674977A (en) | 1993-02-05 | 1997-10-07 | The Ontario Cancer Institute | Branched synthetic peptide conjugate |
US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
US6344436B1 (en) | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
WO1998013059A1 (en) * | 1996-09-27 | 1998-04-02 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
US5929042A (en) | 1997-03-03 | 1999-07-27 | The Trustees Of Columbia University In The City Of New York | Antisense compounds which prevent cell death and uses thereof |
US6635623B1 (en) | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
AU741546B2 (en) * | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
US5823345A (en) * | 1997-07-24 | 1998-10-20 | Berry Plastics Corporation | Stackable receptacle assembly for pourable products |
GB9718609D0 (en) * | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
US6015787A (en) * | 1997-11-04 | 2000-01-18 | New England Medical Center Hospitals, Inc. | Cell-permeable protein inhibitors of calpain |
GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
-
1998
- 1998-07-03 GB GBGB9814527.9A patent/GB9814527D0/en not_active Ceased
-
1999
- 1999-06-22 AT AT99928071T patent/ATE279210T1/de not_active IP Right Cessation
- 1999-06-22 JP JP2000557863A patent/JP2002519392A/ja not_active Withdrawn
- 1999-06-22 DE DE69921138T patent/DE69921138T2/de not_active Expired - Fee Related
- 1999-06-22 AU AU45198/99A patent/AU756014B2/en not_active Ceased
- 1999-06-22 WO PCT/GB1999/001957 patent/WO2000001417A1/en active IP Right Grant
- 1999-06-22 DK DK99928071T patent/DK1093383T3/da active
- 1999-06-22 CA CA002333145A patent/CA2333145C/en not_active Expired - Fee Related
- 1999-06-22 HU HU0300246A patent/HUP0300246A3/hu unknown
- 1999-06-22 GB GB9914577A patent/GB2340121B/en not_active Expired - Fee Related
- 1999-06-22 IL IL14065099A patent/IL140650A0/xx not_active IP Right Cessation
- 1999-06-22 ES ES99928071T patent/ES2230860T3/es not_active Expired - Lifetime
- 1999-06-22 EP EP99928071A patent/EP1093383B1/de not_active Expired - Lifetime
- 1999-07-02 US US09/346,847 patent/US6472507B1/en not_active Expired - Fee Related
-
2002
- 2002-07-31 US US10/210,660 patent/US6992169B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6992169B2 (en) | 2006-01-31 |
US6472507B1 (en) | 2002-10-29 |
ATE279210T1 (de) | 2004-10-15 |
DK1093383T3 (da) | 2005-02-14 |
JP2002519392A (ja) | 2002-07-02 |
ES2230860T3 (es) | 2005-05-01 |
DE69921138T2 (de) | 2005-11-24 |
CA2333145C (en) | 2008-03-25 |
AU4519899A (en) | 2000-01-24 |
AU756014B2 (en) | 2003-01-02 |
EP1093383B1 (de) | 2004-10-13 |
GB9914577D0 (en) | 1999-08-25 |
GB2340121B (en) | 2000-09-06 |
WO2000001417A1 (en) | 2000-01-13 |
GB2340121A (en) | 2000-02-16 |
HUP0300246A2 (en) | 2003-05-28 |
CA2333145A1 (en) | 2000-01-13 |
IL140650A0 (en) | 2002-02-10 |
HUP0300246A3 (en) | 2005-09-28 |
EP1093383A1 (de) | 2001-04-25 |
GB9814527D0 (en) | 1998-09-02 |
US20030119735A1 (en) | 2003-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |