ATE244241T1 - Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung - Google Patents

Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung

Info

Publication number
ATE244241T1
ATE244241T1 AT99904571T AT99904571T ATE244241T1 AT E244241 T1 ATE244241 T1 AT E244241T1 AT 99904571 T AT99904571 T AT 99904571T AT 99904571 T AT99904571 T AT 99904571T AT E244241 T1 ATE244241 T1 AT E244241T1
Authority
AT
Austria
Prior art keywords
telomerase
inhibition
quadruplex
human telomerase
human
Prior art date
Application number
AT99904571T
Other languages
English (en)
Inventor
Sean M Kerwin
Oleg Y Fedoroff
Miguel Salazar
Laurence H Hurley
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE244241T1 publication Critical patent/ATE244241T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
AT99904571T 1998-02-04 1999-02-04 Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung ATE244241T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7362998P 1998-02-04 1998-02-04
PCT/US1999/002353 WO1999040087A2 (en) 1998-02-04 1999-02-04 Inhibition of human telomerase by a g-quadruplex-interaction compound

Publications (1)

Publication Number Publication Date
ATE244241T1 true ATE244241T1 (de) 2003-07-15

Family

ID=22114844

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904571T ATE244241T1 (de) 1998-02-04 1999-02-04 Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung

Country Status (6)

Country Link
US (4) US6156763A (de)
EP (1) EP1053237B1 (de)
AT (1) ATE244241T1 (de)
AU (1) AU2494799A (de)
DE (1) DE69909246D1 (de)
WO (1) WO1999040087A2 (de)

Families Citing this family (40)

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US6156763A (en) * 1998-02-04 2000-12-05 Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
FR2801588B1 (fr) * 1999-11-29 2002-03-01 Aventis Pharma Sa Derives chimiques et leur application comme agent antitelomerase
YU38102A (sh) * 1999-11-29 2004-12-31 Aventis Pharma S.A. Derivati arilamina i njihova primena kao antitelomerazno sredstvo
AU2001282268A1 (en) * 2000-08-08 2002-02-18 Aventis Pharma S.A. Phenantridine derivatives and their use as anti-telomerase agent
FR2821355A1 (fr) * 2001-02-23 2002-08-30 Aventis Pharma Sa Derives chimiques et leur application comme agent antitelomerase
US6887873B2 (en) 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6753411B2 (en) 2001-03-26 2004-06-22 The Regents Of The University Of Colorado Protection-of-telomere-1 (POT-1) proteins
AU2002314252A1 (en) * 2001-05-28 2002-12-09 Aventis Pharma S.A. Chemical derivatives and the use thereof as an anti-telomerase agent
CA2481339A1 (en) * 2002-04-05 2003-10-23 Cyternex, Inc. Methods for targeting quadruplex dna
EP1539154A2 (de) * 2002-08-20 2005-06-15 The Arizona Board Of Regents, On Behalf Of The University Of Arizona Verfahren zur regulierung der transkription durch targeting von quadruplex-dna
EP1587821B1 (de) 2002-12-19 2008-08-20 The Scripps Research Institute Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
US7781163B2 (en) * 2003-01-08 2010-08-24 Lesley Davenport G-quadruplex binding assays and compounds therefor
US20050113324A1 (en) * 2003-01-15 2005-05-26 Bondarev Igor E. Modulation of line-1 reverse transcriptase
US20040180345A1 (en) * 2003-03-14 2004-09-16 Ingeneus Corporation Pre-incubation method to improve signal/noise ratio of nucleic acid assays
EP1673478A4 (de) * 2003-10-14 2007-08-22 Cylene Pharmaceuticals Inc Kompetitionsassay zur identifizierung von modulatoren von quadruplex-nukleinsäuren
US6979738B2 (en) * 2003-10-22 2005-12-27 Academia Sinica Quadruplex stabilizer
US20050249669A1 (en) * 2003-10-22 2005-11-10 Academia Sinica Quadruplex stabilizer
US7691624B2 (en) * 2003-10-22 2010-04-06 Academia Sinica Cancer cell detecting devices
WO2005049867A1 (en) * 2003-11-17 2005-06-02 Cylene Pharmaceuticals, Inc. Methods for identifying modulators of quadruplex nucleic acids
WO2005089094A2 (en) * 2003-11-21 2005-09-29 The Board Of Regents Of The University And Community College System Of Nevada Materials and methods for the preparation of anisotropically-ordered solids
EP2314584A1 (de) 2004-05-20 2011-04-27 Foldrx Pharmaceuticals, Inc. 2-(heteroaryl)-Benzoxazol-Verbindungen und Derivate, Zusammensetzungen und Verfahren zur Stabilisierung von Transthyretin und zur Hemmung von Transthyretin-Fehlfaltung
US20080119492A1 (en) * 2005-07-29 2008-05-22 Jean-Marie Lehn Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation
US20100249175A1 (en) * 2005-12-02 2010-09-30 Wilson W David Dicationic compounds which selectively recognize G-quadruplex DNA
KR100833492B1 (ko) * 2005-12-08 2008-05-29 한국전자통신연구원 핵산 나노구조체 및 그의 제조 방법
US8481529B2 (en) * 2006-05-16 2013-07-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Combination cancer chemotherapy
EP2074223A4 (de) * 2006-09-15 2010-03-10 Foldrx Pharmaceuticals Inc Testverfahren zum nachweis von proteinen im nativen zustand und zur identifizierung von die stabilität von proteinen im nativen zustand modulierenden verbindungen
ITRM20070209A1 (it) * 2007-04-12 2008-10-13 Univ Roma Derivati coronenici idrosolubili attivi come inibitori della telomerasi umana mediante induzione di strutture g-quadruplex e loro uso come agenti antitumorali.
WO2009051796A2 (en) * 2007-10-17 2009-04-23 The University Of North Carolina At Chapel Hill 2,5-diaryl selenophene compounds, aza 2,5-diaryl thiophene compounds, and their prodrugs as antiprotozoal agents
US8377992B2 (en) 2007-10-22 2013-02-19 The Wistar Institute TRBD-binding effectors and methods for using the same to modulate telomerase activity
JP2011500087A (ja) * 2007-10-22 2011-01-06 ザ ウィスター インスティテュート テロメラーゼ活性を調節する化合物の同定方法
PT3029154T (pt) * 2008-10-17 2017-12-06 Geron Corp Método para identificação de sensibilidade de um paciente à terapia de inibição da telomerase
JP5869677B2 (ja) 2011-09-16 2016-02-24 ファイザー・インク トランスサイレチン解離阻害剤の固体形態
CN103910727B (zh) * 2012-12-31 2016-06-15 北京大学 STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用
CN103497154A (zh) * 2013-08-12 2014-01-08 北京化工大学 一种水溶性苝酰亚胺类化合物及其作为dna嵌插剂和在抑制癌细胞生长中的应用
WO2017142609A2 (en) * 2015-12-02 2017-08-24 University Of Utah Research Foundation Chemical self-doping of one-dimensional organic nanomaterials for high conductivity application in chemiresistive sensing gas or vapor
CN105842287B (zh) * 2016-03-16 2019-01-01 济南市农业科学研究院 用于检测二氧化氮的纳米材料及气敏传感器元件
CN110237076A (zh) * 2019-07-29 2019-09-17 河南大学 PDINCl在制备抗肿瘤药物中的应用
US20210333284A1 (en) * 2020-04-28 2021-10-28 Purdue Research Foundation Methods and materials for large-scale assessment of ligand binding selectivity of g-quadruplex recognition using custom g4 microarrays
CN112521388B (zh) * 2020-12-30 2021-11-09 河南大学 一种苝酰亚胺衍生物及应用
CN112724137B (zh) * 2021-01-19 2021-10-26 河南大学 一种苝酰亚胺衍生物及其制备方法和应用

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DD299733A7 (de) * 1980-12-23 1992-05-07 Bitterfeld Chemie Verfahren zur herstellung von schwarzen tarnpigmenten
JP3362865B2 (ja) * 1991-03-21 2003-01-07 クラリアント・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング ペリレン化合物の分子内塩、その製造方法およびその用途
DE4225357A1 (de) * 1992-07-31 1994-02-03 Basf Ag Glanzpigmente auf Basis mit extern basischen, organischen Farbmitteln beschichteter, plättchenförmiger Substrate
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5920429A (en) * 1995-09-29 1999-07-06 Minnesota Mining And Manufacturing Company Fluorescent dye blends
US5672643A (en) * 1995-09-29 1997-09-30 Minnesota Mining And Manufacturing Company Fluorescent dye blends
AU6650198A (en) * 1997-02-05 1998-08-25 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
US6166210A (en) * 1997-12-15 2000-12-26 Ciba Specialty Chemicals Corporation Perylene imide monocarboxylic acids
US6156763A (en) * 1998-02-04 2000-12-05 Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
AU2657499A (en) * 1998-02-04 1999-08-23 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
US6492117B1 (en) * 2000-07-12 2002-12-10 Gendaq Limited Zinc finger polypeptides capable of binding DNA quadruplexes

Also Published As

Publication number Publication date
US20030040525A1 (en) 2003-02-27
US20020107258A1 (en) 2002-08-08
EP1053237B1 (de) 2003-07-02
US6623930B2 (en) 2003-09-23
US6689887B2 (en) 2004-02-10
EP1053237A2 (de) 2000-11-22
US6156763A (en) 2000-12-05
US20040229894A1 (en) 2004-11-18
WO1999040087A2 (en) 1999-08-12
AU2494799A (en) 1999-08-23
WO1999040087A3 (en) 1999-11-11
DE69909246D1 (de) 2003-08-07

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