DE69909246D1 - Hemmung der menschlichen telomerase durch g-quadruplex interaktionverbindung - Google Patents

Hemmung der menschlichen telomerase durch g-quadruplex interaktionverbindung

Info

Publication number
DE69909246D1
DE69909246D1 DE69909246T DE69909246T DE69909246D1 DE 69909246 D1 DE69909246 D1 DE 69909246D1 DE 69909246 T DE69909246 T DE 69909246T DE 69909246 T DE69909246 T DE 69909246T DE 69909246 D1 DE69909246 D1 DE 69909246D1
Authority
DE
Germany
Prior art keywords
telomerase
inhibition
quadruplex
interaction
human telomerase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909246T
Other languages
English (en)
Inventor
M Kerwin
Y Fedoroff
Miguel Salazar
H Hurley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE69909246D1 publication Critical patent/DE69909246D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69909246T 1998-02-04 1999-02-04 Hemmung der menschlichen telomerase durch g-quadruplex interaktionverbindung Expired - Lifetime DE69909246D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7362998P 1998-02-04 1998-02-04
PCT/US1999/002353 WO1999040087A2 (en) 1998-02-04 1999-02-04 Inhibition of human telomerase by a g-quadruplex-interaction compound

Publications (1)

Publication Number Publication Date
DE69909246D1 true DE69909246D1 (de) 2003-08-07

Family

ID=22114844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909246T Expired - Lifetime DE69909246D1 (de) 1998-02-04 1999-02-04 Hemmung der menschlichen telomerase durch g-quadruplex interaktionverbindung

Country Status (6)

Country Link
US (4) US6156763A (de)
EP (1) EP1053237B1 (de)
AT (1) ATE244241T1 (de)
AU (1) AU2494799A (de)
DE (1) DE69909246D1 (de)
WO (1) WO1999040087A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2494799A (en) * 1998-02-04 1999-08-23 Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
EE200200263A (et) * 1999-11-29 2003-06-16 Aventis Pharma S.A. Telomeeride G-kvadrupleksstruktuuri fikseerivad ühendid, nende kasutamine ja terapeutilised kombinatsioonid
FR2801588B1 (fr) * 1999-11-29 2002-03-01 Aventis Pharma Sa Derives chimiques et leur application comme agent antitelomerase
WO2002012194A1 (fr) * 2000-08-08 2002-02-14 Aventis Pharma S.A. Derives de phenanthridine et leur application comme agents antitelomerases
FR2821355A1 (fr) * 2001-02-23 2002-08-30 Aventis Pharma Sa Derives chimiques et leur application comme agent antitelomerase
US6887873B2 (en) 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6753411B2 (en) 2001-03-26 2004-06-22 The Regents Of The University Of Colorado Protection-of-telomere-1 (POT-1) proteins
JP2004534046A (ja) * 2001-05-28 2004-11-11 アベンティス・ファーマ・ソシエテ・アノニム 化学誘導体および抗テロメラーゼ剤としてのその使用
WO2003087317A2 (en) * 2002-04-05 2003-10-23 Cyternex, Inc. Methods for targeting quadruplex dna
US7405041B2 (en) * 2002-08-20 2008-07-29 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for regulating transcription by targeting quadruplex DNA
SI1587821T1 (sl) * 2002-12-19 2009-02-28 Scripps Research Inst Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina
WO2004063339A2 (en) 2003-01-08 2004-07-29 Lesley Davenport G-quadruplex binding assays and compounds therefor
US20050113324A1 (en) 2003-01-15 2005-05-26 Bondarev Igor E. Modulation of line-1 reverse transcriptase
US20040180345A1 (en) * 2003-03-14 2004-09-16 Ingeneus Corporation Pre-incubation method to improve signal/noise ratio of nucleic acid assays
EP1673478A4 (de) * 2003-10-14 2007-08-22 Cylene Pharmaceuticals Inc Kompetitionsassay zur identifizierung von modulatoren von quadruplex-nukleinsäuren
US7691624B2 (en) * 2003-10-22 2010-04-06 Academia Sinica Cancer cell detecting devices
US20050249669A1 (en) * 2003-10-22 2005-11-10 Academia Sinica Quadruplex stabilizer
US6979738B2 (en) * 2003-10-22 2005-12-27 Academia Sinica Quadruplex stabilizer
WO2005049867A1 (en) * 2003-11-17 2005-06-02 Cylene Pharmaceuticals, Inc. Methods for identifying modulators of quadruplex nucleic acids
WO2005089094A2 (en) * 2003-11-21 2005-09-29 The Board Of Regents Of The University And Community College System Of Nevada Materials and methods for the preparation of anisotropically-ordered solids
WO2005112913A1 (en) 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
US20080119492A1 (en) * 2005-07-29 2008-05-22 Jean-Marie Lehn Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation
US20100249175A1 (en) * 2005-12-02 2010-09-30 Wilson W David Dicationic compounds which selectively recognize G-quadruplex DNA
KR100833492B1 (ko) * 2005-12-08 2008-05-29 한국전자통신연구원 핵산 나노구조체 및 그의 제조 방법
US8481529B2 (en) * 2006-05-16 2013-07-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Combination cancer chemotherapy
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
ITRM20070209A1 (it) * 2007-04-12 2008-10-13 Univ Roma Derivati coronenici idrosolubili attivi come inibitori della telomerasi umana mediante induzione di strutture g-quadruplex e loro uso come agenti antitumorali.
WO2009051796A2 (en) * 2007-10-17 2009-04-23 The University Of North Carolina At Chapel Hill 2,5-diaryl selenophene compounds, aza 2,5-diaryl thiophene compounds, and their prodrugs as antiprotozoal agents
CA2703060A1 (en) * 2007-10-22 2009-04-30 The Wistar Institute Method for identifying a compound that modulates telomerase activity
US8377992B2 (en) * 2007-10-22 2013-02-19 The Wistar Institute TRBD-binding effectors and methods for using the same to modulate telomerase activity
LT3029154T (lt) * 2008-10-17 2017-12-27 Geron Corporation Paciento jautrumo telomerazės slopinimo terapijai nustatymo būdas
CN103781770B (zh) 2011-09-16 2016-04-13 辉瑞公司 转甲状腺素蛋白解离抑制剂的固体形式
CN103910727B (zh) * 2012-12-31 2016-06-15 北京大学 STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用
CN103497154A (zh) * 2013-08-12 2014-01-08 北京化工大学 一种水溶性苝酰亚胺类化合物及其作为dna嵌插剂和在抑制癌细胞生长中的应用
CN108290888A (zh) * 2015-12-02 2018-07-17 犹他大学研究基金会 一维有机纳米材料的化学自掺杂在化学电阻感测气体或蒸气中的高电导率应用
CN105842287B (zh) * 2016-03-16 2019-01-01 济南市农业科学研究院 用于检测二氧化氮的纳米材料及气敏传感器元件
CN110237076A (zh) * 2019-07-29 2019-09-17 河南大学 PDINCl在制备抗肿瘤药物中的应用
US20210333284A1 (en) * 2020-04-28 2021-10-28 Purdue Research Foundation Methods and materials for large-scale assessment of ligand binding selectivity of g-quadruplex recognition using custom g4 microarrays
CN112521388B (zh) * 2020-12-30 2021-11-09 河南大学 一种苝酰亚胺衍生物及应用
CN112724137B (zh) * 2021-01-19 2021-10-26 河南大学 一种苝酰亚胺衍生物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD299733A7 (de) * 1980-12-23 1992-05-07 Bitterfeld Chemie Verfahren zur herstellung von schwarzen tarnpigmenten
JP3362865B2 (ja) * 1991-03-21 2003-01-07 クラリアント・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング ペリレン化合物の分子内塩、その製造方法およびその用途
DE4225357A1 (de) * 1992-07-31 1994-02-03 Basf Ag Glanzpigmente auf Basis mit extern basischen, organischen Farbmitteln beschichteter, plättchenförmiger Substrate
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5920429A (en) * 1995-09-29 1999-07-06 Minnesota Mining And Manufacturing Company Fluorescent dye blends
US5672643A (en) * 1995-09-29 1997-09-30 Minnesota Mining And Manufacturing Company Fluorescent dye blends
AU6650198A (en) * 1997-02-05 1998-08-25 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
US6166210A (en) * 1997-12-15 2000-12-26 Ciba Specialty Chemicals Corporation Perylene imide monocarboxylic acids
AU2494799A (en) * 1998-02-04 1999-08-23 Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
AU2657499A (en) * 1998-02-04 1999-08-23 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
US6492117B1 (en) * 2000-07-12 2002-12-10 Gendaq Limited Zinc finger polypeptides capable of binding DNA quadruplexes

Also Published As

Publication number Publication date
US20030040525A1 (en) 2003-02-27
US6623930B2 (en) 2003-09-23
US20040229894A1 (en) 2004-11-18
US20020107258A1 (en) 2002-08-08
ATE244241T1 (de) 2003-07-15
WO1999040087A2 (en) 1999-08-12
US6689887B2 (en) 2004-02-10
US6156763A (en) 2000-12-05
EP1053237B1 (de) 2003-07-02
EP1053237A2 (de) 2000-11-22
WO1999040087A3 (en) 1999-11-11
AU2494799A (en) 1999-08-23

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Legal Events

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