DE69905938D1 - Kombination von duloxetin mit nichtsteroid-entzündungshemmern für die behandlung von schmerz - Google Patents
Kombination von duloxetin mit nichtsteroid-entzündungshemmern für die behandlung von schmerzInfo
- Publication number
- DE69905938D1 DE69905938D1 DE69905938T DE69905938T DE69905938D1 DE 69905938 D1 DE69905938 D1 DE 69905938D1 DE 69905938 T DE69905938 T DE 69905938T DE 69905938 T DE69905938 T DE 69905938T DE 69905938 D1 DE69905938 D1 DE 69905938D1
- Authority
- DE
- Germany
- Prior art keywords
- pain
- duloxetin
- treatment
- combination
- inflammatory inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Processing Of Meat And Fish (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10837098P | 1998-11-13 | 1998-11-13 | |
PCT/US1999/026655 WO2000028980A2 (en) | 1998-11-13 | 1999-11-10 | Combination of duloxetine with non-steroidal antiinflammatory drug for treating pain |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69905938D1 true DE69905938D1 (de) | 2003-04-17 |
DE69905938T2 DE69905938T2 (de) | 2003-11-13 |
Family
ID=22321828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69905938T Expired - Fee Related DE69905938T2 (de) | 1998-11-13 | 1999-11-10 | Kombination von duloxetin mit nichtsteroid-entzündungshemmern für die behandlung von schmerz |
Country Status (9)
Country | Link |
---|---|
US (1) | US6245802B1 (de) |
EP (1) | EP1135121B1 (de) |
JP (1) | JP2002529499A (de) |
AT (1) | ATE234090T1 (de) |
AU (1) | AU1718400A (de) |
CA (1) | CA2350531A1 (de) |
DE (1) | DE69905938T2 (de) |
ES (1) | ES2194536T3 (de) |
WO (1) | WO2000028980A2 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US6586458B1 (en) * | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
WO2001078721A1 (en) * | 2000-04-13 | 2001-10-25 | Mayo Foundation For Medical Education And Research | Aβ42 LOWERING AGENTS |
AR035642A1 (es) * | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
US8680081B2 (en) * | 2000-08-29 | 2014-03-25 | Peter Van Patten | Prophylactic treatment of migraine |
CA2420576C (en) | 2000-08-29 | 2005-06-14 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
US6528076B2 (en) | 2001-07-06 | 2003-03-04 | Magic Herb Corp. | Topical compositions and methods for treating pain |
US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
PT1485078E (pt) * | 2002-03-15 | 2013-01-14 | Cypress Bioscience Inc | Milnacipran para o tratamento do síndrome do intestino irritável |
US20030232805A1 (en) * | 2002-04-24 | 2003-12-18 | Cypress Bioscience, Inc. | Prevention and treatment of functional somatic disorders, including stress-related disorders |
US20100189797A1 (en) * | 2002-06-10 | 2010-07-29 | Julien Mendlewicz | Oral antidepressant formulation |
WO2005039545A1 (en) * | 2003-10-29 | 2005-05-06 | Philippe Kriwin | Oral antidepressant formulation comprising acetylsalicylic acid to accelerate onset of action |
WO2003103643A1 (en) | 2002-06-10 | 2003-12-18 | Philippe Kriwin | Oral antidepressant formulation comprising a selective serotonin_reuptake inhibitor |
US20040235925A1 (en) * | 2002-12-17 | 2004-11-25 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
US7332183B2 (en) * | 2002-12-26 | 2008-02-19 | Pozen Inc. | Multilayer dosage forms containing NSAIDs and triptans |
EP1603548A4 (de) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | Verfahren und zusammensetzung zur behandlung neurodegenerativer erkrankungen |
US20070184109A1 (en) * | 2003-06-06 | 2007-08-09 | Floyd Alison G | Compositions comprising triptans and nsaids |
US20050042284A1 (en) * | 2003-07-11 | 2005-02-24 | Myriad Genetics, Incorporated | Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease |
WO2005051378A1 (en) * | 2003-11-21 | 2005-06-09 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
AU2005241023A1 (en) * | 2004-04-29 | 2005-11-17 | Keystone Retaining Wall Systems, Inc. | Veneers for walls, retaining walls and the like |
HUE028632T2 (en) | 2004-06-28 | 2016-12-28 | Univ Western Australia | To skip an antisense oligonucleotide exon and use it for procedures |
US7932366B2 (en) | 2004-07-07 | 2011-04-26 | Biocon Limited | Synthesis of azo bonded immunoregulatory compounds |
CA2618985A1 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
US8093408B2 (en) * | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
US8153824B2 (en) * | 2005-06-22 | 2012-04-10 | The Wockhardt Company | Antidepressant oral liquid compositions |
US20070116643A1 (en) * | 2005-07-01 | 2007-05-24 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
KR20080039876A (ko) * | 2005-07-22 | 2008-05-07 | 미리어드 제네틱스, 인크. | 높은 약물 충진 제형 및 투여형 |
US20060165776A1 (en) * | 2005-08-31 | 2006-07-27 | Ramesh Sesha | Antidepressant oral pharmaceutical compositions |
WO2007062119A1 (en) * | 2005-11-23 | 2007-05-31 | Auspex Pharmaceuticals, Inc. | Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity |
EP2016066A4 (de) * | 2006-05-10 | 2010-11-24 | Reddys Lab Ltd Dr | Verfahren zur herstellung von duloxetin |
US20080033045A1 (en) * | 2006-07-07 | 2008-02-07 | Myriad Genetics, Incorporated | Treatment of psychiatric disorders |
WO2008009665A1 (en) * | 2006-07-19 | 2008-01-24 | Boehringer Ingelheim International Gmbh | Treatment of pain |
US20090162421A1 (en) * | 2007-12-21 | 2009-06-25 | Paz Arzneimittel-Entwicklungsgesellschaft Mbh | Drugs as well as their production and use in the treatment of pain-associated neuropathies |
ATE526015T1 (de) * | 2007-12-21 | 2011-10-15 | Horizon Pharma Ag | Arzneimittel sowie deren herstellung und verwendung bei der behandlung von schmerzhaften neuropathien |
EP2123626A1 (de) * | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Duloxetin-Kokristalle und Kokristallbildner für Schmerzbehandlung |
TR201902952T4 (tr) | 2008-10-24 | 2019-03-21 | Sarepta Therapeutics Inc | Dmd için ekson atlama bileşimleri. |
KR20230137491A (ko) | 2009-11-12 | 2023-10-04 | 더 유니버시티 오브 웨스턴 오스트레일리아 | 안티센스 분자 및 이를 이용한 질환 치료방법 |
EP2332930A1 (de) * | 2009-11-23 | 2011-06-15 | Laboratorios Del. Dr. Esteve, S.A. | Salze von Duloxetin und NSAIDs zur Behandlung von Schmerz |
EP2663187B1 (de) | 2011-01-11 | 2016-06-01 | Signature Therapeutics, Inc. | Zusammensetzungen mit einem enzymspaltbaren oxycodon-prodrug |
US8685916B2 (en) * | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
EP2683394B1 (de) | 2011-03-09 | 2021-01-06 | Signature Therapeutics, Inc. | Wirkstoff-prodrugs mit heterocyclischen linkern |
US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
RU2506077C1 (ru) * | 2013-01-25 | 2014-02-10 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Комбинация для профилактики, коррекции и терапии боли, связанной с нейродегенерацией или ассоциированной с соматоформными расстройствами |
CN117844807A (zh) | 2013-03-14 | 2024-04-09 | 萨勒普塔医疗公司 | 用于治疗肌营养不良的外显子跳跃组合物 |
EP3662912A1 (de) | 2013-03-15 | 2020-06-10 | Sarepta Therapeutics, Inc. | Verbesserte eteplirsen dosierungen zur behandlung von duchenne muskeldystrophie |
TWI816417B (zh) | 2013-12-24 | 2023-09-21 | 維吉尼亞聯邦大學 | 氧化膽固醇硫酸鹽(ocs)之用途 |
CN114404409A (zh) * | 2022-02-23 | 2022-04-29 | 江苏海洋大学 | 一种可治疗疼痛的药物组合及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2250042A1 (en) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Treating pain using a synergistic combination of an atypical antipsychotic and a drug used in treatment of pain |
AU6966998A (en) * | 1997-04-11 | 1998-11-11 | Eli Lilly And Company | Composition for treating pain |
AU7247898A (en) * | 1997-04-11 | 1998-11-11 | Eli Lilly And Company | Composition for treating pain |
US5942530A (en) * | 1997-08-28 | 1999-08-24 | Eli Lilly And Company | Method for treating pain |
-
1999
- 1999-11-10 ES ES99960277T patent/ES2194536T3/es not_active Expired - Lifetime
- 1999-11-10 JP JP2000582028A patent/JP2002529499A/ja not_active Withdrawn
- 1999-11-10 DE DE69905938T patent/DE69905938T2/de not_active Expired - Fee Related
- 1999-11-10 CA CA002350531A patent/CA2350531A1/en not_active Abandoned
- 1999-11-10 AU AU17184/00A patent/AU1718400A/en not_active Abandoned
- 1999-11-10 WO PCT/US1999/026655 patent/WO2000028980A2/en active IP Right Grant
- 1999-11-10 EP EP99960277A patent/EP1135121B1/de not_active Expired - Lifetime
- 1999-11-10 AT AT99960277T patent/ATE234090T1/de not_active IP Right Cessation
- 1999-11-11 US US09/438,191 patent/US6245802B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1135121B1 (de) | 2003-03-12 |
CA2350531A1 (en) | 2000-05-25 |
AU1718400A (en) | 2000-06-05 |
JP2002529499A (ja) | 2002-09-10 |
WO2000028980A3 (en) | 2000-07-27 |
US6245802B1 (en) | 2001-06-12 |
ATE234090T1 (de) | 2003-03-15 |
DE69905938T2 (de) | 2003-11-13 |
ES2194536T3 (es) | 2003-11-16 |
WO2000028980A2 (en) | 2000-05-25 |
EP1135121A2 (de) | 2001-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |