DE69908909D1 - Verfahren zur herstellung von simvastatin und ihren derivaten - Google Patents

Verfahren zur herstellung von simvastatin und ihren derivaten

Info

Publication number
DE69908909D1
DE69908909D1 DE69908909T DE69908909T DE69908909D1 DE 69908909 D1 DE69908909 D1 DE 69908909D1 DE 69908909 T DE69908909 T DE 69908909T DE 69908909 T DE69908909 T DE 69908909T DE 69908909 D1 DE69908909 D1 DE 69908909D1
Authority
DE
Germany
Prior art keywords
protecting group
formula
derivatives
diol lactone
iia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69908909T
Other languages
English (en)
Other versions
DE69908909T2 (de
Inventor
Silvo Zupancic
Anton Stimac
Joze Gnidovec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KRKA dd
Original Assignee
KRKA Tovarna Zdravil dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KRKA Tovarna Zdravil dd filed Critical KRKA Tovarna Zdravil dd
Application granted granted Critical
Publication of DE69908909D1 publication Critical patent/DE69908909D1/de
Publication of DE69908909T2 publication Critical patent/DE69908909T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69908909T 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten Expired - Lifetime DE69908909T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov
PCT/SI1999/000006 WO1999043665A1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof

Publications (2)

Publication Number Publication Date
DE69908909D1 true DE69908909D1 (de) 2003-07-24
DE69908909T2 DE69908909T2 (de) 2003-12-04

Family

ID=20432210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69908909T Expired - Lifetime DE69908909T2 (de) 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten

Country Status (18)

Country Link
US (1) US6252091B1 (de)
EP (1) EP1056737B1 (de)
AT (1) ATE243207T1 (de)
AU (1) AU3284699A (de)
BG (1) BG64826B1 (de)
CZ (1) CZ297405B6 (de)
DE (1) DE69908909T2 (de)
EA (1) EA002370B1 (de)
EE (1) EE04345B1 (de)
HR (1) HRP20000467B1 (de)
HU (1) HU227916B1 (de)
NO (1) NO326301B1 (de)
PL (1) PL194713B1 (de)
RS (1) RS49712B (de)
SI (1) SI9800057A (de)
SK (1) SK284137B6 (de)
UA (1) UA56303C2 (de)
WO (1) WO1999043665A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
HUP0103021A3 (en) * 1998-12-10 2002-04-29 Kaneka Corp Process for producing simvastatin derivatives
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
AU8298101A (en) 2000-07-27 2002-02-13 Teva Pharma Highly purified simvastatin compositions
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
SK285772B6 (sk) * 2002-11-20 2007-08-02 Zentiva, A. S. Spôsob prípravy simvastatínu
CN102070587B (zh) * 2011-01-13 2015-10-14 广东东阳光药业有限公司 一锅法制备辛伐他汀的方法
CA2944989A1 (en) 2013-04-08 2014-10-16 Cytodyn Inc. Felinized antibodies and methods of treating retroviral infections in felines
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途
CN104356120B (zh) * 2014-10-17 2017-05-03 上海应用技术学院 多取代喹啉类他汀内酯脱水化合物及其用途
CN105111173B (zh) * 2015-06-26 2017-06-23 上海应用技术学院 他汀含氟衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60219A (en) 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4845237A (en) * 1987-04-15 1989-07-04 Merck & Co., Inc. Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
CA2036962C (en) 1990-02-26 1998-09-15 Ann E. Decamp Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI9500238A (en) 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin

Also Published As

Publication number Publication date
HUP0100743A3 (en) 2002-04-29
NO326301B1 (no) 2008-11-03
SK12582000A3 (sk) 2002-01-07
ATE243207T1 (de) 2003-07-15
CZ297405B6 (cs) 2006-12-13
EP1056737B1 (de) 2003-06-18
NO20004221L (no) 2000-08-23
HUP0100743A2 (hu) 2001-11-28
EA002370B1 (ru) 2002-04-25
SK284137B6 (sk) 2004-09-08
BG104749A (en) 2001-04-30
EA200000881A1 (ru) 2001-02-26
AU3284699A (en) 1999-09-15
EE200000479A (et) 2002-02-15
RS49712B (sr) 2007-12-31
PL194713B1 (pl) 2007-06-29
US6252091B1 (en) 2001-06-26
BG64826B1 (bg) 2006-05-31
YU46600A (sh) 2003-12-31
HU227916B1 (en) 2012-06-28
UA56303C2 (uk) 2003-05-15
HRP20000467B1 (en) 2009-02-28
EP1056737A1 (de) 2000-12-06
EE04345B1 (et) 2004-08-16
PL342511A1 (en) 2001-06-18
NO20004221D0 (no) 2000-08-23
DE69908909T2 (de) 2003-12-04
SI9800057A (sl) 1999-08-31
CZ20002857A3 (cs) 2000-11-15
WO1999043665A1 (en) 1999-09-02
HRP20000467A2 (en) 2001-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition